共查询到20条相似文献,搜索用时 67 毫秒
1.
利用手性元途径来合成光学活性化合物近年来受到特别重视。在利用天然易得的糖、氨基酸和萜类化合物来合成各种手性元上,发展了不少十分有价值的策略[1]。(+)二氢香芹酮分子中有两个手性碳,是一种手性合成常用的原料。我们曾报道了由(+)二氢香芹酮合成(+)1... 相似文献
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二氢鞘氨醇(DHS)是2-氨基-1,3-二羟基的饱和长链氨基醇化合物,是构成鞘脂类(包括鞘磷脂和糖鞘脂)的主链部分.由于鞘脂类在自然界中来源稀少,又很难得到纯品.因此,作为鞘脂类主链部分的二氢鞘氨醇的合成有重要的意义[1].二氢鞘氨醇有两个手性碳,共... 相似文献
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以D-甘露糖醇为原料, 在制得了(2E)-4, 5-氧异亚丙基戊烯酸酯(5)以后,经不对称双羟基化反应、环硫酸酯化和叠氮化钠区域选择性开环等12步反应以7.7%的总产率合成了标题化合物的2, 3-二苯甲酰产物, 由此为鞘氨醇和神经鞘脂类化合物的合成开辟了又一新的途径。 相似文献
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采用共沉淀法制备了镁铝类水滑石(Mg-Al-CO3LDH)、镁锌铝类水滑石(Mg-Zn-Al-CO3LDH)和锌铝类水滑石(Zn-Al-CO3LDH),并研究了它们在碳酸二苯酯(DPC)与1,4-丁二醇(1,4-BD)酯交换合成聚碳酸酯二醇(PCDL)反应中的催化活性。在常压反应阶段,以苯酚的产率表征催化剂的活性;在减压缩聚阶段,以产品的数均分子量Mn和羟基值来表征催化剂的活性。结果发现,Zn-Al LDH具有良好的催化活性。在优化反应条件下,获得了Mn和羟基值分别为1600和70.8mg KOH/g的PCDL。 相似文献
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本文报道在室温, 中性介质中研究二碘化钐在合成中的应用. 在二碘化钐作用下,二碲醚发生Te-Te键还原断裂, 生成碲负离子物种, 后者再与α,β-不饱和酯(腈)发生Michael加成, 得到β-碲代酯(腈), 产率较高. 相似文献
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Patil Priyanka T. Warekar Poojali P. Patil Kirti T. Jamale Dattatraya K. Kolekar Govind B. Anbhule Prashant V. 《Research on Chemical Intermediates》2017,43(7):4103-4114
Research on Chemical Intermediates - A convenient and new method has been developed for the synthesis of highly substituted dihydro-2H-dipyrimido[1,2-a,4,5-d]pyrimidine-2,4(3H)-dione derivatives by... 相似文献
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Activated acetylnic reagents add to heterocyclic enamines 4,5-dihydro-1H-benzo[b]azepines and by electrocyclisation, give 6,7-dihydro-1H-benzo[b]azoninines. The structure of those new heterocycles is demonstrated by mass spectra, 1H and 13C nmr. 相似文献
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Anna GliszczyńskaRados?aw Bonikowski Józef Kula Czes?aw WawrzeńczykKornelia Cio?ak 《Tetrahedron letters》2011,52(34):4461-4463
(R)- and (S)-Lavandulol are important compounds in the cosmetics industry and in pheromone research. We have developed syntheses of (R)- and (S)-lavandulol from (S)- and (R)-limonene, respectively, by microbial Baeyer-Villiger oxidation of the intermediate unsaturated hydroxy ketone. It has been found that the same strain of Acremonium roseum can be successfully used in the key step of the synthesis of both enantiomers of lavandulol. 相似文献
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A productive natural method has been produced for the synthesis of 2-aryl-2-methyl-4,5-diphenyl-2,3-dihydro-2H-imidazoles in great yields under catalyst free-conditions utilizing polyethylene glycol (PEG-400) as a green reaction medium. The highlights of this new method are shorter reaction times, good yields, room temperature, and use of nontoxic, inexpensive, and recyclable PEG-400. 相似文献
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Darrell E. O'Brien Louis T. Weinstock Robert H. Springer C. C. Cheng 《Journal of heterocyclic chemistry》1967,4(1):49-53
A number of 2-substituted 4,5-dihydroxy-6-(substituted aminomethyl)pyrimidines (VIII) were prepared from the corresponding 2-substituted 4,5-dihydroxypyrimidines (VII) by a new pyrimidine Mannich reaction. The structure of VIII was proved by an independent synthesis. Further study of this reaction led to the synthesis of a new class of compounds: the pyrimido[4,5-e]dihydro-1,3-oxazines (VI). 相似文献
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A straight forward synthesis of dihydro-3(2h)-furanone is described. An attempted preparation of the oxetan-3-one precursor 10 by this method gave, instead, the ring enlargement product 11. 相似文献
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An efficient method has been developed for the synthesis of 2,3-dihydropyrans and 4-methylenetetrahydropyrans from aldehydes and substituted homoallyl alcohols in benzene mediated by boron trifluoride etherate in good yields. The reaction proceeds via oxonium-ene reaction. 相似文献
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Cosme G. Francisco Raimundo Freire Rosendo Hernández José A. Salazar Ernesto Suárez 《Tetrahedron letters》1984,25(15):1621-1624
A mild and convenient method for ring expansion of 1,3-dithiolans and 1,3-dithians to dihydro-1,4-dithiins and dihydro-1,4-dithiepins, respectively, using phenyl selenenyl chloride in methylene chloride is described. A mechanism involving sulphenyl chloride derivatives as intermediates is proposed. 相似文献