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1.
以2-甲基-3-三氟甲基苯胺(1)为原料,经Balz-Schiemann反应制得3-氟-2-甲基三氟甲苯(3);3经溴代制得2-氟-6-三氟甲基苄溴(4),最后经Gabriel反应合成2-氟-6-三氟甲基苄胺,总收率53.4%,其结构经1H NMR和MS(ESI)确证。 相似文献
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研究了2-(1'-烯丙氧基四氟乙基)全氟-3-甲基-1-戊烯的分子内环加成反应, 反应温度低于100℃时, 未发现重排产物, 在140℃时发生分子内环加成, 得到1-(1'-三氟甲基1'-戊基氟乙基)-戊基氟丙基-2-三氟甲基-2-氟代-7,7-二氟代-3-氧杂二环庚烷[3,2,0]以及相应的二环庚烷[3,1,1]和分子间[2+2]环加成产品. 相似文献
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以3-(2-氯-4-三氟甲基苯氧基)苯甲酸为起始原料,经氯化亚砜氯化后得中间体3-(2-氯-4-三氟甲基苯氧基)苯甲酰氯(1),再与不同取代的苯酚反应,合成了13个未见文献报道的3-(2-氯-4-三氟甲基苯氧基)苯甲酸酯(2).通过1H NMR,IR,EI-MS和元素分析对所合成的化合物进行了结构表征,3-甲基苯基3-(2-氯-4-三氟甲基苯氧)苯甲酸酯(2f)通过单晶X射线衍射进一步确证结构.初步的除草活性测试结果表明:大多数目标化合物在1.5 kg/ha剂量下对双子叶植物油菜和苋菜具有较高的抑制活性. 相似文献
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为了合成手性含氟β-二酮顺磁性镧系螯合物作为~1H NMR手性位移试剂,我们曾试图用2-三氟甲基-3-氧杂八氟己酸乙酯与3,3-二甲基-2-丁酮(1)在乙醇钠存在下进行Claisen酯缩合反应合成β-二酮,结果只发生氟仿型反应,生成碳酸二乙酯.若用三氟乙酸乙酯与1,I,1-三氢_3,6-二(三氟甲基)-4,7-二氧杂-2-十一氟癸酮在乙醇钠存在下反应,也得到氟仿型反应产物2-氢-5-三氟甲基-3,6-二氧杂-十四氟壬烷(2).本文采用碱性较弱的 相似文献
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首次合成了九种[Cr(β-dik)Cl_2L_2]型混合配体配合物。其中五种是:L为γ-甲基吡啶,β-dik分别为乙酰丙酮、苯甲酰丙酮、三氟乙酰丙酮、2-噻吩甲酰三氟丙酮、1,1,1,2,2,3,3-七氟-7,7-二甲基-4,6-辛二酮;四种是:L分别为N,N-二甲基甲酰胺,N,N-二甲基乙酰胺,β-dik分别为苯甲酰丙酮和2-噻吩甲酰三氟丙酮。并对上述配合物进行了电子光谱、红外光谱的表征工作。 相似文献
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3,3-Dialkyl-2,3-dihydro-6-trifluoromethyl-4-pyrones react with hydrazine hydrate to give 2-hydrazino-2-trifluoromethyl-4-tetrahydropyrone hydrazones. When heated, the latter are transformed into 3(5)-(2-hydroxyethyl)-5(3)-trifluoromethylpyrazoles, while their treatment with HCl in ether leads to 3,3-dialkyl-2,3-dihydro-6-trifluoromethyl-4-pyrone azines. 相似文献
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Treatment of 4-aryl-6-trifluoromethyl-2-pyrones with sodium azide in DMSO afforded the corresponding (Z)-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)cinnamic acids in good yields. Similarly, 4-aryl-3-carbethoxy-6-trifluoromethyl-2-pyrones smoothly reacted with sodium azide in acetonitrile to produce (E)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)cinnamic acids in high yields, whereas their reactions in ethanol, accompanied by a configurational change, gave the thermodynamically more stable (Z)-2-ethoxycarbonyl-3-(5-trifluoromethyl-1,2,3-triazol-4-yl)cinnamic acids. 相似文献
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M. V. Yure D. V. Shantare É. Yu. Gurdinietse 《Chemistry of Heterocyclic Compounds》1996,32(4):473-476
The potassium salt of 7-trifluoromethyl-5-phenyl-2-oxooxazolo[5, 4-bjpyridine (IV) was prepared from 3-aminocarbonyl-4-trifluoromethyl-6 phenyl-2(1H)-pyridone by the Hofmann reaction and was converted into 3-anuno-4-trifluoromethyl-6-phenyl-2(1H)-pyridone without isolation. 1-Substituted 7-trifluoromethyl-5phenyl-2-oxooxazolo[5, 4-b]pyridines were formed by alkylation of salt IV. 6-Halogeno-7-trifluoromethyl-S phenyl-2-oxo(1H)-oxazolo[5,4-b]pyridines have been prepared.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 542–545, April. 1996. 相似文献
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E. Suloeva M. Yure E. Gudriniece S. Belyakov M. Petrova I. Kalnite 《Chemistry of Heterocyclic Compounds》2001,37(3):329-337
Syntheses are reported for a series of 2-alkylamino-6-phenyl-4-trifluoromethylpyridines. The reaction of 3-cyano-2-(hydroxyalkylamino)-6-phenyl-4-trifluoromethylpyridines with thionyl chloride gave the corresponding 2-(chloroalkylamino)pyridines, 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydro-imidazo[1,2-a]pyridines, and 9-cyano-6-phenyl-8-trifluoromethyl-2,3,4-trihydropyrido[1,2-a]-pyrimidines. X-ray diffraction structural analysis was used to study 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridine. 相似文献
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O. G. Kuzueva Ya. V. Burgart V. I. Saloutin O. N. Chupakhin 《Chemistry of Heterocyclic Compounds》2001,37(9):1130-1135
4,5-Bis(hydroxy)-4-trifluoromethyl-6-(fluoroalkyl)hexahydropyrimidin-2-ones (thiones) have been obtained for the first time by the reaction of ureas (thioureas) with di(fluoroalkyl)-substituted 1,3-diketones and tetraols, the dehydration of which gave 2-hydroxy(mercapto)-4-trifluoromethyl-6-(fluoroalkyl)pyrimidines. 相似文献
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The reactions of 6-nitro-2-trifluoromethylchromone with benzylamine, ethanolamine, and aniline afforded 3-benzyl(2-hydroxyethyl,phenyl)amino-4,4,4-trifluoro-1-(2-hydroxy-5-nitrophenyl)but-2-en-1-ones, respectively, whereas the reactions with ethylenediamine and diethylenetriamine gave rise to 5-(2-hydroxy-5-nitrophenyl)-7-trifluoromethyl-2,3-dihydro-1H-1,4-diazepine and 5-(2-hydroxy-5-nitrophenyl)-7-trifluoromethyl-1,4,8-triazabicyclo[5.3.0]dec-4-ene, respectively. Morpholine added at the double bond of 2-trifluoromethyl- and 6-nitro-2-trifluoromethylchromones to form 2-morpholino-2-trifluoromethylchroman-4-one and its 6-nitro-substituted analog, respectively, whereas piperidine reacted only with 2-trifluoromethylchromone to yield 2-piperidino-2-trifluoromethylchroman-4-one. 相似文献
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Reactions of 2,2-dimethyl-6-trifluoromethyl-2,3-dihydro-4-pyrone with ethylenediamine, hydrazine, or hydroxylamine yield 5-methyl-7-trifluoromethyl-2,3-dihydro-1H-1,4-diazepine, 3(5)-(2-hydroxy-2-methylpropyl)-5(3)-trifluoromethylpyrazole, and 5-hydroxy-3-(2-hydroxy-2-methylpropyl)-5-triflouromethyl-Δ2, respectively. The same compounds were obtained from 2-amino-1,1,1-trifluoro-6-hydroxy-6-methylhept-2(Z)-en-4-one and 2-hydroxy-6, 6-dimethyl-2-trifluoromethyltetrahydro-4-pyrone. 相似文献
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S. G. Krivokolysko V. D. Dyachenko A. N. Chernega V. P. Litvinov 《Chemistry of Heterocyclic Compounds》2001,37(10):1208-1215
The condensation of 2-chlorobenzaldehyde with cyanothioacetamide and 2-thenoyltrifluoroacetone in the presence of N-methylmorpholine takes place stereoselectively and leads to the formation of N-methylmorpholinium 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy-5-(2-thenoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine-2-thiolate. The latter was used to synthesize the corresponding 2-alkylthiotetrahydropyridines. The structure of 4,5-trans-4-(2-chlorophenyl)-3-cyano-6-hydroxy-2-methallylthio-5-(2-thenoyl)-6-trifluoromethyl-1,4,5,6-tetrahydropyridine was determined by X-ray crystallographic analysis. 相似文献
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Usachev B. I. Usachev S. A. Röschenthaler G.-V. Sosnovskikh V. Ya. 《Russian Chemical Bulletin》2010,59(4):845-847
Treatment of 6-trifluoromethylcomanic acid with sodium hydrosulfide afforded for the first time 4-oxo-6-trifluoromethyl-4H-thiopyran-2-carboxylic acid (6-trifluoromethylthiocomanic acid). When heated or treated with H2SO4, this acid easily underwent decarboxylation leading to 2-trifluoromethyl-4H-thiopyran-4-one. Because of this, both ethyl and methyl 6-tri-fluoromethylthiocomanates were obtained in low yields (15–23%).
Decarboxylation of 6-tri-(di)fluoromethylcomanic acids gave 2-tri(di)fluoromethyl-4H-pyran-4-ones in 77–80% yields. 相似文献
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Shyam K. Singh Meledath Govindan John B. Hynes 《Journal of heterocyclic chemistry》1990,27(7):2101-2105
The target folate analogue 5-trifluoromethyl-5,8-dideazafolic acid has been elaborated in a seven-step reaction sequence beginning with 2-fluoro-6-trifluoromethylbenzonitrile. The bridge-reversed isomer 5-trifluoromethyl-5,8-dideazaisofolic acid was prepared in six steps using the common intermediate 2,6-diamino-3,4-dihydro-4-oxo-5-trifluoromethylquinazoline. The key intermediate 2-amino-3,4-dihydro-4-oxo-5-trifluoromethyl-quinazoline was prepared using two distinct synthetic routes and the resulting products were found to be identical. 相似文献