Carotenoids of the ascidianHalocynthia aurantium

It has been established that the main components of the carotenoid fraction of an extract ofHalocynthia aurantium are astaxanthin and diatoxanthin, the latter possessing a weak antioxidant activity. No prenylated hydroquinones, which are characteristic for colonial species of ascidians were detected in the four species of solitary ascidians from the Sea of Japan investigated.     

Steroid alcohols from the ascidianHalocynthia aurantium

The total sterols have been isolated fromHalocynthia aurantium by column chromatography on silica gel. The following steroid alcohols have been identified in it with the aid of GLC, GLC-MS, and¹H NMR: 5-cholestan-3-ol, 24-methylcholestan-3-ol, 24-ethylcholestan-3-ol, 4-methyl-24-ethyl-5-cholestan-3-ol, cholest-5-en-3-ol, 24-methylcholest-5-en-3-ol, 24-ethylcholes-5-en-3-ol, 5-cholest-22-en-3-ol, 24-nor-5-cholest-22-en-3-ol, cholesta-5,22-dien-3-ol, 24-methylcholesta-5,22-dien-3-ol, 24-norcholesta-5,22-dien-3-ol, 24-ethylcholesta-5,24(28)-dien-3-ol, and 24-methylcholesta-5,24(28)-dien-3-ol.Pacific Ocean Institute of Bioorganic Chemistry of the Far Eastern Scientific Center of the Academy of Sciences of the USSR, Vladivostok, and Far-Eastern State University, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 581–585, September–October, 1981.     

Steroid glycosides from the starfishEchinaster sepositus

Two new steroid glycosides, which have been called echinasterosides B₁ and B₂ have been isolated from the starfishEchinaster sepositus. Using chemical transformations (methylation, hydrolysis) and also spectral methods (¹H and¹³C NMR spectroscopy and GLC-MS) the complete chemical structure of B₁ has been established as 15-acetoxy-5-cholestane-3,4,6,8,24-pentaol 24-O[O-(2)O÷ methyl--D-xylopyranosyl)-(13)--L-arabinofuranoside] (I) and that of glycoside B₂ as 5-cholestane-3,4,6,8,15,24-hexaol 24-O-[O÷(2-O-methyl--D-xylopyranosyl)-(13)--L-arabinofuranoside] (II).Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Pirodnykh Soedinenii, No. 2, pp. 246–249, March–April, 1987.     

Steroid glycosides from the starfish Crossaster papposus

Two new steroid glycosides have been isolated from an ethanolic extract of the starfishCrossaster papposus — crossasterosides P₁ and P₂. On the basis of chemical transformations and spectral characteristics, the structure of crossasteroside P₁ has been established as (24R)-24-ethyl-5-cholestane-3,6,8,15,16,29-hexaol 29-O-[2-O-methyl--D-xylopyranosyl-(1 2)--D-galactofuranoside]. Crossasteroside P₂ is its 4-hydroxy analogue.Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Branch, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 669–673, September–October, 1989.     

Steroid glycosides from the starfish Crossaster papposus

Two new steroid glycosides have been isolated from an ethanolic extract of the starfishCrossaster papposus — crossasterosides P₁ and P₂. On the basis of chemical transformations and spectral characteristics, the structure of crossasteroside P₁ has been established as (24R)-24-ethyl-5α-cholestane-3β,6β,8,15α,16β,29-hexaol 29-O-[2-O-methyl-β-D-xylopyranosyl-(1 → 2)-β-D-galactofuranoside]. Crossasteroside P₂ is its 4β-hydroxy analogue.     

Steroid glycosides from the starfish Crossaster papposus

The following have been isolated from the starfishCrossaster papposus and characterized: the new glycoside (24S)-5-cholestane-3,4,6,8,15,24-hexaol 24-O-[O-(2,4-di-O-methyl--D-xylopyranosyl)-(1 5)--L-arabinofuranoside] (crossasteoside P₄) and the previously known attenuatoside B-1.Pacific Ocean Institute of Bioorganic Chemistry, Far-Eastern Scientific Center, Russian Academy of Sciences, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 257–260, March–April, 1993.     

Steroid hexaol from Crossaster papposus

Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Division, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 3, pp. 432–433, May–June, 1989.     

Steroid compounds from the Pacific starfish Lysastrosoma anthosticta

Two new steroid compounds, 3,6-dihydroxy-5-cholesta-9(11),24-dien-23-one 3-sulfate and 3,6-dihydroxy-5-cholest-9(11)-en-23-one 3-sulfate, were isolated from the Pacific starfish Lysastrosoma anthosticta as the corresponding sodium salts and identified. Two previously known glycosides of 24(S)-5-cholestane-3,6,8,15,24-pentol were also isolated and identified as sodium 24-O--d-glucopyranoside 6"-sulfate (pycnopodioside C) and sodium 24-O--d-xylopyranoside 4"-sulfate (luridoside A).     

Steroid polyols from the Far-Eastern starfish Henricia sanguinolenta

A new polyhydroxylated steroid (20R,24S)-5-cholestane-3,6,15,24-tetraol and a known glycoside, laeviuscoloside G, was isolated from the Far-Eastern starfish Henricia sanguinolenta, collected in the sea of Okhotsk, and characterized.     

Steroid sulfates from the starfish Lethasterias nanimensis chelifera

The sodium salt of 3β-sulfooxythornasterol A and a new glycoside — the disodium salt of 3β-sulfooxy-6α-[β-D-4-sulfooxyquinovopyranosyloxy]-5α-pregn-9(11)-en-20-one (cheliferoside LI) has been isolated from the starfishLethasterias nanimensis chelifera. The structures of the compounds have been established by spectral methods.     

Steroid sulfates from the starfish Lethasterias nanimensis chelifera

The sodium salt of 3-sulfooxythornasterol A and a new glycoside — the disodium salt of 3-sulfooxy-6-[-D-4-sulfooxyquinovopyranosyloxy]-5-pregn-9(11)-en-20-one (cheliferoside LI) has been isolated from the starfishLethasterias nanimensis chelifera. The structures of the compounds have been established by spectral methods.Pacific Ocean Institute of Biochemistry, Far Eastern Branch, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 520–523, July–August, 1991.     

Ni-catalysed, domino synthesis of tertiary alcohols from secondary alcohols

The use of in situ generated (NHC)-Ni catalytic species (NHC = N-heterocyclic carbene) allows for the synthesis, in short reaction times, of a variety of tertiary alcohols from secondary alcohols through a domino oxidation-addition protocol.     

Sex Steroid Extraction from Echinoderm Tissues

Abstract

A method for sex steroid extraction from selected echinoderm tissues is presented. This method utilizes solvent and solid based extraction techniques and is reliable for small tissue samples. Tissue homogenates were incubated in warm acidic conditions prior to organic extraction of steroids. Further isolation of steroids using Sep-Pak cartridges and a simple elution scheme resulted in percent recoveries ranging from 56%-90% depending on steroid and tissue type.     

Iridium-catalyzed synthesis of quinolines from 2-aminobenzyl alcohols with secondary alcohols

The quinoline derivatives were synthesized from 2-aminobenzyl alcohols and secondary alcohols by the direct one-step synthesis using the iridium complexes as catalyst. This efficient and easy method is suitable for all kinds of substituted quinolines.     

Steroid compounds from the Pacific starfishesLuidia quinaria andDistolasterias elegans

One new and four previously known steroid compounds were identified from the Pacific starfishesLuidia quinaria andDistolasterias elegans. The structure of the new steroid was established from spectral data and chemical correlations with other steroids such as 5-cholestane-3,5,6,15,16,26-hexaol 3-sulfate (1). The previously known compounds were identified as 5-cholestane-3,5,6,15,26-pentaol 15-sulfate (2) fromLuidia quinaria and sodium (24S)-O-(-d-giucopyranosyll-5-cholestane-3,6,8,15,24-pentaol 6-sulfate (3), sodium (24S)-5-cholestane-3,6,8,15,24-pentaol 24-sulfate (4), and sodium tornasterol A sulfate (5).Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 473–476, February, 1996.     

地奥心血康原药甾体皂苷成分的液相色谱-质谱联用分析

地奥心血康为2005年版<中国药典>(一部)的收载品种.地奥心血康的活性物质是薯蓣科薯蓣属植物黄山药和穿龙薯蓣的根茎提取物,其制剂地奥心血康胶囊具有活血化瘀、行气止痛、扩张冠脉血管及改善心肌缺血的作用,临床上其主要用于预防和治疗冠心病、心绞痛以及淤血内阻之胸痹、眩晕、气短、心悸、胸闷和胸痛[1].本实验首次采用高效液相色谱与串联质谱联用方法对地奥心血康原药的甾体皂苷成分进行分析.