Phospha-S-triazines. VIII. Chloro-substituted diphospha-S-triazines

1,3-Bis(phenylchlorophospha)-5-perfluoroalkyl-2,4,6- triazine and the corresponding perfluoroalkylether analogue were synthesized by interaction of equimolar amounts of the respective amidines and imido-diphenyl-diphosphinic acid pentachloride. With additional quantities of amidine, 1,3-bis(phenylperfluoro-$\text{n}$-octanoylamidinophospha)-5-perfluoro- $\text{n}$-heptyl-2,4,6-triazine was obtained. The replacement of the chloro- by azido-groups in 1,3-bis(phenylchlorophospha)-5- perfluoro-$\text{n}$-heptyl-2,4,6-triazine proceeded readily. The mass spectral breakdown patterns of the chloro- and the amidino- substituted compounds were directly comparable to those of the bis(diphenylphospha)-s-triazines.     

Phospha-S-triazines. VI. Polymeric systems

Two types of polymeric phospha-s-triazines were synthesized: poly(perfluoroalkylethermonophospha-s-triazines) and monocyclic mono- and diphospha-s-triazines substituted on the carbon ring atoms by poly- (perfluoroalkylether) chains. The polymeric system consisting of the monophospha-s-triazine rings joined by perfluoroalkylether chains were found to have lower thermal oxidative stability than that shown by the corresponding dumbbell compounds. The monocyclic materials substituted by poly(perfluoroalkylether) chains possessed good thermal and oxidative stability, in addition to exhibiting anticorrosive and antioxidative properties.     

Propargylic derivatives. IX. Propargyl-pyrrolidinols and propargyl-perhydro-azepinols and their esters

The authors describe the synthesis of 3-propargyl-pyrrolidin-3-ols and 4-propargylperhydro-azepin-4-ols, and their esters. The antitussive, analgetic, and local anesthetic activities as well as the respiration stimulative effect of these compounds are related.     

Synthesis of carboranyl derivatives of deuteroporphyrin IX

Carboranylporphyrins, which can be used in boron neutron-choture therapy of cancer, were prepared from natural deuteroporphyrin IX, 3-amino-o-carborate, and 9-hydroxymethyl-m-carborane. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2337–2339 December, 1999.     

Fused-s-triazino heterocycles IX. 1,3,4,6,9b-pentaazaphenalenes and 1,3,6,9b-tetraazaphenalenes: Amino and alkoxy derivatives

The trichloromethyl group served as a useful leaving group in nucleophilic displacement reactions by a variety of substituted amines and alcohols (the latter under base catalysis) on 2-trichloromethyl-5-methyl-1,3,4,6,9b-pentaazaphenalene ( 1a ) and 2-trichloromethyl-4-cyano-1,3,6,9b-tetraazaphenalene ( 2a ). The reaction conditions were mild and the yields of the corresponding 2-substituted amino and alkoxy derivatives were generally good.     

Pyrimidine derivatives. IX . Synthesis of bromosubstituted 5-nitro-2,4(1H,3H)-pyrimidinedione derivatives

The following 5-nitro-2,4(1H,3H)-pyrimidinediones possessing bromo substituted side chains at the 1- and 6-positions were prepared by bromination of 3,6-dimethyl-1-(ω-hydroxyalkyl)-5-nitro-2,4(1H,3H)-pyrimidinediones 4a and 4b and its nitrates 2a and 2b . The three of mono-bromo derivatives are: 1-(ω-acetoxyalkyl and ω-hydroxyalkyl)-6-bromomethyl-3-methyl. 6a, 6b, 7a and 7b and 1-(ω-bromoalkyl)-3,6-dimethyl-2,4(1H,3H)- pyrimidinediones 8a and 8b . The one type dibromo derivatives are: 1-(ω-bromoalkyl)-6-bromomethyl-3-methyl-2,4(1H,3H)-pyrimidinediones 5a and 5b .     

Medium-sized organometallic derivatives : IX. transannular nucleophilic substitution in organosilicon and organogermanium eleven-membered rings

Olah's reagent (HF-pyridine) reacts easily at room temperature with 6,6-dimethyl-6-sila-(and 6,6-dimethyl-6-germa-)-cycloundecanols. In each case, the principal product formed is not the expected cyclic organosilicon (or organogermanium) fluoride but the compound resulting from a transannular substitution reaction at the heteroatom with cleavage of one intracyclic heteroatom-carbon bond. The structures of the derivatives obtained were determined by ¹⁹F NMR and, after methylation, by mass spectrometry, ¹H and ¹³C NMR, and chemically.     

开环夹心化合物 IX. STO-3G从头计算法研究戊二烯负离子及其甲基取代衍生物的构象

用STO-3G基组的从头计算和DFP梯度几何优化方法对戊二烯负离子(C5H7^-)及其甲基取代衍生物进行了骨架优化。得到C5H7^-构象异构体的稳定顺序为W>S>U。而甲基取代的戊二烯负离子, 其顺序取决于甲基取代的位置。     

Synthesis and spectral properties of porphyrinquinone derivatives based on deuteroporphyrin IX

A series of diquinone derivatives of deuteroporphyrin IX, having different bond lengths between the chromophores, have been prepared. Deuteroporphyrin IX was condensed with modified hydroxyl-containing quinones by the mixed anhydride method. PMR spectroscopy was used to show that the magnetic anisotropy of the porphyrin ring has a strong effect on the chemical shift of the protons of the quinone ring and its neighboring substituents.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 608–616, May, 1988.     

气相色谱法手性拆分氯代和溴代环氧苯乙烷

用手性毛细管气相色谱法 (使用 2 ,6 戊基 3 丙基 γ 环糊精柱 ,ChiraldexG PN)对 3种溴代环氧苯乙烷和 3种氯代环氧苯乙烷对映体进行了拆分 .初步讨论了对映体在该手性毛细管柱上的保留行为 .已用于此类化合物对映体过量值 (ee值 )的测定