Voice Quality Changes Following Phonatory-Respiratory Effort Treatment (LSVT®) Versus Respiratory Effort Treatment for Individuals with Parkinson Disease

Perceptual ratings of hoarseness and breathiness were used to assess the efficacy of two intensive methods for treating dysarthrophonia in individuals with idiopathic Parkinson disease. One method emphasized phonatory-respiratory effort (the Lee Silverman Voice Treatment, LSVT®) and the other emphasized respiratory effort alone (RET). Perceptual ratings were performed by two expert listeners based on random order presentation of the patients' pretreatment and posttreatment recordings of the “Rainbow Passage.” The listeners were blinded to the patients and their treatment group. Statistically significant pretreatment to posttreatment improvement in hoarseness and breathiness was observed in the LSVT® group but not in the RET group. The present findings are consistent with acoustic and physiologic findings reported previously, providing further evidence for the efficacy of the LSVT®.     

Fundamental Frequency in Speakers of Portuguese for Different Voice Samples

The purpose of this research was to obtain information on the mean fundamental frequency (Fo) levels of Portuguese speakers and to investigate (1) whether differences exist between two groups with different voice qualities (normal and dysphonia), genders, ages, and speech tasks; and (2) which variables contribute to the variance. To this end, 109 subjects (52 dysphonics and 57 controls) participated in the study. Speech material included three sustained vowels ([u], [i], and [a]), a standard written passage, and a conversation produced at a comfortable conversational pitch and loudness level. Electroglottographic (EGG) data were obtained. Although the results show that, overall, the dysphonics had lower Fo than did controls for all speaking conditions, and that there were differences according to age, these contrasts were not statistically significant. Gender and speech task effects were statistically significant. Additionally, the mean Fo variance is explained by a high prediction model (between 59% and 73%).     

Source-filter Comparison of Measurements of Fundamental Frequency Perturbation and Amplitude Perturbation for Synthesized Voice Signals

SUMMARY: An investigation of the effect of glottal source aperiodicities (jitter, shimmer, and aspiration noise) on the estimation of fundamental frequency (f0) perturbation and amplitude perturbation, of synthesized, glottal source and voiced speech waveforms, is considered. Firstly, 4, cycle-event f0 estimators are examined: (1) waveform matching of the low-pass filtered waveform, (2) positive peaks (PPs) from the speech waveform, (3) PPs from the low-pass filtered waveform, and (4) positive zero crossings from the low-pass filtered waveform. The analysis shows that f0 perturbation measures taken from the low-pass filtered waveform are affected by both amplitude perturbation and random glottal noise, whereas, f0 perturbation measures taken from the PPs of the original waveform are affected by noise but not by amplitude perturbation. It is shown for the low-pass filter methods that the effects of amplitude perturbation and noise lead to increased errors in the measurement of f0 perturbation for the synthesized speech waveforms when compared with the synthesized glottal waveforms. Shimmer of the synthesized speech waveform is approximately equal to shimmer of the synthesized glottal source. However, noise and jitter affect measures of amplitude perturbation. The estimation of f0 perturbation from the synthesized speech waveform is shown to be nonlinearly related to f0 perturbation estimation from the synthesized glottal waveform as a consequence of the filtering action of the vocal tract. Low-pass filtering the voiced speech waveform is shown to provide a partial solution to this problem.     

Sensitivity of Elastic Properties to Measurement Uncertainties in Laryngeal Muscles With Implications for Voice Fundamental Frequency Prediction

This paper discusses the effects of measurement uncertainties when calculating elastic moduli of laryngeal tissue. Small dimensions coupled with highly nonlinear elastic properties exacerbate the uncertainties. The sensitivity of both tangent and secant Young's Modulus was quantified in terms of the coefficient of variation, which depended on measurement of reference length and cross-sectional area. Uncertainties in the measurement of mass, used to calculate cross-sectional area of a small tissue sample, affected Young's Modulus calculations when tissue absorption of the hydrating solution was not accounted for. Uncertainty in reference length had twice the effect on elasticity than other measures. The implication of these measurement errors on predicted fundamental frequency of vocalization is discussed. Refinements on isolated muscle experimental protocols are proposed that pay greatest attention to measures of highest sensitivity.     

Revisiting the Pitch Controversy: Changes in Speaking Fundamental Frequency (SFF) After Management of Functional Dysphonia

Speaking fundamental frequency (SFF) and its perceptual correlate "habitual pitch" have been considered important and contentious parameters in voice assessment and treatment. In clinical circles, disagreement exists regarding the role of habitual pitch in the development, maintenance, and treatment of disordered voices. Despite these divergent opinions, few studies have objectively evaluated SFF changes associated with voice improvement after therapy. To determine whether consistent directional and magnitude changes in SFF occur after management, pretreatment and posttreatment audio recordings of 40 women with functional dysphonia were analyzed. All subjects were treated with manual circumlaryngeal therapy, a treatment approach that does not directly target pitch as a perceptual entity to be manipulated. Results indicated that, as a group, no significant change in mean SFF was observed after successful management. Although no consistent directional pattern was identified, 80% of the subjects experienced pitch changes greater than one semitone; this suggests that voice improvement is often accompanied by a shift in SFF. Clinical implications of the data are discussed.     

Fundamental Frequency in Monolingual English, Bilingual English/Russian, and Bilingual English/Cantonese Young Adult Women

Mean F0 of nine young adult English/Russian female bilinguals and nine young adult English/Cantonese female bilinguals were examined from samples of connected speech in each language. Mean F0 were compared in each language and in English with those of a monolingual English control group of ten young adult female speakers. Acoustic measurements were analyzed with the Kay Elemetrics Multispeech program (Kay Elemetrics, Lincoln Park, NJ). The results indicate that the English/Russian bilinguals consistently had a higher mean F0 in Russian than in English. Mean F0 did not change with language switch for the English/Cantonese speakers. There were no significant differences between the groups in their English production. Clinical implications regarding norms for both monolingual and bilingual persons, as well as implications for understanding the nature of bilingualism, in particular code-switching, are discussed.     

The Effect of Cricothyroid Muscle Action on the Relation Between Subglottal Pressure and Fundamental Frequency in an In Vivo Canine Model

The relation between subglottal pressure (P_s) and fundamental frequency (F₀) in phonation was investigated with an in vivo canine model. Direct muscle stimulation was used in addition to brain stimulation. This allowed the P_s-F₀ slope to be quantified in terms of cricothyroid muscle activity. Results showed that, for ranges of 0–2 mA constant current stimulation of the cricothyroid muscle, the P_s-F₀ slope ranged from 10 Hz/kPa to 60 Hz/kPa. These results were compared to similar slopes obtained in a previous study on excised larynges in which the vocal fold length was varied instead of cricothyroid activation. A physical interpretation of the P_s-F₀ slope is that the amplitude-to-length ratio of the vocal folds decreases with CT activity, resulting in a smaller time-varying stiffness. In other words, there is less dependence of F₀ on amplitude of vibration when the vocal folds are long instead of short.     

Multimodal Standardization of Voice Among Four Multicultural Populations: Fundamental Frequency and Spectral Characteristics

A stratified random sample of 20 males and 20 females matched for physiological factors and cultural-linguistic markers were examined to determine differences in fundamental frequency and spectral characteristics during prolongation of three vowels: [a], [i], and [u]. The ethnic-gender breakdown included four sets of five male and five female subjects comprised of Caucasian and African-American speakers of standard American English, native Hindi Indian speakers, and native Mandarin Chinese speakers. Acoustic measures were analyzed using the Multidimensional Voice Program (Kay Elemetrics, Lincoln Park, NJ) (Model 4305) from which fundamental frequency and associated acoustic spectra were extracted from a 200-ms sample of each vowel token. Statistically significant group differences for the main effects of culture, race, and gender were found. The acoustic differences found are attributed to biomechanical, physiological, cultural, and linguistic factors.     

Fundamental frequency and sound pressure level of phonation in pathological states

The fundamental frequency (F₀) for the habitual pitch (F_0HAB), F₀ for the lowest physiological tone (F_0L), F₀ for the highest physiological tone (F_0H), F₀ range of phonation (F₀ Rg), sound pressure level (SPL) for habitual loudness (SPL_HAB), SPL for the softest tone (SPL_S), SPL for the loudest tone (SPL_L), and SPL range of phonation (SPL Rg) were measured in 40 normal adult subjects and 1,563 voice patients with varying diseases. F_0H, F₀ Rg, SPL_L, and SPL Rg were decreased in many disease groups. F_0HAB and F_0L varied. SPL_HAB and SPL_S were increased in some disease groups. F₀-related parameters reflected effects of treatments in the cases with polyp, Reinke's edema, epithelial hyperplasia, carcinoma, and paralysis. Effects of treatments were manifested in SPL-related parameters in the cases with nodule, polyp, carcinoma, and paralysis.     

Intra- and intersubject variability in acoustic measures of normal voice

Twenty-four normal adult women read part of the Rainbow Passage and sustained vowels three trials each. Utterances were assessed for selected parameters measured by Visi-Pitch (average and SD of fundamental frequency (F₀), average and SD of dBA, perturbation, and percent voiced/unvoiced/pause). Assessment of each parameter included measures of central tendency, dispersion, and distribution characteristics (skewness and kurtosis) of the data and of the ranges of values that would include 95% of the scores (95% fiduciary limits). Generally, differences for the group between the three trials were not significant. Intersubject variability for only a few parameters was less than 20% of the parameter's mean. For vowels, variability of jitter was 30–48% of the mean. Eight subjects provided performances 2 months later to obtain an estimate of intrasubject variability over time. There were desirable intrasubject correlations between performances for mean F₀, jitter in reading and on vowels /i/ and /a/, and percent of voicing. Inter- and intrasubject variability seems restricted and the data appear to resemble a normally distributed function for mean F₀ on reading, jitter on /i/, and percent of voicing. Thus, these parameters may have statistical merit for use in vocal testing.     

Diffusional kurtosis imaging of cingulate fibers in Parkinson disease: Comparison with conventional diffusion tensor imaging

Objective

The pathological changes in Parkinson disease begin in the brainstem; reach the limbic system and ultimately spread to the cerebral cortex. In Parkinson disease (PD) patients, we evaluated the alteration of cingulate fibers, which comprise part of the limbic system, by using diffusional kurtosis imaging (DKI).

Methods

Seventeen patients with PD and 15 age-matched healthy controls underwent DKI with a 3-T MR imager. Diffusion tensor tractography images of the anterior and posterior cingulum were generated. The mean kurtosis (MK) and conventional diffusion tensor parameters measured along the images in the anterior and posterior cingulum were compared between the groups. Receiver operating characteristic (ROC) analysis was also performed to compare the diagnostic abilities of the MK and conventional diffusion tensor parameters.

Results

The MK and fractional anisotropy (FA) in the anterior cingulum were significantly lower in PD patients than in healthy controls. The area under the ROC curve was 0.912 for MK and 0.747 for FA in the anterior cingulum. MK in the anterior cingulum had the best diagnostic performance (mean cutoff, 0.967; sensitivity, 0.87; specificity, 0.94).

Conclusions

DKI can detect alterations of the anterior cingulum in PD patients more sensitively than can conventional diffusion tensor imaging. Use of DKI can be expected to improve the ability to diagnose PD.     

相干光OFDM系统中基于导频辅助的采样时钟频率偏差估计和补偿算法

基于导频辅助法,对相干光正交频分复用系统中采样时钟频率偏差进行估计和补偿,并研究了导频的插入位置对该算法补偿效果的影响,通过对五种不同的导频插入位置进行分析和比较,得到最优导频插入位置.仿真结果表明:本文算法即使在较大的频率偏移情况下也有较好的补偿效果,并且采用该方法得到的光信噪比损耗不到1dB,可以有效地降低系统成本;不同导频插入位置对算法的补偿效果会产生影响,在较小采样频率偏移范围内时,导频平均插入方式为最优.如果采样频率偏移量较大,在导频平均插入不能很好地补偿的情况下,导频应尽量插在低频位置.