共查询到20条相似文献,搜索用时 15 毫秒
1.
I. V. Ukrainets I. A. Tugaibei N. L. Bereznyakova V. N. Kravchenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2008,44(5):565-575
Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view
to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties
and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 718–729, May, 2008. 相似文献
2.
I. V. Ukrainets E. A. Taran O. V. Gorokhova N. A. Jaradat L. N. Voronina I. V. Porokhnyak 《Chemistry of Heterocyclic Compounds》2000,36(3):346-350
A preparative method for the synthesis of 1-R-2-oxo-3-(2H-1,2,4-benzothiadiazine-1,1-dioxid-3-yl)-4-hydroxyquinolines has been developed. The diuretic and antitubercular activity of the obtained compounds have been studied.For Communication 41 see [1].National Pharmaceutical Academy of Ukraine, Khar'kov 310002; e-mail: igor@uiv.kharkov.ua. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 409–414, March, 2000. 相似文献
3.
V. I. Tyvorskii I. G. Tishchenko A. S. Kukharev E. V. Yushkevich S. F. Vlasov 《Chemistry of Heterocyclic Compounds》1985,21(11):1210-1213
The reaction of esters of alkyl-substituted (E)-5-amino-4-hydroxy-2,3,epoxyvaleric acids with some hydrohalic acids gave the corresponding 2-halo-4-amino-methyl-2-buten-4-olides, the hydrochlorides of which have diuretic activity.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1471–1474, November, 1985. 相似文献
4.
I. V. Ukrainets N. L. Bereznyakova E. V. Mospanova 《Chemistry of Heterocyclic Compounds》2007,43(7):856-862
A simple method is proposed for preparing 1-hydroxy-3-oxo-5,6-dihydro-3H-pyrrolo[3,2,1-ij]-quinoline-2-carboxylic acid alkylamides.
For the case of the secondary butylamide features of the steric structure of the synthesized compounds is discussed. The results
of a study of their anti-inflammatory and diuretic activities are presented.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1015–1022, July, 2007. 相似文献
5.
D. V. Moiseev V. I. Goncharov A. V. Aksenov 《Chemistry of Heterocyclic Compounds》2006,42(10):1308-1310
A method has been developed for the synthesis of 2′-and 4′-aryl-2,3′-biquinolyls based on the reaction of 1′-alkyl-2′-aryl-1′,2′-dihydro-2,3′-biquinolyls
and 1′-alkyl-4′-aryl-1′,4′-dihydro-2,3′-biquinolyls with sulfur in DMF.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1517–1519, October, 2006. 相似文献
6.
Kiril B. Gavazov Vanya D. Lekova Atanas N. Dimitrov Georgi I. Patronov 《Central European Journal of Chemistry》2007,5(1):257-270
The formation and extraction of ion-associate complexes between the vanadium(V)-4-(2-thiazolylazo)resorcinol (TAR) anionic
chelate and the cations of some mono-and ditetrazolium salts {3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide
(Thiazolyl blue, MTT), 3-(2-naphtyl)-2,5-diphenyl-2H-tetrazolium chloride (Tetrazolium violet), 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium
chloride (Iodonitrotetrazolium chloride), 3,3′-[3,3′-dimetoxy(1,1′-biphenyl)-4,4′-diyl]-bis[2,5-diphenyl-2H-tetrazolium] chloride
(Tetrazolium blue chloride) and 3,3′-(3,3′-dimetoxy-4,4′-biphenylene)bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride]
(Nitro blue tetrazolium chloride)} have been studied. The optimum extraction conditions have been found. The composition of
the V-TAR-monotetrazolium and V-TAR-ditetrazolium complexes extracted into chloroform has been determined to be 1:2:3 and
2:4:3 respectively. The extraction, distribution and association constants, and the recovery factors have been calculated.
The relationship between the molecular weight of tetrazolium cations, and the association constants of their complexes has
been discussed. The special behavior of the tetrazolium cations, containing-NO2 groups has been noticed. The effects of foreign ions and reagents on the extraction of vanadium with TAR and the best tetrazolium
salt-MTT have been studied. A sensitive, selective, simple and fast method for the determination of vanadium has been developed.
相似文献
7.
I. V. Ukrainets O. V. Gorokhova L. V. Sidorenko 《Chemistry of Heterocyclic Compounds》2005,41(8):1019-1021
The behavior of 2-chloro-4-hydroxy- and 4-chloro-2-oxoquinoline-3-carboxylic acids under acid catalyzed esterification conditions
with methanol has been studied. A method is proposed for obtaining 2-chloro-4-hydroxyquinoline-3-carboxylic acid ethyl ester.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1195–1197, August, 2005. 相似文献
8.
The synthesis of some derivatives of β-triketones based on a new synthon — 4-hydroxycyclohexane-1,3-dione — is described.
Using the proposed scheme, 4-hydroxy-2-(octadec-9Z,12Z-dienoyl)cyclohexane-1,3-dione, a kairomone of some species of Lepidoptera,
has been obtained.
Institute of Bioorganic Chemistry, Belorussian Academy of Sciences, Minsk. Belorussian State University, Minsk. Translated
from Khimiya Prirodnikh Soeinenii, No. 2, pp. 197–203. March–April, 1994. 相似文献
9.
Walter Purcell Izak M. Potgieter Llewellyn J. Damoense Johann G. Leipoldt 《Transition Metal Chemistry》1992,17(5):387-389
The crystal structure of (AsPh4)2[ReN(H2O)(CN)4]·5H2O has been determined from three-dimensional X-ray diffraction data. The yellow crystals are monoclinic, space group P21/n with cell dimensionsa=15.482(1),b=19.950(2),c=16.999(1)? and β=101.69(6)o,Z=4,D
expt=1.48(1)g cm−3 andD
calc=1.52g cm−3. The anisotropic refinement of 7858 observed reflections converged toR=0.055. The [ReN(H2O)(CN)4]2− ion has a distorted octahedral geometry. Bond distances: Re≡N=1.639(8), Re−OH2=2.496(7) and Re−C(av)=2.11(1) ?. The rhenium atom is displaced by 0.35 ? out of the plane formed by the four carbon atoms of the cyano ligands
towards the terminal nitrido ligand.
TMC 2479 相似文献
10.
Summary The proportion of organic modifier and the pH of the acetonitrile-water mixtures used as mobile phases were optimized in order
to separate a group of diuretic compounds covering a wide range of physyco-chemical properties. The Linear Solvation Energy
Relationship (LSER) formalism based either on the multiparameter π*, β and α scales or the single solvent polarity parameterE
T
N
, have been used to predict their chromatographic behaviour as a function of the percentage of acetonitrile in the eluent.
Moreover, correlation established between retention and pH of the aqueous-organic mobile phases have been used to predict
the chromatographic behaviour of the diuretic compounds studied as a function of the eluent pH. Linear correlation between
a function of the eluent pH. Linear correlation between the chromatographic retention and theE
T
N
polarity parameter of mobile phases containing different percentages of organic modifier has been obtained Based on the knowledge
of the acid-base dissociation constant the relation between retention and mobile phase pH has also been linearized. These
relationship allowed an important reduction of the experimental retention data needed for developing a given separation and
a great improvement in chromatographic optimization schemes. 相似文献
11.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova O. V. Shishkin 《Chemistry of Heterocyclic Compounds》2006,42(2):191-196
The reaction of ethyl aminocrotonates with derivatives of malonic acid is a suitable method for the preparation of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-5-carboxylates.
One of the synthesized materials has been studied by X-ray crystallography.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, 217–223, February, 2006. 相似文献
12.
A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A
comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related
N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
*For Communication 151 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 214–222, February, 2009. 相似文献
13.
I. V. Ukrainets L. V. Sidorenko O. S. Golovchenko 《Chemistry of Heterocyclic Compounds》2007,43(11):1434-1439
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding
quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical
N,N′-di(4-hydroxy-2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds
has been carried out.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1687–1692, November, 2007. 相似文献
14.
M. N. Khimich F. E. Gostev I. V. Shelaev O. M. Sarkisov E. A. Birgen B. M. Bolotin B. M. Uzhinov 《High Energy Chemistry》2010,44(6):482-491
Femtosecond dynamics of processes in the excited state of 2-(2-aminophenyl)-4H-3,1-benzoxazin-4-ones has been studied by femtosecond
absorption spectroscopy. The rate constants of intramolecular photoinduced proton transfer (IPPT) have been determined for
the N-substituted derivatives (0.7–11 ps−1). The IPPT rate constant depends on the inductive constant of the substituent and the potential barrier height, which was
calculated by a quantum-chemical method (TDDFT). The multiexponential character of the kinetics of photoinduced absorption
by the compounds with a low inductive constant of the N-substituent in the spectral region of the S1 → SN absorption and the stimulated emission of the IPPT product is explained by the rapid (∼10 ps−1) relaxation process preceding the IPPT. 相似文献
15.
A. N. Vasyanin O. S. Kudryashova S. F. Kudryashov L. P. Filippova 《Russian Journal of Inorganic Chemistry》2006,51(1):131-142
The solubility in the water-salt quaternary reciprocal system Na2Cr2O7 + 2NH4Cl ⇆ (NH4)2Cr2O7 + 2NaCl-H2O has been investigated for the first time at 25, 50, and 75°C. Using a formal analytical model, the boundaries of the phase
fields have been determined, and the univariant lines and invariant points have been calculated. The experimental data have
been used to calculate the temperature and concentration parameters of the circular isohydric process of potassium dichromate
preparation with the participation of ammonium salts as intermediates. 相似文献
16.
Gennady I. Ostapenko 《Journal of Solid State Electrochemistry》2001,5(7-8):550-552
The kinetics of electrochemical processes at a vitreous carbon electrode in contact with the solid electrolyte RbCu4Cl3I2 has been investigated. In the range of potentials from zero up to the decomposition potential of the electrolyte (0.57 V),
the rate of the reversible electrode reaction Cu+–e–↔Cu2+ is controlled by slow diffusion of the electronic defects (Cu2+ ions or holes) in the electrolyte. The diffusion coefficient of these defects is equal to 1.5×10–8 cm2 s–1. The exchange current density of the electrode reaction is equal to 20×10–6 A cm–2.
Electronic Publication 相似文献
17.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova N. L. Bereznyakova S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2006,42(10):1296-1300
The alkylation of the ethyl esters of 4-methyl, 4-chloro-, and 4-amino substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic
acid by ethyl iodide in the system DMF/K2CO3 has been studied. Features of the structure of the starting compounds and their effect on the ratio of the N-and O-alkyl
products formed are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1502–1507, October, 2006. 相似文献
18.
I. V. Ukrainets A. A. Tkach L. V. Sidorenko O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2006,42(10):1301-1307
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides have been prepared. It has been shown experimentally that
these compounds are brominated by molecular bromine in glacial acetic acid at position 4 of the anilide fragment. The antitubercular
properties of the compounds synthesized are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1508–1516, October, 2006. 相似文献
19.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova N. A. Jaradat 《Chemistry of Heterocyclic Compounds》2006,42(3):343-351
A preparative method is proposed and the synthesis of 4-arylamino-2-oxo-1,2-dihydroquinolines has been effected. An X-ray
structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried
out enabling the ease of decarboxylating such compounds to be substantiated. Results are given of a study of the anti-inflammatory
activity of the synthesized compounds.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 386–395, March, 2006. 相似文献
20.
Xu-Da Wang Mao Liang Li-Cun Li Zong-Hui Jiang Dai-Zheng Liao Shi-Ping Yan Peng Cheng 《Structural chemistry》2007,18(1):5-8
A novel malonate-bridged copper (II) compound of formula {[Cu4(4,4′-bpy)8(mal)2(H2O)4](ClO4)2(H2O)4(CH3OH)2}n (4,4′-bpy = 4,4′-bipyridine; mal = malonate dianion) has been prepared and structurally characterized by X-ray crystallography.
This compound exhibits a novel three-dimensional network being composed of Cu-4,4′-bipyridine layers which are pillared by
malonate bridge ligands. The copper(II) ions has two different coordination environment. 相似文献