共查询到20条相似文献,搜索用时 10 毫秒
1.
Ivanova N. I. Reutskaya A. M. Gusarova N. K. Medvedeva S. A. Afonin A. V. Ushakov I. A. Tatarinova A. A. Trofimov B. A. 《Russian Journal of General Chemistry》2003,73(9):1354-1357
Nucleophilic addition of secondary phosphine oxides to aromatic aldehydes proceeds under mild conditions (20-60°C, 10-40 h) and provides [bis(2-organylethyl)](arylhydroxymethyl)phosphine oxides in high yields. 相似文献
2.
3.
Roger G. Hall Peter Riebli 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6-7):1557-1562
Phosphine oxide analogues of Triazole fungicides and protected Threonine have been prepared. The enzymatic hydrolysis of phosphine oxide di-acetates has been investigated. 相似文献
4.
Tetiana Krachko Volodymyr Lyaskovskyy Martin Lutz Koop Lammertsma J. Chris Slootweg 《无机化学与普通化学杂志》2017,643(14):916-921
Recently, Brønsted acids, such as phosphoric acids, carboxylic acids, and triflic acid, were found to catalyze the reduction of phosphine oxides to the corresponding phosphines. In this study, we fully characterize the HCl, HOTf, and Me2SiHOTf adducts of triphenylphosphine oxide and find that the thermally stable adduct Ph3POH+OTf– is efficiently converted into triphenylphosphine at 100 °C in the presence of readily available hydrosiloxanes. Under the same reaction conditions, also Ph3POSiMe2H+OTf– selectively affords triphenylphosphine indicating that silylated phosphine oxides are likely intermediates in this process. 相似文献
5.
The structures, energies, and natural atomic charges of 2-dimethylaminophenol oxide, 2-Me2N-(O)C6H4OH, and 2-dimethylphosphinylphenol, 2-Me2P(O)C6H4OH, in three different conformations were computed at the ab initio MP2/6-31G* level. Computed natural charges indicate distributions of electron density in amine oxides and phosphine oxides that are quite different from what is normally assumed on the basis of the formal charges in the usual representations of these compounds. The charges on nitrogen and phosphorus in these compounds are typically computed to be approximately zero on nitrogen and +2 on phosphorus, and the oxygen is considerably more negative in the phosphine oxide than in the amino oxide. Electronegativity differences thus play a larger role and formal charges a smaller one in determining atomic charges in these compounds than is generally believed. Despite the more negative oxygen in phosphine oxides, amine oxides are computed to be considerably more basic when participating in hydrogen bonding. Calculations treating the computed natural charges on these six conformations as point charges for classical approximations of the coulombic energies support the idea that the quantum mechanically computed relative energies are largely determined by coulombic interactions. 相似文献
6.
Katarzyna Sokolowska 《合成通讯》2014,44(20):2943-2954
This article describes efficient preparation of isomeric allyl phosphine oxides possessing a protected cyclohexanediol fragment. Their base-catalyzed interconversions are examined and reactions with the Grundmann ketone provide an adduct containing the rearranged vinyl phosphine oxide moiety, instead of 19-norvitamin D3 analogs, the expected products of the Horner–Wittig process. 相似文献
7.
The mechanism of the reduction of phosphine oxides by PhSiH3 was established on the basis of kinetic measurements and Density Functional Theory (DFT) calculations. In particular, it has been proved that the model reaction between tri‐n‐butylphosphine oxide and phenylsilane occurs via a nonpolar mechanism. The data presented herein allow prediction and verification of the applicability of the new reduction reagents and conditions for industrially attractive processes. 相似文献
8.
Prof. Dr. Chuanyong Wang Xiaobo Hu Cheng Xu Qiangqiang Ge Qingliang Yang Jianqi Xiong Prof. Dr. Wei-Liang Duan 《Angewandte Chemie (International ed. in English)》2023,62(15):e202300011
A general and mild nickel-catalyzed enantioselective C(sp2)−P cross-coupling for synthesizing P-stereogenic phosphine oxides has been developed. The asymmetric alkenylation/arylation of racemic secondary phosphine oxides with alkenyl/aryl bromides generated P-stereogenic phosphine oxides with high yields and enantioselectivities. Various functional groups were tolerated, and the applications of this method were demonstrated through late-stage functionalization and product transformations. 相似文献
9.
Kazantseva M. V. Timokhin B. V. Rokhin A. V. Blazhev D. G. Golubin A. I. Rybakova Ya. V. 《Russian Journal of General Chemistry》2001,71(8):1233-1235
The reaction of tertiary phosphine oxides with phosphorus oxychloride was found to give triorganylphosphonium dichlorophosphates R3PCl+PO2Cl2
- rather than phosphorylphosphonium salts R3P·OPOCl2. Mixtures of the reagents, called binary system, possess a considerable synthetic potential. They are capable of converting alcohols to the corresponding alkyl chlorides. 相似文献
10.
Pryadeina M. V. Kuzueva O. G. Burgart Ya. V. Saloutin V. I. 《Russian Journal of Organic Chemistry》2002,38(2):224-231
Fluorinated 3-oxoesters in reactions with benzaldehyde depending on conditions afford either 2-benzylidene-3-fluoroalkyl-3-oxoesters or 3,5-dialkoxycarbonyl-2,6-dihydroxy-2,6-difluoroalkyl-4-phenyltetrahydropyrans. The latter were also obtained by treating 3-oxoesters with 2-benzylidene-3-oxoesters. Pentafluorobenzoylacetate with benzaldehyde furnishes 3,5-diethoxycarbonyl-2-pentafluorophenyl-4-phenyl-7,8,9,10-tetrafluoro-4,5-dihydrobenzo[b]oxacin-6-one. 相似文献
11.
S. Varbanov T. Tosheva G. Borisov 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4)
Abstract In the poster presentation is reported the preparation of the new dimethyl(methylenoxyaryl)phosphine oxides via ZVilliamson reaction from dimethyl-chloromethyl-phoaphine oxide and sodium solts of the coresponding phenols: l-di-methylphosphinylmethylenoxy-4-methyl-2,6-bis(l,l -dimethylethyl)benzene; 1,3-bis(dimethylphosphinylmethylenOxy)benzene; 1,4-bis(dimethylphosphinylmethylenoxy)ben-zene; 1,3,5-tris(dimethylphosphinylmethylenoxy)benzene; 1,2,3-tris(dimethylphosphinylmethylenoxy~benzene; 2,2′-methylene-bia(6-tert-butyl-4-methyl-l-dimethyl-phosphinylmethylenoxybenzene); 2,2′-rnethylene-bis-(6-tert-butyl-4-ethyl-l-dimethylphosphinylmethyleno~-benzene) and 1,1,3-tris(5-tert-butyl-4-dimethylphoa-phinylmethylenoxy-2-methyl-phenyl)butan. 相似文献
12.
N. I. Ivanova N. K. Gusarova E. A. Nikitina S. A. Medvedeva M. L. Al'pert B. A. Trofimov 《Chemistry of Heterocyclic Compounds》2004,40(4):426-429
Nucleophilic addition of secondary phosphine oxides to furfural takes place under mild conditions and gives quantitative yields of 2-(diorganylphosphorylhydroxymethyl)furans, which are polyfunctional building blocks for organic synthesis and prospective amphiphilic ligands for the design of metal complex catalysts. 相似文献
13.
Sławomir Makowiec Janusz Rachon 《Phosphorus, sulfur, and silicon and the related elements》2013,188(4):941-955
The reaction of iodosylbenzene with >P(O)H type of acids (dialkyl phosphites, secondary phosphine oxides) was studied. The acids of >P(O)H type add to iodosylbenzene to yield intermediate 6 which in the aprotic solvents yields oxidation products, it means >P(O)OH acids and/or anhydride of >P(O)OP(O)< type. On the other hand if the reaction is performed in alcohol as a solvent in the presence of sodium alcoholate >P(O)OR ester is the major product. 相似文献
14.
《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(50):16205-16208
A new method for the iodine‐catalyzed reduction of phosphine oxides with phosphites at room temperature is reported. The mild reaction conditions, scalability, and simple purification requirements render it a method of choice for the large‐scale production and facile regeneration of a variety of phosphines. Mechanistic studies, supported by DFT calculations of the oxygen transfer between the starting phosphine oxide and the phosphite reagent, are also presented. Such transmutations of phosphorus species were previously unknown. 相似文献
15.
Shunsuke Kotani Masaharu Sugiura Makoto Nakajima 《Chemical record (New York, N.Y.)》2013,13(4):362-370
The development of enantioselective aldol reactions catalyzed by chiral phosphine oxides is described. The aldol reactions presented herein do not require the prior preparation of the masked enol ethers from carbonyl compounds as aldol donors. The reactions proceed through a trichlorosilyl enol ether intermediate, formed in situ from carbonyl compounds, which then acts as the aldol donor. Phosphine oxides activate the trichlorosilyl enol ethers to afford the aldol adducts with high stereoselectivities. This procedure was used to realize a directed cross‐aldol reaction between ketones and two types of double aldol reactions (a reaction at one/two α position(s) of a carbonyl group) with high diastereo‐ and enantioselectivities. 相似文献
16.
Bin Zhang Prof. Dr. Xiao-Ming Zhang Prof. Dr. Qing-Wei Zhang 《European journal of organic chemistry》2023,26(24):e202300265
Phosphine oxides and spirocyclic compounds are privileged molecules widely employed in a variety of catalytic transformations either as chiral ligands for metals or bifunctional organocatalysts. Herein, we developed a Pd-catalysed cross-coupling reaction to synthesize spirocyclic amino-phosphine oxides with a P-stereogenic centre which could serve as potential P*(O), N-ligands or organocatalysis. 相似文献
17.
Volkov P. A. Telezhkin A. A. Ivanova N. I. Khrapova K. O. Gusarova N. K. Trofimov B. A. 《Russian Journal of General Chemistry》2019,89(3):543-545
Secondary phosphine chalcogenides reacted with acridine under mild conditions according to the nucleophilic addition scheme to form 9-chalcogenophosphoryl-9,10-dihydroacridines.
相似文献18.
19.
T. Ya. Medved N. P. Nesterova M. I. Kabachnik A. N. Nesmeyanov 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3-4)
Abstract Dialkyl(diaryl)Carbamoylmethylphosphine oxides (I) were prepared by interaction of tervalent phosphorous acid esters with chloracetic amides: 相似文献
20.
The deoxygenation of a few diaryl‐phenylphosphine oxides, dimethyl‐phenylphosphine oxide, and 3‐methyl‐1‐phenyl‐3‐phospholene 1‐oxide was studied by phenylsilane, tetramethyldisiloxane (TMDS), and polymethylhydrosiloxane (PMHS) under conventional or microwave (MW) heating, in toluene or in the absence of any solvent at different temperatures. It was found that the deoxygenation with TMDS or PMHS under MW and solvent‐free conditions may be the method of choice and provides a green chemical approach. 相似文献