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1.
Summary Eight of the most important single compounds of technical toxaphene were separated on t-butyldimethylsilylated β-cyclodextrin
(β-BSCD) diluted in a medium polar phase using gas chromatography with electron capture detectors (GC-ECD). The enantiomeric
resolution of all compounds was obtained in one GC run. The β-BSCD phase also separated the enantiomers of oxychlordane, cis-
and trans-chlordane as well as α-HCH. Problems in the enantioselective determination of CTTs in biological samples are discussed.
Finally, the enantioselective determination of the two most recalcitrant CTTs in biological samples was achieved using electron
capture negative ionization mass spectrometry (GC-ECNI-MS) in the single ion monitoring (SIM) mode.
Presented at the 21st ISC held in Stutgart, Germany, 15th–20th September, 1996. 相似文献
2.
A reversed phase HPLC method has been investigated for separation and determination of the structural isomers of madecassoside
(madecassoside and asiaticoside-B). The isomeric compounds can be isolated with high resolution by adding β-CD in mobile phase
on a C18 column. The effect of β-CD concentration on resolution is discussed. The functional group in the separation process is investigated.
The correlation coefficient (R
2) of the calibration was 0.9995 over the range of 0.1–5.0 mg mL−1. The method was successfully applied to characterize and determine the madecassoside in Centella extract. 相似文献
3.
Sr-doped calcium phosphates have been prepared by sol–gel chemistry. All samples exhibit two phases: hydroxyapatite (HAp)
and tricalcium phosphate (β-TCP). With respect to undoped sample, the Sr-doped samples exhibit higher proportion of β-TCP
phase but the quantity appears to be quite independent of the doping level. To explain the mismatch with the nominal stoichiometry,
the presence of amorphous CaO and SrO compounds have been postulated and their proportions evaluated. The insertion of Sr2+ ions in the two crystalline phases HAp and β-TCP is almost total for low doping levels but quite incomplete for the highest
doping level. The majority of the inserted Sr2+ ions are in the β-TCP phase. Considering the acknowledged beneficial effect of Sr2+ on the bone regeneration process, the effective partial substitution of Sr in biphasic calcium phosphate makes these materials
very interesting for clinical applications.
The Sr-substituted HAp and β-TCP cell parameters agree fairly well with the Vegard’s law and Sr2+ ions substitute preferentially for Ca2+ in the Ca2 site for hydroxyapatite and in the Ca4 site for β-TCP. The microstructural parameters confirm the previous observation
and give a new evidence of clear stabilizing effect of Sr2+ ions towards the β-TCP structure. 相似文献
4.
Two new bisazo chromophores—derivatives of bis-2,2-(4-hydroxyphenyl)propane (bisphenol A), heterocyclic amines (2-aminobenzothiazole,
and 2-amino-6-nitrobenzothiazole) and aniline—were synthesized. Nonlinear optical properties of these chromophores were studied
by solvatochromic method (obtained compounds have βCT value ∼10−29 esu). Dependence among the structure of molecules, their dipole moments, and first hyperpolarizabilities was considered on
the basis of semi-empirical calculations. A correlation between the measured and calculated β values was studied. The NLO
chromophores were used as special monomers to synthesize copolyarylates. The basic characterization of obtained polymers was
carried out. 相似文献
5.
P. Madhavan B. M. Rao Pravin Abhishek P. R. Kumar M. Sreenivasulu K. B. Chandrasekhar 《Chromatographia》2007,65(1-2):81-84
A normal phase chiral LC method for chiral purity evaluation of β-amino-β-(4-methoxyphenyl) propionic acid was developed on
donor–acceptor (pirkle) column. The chiral stationary phase used was a 250 × 4.6 mm (R, R) Whelk-01 with 5 μm particle size,
which was accompanied with a 1 cm long guard column. The “hybrid” pi-electron donor–acceptor based stationary phase (R, R)
Whelk-01 was found to be enantiomeric selective for (R) and (S) enantiomers of β-amino-β-(4-methoxyphenyl) propionic acid
with a resolution >2.5. The concentration of 2-propanol and TFA in the mobile phase plays an important role on the chrmatographic
efficiency and resolution between the enantiomers. The limit of detection and limit of quantification of (S) enantiomer was
0.3 and 1.0 μg mL-1 for 20 μL injection volume. The percentage RSD of the peak area of six replicate injections of (S) enantiomer at LOQ concentration
was 4.5. The percentage recovery of (S) enantiomer from (R) enantiomer samples ranged from 92 to 100. The test solution was
observed to be stable up to 24 h after the preparation. The developed method was also checked by different analysts and on
different lots of columns, reagents and it was proved to be rugged. The developed normal phase chiral LC method can be used
for the determination of the enantiomeric purity of R-β-amino-β-(4-methoxyphenyl) propionic acid. 相似文献
6.
Sofia Nikolaou Sérgio Hiroshi Toma Vagner Roberto de Souza Juliano B. Alves Koiti Araki Henrique Eisi Toma 《Transition Metal Chemistry》2011,36(7):775-783
The triruthenium carboxylate cluster [Ru3O(OAc)6(py)2(bpp)]+ (OAc = acetate) containing the bridging 1,3-bis(4-pyridyl)propane (bpp) ligand, and its dimeric species [{Ru3O(OAc)6(py2)}2(μ-bpp)]2+ were synthesized in order to investigate their inclusion compounds with β-cyclodextrin (β-CD). Characterization of the complexes
was carried out based on spectroscopic, electrochemical and spectroelectrochemical techniques, while the formation of inclusion
complexes was evaluated using 1H NMR/NOESY spectroscopy. Since bpp is a flexible ligand, a DFT study was carried out in order to characterize its conformational
isomers and their possible role in the host–guest chemistry with β-CD. Instead of observing the formation of inclusion compounds
with different stoichiometries, we observed the formation of 1:1 bpp/β-CD compounds in which the bpp ligand assumes different
conformations. The assembly of polymetallic rotaxane species was successfully demonstrated by monitoring the 1H NMR spectra of the monomeric cluster species in the presence of aquapentacyanoferrate(II) ions and β-CD. 相似文献
7.
Three chiral compounds were successfully separated in a short time with two enantiomer separation models on packed-capillary
electrochromatography (CEC). (i) 75 μm I.D. capillaries were packed with 5 μm β-cyclodextrin (βCD) chiral stationary phase
(CSP). Effects of voltage, pH and concentration of organic modifier on electroosmotic flow (EOF) and chiral separations were
investigated systematically. Enantiomers of a neutral compound (benzoin) and a neutral drug (mephenytoin) were separated within
a short time with high efficiency. Efficiency of 32 000 theoretical plates per meter and resolution (R8) of 1.42 were achieved for enantiomers of benzoin using a βCD packed column with 6.2crn packed length. Efficiency of 45 000
theoretical plates per meter andR8 of 3.40 were obtained for enantiomers of mephenytoin. Especially, the enantiomer separation of mephenytion was performed
in just 3.4 min with R8 of 2.60. (ii) 75 μm I.D. capillary was packed with octadecylsilica particles (ODs). Chiral separation of a basic drug, propranolol,
was studied with chiral agent, via addition of the dimethyl-β-cyclodextrin (DM β-CD) directly into the mobile phase on this
column. Baseline separation and efficiency of 81 000 theoretical plates per meter were achieved for propranolol.
Project supported by the Natural Science Foundation of Liaoning Province, China, the National Natural Science Foundation of
China (Grant No.29875030), and the Excellent Young Scientist Award from the National Natural Science Foundation of China.
(Grant No.29725512). 相似文献
8.
Silvana L. Giudicessi M. Kaniz Fatema Hiroshi Nonami Rosa Erra-Balsells 《Journal of the American Society for Mass Spectrometry》2010,21(9):1526-1529
The effect of Ca2+ (and Mg2+) and the disodium salt of ethylenediaminetetraacetic acid (EDTA), a well known Ca2+ (and Mg2+) chelating agent, on the volatilization/ionization of carbohydrates by using electrospray ionization mass spectrometry has
been studied. Model compounds such as maltoses (maltose to maltoheptaose), β-cyclodextrins (β-cyclodextrin, methyl-β-cyclodextrin,
heptakis(2,6-di-O-methyl)-β-cyclodextrin, heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, and 2-hydroxypropyl-β-cyclodextrin)
and fructans (sucrose, 1-ketose, nystose, and 1F-fructofuranosylnystose) were used. 相似文献
9.
Several host–guest inclusion compounds of eugenol as a guest molecule and cyclodextrins (α-,β-,γ-CD) and heptakis (2,6-di-O-methyl)-β-cyclodextrin (DMβ-CD) as hosts were investigated in the solid state and in aqueous solution. The one-to-one solid inclusion compounds of eugenol
and β-CD or γ-CD were prepared, but those of eugenol with α- or DMβ-CD were not obtained under the same condition. However, the UV-visible absorption spectroscopy data indicated that the liquid
guest could form a 1:1 inclusion compound with all four hosts respectively in aqueous solution. The two solid inclusion compounds
were characterized by powder X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TG), differential
scanning calorimetry (DSC) and nuclear magnetic resonance (NMR). The association constants (K), calculated from the modified Benesi–Hidebrand equation, of eugenol with α-, β-, γ- and DMβ-CD is 4.95 × 104, 3.96 × 105, 1.47 × 105 and 9.33 × 104 mol−1 dm3, respectively. 相似文献
10.
A new method was proposed for determining the most probable mechanism function of a solid phase reaction. According to Coats-Redfern's
integral equation Eβ→0 was calculated by extrapolating β to zero using a series of TG curves with different heating rates. Similarly, Eα→0 was calculated according to Ozawa's equation. The most probable mechanism function of the solid phase dehydration of manganese(II)
oxalate dihydrate was confirmed to be G(α)=(1-α)1/2 by comparing Eα→0 with Eβ→0.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
11.
K. I. Pashkevich V. I. Filyakova V. G. Ratner O. G. Khomutov 《Russian Chemical Bulletin》1998,47(7):1239-1247
Efficient procedures for the regioselective synthesis of fluoroalkyl-containing threefive-, six-, and seven-membered heterocycles
as well as of related fused compounds, namely, α,β-epoxyketones, α,β-aziridinylketones, pyrazoles, pyrazolines, isoxazolines,
1,2-dithiolenes, amino- and mercaptopyrimidines, Δ3,5-2-thioxo-1,3,2-thiazaphosphorines, Δ3,5-2-thioxo-1,3,2-oxazaphosphorines, 2,3-dihydro-1,4-diazepines, azirino[1,2-a]quinoxalines, benzo[b]-and naphtho[2,3-b]-1,4-diazepines, and triazolopyridazines, which have been developed by the authors and coworkers, are summarized. The α-
and β-functionalized fluoroalkylcontaining carbonyl compounds (β-diketones, β-ketoesters, their salts, regioisomeric β-aminovinyl
ketones, β-aminovinylthiones, β-hydroxyketones, α,β-enones, and their halogen derivatives) were used as synthons in the processes
of formation of the above-mentioned heterocycles.
Dedicated to the memory of Academician I. Ya. Postovskii on his 100th birthday.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1279–1286, July, 1998. 相似文献
12.
Improvement of Steroid Biotransformation with Hydroxypropyl-β-Cyclodextrin Induced Complexation 总被引:1,自引:0,他引:1
Liting Zhang Min Wang Yanbing Shen Yinhu Ma Jianmei Luo 《Applied biochemistry and biotechnology》2009,159(3):642-654
The inclusion complexes induced by cyclodextrins and its derivates have been shown previously to enhance the biotransformation
of hydrophobic compounds. Using hydroxypropyl-β-cyclodextrin (HP-β-CD; 20% w/v), the water solubility of cortisone acetate increased from 0.039 to 7.382 g L−1 at 32 °C. The solubilization effect of HP-β-CD was far superior to dimethylformamide (DMF) and ethanol. The dissolution rate
also significantly increased in the presence of HP-β-CD. The enzymatic stability of Δ1-dehydrogenase from Arthrobacter simplex TCCC 11037 was not influenced by the increasing concentrations of HP-β-CD contrary to the organic cosolvents which negatively
influenced in the order DMF > ethanol. The activity inhibition effect caused by HP-β-CD was not so conspicuous as ethanol
and DMF. Inactivation constants of ethanol, DMF, and HP-β-CD were 5.832, 4.541, and 1.216, respectively. The inactivation
energy (E
a) was in the order of HP-β-CD (55.1 kJ mol−1) > ethanol (39.9 kJ mol−1) > DMF (37.1 kJ mol−1). 相似文献
13.
Tomáš Trojan Jindřich Jindřich Vladimír Vrkoslav Ivan Jelínek Juraj Dian 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):343-348
A set of permethylated 6I-(ω-alkenoyl)-6I-amino-6I-deoxy-β-cyclodextrin derivatives with different chain length of the alkenoyl group (used as a spacer) was synthesized. These
derivatives were attached by photochemically activated hydrosilylation reaction to the surface of porous silicon. Photoluminescence
response of the modified PS to controlled concentrations of various molecules in gas phase revealed strong host-guest interactions
between β-cyclodextrin and the detected molecules. The strongest interaction was observed for aromatic molecules, which have
the optimal size to fit into the β-cyclodextrin molecular cavity. 相似文献
14.
Toshinobu Yogo Koichi Kikuta Kazuo Niwa Masao Ichida Arao Nakamura Shin-ichi Hirano 《Journal of Sol-Gel Science and Technology》1997,9(2):201-209
β-BaB2O4 (β-BBO) thin films were successfully synthesized by the sol-gel method using metallo-organic compounds. A stable BBO precursor
solution was prepared from barium metal and boron triethoxide or 2,4,6-triethoxycyclotriboroxane in a mixture solvent of ethanol
and 2-ethoxyethanol. As-precipitated powder formed by hydrolysis of the precursor solutions crystallized to ψ phase, which
was transformed to β phase at higher temperatures. The transformation temperatures of powders from ψ to β phase of the ethoxide
system and the boroxane system were 600 and 680°C, respectively. The calcination of precursor films in a mixture gas of water
and oxygen was found to decrease the crystallization temperature of β-BBO films on Pt sheet substrates. The precursor films
prepared from the ethoxide system and the boroxane system crystallized to β-BBO on Pt (111)/glass substrates at 500 and 550°C,
respectively. The BBO films on Pt(111)/glass substrates showed the strong (006) preferred orientation. The β-BBO films on
Pt(111)/glass substrates showed the second harmonic generation (SHG) of the 532 nm light on irradiation with 1064 nm light.
The SH power from the BBO films was correlated with the fundamental power through the square-law proportionality based on
the theory. The SHG efficiency of the BBO films was dependent upon the film thickness. 相似文献
15.
Klára Balogh Nikolett Szaniszló Klára H-Otta Éva Fenyvesi 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):457-462
Solubility of BTEX compounds was determined in aqueous solutions of natural CDs (α-, β-, γCD) as well as of some industrial
βCD derivatives (RAMEB, HPBCD, AcβCD) measured by UV photometry. From the phase solubility diagrams the complex association
constants were determined. The βCD derivatives increased the solubility of individual monoaromatic compounds, depending on
the structure of the guest molecule. We have found that RAMEB (randomly methylated βCD) and AcβCD (partially acetylated βCD)
are the most effective solubilizers while the effect of natural CDs is not significant because the complexes precipitate from
the solutions. Extraction experiments were performed to see how the complexation of components influences the extraction using
a mixture modeling the composition of these pollutants in soil. We have found that although the soluble CD derivatives are
not as selective as expected based on complex association constants, they increased the efficacy of extraction by 4–6 times.
The reason of the low selectivity is that the concentration ratio of certain BTEX compounds in CD solutions is smaller than
in water. CD derivatives seem to have an equalizing effect: the solubility of the least soluble p-xylene is improved in the
highest extent, but that of benzene the least. This result, however, is an advantage in the application of these CD derivatives
in soil remediation (the availability of each BTEX compounds will be enhanced). 相似文献
16.
Chusaksri S Sutthivaiyakit S Sutthivaiyakit P 《Analytical and bioanalytical chemistry》2006,384(5):1236-1245
A confirmatory method for the determination of organochlorine pesticides (OCPs) and their metabolites (endrin, α-endosulfan,
β-endosulfan, endosulfan sulfate, heptachlor, heptachlor epoxide, 2,4′-DDD, 4,4′-DDD, 2,4′-DDE 4,4′-DDE, 2,4′-DDT, and 4,4′-DDT)
in surface waters using liquid chromatography /APCI/tandem mass spectrometry has been developed. Chromatographic separation
was carried out on a ChromSpher 5 Pesticide column using a gradient elution with mobile phase 1mM ammonium acetate-acetonitrile.
Endrin, α-endosulfan, β-endosulfan , endosulfan sulfate, heptachlor and heptachlor epoxide were determined in the negative
ionization mode, while the rest compounds in positive ionization mode. For the identification of the analytes, two multireaction
monitoring transitions were selected per compounds except for the heptachlor which selected ion monitoring was used. The linearity
of the optimized method ranges after SPE concentration, from 0.009 to 30.60 μgL−1 with correlation coefficients greater than 0.99. The method recovery values varied from 72 to 119 % for the different fortification
levels . The developed method was successfully applied to determine OCPs and their metabolites in surface water samples collected
near paddy fields in growing season of rice, at year 2005 in Pathumthani province, Thailand. Endosulfan sulfate was detected
in five out of seven samples and three of them could be quantitated in the range of 0.31to 0.50 μgL−1. 相似文献
17.
Andrés G. León Ana I. Olives M. Antonia Martín Benito del Castillo 《Journal of inclusion phenomena and macrocyclic chemistry》2007,57(1-4):577-583
The use of cyclodextrins (CDs) in HPLC as mobile phase additives provides a flexible alternative for the separation of chemically
related compounds because these separations can be performed on conventional columns and are economically advantageous over
the use of chiral stationary phases. The present paper describes the influence of the presence of β-cyclodextrin (β-CD) and
2-hydroxypropyl-β-cyclodextrin (HPβ-CD) on the separation of the β-carboline alkaloids norharmane, harmane and harmine. The
nature of the stationary phase (reverse phases C1 and C18) affects the chromatographic separations and also the stability of the inclusion complexes that are developed. The changes
in the proportion of the organic solvents at constant concentration of CDs (3 mM for β-CD and 15 mM for HPβ-CD) modify the
retention factors (k′) for all alkaloids studied. The nature of the organic solvent in the mobile phase also changes the chromatographic parameters.
The logarithm of the capacity factor (k′) is linearly increased with the proportion of water in the hydro-organic mobile phase (ethanolic or methanolic) but the
slopes obtained vary depending on the CD added to the mobile phase. The role of competitive equilibria, i.e., chromatographic
distribution and inclusion complexes formation is discussed.
This paper was presented at XIIIth International Cyclodextrin Symposium. Torino, Italy, May, 14–17, 2006 相似文献
18.
Chengkuan Qin Jinling Chai Jingfei Chen Yan Xia Xiaoying Yu Jing Liu 《Colloid and polymer science》2008,286(5):579-586
The phase behavior and the solubilization of the microemulsion systems surfactant-like ionic liquids 1-hexadecyl-3-methylimidazolium
bromide (C16mimBr), 1-tetradecyl-3-methylimidazolium bromide (C14mimBr), or 1-dodecyl-3-methylimidazolium bromide (C12mimBr)/alcohol/alkane/brine have been studied with ɛ–β-fish-like phase diagram method at 40 °C and an oil-to-water mass ratio of 1:1. From the ɛ–β-fish-like phase diagram, the physicochemical parameters, such as the mass fraction of alcohol in the hydrophile–lipophile-balanced
interfacial layer (A
S), and the solubilities of ionic liquid (S
O) and alcohol (A
O) in alkane phase, were calculated. The solubilization of the microemulsion system has been discussed based on the ɛ–β-fish-like phase diagram. The smaller the oil molecule, the longer the alcohol chain length, and the larger the NaCl concentration
in water, the larger the solubilization of the microemulsion system. In this paper, the solubilization of the microemulsion
stabilized by both C12mimBr and sodium dodecyl sulfonate (sodium dodecyl sulfate) was also investigated with the ɛ–β-fish-like phase diagram. The unequimolar composite of anionic and cationic surfactants can avoid the sedimentation aroused
by the strong electrostatic attraction, and an obvious synergism effect in solubilization was obtained. 相似文献
19.
Morin N. Chilouet A. Millet J. Rouland J.-C. 《Journal of Thermal Analysis and Calorimetry》2000,62(1):187-201
The complexation of bifonazole, an antimycotic hydrophobic imidazole derivative, with β-cyclodextrin (β-CD) was investigated
in solid phase, using the following complementary techniques: differential scanning calorimetry (DSC), thermogravimetric analysis
(TG) and X-ray powder diffractometry. The β-CD-bifonazole samples were prepared in both aqueous medium by coprecipitation
and in solid state by kneading method and the β-CD-bifonazole binary diagrams were drawn. The experimental results demonstrate
the formation of two binary compounds, β-CD-bifonazole and (β-CD)x bifonazole (x =2 or 4). The first compound may be an inclusion compound and the second a crystallized compound, in which the bifonazole
is not necessarily included in the cyclodextrin internal cavity.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
20.
Wojciech Zielenkiewicz Małgorzata Koźbiał Bożenna Golankiewicz Jarosław Poznański 《Journal of Thermal Analysis and Calorimetry》2010,101(2):555-560
Solubilities of tricyclic acyclovir derivatives in buffered aqueous solutions of hydroxypropyl-β-cyclodextrin (HP-β-CD) at
pH 5.5 and 7.0 were determined at 25 and 37 °C. Complexation of these compounds with HP-β-CD resulted in a noticeable increase
of their solubility; nevertheless it was limited to tricyclic derivatives of acyclovir carrying an aryl substituent. Combination
of 1H NMR and DSC techniques demonstrated the existence of inclusion complexes between acyclovir derivatives and HP-β-CD. The
stability constants, estimated using the Higuchi–Connors method, were found in the range of 10–100 M−1. Additionally, the pK
a values at 25 °C and molar extinction coefficients in aqueous buffered solutions were also determined for all studied compounds. 相似文献