沉积法自组装三维有序的Eu(DBM)3Phen/SiO2胶体球

采用修饰的St ber法合成了300 nm的Eu(DBM)3Phen/SiO2胶体杂化球,并通过沉积法将这种胶体杂化球组装成厚度为5 mm,面积为12 cm2的三维有序结构。通过扫描电子显微镜观察发现这些胶体球在垂直于烧杯底面的所有层面中都显示了立方密堆积的结构。元素分析进一步证实了荧光分子被包埋在SiO2胶体球中。在355 nm的激发下,这种三维有序结构具有铕离子的特征发射。     

3D molecular imaging SIMS

Thin monolayer and bilayer films of spin cast poly(methyl methacrylate) (PMMA), poly(2-hydroxyethyl methacrylate) (PHEMA), poly(lactic) acid (PLA) and PLA doped with several pharmaceuticals have been analyzed by dynamic SIMS using SF₅⁺ polyatomic primary ion bombardment. Each of these systems exhibited minimal primary beam-induced degradation under cluster ion bombardment allowing molecular depth profiles to be obtained through the film. By combing secondary ion imaging with depth profiling, three-dimensional molecular image depth profiles have been obtained from these systems. In another approach, bevel cross-sections are cut in the samples with the SF₅⁺ primary ion beam to produce a laterally magnified cross-section of the sample that does not contain the beam-induced damage that would be induced by conventional focussed ion beam (FIB) cross-sectioning. The bevel surface can then be examined using cluster SIMS imaging or other appropriate microanalysis technique.     

光学三维成像实验系统

建立光学投影层析三维成像系统,该系统包括光学成像、图像采集、断层重建及三维显示,重建算法为滤波反投影算法.实验结果表明:利用该系统得到的重建图像与样品的形状吻合,重建结果边缘清晰,伪迹较小.     

3D spin-lock imaging of human gliomas

We investigated whether the simultaneous use of paramagnetic contrast medium and 3D on-resonance spin lock (SL) imaging could improve the contrast of enhancing brain tumors at 0.1 T. A phantom containing serial concentrations of gadopentetate dimeglumine (Gd-DTPA) in cross-linked bovine serum albumin (BSA) was imaged. Eleven patients with histologically verified glioma were also studied. T₁-weighted 3D gradient echo images with and without SL pulse were acquired before and after a Gd-DTPA injection. SL effect, contrast, and contrast-to-noise ratio (CNR) were calculated for each patient. In the glioma patients, the SL effect was significantly smaller in the tumor than in the white and gray matter both before (p = 0.001, p = 0.025, respectively), and after contrast medium injection (p < 0.001, p < 0.001, respectively). On post-contrast images, SL imaging significantly improved tumor contrast (p = 0.001) whereas tumor CNR decreased slightly (p = 0.024). The combined use of SL imaging and paramagnetic Gd-DTPA contrast agent offers a modality for improving tumor contrast in magnetic resonance imaging (MRI) of enhancing brain tumors. 3D gradient echo SL imaging has also shown potential to increase tissue characterization properties of MR imaging of human gliomas.     

Harvesting vibrations via 3D phononic isolators

We report on the existence of unidirectional phononic band gaps that may span over extended regions of the Brillouin zone and can find application in trapping elastic (acoustic) waves in properly designed multilayered 3D structures. Phononic isolators operate as a result of asymmetrical wave transmission through a slab of a crystallographic phononic structure with broken mirror symmetry. Due to the use of lossless materials in the crystal, the absorption rate is dramatically enhanced when the proposed isolator is placed next to a vibrational harvesting cell.     

Feasibility of 3D harmonic contrast imaging

Improved endocardial border delineation with the application of contrast agents should allow for less complex and faster tracing algorithms for left ventricular volume analysis. We developed a fast rotating phased array transducer for 3D imaging of the heart with harmonic capabilities making it suitable for contrast imaging. In this study the feasibility of 3D harmonic contrast imaging is evaluated in vitro. A commercially available tissue mimicking flow phantom was used in combination with Sonovue. Backscatter power spectra from a tissue and contrast region of interest were calculated from recorded radio frequency data. The spectra and the extracted contrast to tissue ratio from these spectra were used to optimize the excitation frequency, the pulse length and the receive filter settings of the transducer. Frequencies ranging from 1.66 to 2.35 MHz and pulse lengths of 1.5, 2 and 2.5 cycles were explored. An increase of more than 15 dB in the contrast to tissue ratio was found around the second harmonic compared with the fundamental level at an optimal excitation frequency of 1.74 MHz and a pulse length of 2.5 cycles. Using the optimal settings for 3D harmonic contrast recordings volume measurements of a left ventricular shaped agar phantom were performed. Without contrast the extracted volume data resulted in a volume error of 1.5%, with contrast an accuracy of 3.8% was achieved. The results show the feasibility of accurate volume measurements from 3D harmonic contrast images. Further investigations will include the clinical evaluation of the presented technique for improved assessment of the heart.     

Simultaneous magnetic resonance gadolinium-enhanced 2D perfusion and 3D angiographic imaging

A method was implemented and tested that allows the simultaneous acquisition of magnetic resonance 2D slice selective perfusion and 3D angiographic data during a single bolus injection of a contrast agent. High quality contrast-enhanced perfusion images and angiograms of the lung, kidney and heart were obtained in healthy volunteers. Combined perfusion and angiography provided additional information with an acceptable increase in acquisition time. No image artifacts were attributed to the technique. The combined information may be useful in detecting, as well as characterizing, vascular abnormalities.     

Assessment of 3D inhomogeneous microstructure of highly alloyed aluminium foam via dual energy K-edge subtraction imaging

X-ray microtomography was used to evaluate the inhomogeneous characteristics of newly-developed Al–Zn–Mg foam. Using the synchrotron K-edge subtraction technique, a highly heterogeneous distribution of Zn was quantified three-dimensionally (3D) in the cell wall of as-cast foam. Time-resolved analysis of the concentration evolution revealed a tendency to a homogeneous Zn distribution as solution time prolonged. This was accompanied by a declined variation in hardness measurement. Other microstructural features after solution treatment, such as number and size distribution of micropores, were also characterised. By utilising various quenching rates, the inhomogeneities in microstructure and compression properties inside the foam were also clarified. Thus, element-sensitive tomography provides a novel solution for the 3D/4D analysis in the study of foams.     

基于扫描相机的激光三维成像研究

随着条纹管器件技术的发展,条纹管作为瞬态光学器件的应用不再局限于高速摄影和光谱学研究领域。建立以单狭缝条纹管为核心器件的扫描相机激光成像系统,对目标进行推扫成像,获得原始条纹图像,并进行特征数据提取和三维重建。理论计算出的两目标的距离差与实际距离差较接近,从而验证采用该系统作激光雷达成像的可行性。实验结果表明,基于扫描相机激光雷达具有高分辨率,具有较好的应用前景。     

Colloidal monolayer self-assembly and its simulation via cellular automaton model

A wafer-scale colloidal monolayer consisting of SiO2 spheres is fabricated by a method combining spin coating and thermal treatment for the first time. Moreover, a new cellular automaton model describing the self-assembly process of the colloidal monolayer is introduced. Rather than simulate molecular self-assembly to establish the most energetically favored position, we reconstruct the self-assembly of the colloidal monolayer by adjusting several simple transition rules of a cellular automaton. This model captures the main self-assembly characteristics of SiO2 spheres, including experimental processing time, morphology, and some statistics. It possesses the advantage of less calculation and higher efficiency,paving a new way to simulate a mesoscopic system.     

Glasses-free 3D viewing systems for medical imaging

In this work we show two different glasses-free 3D viewing systems for medical imaging: a stereoscopic system that employs a vertically dispersive holographic screen (VDHS) and a multi-autostereoscopic system, both used to produce 3D MRI/CT images. We describe how to obtain a VDHS in holographic plates optimized for this application, with field of view of 7 cm to each eye and focal length of 25 cm, showing images done with the system. We also describe a multi-autostereoscopic system, presenting how it can generate 3D medical imaging from viewpoints of a MRI or CT image, showing results of a 3D angioresonance image.     

Volumetric q-space imaging by 3D diffusion-weighted MRI

High b-value diffusion magnetic resonance imaging (MRI) enables us to detect far smaller architectures, by using q-space analysis, than the resolution in conventional MRI. Average displacement, one of the q-space parameters, quantitatively reflects architecture size and is very useful in observing small changes in microstructures in vivo (e.g., neurodegeneration, tumor heterogeneity, and others). Diffusion-weighted imaging (DWI) is performed by a two-dimensional (2D) multislice method; however, due to finite slice thickness and slice gap, there is a partial-volume effect that makes it difficult to detect the net q-space signal. On the other hand, three-dimensional (3D) MRI, having the advantages of very thin slice thickness and no slice gap (contiguous slices), allows volumetric evaluation acquired in a small isotropic voxel, as compared to 2D multislice imaging. Little is known about the isotropic high-resolution 3D DWI application to q-space analysis. In this study, we have developed and implemented a high b-value 3D DWI sequence, applied q-space analysis to study the reliability of high b-value 3D DWI and obtained a microscopic analytical map with isotropic high resolution and less contamination.     

3D high-resolution acoustic imaging of the sub-seabed

Chirp sub-bottom profilers are marine acoustic devices that use a known and repeatable frequency-modulated source signature to produce vertical seismic reflection cross-sections of the sub-seabed. Here a 3D Chirp system is described that operates in the frequency range of 1.5-13 kHz, to produce a three-dimensional image of the sub-seabed, with typical penetration of 10-30 m and decimetric horizontal and vertical resolution. The system design incorporates a rigid frame that contains the Chirp source array together with 60 receiver elements, with positioning provided by an integrated real-time-kinematic (RTK) global positioning system (GPS). The system can be surface towed from a small survey vessel and can be applied to targets of marine geological, engineering, archaeological and defence interest. Data acquisition and processing are described for a case study which images a buried engineering structure in the Port of Southampton.     

3D atomic imaging by internal-detector electron holography

A method of internal-detector electron holography is the time-reversed version of photoelectron holography. Using an energy-dispersive x-ray detector, an electron gun, and a computer-controllable sample stage, we measured a multiple-energy hologram of the atomic arrangement around the Ti atom in SrTiO3 by recording the characteristic Ti Kα x-ray spectra for different electron beam angles and wavelengths. A real-space image was obtained by using a fitting-based reconstruction algorithm. 3D atomic images of the elements Sr, Ti, and O in SrTiO3 were clearly visualized. The present work reveals that internal-detector electron holography has great potential for reproducing 3D atomic arrangements, even for light elements.     

3D reconstruction of objects using stereo imaging

This paper describes two stereo imaging experimental set-ups useful in measuring the 3D geometry of objects: a parallel optical-axis model and a converging optical-axis model. Digital image correlation is used to find the disparities between corresponding points in a pair of images, for each of these models, with subpixel accuracy. To show the application of the developed algorithms and the stereo imaging experimental set-ups, four different body geometries are used. For some of the objects tested a higher measuring accuracy is obtainable from the converging optical-axis experimental set-up.     

机载激光3D探测成像系统的发展现状

机载激光3D探测成像是通过激光主动成像产生目标的角-角-距、角-角-速度3D图像的一种新的探测成像技术.本文重点阐述了机载激光3D探测成像系统的原理、功能和系统的组成.介绍了该系统在军事和民用两大领域的应用,详细地讨论了近几年机载激光3D探测成像技术的国内外发展现状及动态,总结了该项技术的发展方向.认为国外的机载激光3...     

3D acousto-optic modulated-speckle imaging in biological tissues

A parallel, 64K-channel implementation of the acousto-optic method of imaging optical contrasts buried in organs is presented. This implementation also associates this method with echography in a single apparatus. This allows us to prove that sensitivity to purely optical contrast is achieved. Moreover, this enables any potential user to distinguish easily optical contrast, acoustic contrast, and mixtures of both. We plan to improve this prototype with a view to future use by physicians in a hospital environment.     

单个病毒的X射线3D成像

自从1957 年确立肌红蛋白的结构以来,研究人员利用X射线晶体学确定了数以万计蛋白、核酸和其他生物分子的结构,并由此展开了分子功能研究。这种方法要求被研究的分子必须可以形成晶体,当X射线通过晶体时会发生衍射,由此可获得结构信息。但是,很多重要的分子无法结晶,因此不能用这种方法来研究。这就是X射线晶体学的“阿喀琉斯之踵”。科学家们正在寻找重建分子结构的新方案：他们希望只需要将单分子注入到自由电子激光(XFEL)的强激光束中即可通过X 射线衍射信息重建分子结构。由瑞典Uppsala 大学Hajdu 领导的研究小组报道了一项关键进展：如果利用随机取向的单个病毒获得大量的衍射图样,那么就有可能重建病毒的三维结构。     

64 elements two-dimensional piezoelectric array for 3D imaging

Ultrasound has a large potential on non-invasive inspection with main applications in medical imaging and non-destructive testing (NDT). The increasing interest in 3D imaging applications leads to investigate new solutions for two-dimensional (2D) ultrasonic arrays with an affordable number of electronic channels without resolution degradation. 2D segmented annular arrays (SAAs) are a good compromise between resolution--image quality--and number of electronically active channels. A 1-3 piezoelectric composites are used as basis material to manufacture the array transducers due to their low planar coupling and high electromechanical coupling coefficients. A 1.5 MHz SAA of 64 elements and 20 mm of diameter was designed, manufactured and tested. The design key point is the use of a flexible circuit with electrodes and tracks that define the array geometry. The piezocomposite was used as a monolithic support. Soft backing and one matching layer were used. The array elements have been tested electrically and acoustically showing good agreement with a KLM-based simulation model. Acoustical field measurements in water at different steering angles were made and compared with simulations performed with a model that uses an exact solution of the impulse response approach. Side lobes are important because the array geometry used was designed to work in metals for NDT purposes. Smaller array elements should be made for medical applications.     

机载激光3D探测成像系统的发展现状

机载激光3D探测成像是通过激光主动成像产生目标的角-角-距、角-角-速度3D图像的一种新的探测成像技术。本文重点阐述了机载激光3D探测成像系统的原理、功能和系统的组成。介绍了该系统在军事和民用两大领域的应用,详细地讨论了近几年机载激光3D探测成像技术的国内外发展现状及动态,总结了该项技术的发展方向。认为国外的机载激光3D探测系统正向远距离、高分辨率、轻量化、低功耗、高实时性和人眼安全方向发展,而目前国内的相关研究仍处于实验室阶段,与国外相比还存在一定差距。文章最后以用户需求为例,从设计的角度对机载激光3D探测成像系统进行了分析,讨论了该系统在测距机制、扫描机构、探测器、数据处理和显示等方面的处理。