Investigation of DNA Binding Interaction of Newly Synthesized Nickel(II) and Palladium(II) Complexes Containing Ferrocenyl Schiff Base Ligand

New complexes of nickel(II) and palladium(II) were synthesized using the ferrocenyl imine ligand, which was formed by the condensation of 2‐aminothiophenol and acetylferrocene. This bidentate Schiff base ligand was coordinated to the metal ions through the NS donor atoms. Monomeric complexes of nickel(II) and palladium(II) were synthesized by the reactions of the Schiff base ligand with nickel(II) and palladium(II) chloride in a 2:1 M ratio. In these complexes, the thiol group was deprotonated and coordinated to the metals. The molar conductivity values of the complexes in DMSO showed the presence of non‐electrolyte species. The fluorescence characteristics of the Schiff base ligand and its complexes were studied in DMSO. The synthesized complexes were characterized by FT‐IR, ¹H NMR, UV–vis spectroscopy, elemental analysis, and conductometry. Furthermore, the binding interactions of the complexes with DNA were investigated by electronic absorption spectroscopy, and the intrinsic binding constant (K _b) was calculated. Moreover, viscosity and melting temperature (T _m) were investigated in order to further explore the nature of interactions between the complexes and DNA.     

Synthesis,Spectroscopic Studies,and Biological Activity of Some New N2O2 Tetradentate Schiff Base Metal Complexes

Russian Journal of General Chemistry - The new tetradentate Schiff base N,N′-ethylene bis[1-ethyl-6-fluoro-4-imine-7-(piperazine-1-yl)-quinoline-3-carboxylic acid] (Nor-en) has been...     

硫氮西夫碱配体及其金属配合物的合成与表征

合成了1，7－二（2′-苯甲酰）－1，4，7－三氧庚烷双缩肼基二硫以苄酯西夫碱配体及其Cu(Ⅱ），Ni(Ⅱ），Zn(Ⅱ）的配合物，并通过元素分析，IR和UV-vis对其进行了表征。     

含乙酰氧肟酸配体的席夫碱钒配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究

本文合成了2个新的含乙酰氧肟酸配体的席夫碱钒配合物,[V^ⅢL¹(HAHA)](1)和[V^ⅤOL²(AHA)](2),其中L¹为N,N’-二(5-甲基水杨基)乙烷-1,2-二胺的二价阴离子,L²为2-{[2-(2-羟乙基氨基)乙亚胺基]甲基}-6-甲基苯酚的一价阴离子,HAHA和AHA分别为乙酰氧肟酸的一价和二价阴离子,通过物理-化学方法以及单晶X-射线衍射表征了它们的结构。在每个化合物中,V原子都采取八面体配位构型。本文还研究了配合物的热稳定性以及其对幽门螺旋杆菌脲酶的抑制活性。在浓度为100μmol·L^-1时,配合物1和2对脲酶的抑制率分别为37.2%和81.5%,其中配合物2的IC₅₀值为21.5μmol·L^-1。分子对接研究表明配合物2与脲酶活性中心存在有效的作用力。     

含乙酰氧肟酸配体的席夫碱钒配合物的合成、结构及其抑制幽门螺旋杆菌脲酶研究(英文)

本文合成了2个新的含乙酰氧肟酸配体的席夫碱钒配合物,[VⅢL1(HAHA)](1)和[VⅤOL2(AHA)](2),其中L1为N,N′-二(5-甲基水杨基)乙烷-1,2-二胺的二价阴离子,L2为2-{[2-(2-羟乙基氨基)乙亚胺基]甲基}-6-甲基苯酚的一价阴离子,HAHA和AHA分别为乙酰氧肟酸的一价和二价阴离子,通过物理-化学方法以及单晶X-射线衍射表征了它们的结构。在每个化合物中,V原子都采取八面体配位构型。本文还研究了配合物的热稳定性以及其对幽门螺旋杆菌脲酶的抑制活性。在浓度为100μmol·L-1时,配合物1和2对脲酶的抑制率分别为37.2%和81.5%,其中配合物2的IC50值为21.5μmol·L-1。分子对接研究表明配合物2与脲酶活性中心存在有效的作用力。     

Antimicrobial and DNA Cleavage Studies of New N2O2 Diazadioxa Macrocyclic Schiff Base Co(II), Ni(II) and Cu(II) Complexes Containing Triazole Head Unit: Synthesis and Spectroscopic Approach

A novel series of N₂O₂ diazadioxa macrocyclic complexes [MLCl₂] (M=Co²⁺, Ni²⁺ and Cu²⁺) have been synthesized with newly derived biologically active ligands (L^I-L^IV). These ligands were synthesized by the condensation of 1, 6-bis(2-formylphenyl)hexane and 3-subtituted-4-amino-5-hydrazino-1, 2, 4-triazole. The mode of bonding and overall geometry of the complexes have been inferred through IR, EPR, electronic spectral studies, conductivity, magnetic, thermal and electrochemical studies. All the complexes are soluble in DMF and DMSO and are non-electrolytes. All these complexes have been screened for their antibacterial (Escherichia coli, Staphylococus aureus, Salmonella typhi, Pseudomonas aeruginosa) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by the MIC method. The DNA cleavage study was done by Agarose gel electrophoresis.     

含5-氯水杨醛Schiff碱配体的镍和铜配合物的合成及晶体结构

合成了2个含三齿Schiff碱配体和单齿N-杂环分子的多核过渡金属配合物:1个含5-氯水杨醛缩对硝基苯甲酰腙(H2L1)和吗啡啉(Mf)的镍髤配合物[Ni(L1)(Mf)](1),1个含5-氯水杨醛缩水杨酰腙(H2L2)和吡啶(Py)的铜髤配合物[Cu2(L2)2(Py)2](2),并通过元素分析、红外光谱、紫外光谱以及单晶衍射等手段进行表征。在配合物1中,中心Ni髤与酰腙配体(L12-)的酚氧、亚胺氮、去质子酰胺氧原子以及中性吗啡啉氮原子配位形成平面四方形的N2O2配位构型,相邻配合物通过分子间氢键作用构筑成一维超分子链状结构。配合物2中含有2个晶体学上独立的双核铜髤配合物,相邻配合物分子的酚氧原子分别桥联2个[Cu(L2)(Py)]基本单元,形成2个含有Cu2(μ-O)2核心的配合物。每个Cu髤原子具有五配位的NONO(O)四角锥配位构型。     

Synthetic and Spectral Studies of Some Nickel Complexes Involving the Iminoquinolinone-Type Ligand

In this study we prepared N,O-bidentate ligands, sodium salt of 5-(4′-hydroxyphenylimino)quinolin-8-one, and sodium salt of 5,8-quinolinequinone-5-(8-hydroxy-5-quinolylimide) [indoöxine]. According to experimental results, formation of nickel complexes causes a large bathochromic shift of the absorption bands; in addition, these absorption bands appear in the near-infrared region at 678-812 nm. Also, EA, ¹³C NMR, UV, and IR were performed to characterize these complexes. The above results suggest that coordination occurs via the oxygen atom of the quinoneimine moiety and the nitrogen atom of the pyridine moiety.     

含NS和NNSS供电子原子的钌(Ⅲ)席夫碱配合物:催化性能和抗微生物活性

通过[RuX₃(EPh₃)₃] 或 [RuBr₃(PPh₃)₂(MeOH)] (式中X=Cl或Br; E=P或As)与适当的席夫碱以1∶1的物质的量的比反应合成了[RuX₂(L′)(EPh₃)₂]或[RuX(LL′)(PPh₃)](式中L′=席夫碱配体1，即[S-benzyl     

邻氨基苯酚Schiff碱多核配合物的合成与表征

合成了3-羧基水杨醛缩邻氨基苯酚Sch iff碱及其三核铜,三核镍配合物.用质谱分析,核磁共振,红外光谱,元素分析对配体和配合物的结构进行了表征.磁性研究表明,这两种配合物的金属离子间均存在着较强的反铁磁性自旋交换相互作用.     

席夫碱及其金属配合物的合成及生物活性研究进展

席夫碱及其金属配合物具有独特的抗菌、抗肿瘤和抗氧化等生物活性.为筛选高效低毒的药物,人们合成了大量不同类型的席夫碱及其金属配合物并对其生物活性进行了研究.本文综述了近年来席夫碱及其金属配合物的合成,以及在抗菌、抗氧化、抗肿瘤等方面生物活性的研究进展,并为进一步研究其在医药领域的应用提供了信息支持.     

Spectral,Antimicrobial, and Thermal Studies of Some Transition Metal Complexes Derived from Bidentate Ligands Containing N and S Donor Atoms

Abstract

Bidentate ligands have been synthesized by the reaction of 2,4-dichlorobenzaldehyde with 4-amino-5-mercapto-1,2,4-triazole and 4-amino-5-mercapto-3-propyl-1,2,4-triazole. The ligands react with acetates of Co(II), Ni(II), Cu(II), and Zn(II) to yield 1:2 [metal:ligand] complexes. The newly synthesized compounds were characterized by elemental analyses, spectral (UV-Vis, IR, ¹H NMR, fluorescence, ESR) studies, thermal techniques, and magnetic measurements. Thermal studies of the complexes showed a multistep decomposition pattern. A square planar geometry for Cu(II) and octahedral geometry for Co(II), Ni(II), and Zn(II) complexes have been proposed. The synthesized complexes exhibit enhanced antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, and A. flavus compared to parent ligands. However, tested compounds did not exhibit any activity against Escherichia coli and Pseudomonas aeruginosa.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.     

高分子希夫碱金属配合物的研究进展 (Ⅰ)高分子担载希夫碱金属配合物的制备与性能

综述了近十几年来有关高分子担载希夫碱金属配合物的研究进展。此类配合物所采用的合成方法主要有：（ａ）含乙烯侧基的配体或金属配合物共聚；（ｂ）小分子配体或配合物锚连于高分子载体。其主要性能为结合分子氧和催化活性。     

过渡金属氨基酸席夫碱配合物的合成

合成了6个过渡金属氨基酸席夫碱配合物——L-酪氨酸缩水杨醛合铬(钼),L-赖氨酸缩水杨醛合铬(钼),DL-α-丙氨酸缩水杨醛合铬(钼),其结构经UV,IR和元素分析表征。UV测定结果表明,配合物均可与DNA发生插入作用。     

Synthesis of Two Blue-light-emitting Complexes with Schiff Base Calixarene as the Ligand

Two new blue luminescent zinc and beryllium complexes with Schiff base calixarene derivative as the ligand were prepared.Their luminescent properties were determined,which indicated that they had strong blue fluorescent properties.They also had good solubility and film formation.These new complexes can be used as blue organic electroluminescent materials (OELMs) in organic electroluminescent devices.     

以咪唑为配体的钴和镍的配合物的合成、晶体结构及电化学性质

合成了2种新颖的配合物[M(ImH)6](tfbdc)(M=Co,Ni;tfbdc=2,3,5,6-四氟对二苯甲酸根;ImH=咪唑),并通过元素分析,红外光谱,热重分析,循环伏安及X-射线单晶结构分析对其结构及性质进行了表征。2个配合物[Co(ImH)6](tfbdc)(1)和[Ni(ImH)6](tfbdc)(2)都属单斜晶系,空间群为P21/c,且Z=2。每1个金属离子与来自6个咪唑分子的6个氮原子配位,形成八面体配位构型。独立组分,[M(ImH)6]2+阳离子和四氟对二苯甲酸阴离子之间通过两种氢键(N-H…O和C-H…F)连接形成了一种三维的超分子网络结构。     

两个含氮、氧杂原子有机配体的铀酰配合物溶剂热自组装合成、结构及其性质

在溶剂热条件下,利用含氮、氧杂原子有机配体N'',N‴-（（2E,3E）-butane-2,3-diylidene）bis（4-hydroxybenzohydrazide）（L1）、2,4,5-三氟-3-甲氧基苯甲酸（L2）以及菲咯啉（Phen）自组装反应合成了2个新的铀酰配合物[UO₂（L1）（CH₃COO）]·3CH₃OH（C1）、[UO₂（L2）（Phen）（CH₃O）]（C2）,通过元素分析、红外光谱以及X射线单晶衍射等表征了配合物结构。结果表明,2个配合物中的U均为+6价,配合物C1和C2中铀离子分别采取八配位和七配位模式,C1通过丰富的O-H…O氢键作用形成一维无限链状结构,C2中存在π-π堆积作用。研究了配合物的热稳定性和光谱性质,并且对其结构进行理论计算,探讨了配合物的动力学稳定性。     

Synthesis,Characterization and Crystal Structures of Four Dinuclear Schiff Base Nickel(II) and Copper(II) Complexes with Versatile Bridging Groups

Four novel Schiff base nickel(II) and copper(II) complexes, derived from the end‐on (μ_1,1‐N₃) azide, end‐to‐end (μ_1,3‐NCS) thiocyanate, or phenolate oxygen bridges, have been synthesized and their crystal structures determined by X‐ray diffraction methods. They are the dinuclear double end‐on azide‐bridged [Ni₂(L1)₂(MeCN)₂(μ_1,1‐N₃)₂]·MeOH ( 1 ), the dinuclear double end‐on azide‐bridged [Ni₂(L2)₂(MeOH)₂(μ_1,1‐N₃)₂][Ni₂(L2)₂(OH₂)₂(μ_1,1‐N₃)₂]·MeOH ( 2 ), the dinuclear double end‐to‐end thiocyanate‐bridged [Cu₂(L3)₂(μ_1,3‐NCS)₂] ( 3 ), and the dinuclear double phenolate O‐bridged [Cu₂(L4)₂(NCS)₂] ( 4 ), where HL1, HL2, HL3 and HL4 are four tridentate Schiff bases obtained by the condensation of 3,5‐dibromosalicylaldehyde with N‐ethylethane‐1,2‐diamine, of 3,5‐dichlorosalicylaldehyde with N‐methylpropane‐1,3‐diamine, of 3‐bromo‐5‐chlorosalicylaldehyde with 2‐aminomethylpyridine, and of 5‐nitrosalicylaldehyde with 2‐aminomethylpyridine, respectively. Each nickel(II) atom in 1 and 2 is in an octahedral coordination, while each copper(II) atom in 3 and 4 is in a square pyramidal coordination. There exists crystallographic inversion centre symmetry in each of the complexes.     

直链醚席夫碱与Ln3+-Zn2+异双核配合物的合成和表征

合成并表征了直链醚席夫碱双水杨醛缩二甘醇二胺与Ｌｎ＾３＋和Ｚｎ２＋的８种异双核配合物「ＬｎＺｎ（ＳＡＬＤＡ０２（ＮＯ３）３」（ＮＯ３）２．２Ｈ２Ｏ（Ｌｎ＝Ｐｒ,Ｓｍ,Ｇｄ,Ｔｂ,Ｅｒ,Ｙｂ,Ｙ）。以ＩＲ,ＵＶ光谱,特别是＾１Ｈ及＾１３ ＣＮＭＲ谱等方法研究并讨论了配合物的合成方法,组成,结构及配位方式。     

Manganese(II), Cobalt(II), and Nickel(II) Perchlorate Complexes Containing N,O Donor Macrocyclic Ligands

Mononuclear macrocyclic complexes of manganese(II ), cobalt(II ) and nickel(II ) perchlorate using 10 different oxaazamacrocyclic ligands (L¹ — L¹⁰) have been prepared and characterized. The complexation reactions with the diiminic ligands were obtained by template condensation of the appropriate dialdehyde and diamine precursors; the reduced macrocycle complexes were synthesized using a direct route. The complexes have been characterized by elemental analyses, molar conductivity, mass spectrometry, IR, UV‐vis spectroscopy, diffuse reflectance and magnetic susceptibility measurements.