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1.
V. I. Terenin A. V. Borisov E. L. Ruchkina A. P. Pleshkova 《Chemistry of Heterocyclic Compounds》1999,35(2):211-215
We have synthesized a series of previously unreported azo dyes via the azo coupling of alkyl substituted dipyrrolopyrazines with aryldiazonium chloride. For this type of substrate where one or both -positions of the pyrrole rings of the molecules are not occupied by substituents, electrophilic attack was found to occur initially at carbon atom C(3).For communication 4 see [1]M. V. Lomonosov State University, Moscow 119899, Russia Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 236–240, February, 1999. 相似文献
2.
V. I. Terenin K. V. Karapetyan E. L. Ruchkina V. M. Mamaev Yu. G. Bundel' 《Chemistry of Heterocyclic Compounds》1995,31(11):1353-1359
The semiempirical quantum-chemical method PM3 has been used in a study of the electronic and spatial structure of dipyrrolo[l , 2-a; 2,1-cjpyrazines and 5,6-dihydrodipyrrolo[1,2-a; 2,1-cjpyrazines, and also their reactivities in electrophilic substitution reactions (protonation, acylation).M. V. Lomonosov Moscow State University, Moscow 119899 Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1559–1565, November, 1995. Original article submitted September 13, 1995 相似文献
3.
V. I. Terenin E. L. Ruchkina K. V. Karapetyan V. M. Mamaev Yu. G. Bundel' 《Chemistry of Heterocyclic Compounds》1995,31(11):1360-1366
A number of alkyl-substituted dipyrrolo[l,2-a; 2,1-cIpyrazines have been synthesized and investigated to determine their behavior in reactions of protonation, trifluoroacetylation, and acetylation. The experimental results correlate well with the calculated data in most cases.For communication 1, see [1].M. V. Lomonosov Moscow State University, Moscow 119899. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp, 1566–1572, November, 1995 Original article submitted September 13, 1995. 相似文献
4.
《Tetrahedron》2019,75(26):3657-3665
Novel diimidazo[1,2-a:5′,1′-c]quinoxaline derivatives were synthesized by a Pd-catalyzed intramolecular coupling reaction of 1,2-bis(2-iodo-1H-imidazol-1-yl)benzene. This method was applied to the selective introduction of an aryl substituent at the 10 position by the addition of a boronic ester. Moreover, a stepwise introduction of the aryl substituent could be achieved by the further coupling reaction at the 3 position. Focused on the optical properties, a more efficient substituent effect at the 10 position was obtained compared with the analogous structure, diimidazo[1,2-a:2′,1′-c]quinoxaline derivatives. In addition, we revealed that the diimidazo[1,2-a:5′,1′-c]quinoxaline skeleton potentially has an electron-donating character on the optical properties by introducing an electron-withdrawing substituent. 相似文献
5.
《Tetrahedron letters》2019,60(31):2070-2073
A series of 11-aryl-11H-indeno[1′,2′:4,5]imidazo[1,2-a]pyridines was obtained via AlCl3-promoted, dehydrative cyclization of the corresponding aryl(2-arylimidazo[1,2-a]pyridin-3-yl)methanols in moderate to good yields. The synthesized compounds can be considered as conformationally restricted, privileged aza-heterocyclic scaffold bearing triarylmethane analogs. 相似文献
6.
Russian Journal of General Chemistry - The 1,3-dipolar cycloaddition reaction of ethyl (Z)-2-(2-methoxy-2-oxoethylidene)-7-methyl-3-oxo-5-aryl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate... 相似文献
7.
A. V. Zadorozhny V. A. Kovtunenko A. V. Turov T. T. Kucherenko 《Chemistry of Heterocyclic Compounds》2008,44(7):845-851
Treatment of 2-(4-oxo-3,4-dihydrothieno[2,3-d]-and-[3,2-d]pyrimidin-2-ylmethyl)benzoic acids and 2-(4-oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic
acid with acetic anhydride gave thieno[3′,2′:5,6]-and-[2′,3′:5,6]pyrimido[1,2-b]isoquinoline-4,11-diones and isoquino[2,3-a]quinazoline-5,12-dione
respectively. NMR spectroscopy showed that an intramolecular acylation of the above acids occurs at the atom N-1 of the pyrimidinone
part of the bicycle.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1053–1061, July, 2008. 相似文献
8.
Korolev V. L. Toporov V. V. Merkulova N. L. Danilenko V. M. Ivshin V. P. Pivina T. S. 《Russian Chemical Bulletin》2017,66(11):2126-2130
N-Substituted imidazo[4,5-e]benzo[1,2-c;3,4-c’]difuroxans were synthesized by phase-transfer catalyzed alkylation of imidazo[4,5-e]benzo[1,2-c;3,4-c’]difuroxan salts with various alkylating agents. Acid hydrolysis of N-(ethoxycarbonylmethyl)imidazo[4,5-e]benzo-[1,2-c;3,4-c’]difuroxans gives the corresponding carboxylic acids. Structures of the synthesized compounds were confirmed by NMR spectroscopy, high resolution mass spectrometry, IR spectroscopy, and elemental anslysis.
相似文献9.
1-Phenyl-5-(benzotriazol-1-yl)hexahydro-1H-pyrrolo[1,2-a]?midazole (18) and 1-phenyl-5-benzotriazolyloctahydroimidazo[1,2-a]pyridine (27) were readily prepared from succindialdehyde or glutaraldehyde, benzotriazole, and N-phenylethylenediamine. Synthons 18 and 27 reacted with Grignard reagents, allylsilanes, silyl ethers, and triethyl phosphite to produce 1-phenyl-5-substituted-hexahydro-1H-pyrrolo[1,2-a]?midazoles 20a-f, 22, 24a,b, and 25 and 1-phenyl-5-substituted-octahydroimidazo[1, 2-a]pyridines 28a-e, 32, 33a,b, and 34 in good to excellent yields. The configurations of 20, 22, 24, and 25 were determined to be cis isomers by NOE experiment, while the configurations and conformations of 28a-e, 32, 33a,b, and 34 were elucidated by (1)H-(1)H COSY and (1)H-(13)C COSY. 相似文献
10.
V. A. Dorokhov M. F. Gordeev Z. K. Dem'yanets L. G. Vorontsova M. G. Kurella V. I. Andrianov O. A. Rekhlov 《Russian Chemical Bulletin》1991,40(11):2262-2266
3-Phenyl-5-methyl(phenyl)-1H,3H-pyrimido[4,5:4,5]pyrimido[1,2-a]benzimi-dazole-2,4-diones were obtained by the cyclization of N-phenyl-N-[3-ethoxycar-bonyl-4-methyl(phenyl)pyrimido [1,2-a]benzimidazol-2-yl]ureas by the action of potassium carbonate. 2-Methyl-5-phenyl-1H-pyrimido[4,5:4,5]pyrimido[1,2-a]benzimidazol-4-one was obtained by the reaction of N-3-ethoxycarbonyl-4-phenylpyrimido[1,2-a]benzimidazol-2-yl]-N,N-dimethylacetamidine with ammonium acetate in ethanol. The synthesized compounds are members of a new heterocyclic system. The molecular and crystal structure of the solvate of 3-phenyl-5-methyl-1H,3H-pyrimido[4,5:4,5] pyrimido[1,2-a]benzimidazole-2,4-dione with two molecules of DMF was studied by x-ray crystallographic analysis.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2587–2592, November, 1991. 相似文献
11.
An approach to the synthesis of derivatives of new heterocyclic system, pyrido[3′,2′:4,5]-furo[3,2-c]isoquinoline, was suggested. A condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation product with potassium tert-butoxide leads to substituted pyrido[3′,2′:4,5]furo[3,2-c]-isoquinolin-5(6H)-ones. Similarly, a condensation reaction of substituted 3-cyanopyridin-2(1H)-ones with 2-(chloromethyl)benzonitrile and subsequent treatment of the condensation product with potassium tert-butoxide gives substituted 5-aminopyrido[3′,2′:4,5]furo[3,2-c]-isoquinolines. 相似文献
12.
N. Z. Tugusheva S. Yu. Ryabova N. P. Solov'eva V. G. Granik 《Chemistry of Heterocyclic Compounds》1994,30(7):793-799
Alkylatio of 2-piperidinomethylene-2H-pyrrolo[1,2-a]indole-3,9-dione with dimethyl sulfate, followed by hydrolysis of the intermediate immonium salts. yielded 2-formyl derivatives, the reaction of which with substances possessing on active methylene unit leads to the formation of 2-substituted vinyl-3-oxo-9-alkoxypyrrolo[1,2-aindoles. Cyclization of the 9-methoxy derivative yielded a new heterocyclic system of 2-amino-3-cyano-5H-4,5-dihydropyrodol[32:4,5]pyrroloindoledione-4,11.Center for the Chemistry of Drugs, S. Ordzhonikidze All-Russian Scientific Research Institute Moscow119021 Translated from Khimiya Geterotsiklicheskikh Soedinenii.No. 8, pp, 919–925, August, 1994. Orginally article submitted June 22, 1994. 相似文献
13.
Russian Journal of General Chemistry - The 1,3-dipolar cycloaddition reaction of (Z)-1-aryl-2-(11H-indeno[1,2-b]quinoxalin-11-ylidene)ethan-1-one with generated in situ azomethine ylide leads to... 相似文献
14.
15.
V. A. Artemov V. L. Ivanov A. V. Koshkarov A. M. Shestopalov V. P. Litvinov 《Chemistry of Heterocyclic Compounds》1998,34(1):96-101
Pyrido[3,2:4,5]thieno[2,3-c]cinnolines, new heterocyclic compounds, were obtained in three steps: 1) alkylation of 3-cyanopyridine-2(1H)-thiones by o-nitrobenzyl bromide to give 2-(o-nitrobenzyl)thio-3-cyanopyridines, 2) closure of the thiophene ring in these intermediates to give 3-amino-2-(o-nitrophenyl)thieno[2,3-b]pyridines, and 3) closure of the pyridazine ring by condensation of the amino and nitro groups in triethyl phosphite, leading to the final heterocyclic system.N. D. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 117913 Moscow. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 104–109, January, 1998. 相似文献
16.
4-chloroquinoline-3-carboxylates 2 and 5-mercapto-1,2,4-triazoles 3 have been cyclised to a novel heterocyclic system 4 . 相似文献
17.
18.
Rajkumar Samala Ranadheer Kumar M Ashok Kumar Bapuram Venkatarathnam Nasipireddy Sirassu Narsimha 《Journal of heterocyclic chemistry》2024,61(4):600-610
In this study, we designed and synthesized several novel fused [1,2,3]triazolo [4′,5′:3,4]pyrrolo[1,2-a]thieno[2,3-d]pyrimidine derivatives using in a single [3 + 2] reaction cycloaddition reaction of 3-(3-iodoprop-2-yn-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one ( 4 ) followed by C-C bond coupling with various aryl azides in a PEG-400 medium. All of the newly synthesized compounds were evaluated in vitro for EGFR kinase inhibitory action as well as anti-breast cancer activity against MDA-MB-231 and MCF-7 breast cancer cell lines. When compared to the reference molecule, erlotinib, the majority of the compounds demonstrated adequate efficacy. The most promising compounds, 5g and 5i , demonstrated excellent anticancer activity against both cancer cell lines, with IC50 values ranging from 04.17 ± 0.55 to 8.65 ± 0.89 μM, respectively, as well as excellent kinase inhibitory activities (EGFR: IC50 = 0.467 ± 0.063 and 0.412 ± 0.081 μM). The in silico studies of five potent compounds 5f , 5g , 5h , 5i , and 5k were also carried out to identify the interactions against the EGFR receptor and found that the energy calculations were covenant with the obtained IC50 values. 相似文献
19.
L. G. Levkovskaya I. E. Mamaeva L. A. Serochkina T. S. Safonova 《Chemistry of Heterocyclic Compounds》1993,29(4):480-483
Representatives of new heterocyclic systems were obtained — pyrido[3,25,6][1,4]thiazino[3,4-c]- and pyrimido[5,45,6][1,4]thiazino[3,4-c][1,2, 4]triazines. Hydrazides of N-(pyrid-3-yl)- and N-(pyrimid-5-yl)oxamic acids were isolated and characterized. Their acylation products were investigated.For communication 45, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 559–562, April, 1993. 相似文献
20.
Dotsenko V. V. Lukina D. Yu. Buryi D. S. Strelkov V. D. Aksenov N. A. Aksenova I. V. 《Russian Journal of General Chemistry》2021,91(7):1292-1296
Russian Journal of General Chemistry - The reaction of partially saturated derivatives of 3-aminothieno[2,3-b]pyridine-2-carboxamide with phthalic anhydride in acetic acid or DMF on heating leads... 相似文献