Well-posedness and stability for an elliptic-parabolic free boundary problem modeling the growth of multi-layer tumors

In this paper we study a free boundary problem modeling the growth of multi-layer tumors. This free boundary problem contains one parabolic equation and one elliptic equation, defined on an unbounded domain in R2 of the form 0 〈 y 〈p（x,t）, where p（x,t） is an unknown function. Unlike previous works on this tumor model where unknown functions are assumed to be periodic and only elliptic equations are evolved in the model, in this paper we consider the case where unknown functions are not periodic functions and both elliptic and parabolic equations appear in the model. It turns out that this problem is more difficult to analyze rigorously. We first prove that this problem is locally well-posed in little H61der spaces. Next we investigate asymptotic behavior of the solution. By using the principle of linearized stability, we prove that if the surface tension coefficient y is larger than a threshold value y〉0, then the unique flat equilibrium is asymptotically stable provided that the constant c representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficiently small.     

A hyperbolic free boundary problem modeling tumor growth: Asymptotic behavior

In this paper we study a free boundary problem modeling the growth of radially symmetric tumors with two populations of cells: proliferating cells and quiescent cells. The densities of these cells satisfy a system of nonlinear first order hyperbolic equations in the tumor, and the tumor's surface is a free boundary . The nutrient concentration satisfies a diffusion equation, and satisfies an integro-differential equation. It is known that this problem has a unique stationary solution with . We prove that (i) if , then , and (ii) the stationary solution is linearly asymptotically stable.

     

Regularity of solutions to a free boundary problem modeling tumor growth by Stokes equation

In this paper we investigate regularity of solutions to a free boundary problem modeling tumor growth in fluid-like tissues. The model equations include a quasi-stationary diffusion equation for the nutrient concentration, and a Stokes equation with a source representing the proliferation density of the tumor cells, subject to a boundary condition with stress tensor effected by surface tension. This problem is a fully nonlinear problem involving nonlocal terms. Based on the employment of the functional analytic method and the theory of maximal regularity, we prove that the free boundary of this problem is real analytic in temporal and spatial variables for initial data of less regularity.     

Bifurcation for a free boundary problem with surface tension modeling the growth of multi-layer tumors

This paper is devoted to the study of the bifurcation of a free boundary problem modeling the growth of tumors with the effect of surface tension being considered. The existence of infinitely many branches of bifurcation solutions is proved. The method of analysis is based on reducing the problem to an operator equation in certain Hölder space with a nonlinear Fredholm operator of index 0. The desired result then follows from the Crandall-Rabinowitz bifurcation theorem.     

Analysis of a Free Boundary Problem Modeling Multi- Layer Tumor Growth in Presence of Inhibitor

In this paper we study well-posedness and asymptotic behavior of solution of a free boundary problem modeling the growth of multi-layer tumors under the action of an external inhibitor. We first prove that this problem is locally well-posed in little Holder spaces. Next we investigate asymptotic behavior of the solution. By making delicate analysis of spectrum of the linearization of the stationary free boundary problem and using the linearized stability theorem, we prove that if the surface tension coefficient γ is larger than γ^＊ 〉 0 the fiat stationary solution is asymptotically stable provided that the constant c representing the ratio between the nutrient diffusion time and the tumor-cell doubling time is sufficient small.     

Bifurcation for a free boundary problem modeling the growth of a tumor with a necrotic core

We consider a free boundary problem for a system of partial differential equations, which arises in a model of tumor growth with a necrotic core. For any positive numbers ρ<R, there exists a radially symmetric stationary solution with tumor boundary r=R and necrotic core boundary r=ρ. The system depends on a positive parameter μ, which describes the tumor aggressiveness. There also exists a sequence of values μ₂<μ₃<? for which branches of symmetry-breaking stationary solutions bifurcate from the radially symmetric solution branch.     

一个关于肿瘤治疗的自由边界问题的数学分析

§1Introduction Avarietyofpartialdifferentialequationmodelsfortumorgrowthortherapyhave beendevelopedinthelastthreedecades[see2,3,16-18,21-26].Mostofthosemodelsare informoffreeboundaryproblems,andareverydiversified.Rigorousmathematical analysisofsuchfreeboundaryproblemshasdrawngreatinterest,andmanyinteresting resultshavebeenestablished[4-15].Inthispaperwedealwithamathematicalmodeldescribingtumorchemotherapy.In thismodelthetumorisviewedasdenselypacked,radially-symmetricsphereofradiusR(t)contain…     

一种肿瘤生长自由边界问题整体解的存在唯一性

研究了一种肿瘤生长模型中自由边界问题,该肿瘤生长模型异于其它此类模型之处就在于采用了新的方式来描述繁衍细胞和休眠细胞的运动．运用抛物型方程的Lp理论和不动点原理,证明了该模型存在唯一的整体解．     

Computing steady-state solutions for a free boundary problem modeling tumor growth by Stokes equation

We consider a free boundary problem modeling tumor growth where the model equations include a diffusion equation for the nutrient concentration and the Stokes equation for the proliferation of tumor cells. For any positive radius R$R$, it is known that there exists a unique radially symmetric stationary solution. The proliferation rate μ$\mu$ and the cell-to-cell adhesiveness γ$\gamma$ are two parameters for characterizing “aggressiveness” of the tumor. We compute symmetry-breaking bifurcation branches of solutions by studying a polynomial discretization of the system. By tracking the discretized system, we numerically verified a sequence of μ/γ$\mu /\gamma$ symmetry breaking bifurcation branches. Furthermore, we study the stability of both radially symmetric and radially asymmetric stationary solutions.     

一个早期肿瘤生长模型的数学分析

研究了乳腺癌的早期生长模型（DCIS）,它为耦合了抛物方程、椭圆方程的自由边界问题,运用椭圆型方程的变分理论、抛物方程的L^p理论和压缩映照原理,证明了这个问题局部解的存在惟一性,然后用延拓方法得到了整体解的存在惟一性。     

ASYMPTOTIC BEHAVIOR FOR A CLASS OF ELLIPTIC EQUIVALUED SURFACE BOUNDARY VALUE PROBLEM WITH DISCONTINUOUS INTERFACE CONDITIONS

Spontaneous potential well-logging is one of the important techniques in petroleum exploitation. A spontaneous potential satisfies an elliptic equivalued surface boundary value problem with diseontinuous interface conditlons. In practice, the measuring electrode is so small that we can simplify the corresponding equivalued surface to a point. In this paper, we give a positive answer to this approximation process: when the equivalued surface shrinks to a point, the solution of the original equivalued surface boundary value problem converges to the solution of the corresponding limit boundary value problem.     

Analysis of a free boundary problem for vascularized tumor growth with a necrotic core and time delays

In this paper a free boundary problem for vascularized tumor growth with a necrotic core and time delays is studied. In the problem, there are two free boundaries, one is the outer boundary of the tumor, the other is the necrotic core boundary inside the tumor. The time delay exists in the process of tumor growth and represents the time required for tumor cell division. Sufficient conditions for the existence, uniqueness and stability of the stationary solution to the model are given. The results show that the time delay does not affect the final growth behavior of tumor.     

A free boundary problem for a singular system of differential equations: An application to a model of tumor growth

In this paper we consider a free boundary problem for a nonlinear system of two ordinary differential equations, one of which is singular at some points, including the initial point . Because of the singularity at , the initial value problem has a one-parameter family of solutions. We prove that there exists a unique solution to the free boundary problem. The proof of existence employs two ``shooting' parameters. Analysis of the profiles of solutions of the initial value problem and tools such as comparison theorems and weak limits of solutions play an important role in the proof. The system considered here is motivated by a model in tumor growth, but the methods developed should be applicable to more general systems.

     

Symmetry-breaking bifurcation of analytic solutions to free boundary problems: An application to a model of tumor growth

In this paper we develop a general technique for establishing analyticity of solutions of partial differential equations which depend on a parameter . The technique is worked out primarily for a free boundary problem describing a model of a stationary tumor. We prove the existence of infinitely many branches of symmetry-breaking solutions which bifurcate from any given radially symmetric steady state; these asymmetric solutions are analytic jointly in the spatial variables and in .

     

Analysis of an elliptic-parabolic free boundary problem modelling the growth of non-necrotic tumor cord

We study a free boundary problem modelling the growth of a tumor cord in which tumor cells live around and receive nutrient from a central blood vessel. The evolution of the tumor cord surface is governed by Darcy's law together with a surface tension equation. The concentration of nutrient in the tumor cord satisfies a reaction-diffusion equation. In this paper we first establish a well-posedness result for this free boundary problem in some Sobolev-Besov spaces with low regularity by using the analytic semigroup theory. We next study asymptotic stability of the unique radially symmetric stationary solution. By making delicate spectrum analysis for the linearized problem, we prove that this stationary solution is locally asymptotically stable provided that the constant c representing the ratio between the diffusion time of nutrient and the birth time of new cells is sufficiently small.     

Well-posedness of a multidimensional free boundary problem modelling the growth of nonnecrotic tumors

In this paper we study a free boundary problem modelling the growth of nonnecrotic tumors. The main trait of this free boundary problem is that it is essentially multidimensional, so that its well-posedness is hard to establish by using the usual methods in the classical theory of free boundary problems. In this paper we use the functional analysis method based on the theory of analytic semigroups to prove that this problem has a unique local solution in suitable function spaces. Continuous dependence of the solution on the initial data and regularities of the solution can also be easily obtained by using the argument of this paper.