共查询到20条相似文献,搜索用时 0 毫秒
1.
General methods for the preparation of a variety of pyridone and oxypyridine derivatives are described. 2‐,3‐,4‐Hydroxy pyridine and 2‐pyridinemethanol were alkylated with ethylene‐, propylene‐, and stryrene‐oxide and epichlorohydrin in the presence of different Lewis acids as a catalyst. The best yield of 3a was achieved in the presence of CdI2/BF3 · OEt2. The corresponding pyridone derivatives (3a–d, 7a–d) were obtained from the reaction of 2‐and 4‐hydroxypyridine with oxiranes in good yields, whereas oxypyridine derivatives (5a–d, 9a,b) were obtained from reactions of 3‐hydroxypyridine and 2‐pyridinemethanol with oxiranes. Chlorohydrines (3d, 5d, 7d) were easily converted to corresponding epoxy derivatives (10, 11, 12) in basic medium; then amino alcohols (13–17) were obtained from the reaction of these epoxy derivatives with amines. 相似文献
2.
Mohammad Ghafarzadeh Ebrahim Saeedian Moghadam Fereshteh Faraji 《Journal of heterocyclic chemistry》2013,50(4):754-757
Dibenzo[b,f][1,4]oxazepine derivatives were synthesized in good yields and short reaction times by the reaction of 2‐chlorobenzaldehydes and 2‐aminophenoles in basic conditions under microwave irradiation. 相似文献
3.
在微波促进下, 利用酮糖(1)及糖酸内酯(4)与叶立德(2, Ph3PCHCOOEt)的Wittig反应, 立体选择性地合成了糖基烯丙酸酯类化合物(3和5), 反应效率显著提高, 反应时间由原来的20 h缩短为10 min; 并且研究了不同反应溶剂对反应立体选择性的影响. 提供了一种高效、 简便合成含有烯丙酸酯类高碳糖衍生物的方法. 相似文献
4.
Adam Sobczak 《合成通讯》2013,43(23):2993-3001
The reaction of diethyl aminomethylenemalonate with ethyl acetoacetate proceeded, when catalyzed by anhydrous hydrogen chloride, toward a respectively substituted α‐ instead of γ‐pyridone derivative formation, contrary to the literature report. Additionally, it was found that the amine used as a starting component in this reaction showed a great tendency to autocondensation under the influence of anhydrous hydrogen chloride to yield 5‐ethoxycarbonyl‐2‐pyridone. The most convenient method to prepare 4‐pyridone 2,3‐disubstituted derivative appeared to be a three‐step synthesis, starting from a chain enamine formation, which was subjected to cyclization, followed by oxidation of the last intermediate. The usefulness of the stepwise synthesis was demonstrated on the 3‐ethoxycarbonyl‐2‐methyl‐4‐pyridone preparation as an example. 相似文献
5.
Y. A. Ammar A. M. Sh. El‐Sharief A. G. Al‐Sehemi Y. A. Mohamed M. A. Senussi M. S. A. El‐Gaby 《中国化学会会志》2005,52(3):553-558
Ketene dithioacetal 3 , aminopyrazole 5 , tetrazine 7 , benzoazole 9 and pyridone 11 , 12 , 13 and 16 derivatives were prepared from cyanoacetanilide 1 as a starting material. 相似文献
6.
N. Foroughifar A. Mobinikhaledi H. FathinejadJirandehi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):1241-1246
Pyrimidine derivatives, 4a-4m , were synthesized in high yield using a newly developed microwave-assisted cyclocondensation reaction of g -ketoester, aryl aldehyde, and (thio)urea. In all of these Biginelli reactions, a mixture of the appropriate g -ketoester, aryl aldehyde, and (thio)urea were subjected to microwave irradiation by using polyphosphate ester (PPE) as a reaction moderator. 1 H NMR and IR spectroscopies were used for characterization of compounds 4a-4m . 相似文献
7.
8.
以巯基丙酸(MPA)为稳定剂, 利用微波辐射加热方法制备了水溶性的Cu掺杂的ZnS纳米晶. 通过改变微波条件, 可以在460~572 nm之间实现对ZnS∶Cu纳米晶发射峰位的连续调控. 通过XRD、 UV-Vis、荧光及荧光衰减对ZnS∶Cu纳米晶的结构和发光性质进行了详细探索, 并利用时间分辨荧光光谱对其发光机理进行了初步研究. 相似文献
9.
An efficient and a quick microwave‐assisted synthesis of benzimidazoles and trisubstituted imidazoles was developed. Three benzimidazoles were obtained as a result of the condensation of 1,2‐phenylenediamine with carboxylic acids and acetoacetic ester without catalyst. A series of trisubstituted imidazoles were synthesized by condensation of benzil, aromatic aldehyde and ammonium acetate in the presence of glacial acetic acid. 相似文献
10.
11.
Microwave assisted synthesis of 1-acetyl-2-benzylpyrrolidine-2-carboxylic acid and its derivatives has been developed with highly encouraging yields. 2-Benzyl-tert-butylpyrrolidine-1,2-dicarboxylate is used as an initial compound in the four steps synthesis of the target compounds. Structures of the products 5a–5h have been confirmed by spectroscopic methods. According to antimicrobial tests 1-acetyl-2-benzylpyrrolidine-2-carboxamide 5c is determined to be the most potent product. 相似文献
12.
A simple, straightforward method to synthesize 2,9-dicarbanitrile-1, 10-phenanthroline from 2,9-dimethyl-1, 10-phenanthroline via 2,9-dicarbamoyl-1, 10-phenanthroline is described. 相似文献
13.
Hyperglycemia is frequently accompanying with hyperlipidemia. To explore the potent drugs with dual-activity and dual-site effects that could reduce blood glucose and blood lipid at the same time, fibrate group with lipid-lowering effect on the 9th position of berberine(BBR) was introduced using the drug design combination principle and the multi-target collaborative treatment method. Moreover, the molecular structure of BBR was modified, and six 9-substituted derivatives of BBR were designed and synthesized, among which, five compounds have never been reported before. In addition, the molecular structures of these derivatives were identified using liquid chromatography-mass spectrometry(LC-MS), 1H nuclear magnetic resonance(1H NMR) and 13C NMR, respectively. Furthermore, the microwave irradiation experimental technique was applied in the synthesis reaction using the novel microwave synthesizer, which accelerated the reaction rate, enhanced the reaction yield, reduced the reaction by-products, and simplified the post-processing steps. In the meantime, the 9-position regioselective demethylation of BBR was explored through quantum chemical calculation during the synthesis of berberrubine. The computations were consistent with the experimental results, which contributed to deducing the mechanism of its selective methylation. 相似文献
14.
JIANG Zhenlei LIU Jie ZHOU Fan ZHANG Jianrun LIU Zhijun ZHANG Chao CHEN Heru 《高等学校化学研究》2018,34(6):918-922
An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid(DMXAA) was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation. 相似文献
15.
《合成通讯》2013,43(15):2599-2604
Abstract 2,4,6-Triarylamino-1,3,5-triazines was synthesized in a few minutes by reaction of cyanuric chloride with aromatic amines under microwave irradiation. This method is featured with rapid reaction, convenient operation, high yield, and clean. UV-absorption was tested for each compound. 相似文献
16.
17.
M. M. Sidky M. R. Mahran A. A. El-kateb I. T. Hennawy 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):409-412
Abstract Trialkyl phosphites react with quinisatin (1) and its monohydrate 3 to give the corresponding phosphate derivatives 2a-c. The same compounds are obtained upon reacting 1 and/or 3 with the proper dialkyl phosphite. Structural reasonings based on IR, MS and NMR spectral data, are presented. 相似文献
18.
Alapafuja SO Nikas SP Shukla VG Papanastasiou I Makriyannis A 《Tetrahedron letters》2009,50(50):7028-5332
We describe the use of a microwave reaction for the conversion of various bromides to sodium sulfonates that have been further elaborated to sulfonyl chlorides. This new approach leads to much improved yields and shorter reaction times. Representative sulfonyl chlorides serve as precursors for the respective sulfonyl fluorides that are potent inhibitors of the fatty acid amide hydrolase. 相似文献
19.
LINMin ZHOUJin-mei XIAHai-ping YANGRui-feng LINChen 《高等学校化学研究》2004,20(2):213-215
Several aryloxy acetic acids were synthesized under microwave irradiation. The factors, which affect the reaction, were investigated and optimized. It was revealed that the best yields(92. 7%--97.4%) were obtained when the molar ratio of the reactants was n(ArOH) : n(NaOH) : n(CICH2CO2H) = 1:2.5: 1.2 with microwave irradiation power of 640 W for 65--85 s. 相似文献
20.
Shadpour Mallakpour Abdol Reza Hajipour Hedayat A. Taghizadeh 《Monatshefte für Chemie / Chemical Monthly》2003,134(7):1015-1017
Summary. A rapid and simple method for the preparation of 4-substituted 1-ethoxycarbonyl semicarbazide is reported. The reaction is
carried out under microwave irradiation by the reaction of five different isocyanates with ethyl carbazate.
Corresponding author. E-mail: mallak@cc.iut.ac.ir
Previous name. Shadpour E. Mallakpour
Received October 28, 2002; accepted October 31, 2002
Published online May 15, 2003 相似文献