共查询到20条相似文献,搜索用时 92 毫秒
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1,4-二烯结构广泛存在于一系列具有生物活性的化合物分子中,其构建是有机合成中的重要研究领域之一.使用简单易得的原料合成1,4-二烯具有重要的研究意义.发展了镍催化的1,3-丁二烯、醛、炔和氢氯二茂锆的多组分偶联反应,用于高效合成1,4-二烯产物.该反应的原料均简单易得,其中1,3-丁二烯更是大宗化工产品.通过简单的炔... 相似文献
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α-卤代酮与芳香二胺经氧化-缩合过程一锅法合成喹喔啉衍生物 总被引:2,自引:0,他引:2
在二甲亚砜作用下, α-卤代酮与芳香1,2-二胺反应, 得到较高产率的喹喔啉衍生物. 结果表明反应经历一个串联的氧化-缩合过程. 二甲亚砜现场氧化α-卤代酮, 生成的二羰基化合物与芳香1,2-二胺缩合成喹喔啉衍生物. 相似文献
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《有机化学》2021,(5)
1,3-共轭烯烃不仅是有机合成不可或缺的原料或中间体,许多聚合物、天然产物和具有生理活性化合物的核心骨架都含有1,3-丁二烯结构单元.简便而有效的1,3-共轭烯烃合成方法一直是化学家们感兴趣的研究课题,在已有共轭烯烃的合成方法中,钯催化烯基卤与端烯的Heck交叉偶联反应占据了主要地位.最近,简单化合物的"一锅法"串联反应构建碳碳键具有操作及反应后处理简单、原子经济性高等优点而备受关注.以价廉易得端炔和联硼酸频哪醇酯为原料,在碱催化下进行硼氢化反应生成烯基硼酸频哪醇酯,这一中间体无需分离纯化,在Pd(OAc)_2和碱的作用下实现一锅串联反应得到目标产物1,4-二芳基取代-1,3-丁二烯化合物,所有化合物的结构用~1HNMR和~(13)CNMR进行表征,该一锅串联法合成途径简捷,反应条件温和,为共轭烯烃化合物合成提供了简便的途径. 相似文献
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ZnO-CeO2/SBA-15 catalysts were prepared by two kinds of solid-state grinding method and used for the production of 1,3-butadiene(1,3-BD) from ethanol.A mixture of SBA-15(with or without organic template) and metal precursors were ground in solid-state.The obtained catalysts were characterized by TG,N2 adsorption-desorption,TEM,XRD,Py-FTIR and NH_3-TPD techniques.Superior dispersion of metal oxides and more exposed acid sites were achieved on the catalyst lOZn_1Ce_5-AS with the presence of organic template in SBA-15 during the solid-state grinding process.The catalytic performance was evaluated in a fixed-bed reactor and a 1,3-butadiene selectivity of as high as 45% is achieved.This is attributed to the coupling effect of Zn and Ce species in the mesopores of SBA-15,in which Zn promotes ethanol dehydrogenation and Ce enhances aldol-condensation,respectively.Additionally,solvent-free method inspires new catalyst synthesis strategy for the production of 1,3-butadiene from ethanol. 相似文献
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Barluenga J Rodríguez F Alvarez-Rodrigo L Fañanás FJ 《Chemistry (Weinheim an der Bergstrasse, Germany)》2004,10(1):101-108
A diastereoselective synthesis of 1,3-butadiene or cyclobutene derivatives by a zirconium-mediated reaction of alkenyllithium compounds and vinyl bromides is reported. The key steps involve the generation of zirconocene-alkyne complexes from haloalkenes and subsequent coupling with alkenyl bromides. Thus, formally the process supposes the cross-coupling reaction between a terminal alkyne and an alkenyl bromide. Moreover, the use of butyl vinyl ether instead of vinyl bromide as the unsaturated system allows an alternative access to different 1,3-butadiene regioisomers. 相似文献
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An efficient one-to-one coupling reaction of atmospheric pressure carbon dioxide with 1,3-dienes is realized for the first time through PSiP-pincer type palladium-catalyzed hydrocarboxylation. The reaction is applicable to various 1,3-dienes including easily available chemical feedstock such as 1,3-butadiene and isoprene. This protocol affords a highly useful method for the synthesis of β,γ-unsaturated carboxylic acid derivatives from CO(2). 相似文献
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Wang C Wang C Wang Q Wang Z Sun H Guo X Xi Z 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(22):6484-6494
Stereodefined multisubstituted 1-cyano- and 1,4-dicyano-1,3-butadiene derivatives were obtained in excellent yields of the isolated product from their corresponding monohalo- and dihalobutadienes and CuCN. This reaction proceeded with high stereoselectivity and retention of the stereochemistry of the starting halobutadienes. A study of the utility of the thus-obtained 1-cyano- and 1,4-dicyano-1,3-butadiene derivatives was demonstrated by their reactions with organolithium reagents. 2H-Pyrrole or iminocyclopentadiene derivatives were formed in high yields from 1-cyano-4-halo-1,3-butadienes and organolithium reagents. When 1,4-dicyano-1,3-butadienes were treated with organolithium reagents followed by trapping with electrophiles, a tandem process took place to afford 2H-pyrrolyl nitriles in excellent yields. Reduction of 1,4-dicyano-1,3-butadiene derivatives with LiAlH4 showed novel reaction patterns relative to normal nitriles. 相似文献
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The C-H bond of a terminal alkyne adds to a carbon-carbon double bond of 1,3-dienes, styrenes, and norbornene at room temperature in the presence of a nickel catalyst in regio- and stereoselective manners. Reaction of triisopropylsilylacetylene with 1-substituted 1,3-butadiene derivatives afforded hydroalkynylation products via introduction of a hydrogen atom and a triisopropylsilylethynyl group to 4- and 3-positions of the dienes, respectively. Likewise, 1-triisopropylsiloxy-1,3-butadiene, 1,3-pentadiene, 1-cyclohexen-1-yl-1,3-butadiene, and 1,3-cyclohexadiene underwent the hydroalkynylation reaction, giving the corresponding 1,4-enyne derivatives in good yields at room temperature. Reaction of p-substituted styrene with triisopropylsilylacetylene also proceeded in the presence of the nickel catalyst, giving the branched hydroalkynylation products in good yields. Norbornene gave a exo-addition product in good yield under the same reaction conditions. 相似文献
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Attanasi OA De Crescentini L Favi G Filippone P Lillini S Mantellini F Santeusanio S 《Organic letters》2005,7(12):2469-2471
[reaction: see text] Here, we report the protocol for the preparation of new poly(ethylene glycol)-supported 1,2-diaza-1,3-butadiene. In addition, we discuss an application of this supported reagent in an efficient and environmentally friendly one-pot synthesis of 2-thiazol-4-one derivatives by reaction with thioamides. 相似文献
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Fujita R Yoshisuji T Wakayanagi S Wakamatsu H Matsuzaki H 《Chemical & pharmaceutical bulletin》2006,54(2):204-208
Diels-Alder reactions of 3-nitro-2(1H)-quinolones with 1,3-butadiene derivatives were carried out to give the phenanthridone derivatives under both atmospheric and high pressure conditions. Furthermore, the reactivity of 3-substituted 2(1H)-quinolones acting as a dienophile with 2,3-dimethyl-1,3-butadiene was examined using molecular orbital (MO) calculation. 相似文献
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A practical and chromatography-free synthesis of vinamidinium salts and their use as diene precursors in Diels-Alder reactions is reported. Additionally, 1,3-dipyrrolidino-1,3-butadiene was shown to be significantly more reactive than Rawal's diene in a competition experiment. 相似文献
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适用于活性阴离子聚合的单体拓展研究是有关活性阴离子聚合的一项重要的研究工作.本文重点介绍了近十年在活性阴离子聚合领域出现的新型单体的结构设计、合成及其聚合过程的研究进展.文中涉及到的新型单体主要包括非(弱)极性类单体、极性单体及其它单体.进一步细分,非(弱)极性类单体分为苯乙烯衍生物类单体和丁二烯衍生物类单体,极性单体中含有丙烯酸酯类单体、丙烯酰胺类单体、氯乙烯以及N-乙烯基咔唑,其它单体包括异氰酸酯类、烯酮类以及杂环类单体.最后本文对上述这些新型单体中的一些单体用于复杂大分子拓扑结构的设计合成情况也作了简要介绍. 相似文献
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Dr. Anja Weber Priv.-Doz. Dr. Martin Breugst Prof. Dr. Jörg Pietruszka 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(42):18868-18875
The reactions of α,β-unsaturated δ-lactones with activated dienes such as 1,3-dimethoxy-1-[(trimethylsilyl)oxy]-1,3-butadiene (Brassard's diene) are barely known in literature and show high potential for the synthesis of isocoumarin moieties. An in-depth investigation of this reaction proved a stepwise mechanism via the vinylogous Michael-products. Subsequent cyclisation and oxidation by LHMDS and DDQ, respectively, provided six mellein derivatives (30–84 %) and four angelicoin derivatives (40–78 %) over three steps. DFT-calculations provide insights into the reaction mechanism and support the theory of a stepwise reaction. 相似文献