共查询到20条相似文献,搜索用时 46 毫秒
1.
N. I. Nechai E. A. Dikusar V. I. Potkin R. V. Kaberdin 《Russian Journal of Organic Chemistry》2004,40(7):1009-1014
Previously unknown 4,5-dichloroisothiazole-3-carboxylic acid amides and esters were synthesized by reactions of 4,5-dichloroisothiazole-3-carbonyl chloride with ammonia, heterocyclic and aromatic amines, and functionally substituted alcohols and phenols. 相似文献
2.
V. I. Potkin S. K. Petkevich A. V. Kletskov E. A. Dikusar Yu. S. Zubenko N. A. Zhukovskaya V. V. Kazbanov S. G. Pashkevich 《Russian Journal of Organic Chemistry》2013,49(10):1523-1533
Acylation of benzene and toluene with 5-phenyl- and 5-(p-tolyl)isoxazole-3-carbonyl chlorides gave 5-phenyl(or p-tolyl)isoxazol-3-yl phenyl(or p-tolyl)ketones which were reduced to the corresponding alcohols with sodium tetrahydridoborate in propan-2-ol. Selective reduction of the carboxy group in 4,5-dichloroisothiazole-3-carboxylic acid was achieved by the action of BH3, and the aldehyde group in 4-formyl-2-methoxyphenyl 5-arylisoxazole-3-carboxylates and 4,5-dichloroisothiazole-3-carboxylates was reduced to hydroxymethyl group with sodium triacetoxyhydridoborate in benzene. Acylation of the resulting hydroxymethyl derivatives with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides afforded the corresponding esters containing two azole fragments in their molecules. 相似文献
3.
The reaction of cinnamic acid derivatives with thionyl chloride and pyridine is a general procedure for the preparation of derivatives of 3-chlorobenzo[b] thiophene-2-carbonyl chloride from readily accessible starting materials. These compounds are easily converted to the corresponding acids, esters and amines. 相似文献
4.
M. V. Vovk N. V. Mel'nichenko V. A. Chornous M. K. Bratenko 《Russian Journal of Organic Chemistry》2001,37(12):1747-1752
1,3-Diaryl-4-isocyanatopyrazoles were obtained by reaction of 1,3-diarylpyrazole-4-carboxylic acids with ethyl chloroformate and sodium azide or by reaction of 1,3-diarylpyrazole-4-carbonyl chloride with trimethylsilyl azide. The title compounds react with amines, hydrazine hydrate, alcohols, phenols, and monochloroacetic acid to afford 4-pyrazolyl-substituted ureas, semicarbazides, urethanes, and amides respectively. 相似文献
5.
Acylation of a variety of alcohols, phenols, aliphatic and aromatic amines, a thiol and a thiophenol proceeds efficiently using BiCl3 generated in situ from the procatalyst BiOCl and acetyl chloride in a solvent or under solventless conditions, furnishing the corresponding acylated derivatives in very good to excellent yields. 相似文献
6.
Zakharov D. O. Lipeeva A. V. Gatilov Yu. V. Makarov A. G. Shults E. E. 《Russian Journal of Organic Chemistry》2019,55(10):1518-1526
Russian Journal of Organic Chemistry - Umbelliferone-6-carbonyl chloride reacted with amines and α-, β-, and ω-amino acid methyl esters to afford the corresponding N-substituted... 相似文献
7.
Plekhanova N. G. Ovchinnikov D. V. Glibin E. N. 《Russian Journal of Organic Chemistry》2004,40(3):372-376
N-Methylcarbazole-3-carboxylic acid was synthesized from N-methyl-2-amino-4-carboxydiphenyl-amine through the corresponding diazo compound by a modified Pschorr procedure. The acid was converted into N-methylcarbazole-3-carbonyl chloride which was treated with amines containing benzo- and aza-crown ether moieties, as well as with 3-(dimethylamino)propylamine, to obtain the respective N-substituted amides. 相似文献
8.
Kazunori WakasugiAtsushi Nakamura Akira IidaYoshinori Nishii Nobuji NakataniShoji Fukushima Yoo Tanabe 《Tetrahedron》2003,59(28):5337-5345
Various carboxylic esters or amides were prepared in good to excellent yield between carboxylic acids and equimolar amounts of alcohols or amines under very mild conditions (0-45°C; within 3 h) using dimethylsulfamoyl chloride (Me2NSO2Cl; 1) combined with N,N-dimethylamines (Me2NR: 2a; R=Me, 2b; R=Bu). The choice of the sulfamoyl chloride and the amine is crucial for the reaction; that is, sterically uncrowded amines accelerated the present esterification and amidation. This agent had some advantages over methanesulfonyl chloride (3)/amines as for the atom-economy, avoidance of side reactions, and had very high chemoselectivity toward the carboxyl group vs the hydroxyl group; the experiment was performed by the addition of 1 to the mixture of carboxylic acids and alcohols. Application of this method to the synthesis of coumaperine, a chemopreventive natural product, was performed using the present amidation as a key step. 相似文献
9.
Rajab Abu-El-Halawa Alaa Sarabi Mustafa M. El-Abadelah 《Monatshefte für Chemie / Chemical Monthly》2008,44(8):1251-1255
Interaction between 2,5-dichlorothiophene-3-carbonyl isothiocyanate, accessible via 2,5-dichlorothiophene-3-carbonyl chloride, and model heterocyclic amines produced the respective 2,5-dichloro-N-(substituted aminocarbonothioyl)thiophene-3-carboxamides. Upon heating, the deprotonated form of the latter underwent intramolecular
cyclization to deliver the corresponding 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones. The structures of these new bicyclic derivatives and their acyclic precursors are based on microanalytical
and spectral (IR, MS, and NMR) data. 相似文献
10.
《Journal of organometallic chemistry》1987,320(2):163-170
A new procedure has been developed for removing the SiCl3 group from α-trichlorosilyl-substituted amines. In this procedure the trichlorosilyl substrate is treated first with amine hydrochloride in CH3CN, followed by hydrolysis with aqueous hydroxide. Using this sequence, amines corresponding to replacement of the trichlorosilyl group with hydrogen can be conveniently isolated in good yields for all tested cases. Evidence suggests the intermediacy of an unstable chlorosilane species formed by probable nucleophilic attack of chloride. In conjunction with the addition reaction fo HSiCl3 to enamines to form the α-trichlorisilyl amines, the cleavage completes a new method for the transformation of enamines to amines which could be a useful alternative to either catalytic hydrogenation or metal hydride reduction. 相似文献
11.
3,4-Dhydro-6,7-dimethoxy-4-methyl-3-oxo-quinoxaline-2-carbonyl azide is a highly senstive fluorescence derivatization reagent for primary, secondary and tertiary alcohols for high-performance liquid chromatography. Reaction conditions are optimized with benzyl alcohol, n-hexanol, cyclohexanol and 2-methyl-2-butanol. The reagent reacts with the alcohols in benzene to produce the corresponding fluorescent carbamic acid esters, which can be separated on a reversed-phase column YMC Pack C8 with aqueous methanol as eluent. the detection limits for the alchols are 2–5 fmol per 10-μl njection. The reagent also reacts with hydroxysteroids with primary, secondary and/or tertiary alcoholic group(s) to form fluorescent derivatives. Hydroxycarboxylic acids and phenols do not give any chromatographic peaks. 相似文献
12.
Kazuya Yamaguchi Dr. Jinling He Dr. Takamichi Oishi Noritaka Mizuno Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2010,16(24):7199-7207
The N‐alkylation of ammonia (or its surrogates, such as urea, NH4HCO3, and (NH4)2CO3) and amines with alcohols, including primary and secondary alcohols, was efficiently promoted under anaerobic conditions by the easily prepared and inexpensive supported ruthenium hydroxide catalyst Ru(OH)x/TiO2. Various types of symmetrically and unsymmetrically substituted “tertiary” amines could be synthesized by the N‐alkylation of ammonia (or its surrogates) and amines with “primary” alcohols. On the other hand, the N‐alkylation of ammonia surrogates (i.e., urea and NH4HCO3) with “secondary” alcohols selectively produced the corresponding symmetrically substituted “secondary” amines, even in the presence of excess amounts of alcohols, which is likely due to the steric hindrance of the secondary alcohols and/or secondary amines produced. Under aerobic conditions, nitriles could be synthesized directly from alcohols and ammonia surrogates. The observed catalysis for the present N‐alkylation reactions was intrinsically heterogeneous, and the retrieved catalyst could be reused without any significant loss of catalytic performance. The present catalytic transformation would proceed through consecutive N‐alkylation reactions, in which alcohols act as alkylating reagents. On the basis of deuterium‐labeling experiments, the formation of the ruthenium dihydride species is suggested during the N‐alkylation reactions. 相似文献
13.
Farhad Shirini Mohammad Ali Zolfigol Kamal Mohammadi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1567-1570
Reaction of alcohols with hexamethyldisilazane in the presence of silica chloride provides efficiently the corresponding trimethylsilyl ethers. This system discriminates absolutely amines and thiols from alcohols. 相似文献
14.
A novel method for the preparation of alkyl azides from alcohols by way of oxidation-reduction condensation is described. In this reaction, the sterically-hindered tert-alkyl phosphinites that are prepared from the corresponding alcohols are converted into tert-alkyl azides with almost complete inversion of their stereochemistry: the obtained alkyl azides are then successfully reduced to afford the corresponding amines on treatment with LiAlH4, thus, a versatile method for the preparation of chiral amines from the corresponding chiral alcohols is established. 相似文献
15.
A variety of conjugated cyclopropyl ketones and cyclopropylcarbinyl alcohols were reacted with two nitriles viz. CH3 CN and CH2[dbnd]CH-CN in presence of cone. H2 SO4. It was found that with appropriate substitutions cyclopropyl ketones gave N-Acyl-γ-keto amines whereas cyclopropylcarbinyl alcohols gave the corresponding N-Acyl homoallylic amines in reasonably good yields. The olefins obtained had E-stereo-chemistry. With bicyclic cyclopropylcarbinyl alcohols the ring expanded products were formed. A plausible rationale is provided to account for these observations 相似文献
16.
In the presence of a catalytic amount of Bi(OTf)3·4H2O and under microwave irradiation, neat mixtures of epoxides and amines afforded smoothly the corresponding 2-amino alcohols. A wide variety of aliphatic amines were reacted with cycloalkene oxide, styrene oxide, and stilbene oxide. The reaction proceeded rapidly and afforded the 2-amino alcohols in high up to quantitative yields. All products could be obtained without aqueous work-up by simple filtration. 相似文献
17.
N. L. Poznanskaya S. N. Ivanova N. N. Mel'nikov N. I. Shvetsov-Shilovskii 《Chemistry of Heterocyclic Compounds》1967,3(3):339-340
Phosgene and benzoxazolin-2-one in the presence of diethylaniline gives benzoxazolin-2-one-3-carbonyl chloride. The latter and aliphatic alcohols, in the presence of a hydrogen chloride acceptor, gives esters of benzoxazolin-2-one-3-carboxylic acid. 相似文献
18.
Rajab Abu-El-Halawa Alaa Sarabi Mustafa M. El-Abadelah 《Monatshefte für Chemie / Chemical Monthly》2008,139(10):1251-1255
Interaction between 2,5-dichlorothiophene-3-carbonyl isothiocyanate, accessible via 2,5-dichlorothiophene-3-carbonyl chloride, and model heterocyclic amines produced the respective 2,5-dichloro-N-(substituted aminocarbonothioyl)thiophene-3-carboxamides. Upon heating, the deprotonated form of the latter underwent intramolecular
cyclization to deliver the corresponding 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones. The structures of these new bicyclic derivatives and their acyclic precursors are based on microanalytical
and spectral (IR, MS, and NMR) data.
Correspondence: Rajab Abu-El-Halawa, Chemistry Department, Faculty of Science, Al al-Bayt University, Mafraq, Jordan. 相似文献
19.
Enantiomerically pure phosphoroselenoyl chloride bearing a binaphthyl group was synthesized. This phosphoroselenoyl chloride was used to discriminate and resolve simple secondary alcohols. Stereospecific conversions of diastereomerically pure phosphoroselenoic acid esters, obtained by reaction of the chloride with simple secondary alcohols, to enantiomerically pure alcohols and amines were also achieved. 相似文献
20.
Hongfeng LiXiaolei Xu Jingyu YangXin Xie He HuangYanzhong Li 《Tetrahedron letters》2011,52(4):530-533
An efficient iron-catalyzed cascade Michael addition-cyclization of o-aminoaryl compounds including o-aminoaryl aldehydes, o-aminoaryl ketones, and o-aminobenzyl alcohols with ynones for the synthesis of 3-carbonyl quinolines is reported. The reactions proceed to afford 3-carbonyl quinoline derivatives with or without substituent at the C-4 position in good to high yields using Iron(III) chloride hexahydrate as the catalyst in the air. 相似文献