共查询到20条相似文献,搜索用时 0 毫秒
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A new additive scheme is proposed for the precalculation of gas chromatographic retention indices of complex organic compounds. The principal feature of this approach is the absence of previously calculated I increments for any structural fragments or functional groups in the molecule. Instead, arithmetical operations involving I values of simpler structural analogues of target compounds are used directly. I precalculation for polychlorinated hydroxybiphenyls (839 congeners) on the HP-5 stationary phase was chosen as one of the most important applications of the method under discussion. Such a large number of congeners cannot be obtained as reference samples and their gas chromatographic (GC)-mass spectrometric (MS) identification should therefore be based currently on precalculated I values. 相似文献
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Kováts retention indices for a series of linear, branched, and cyclic alkanes on squalane at any temperature, and on other stationary phases of different polarity at a given temperature, are related to physicochemical properties of the solutes, such as boiling point and molar refraction, by multiple regression analysis. The equations found permit calculation of the Kováts retention index for all alkanes, with standard deviations close to experimental error. The same equations can also be used for calculating the physicochemical parameters they contain. 相似文献
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I.G. Zenkevich V.I. Babushok P.J. LinstromE. White V S.E. Stein 《Journal of chromatography. A》2009,1216(38):6651-6661
The effective use of gas chromatographic retention data presented in the form of retention indices (RI) requires the development of a comprehensive structure-based digital archive of retention parameters. Development of such an archive includes the collection of all available RI values for a variety of compounds including replicates measured under slightly different conditions. Review of retention data often shows a relatively wide range of RI values for certain well studied compounds that is larger than expected on the basis of the simple reproducibility of experimental measurements. The finding of unusual RI data distributions and their examination presents a possible way to detect and correct errors during the development of comprehensive RI libraries. 相似文献
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Summary A new method is presented for the calculation of the retention indices under linear temperature programming with or without an initial isothermal period. The data calculated by the method are in good agreement with the isothermal retention indices. 相似文献
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Summary The retention indices of mono and polycycloolefins with endo or exo double bonds, on squalane or polypropylenglycol 425 are related to their physico-chemical properties such as boiling point, molar volume, molar refraction, and refractive index. Equations have been empirically obtained, from which accurate retention indices of these compounds can be predicted. Unknown boiling points of some of these compounds can also be calculated from their lineal relation with the retention index on squalane. 相似文献
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Pappa-Louisi A Nikitas P Balkatzopoulou P Malliakas C 《Journal of chromatography. A》2004,1033(1):29-41
Two-parameter equations that describe the dependence of ln kappa upon psi, where kappa is the retention factor and psi the volume fraction of the organic modifier in the mobile phase, are examined in what concerns the underlying approximations and their performance to fit experimental data obtained from reversed-phase liquid chromatography. Using 293 experimental systems, it was found that the performance of these equations to describe ln kappa versus psi data is rather low, since the percentage of the systems that can be described satisfactorily ranges from 40 to 60% depending on the fitting equation. This percentage may be raised to 75%, if the discreteness effect is properly taken into account. A further improvement to 90% of the systems studied can be achieved only by the use of three-parameter equations, which may arise by refinements of the rough approximations of the two-parameter equations. Although the refinements do not lead always to better equations, we developed a new three-parameter expression of In kappa that works more satisfactorily, since it combines simplicity, linearity of its adjustable parameters and the highest applicability. 相似文献
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This work presents linear temperature programmed retention indices on the columns with stationary phases of 5% phenylpolydimethyl silicone of 389 organic compounds, including extractive substances of plant tissues and environmentally important compounds. Certain factors which influence the values and reproducibility of retention indices during gas chromatographic analysis of multicomponent mixtures are discussed. 相似文献
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Edward A. Dietz 《Journal of separation science》1996,19(9):485-491
Gas chromatrography (GC) with sulfur chemiluminescence detection (SCD) is an outstanding combination for selectively determining trace concentrations of sulfur compounds in hydrocarbon samples. GC peaks can be identified by retention times when reproducible, automated injection techniques are used. However, as described in this work, analysts should be on the look out for retention shifting due to solvent effects from sample components. Three examples of retention shifting are presented: (1) thiophene by benzene; (2) methylthiophenes by toluene; and (3) dibenzothiophene by gas oil. Depending on samples and analysis conditions, retention shifts from a few hundredths to 1.5 min have been observed. Such retention shifts are likely to cause errors in peak identifications. Therefore, when using SCD, simultaneous FID monitoring is recommended as an aid in evaluating chromatograms for possible retention shifting due to solvent effects. 相似文献
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A straightforward group contribution model based on thermodynamic parameters was developed to predict retention times for a series of alcohols and ketones on three different stationary phases. Thermodynamic parameters determined from gas chromatographic retention data for structurally similar compounds via a three-parameter model were used to predict the retention times of test molecules consisting of ketones and alcohols. The model worked well for the compounds tested with a root mean square error of prediction of 5.50 s across all compounds, phases, and temperature ranges studied. Considering just the alcohols, the error of prediction was 2.79 s across all phases and temperatures. 相似文献
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Vendeuvre C Bertoncini F Thiébaut D Martin M Hennion MC 《Journal of separation science》2005,28(11):1129-1136
Modeling the retention in comprehensive two-dimensional gas chromatography (GC x GC) was achieved using retention indices obtained in conventional GC. Predicted results were compared with experimental data obtained in the two-dimensional separation of a synthetic hydrocarbon mixture. This proved to be helpful in optimizing the operating conditions of GC x GC separation of a complex petroleum sample and in identifying chemical families. 相似文献
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Ilpo Rasanen Ilkka Ojanper Juhani Vartiovaara Erkki Vuori Pekka Sunila 《Journal of separation science》1996,19(6):313-321
A dual-column gas chromatographic retention index method was evaluated for the toxicological screening for basic drugs in autopsy blood samples. The dual-column approach with DB-5 and DB-1701 capillary columns doubles the Identification Power of the corresponding single column methods. The long-term intralaboratory variation of the dialkylfluoroaniline series based retention indices of drugs in blood ranged from 0.03% to 0.2% which was generally better than that obtained using the relative retention time. Novel software is described for the processing and reporting of the dual-column chromatographic data in analytically useful form. Besides retention data, the response factors served as an additional identification factor. 相似文献
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Summary The proportion of organic modifier and the pH of the acetonitrile-water mixtures used as mobile phases were optimized in order
to separate a group of diuretic compounds covering a wide range of physyco-chemical properties. The Linear Solvation Energy
Relationship (LSER) formalism based either on the multiparameter π*, β and α scales or the single solvent polarity parameterE
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, have been used to predict their chromatographic behaviour as a function of the percentage of acetonitrile in the eluent.
Moreover, correlation established between retention and pH of the aqueous-organic mobile phases have been used to predict
the chromatographic behaviour of the diuretic compounds studied as a function of the eluent pH. Linear correlation between
a function of the eluent pH. Linear correlation between the chromatographic retention and theE
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polarity parameter of mobile phases containing different percentages of organic modifier has been obtained Based on the knowledge
of the acid-base dissociation constant the relation between retention and mobile phase pH has also been linearized. These
relationship allowed an important reduction of the experimental retention data needed for developing a given separation and
a great improvement in chromatographic optimization schemes. 相似文献
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Summary The influence of the isothermal temperature, program rate, initial temperature and flow rate on retention indices was studied. The methods of Kováts, Van Den Dool and Local Lagrange Interpolation are compared. Ten experimental measurements were carried out on a capillary column coated with OV-101 stationary phase. 相似文献