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1.
Xiao-fei Zhu Yan-hong Liang Di Zhang Le Wang Yong Ye Yufen Zhao 《Phosphorus, sulfur, and silicon and the related elements》2013,188(2):281-286
Abstract Two novel cyclotetraphosphazene derivatives were synthesized by the reaction of octachlorocyclotetraphosphazene with the potassium salt of 4-hydroxybenzaldehyde, and subsequent reduction of aldehyde groups to alcohol groups using sodium borohydride. The bromination reaction was carried out using PBr3 to give N4P4(OC6H4-p-CH2Br)8 (4). This compound was employed in reaction with imidazole or morpholine to produce eight-armed, star-branched title compounds. The target compounds were characterized by 1H, 31P, and 13C NMR as well as IR and ESI-MS. The Cu complex of 5a was effective in oxidative cleavage reactions. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT 相似文献
2.
Li Shao Yutong Pan Bin Hua Shidang Xu Guocan Yu Mengbin Wang Bin Liu Feihe Huang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(29):11877-11881
In order to promote the development of photodynamic therapy (PDT), undesired side effects like low tumor specificity and the “always-on” phenomenon should be avoided. An effective solution is to construct an adaptive photosensitizer that can be activated to generate reactive oxygen species (ROS) in the tumor microenvironment. Herein, we design and synthesize a supramolecular switch based on a host–guest complex containing a water-soluble pillar[5]arene ( WP5 ) and an AIEgen photosensitizer ( G ). The formation of the host–guest complex WP5 ⊃ G quenches the fluorescence and inhibits ROS generation of G . Benefitting from the pH-responsiveness of WP5 , the binding site between G and WP5 changes in an acidic environment through a shuttle movement. Consequently, fluorescence and ROS generation of the host–guest complex can be switched on at pH 5.0. This work offers a new paradigm for the construction of adaptive photosensitizers by using a supramolecular method. 相似文献
3.
Magdaléna Hromadová Lubomír Pospíšil Stanislav Záliš Nicolangelo Fanelli 《Journal of inclusion phenomena and macrocyclic chemistry》2002,44(1-4):373-380
Electrochemical methods sensitively detect the formation of host–guest complexes of cyclodextrins and three redox-active pesticides: vinclozoline (3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione), iprodione (3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide), and procymidone (3-(3,5-dichloro-phenyl)-1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione). The protecting environment of the CD cavity allows a four-electron heterogeneous reaction leading to a preferential cleavage of the C–Cl bonds and conservation of the heterocycle structure for a further second electron transfer step. This interpretation is supported by numerical simulation of the voltammetric curves and by quantum-chemical calculations of the LUMO changes of vinclozoline. Electrochemical detection of these host–guest interactions is far superior to the spectral methods. 相似文献
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α-Bromo chalcones containing 2-thiene ring were prepared in good yields by the condensation of 1-(thien-3-yl)ethanone with aromatic aldehydes, followed by bromination with bromine and selective dehydrobromination with triethyl amine at room temperature. 相似文献
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XianHongYIN 《中国化学快报》2003,14(5):445-447
A novel β-cyclodextrin-based terpyridine derivatives has been prepared by the coupling of 4‘‘‘‘‘‘‘‘-(4“-bromomethyl phenyl)-2,2‘‘‘‘‘‘‘‘:6‘‘‘‘‘‘‘‘,2“-terpyridine with mono-6-hydroxy permethylated β-cyclodextrin.The cyclodextrin dimmer appending a 4‘‘‘‘‘‘‘‘-phenyl-2,2‘‘‘‘‘‘‘‘:6‘‘‘‘‘‘‘‘,2“-terpyridine spacer on the primary faces was synthesized by reaction of 4‘‘‘‘‘‘‘‘-phenyl-2,2‘‘‘‘‘‘‘‘:6‘‘‘‘‘‘‘‘,2“-terpyridine-6,6‘‘‘‘‘‘‘‘-dicarbonitrile with an excess of 6-deoxy-6-O-tosyl-β-cyclodextrin. 相似文献
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Reactions of 5-(p-aminophenyl)-10,15,20-triphenyl porphyrin (1) with Ru3(CO)12 or M(OCOCH3)2 (M=Ni,Mn) afforded metalloporphyrins(4-6),respectively.6-Deoxy-6-io-do-β-cyclodextrin(2) and mono(6-O-trifluoromethanesulfonyl) permethylated β-cyclodextrin(3) reacted with complexes 4-6 to give β-cyclodextrin bonded metal porphyrins (7-9) and permethylated β-cyclodextrin bonded me-tal porphyrins (10-12) respectively.These new complexes were identified by MS,IR,UV-visible and ^1H NMR spectra,and elemental analysis. 相似文献
7.
Skuredina A. A. Kopnova T. Yu. Le-Deygen I. M. Kudryashova E. V. 《Moscow University Chemistry Bulletin》2020,75(4):218-224
Moscow University Chemistry Bulletin - We study the effect of the nature of the substituent in the β-cyclodextrin derivative on the physicochemical properties of the antibacterial drug... 相似文献
8.
Jinhao Zhang Nannan Jing Xinli Fan Prof. Xinjing Tang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(61):14002-14010
RNA interference is an essential and powerful tool for targeting and verifying specific gene functions. Conditional control of small interfering RNA (siRNA) activity, especially using light activation, is a potential method for regulating target gene expression and functions. In this study, a series of photolabile siRNAs with amantadine modification have been rationally designed and developed through host–guest interactions between amantadine and β-cyclodextrin derivatives to enhance the blocking effect of siRNA binding and/or RNA-induced silencing complex processing. These caged siRNAs with amantadine modification at the 5′ end of antisense-strand RNA were efficiently inactivated through the host–guest interactions between amantadine and β-cyclodextrin. Photomodulation of the gene silencing activity of these amantadine-modified caged siRNAs targeting both exogenous and endogenous genes was successfully achieved, which indicates that host–guest interactions could be a new strategy for developing new caged siRNAs for gene photoregulation with low leaking activity. 相似文献
9.
Jinyun Zheng Yujian Yu Xiaomin Zhen Erbing Yang Yufen Zhao 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):1564-1575
Abstract A series of new nitrogen heterocyclic compounds containing sulfur–ether (8a–8f) and Schiff-base (9a–9q) functionalities were synthesized by the reaction of the pharmaceutical lead compound containing both benzimidazole and 1,2,4-triazole rings. The compounds were characterized by 1H NMR, 13C NMR, FT-IR, HR-MS, and ESI-MS. 相似文献
10.
A series of 3-chloro-1-(aryl)-4-(2-(2-chloroquinolin-3-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)-4-ethyl-azetidin-2-ones (5a–l) have been synthesized and characterized by IR, 1H NMR, and13C NMR. Synthesized compounds were screened for their antimicrobial activity against different strains of bacteria (E. coli, P. aeruginosa, S. aureus, S. pyogenes, C. albicans, A. niger, and A. clavatus). On the basis of statistical analysis, it has been observed that compounds had significant correlations. 相似文献
11.
IntroductionSulfonylureas, as inhibitors of acetohydroxyacidsynthase(AHAS), are a class of herbicides that areused for crop protection. They are used for lowconcen-tration ranges(10—100 g of active ingredient/ha) andare advanced herbicides used in agricu… 相似文献
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Honghong Duan Yawen Li Qingfang Li Pinpin Wang Xueru Liu Lin Cheng Yang Yu Prof. Liping Cao 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(25):10187-10196
We report the synthesis and characterization of a three-dimensional tetraphenylethene-based octacationic cage that shows host–guest recognition of polycyclic aromatic hydrocarbons (e.g. coronene) in organic media and water-soluble dyes (e.g. sulforhodamine 101) in aqueous media through CH⋅⋅⋅π, π–π, and/or electrostatic interactions. The cage⊃coronene exhibits a cuboid internal cavity with a size of approximately 17.2×11.0×6.96 Å3 and a “hamburger”-type host–guest complex, which is hierarchically stacked into 1D nanotubes and a 3D supramolecular framework. The free cage possesses a similar cavity in the crystalline state. Furthermore, a host–guest complex formed between the octacationic cage and sulforhodamine 101 had a higher absolute quantum yield (ΦF=28.5 %), larger excitation–emission gap (Δλex-em=211 nm), and longer emission lifetime (τ=7.0 ns) as compared to the guest (ΦF=10.5 %; Δλex-em=11 nm; τ=4.9 ns), and purer emission (ΔλFWHM=38 nm) as compared to the host (ΔλFWHM=111 nm). 相似文献
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R. Murugesan A. Thamaraichelvan P. Sami 《Journal of inclusion phenomena and macrocyclic chemistry》1999,34(3):235-243
Synthesis and IR spectra of novel Hofmann-T
d
-type aniline clathrates, M(NH3)2Zn(CN)4· 2C6H5NH2 (M = Zn or Cd) are reported for the first time. All the vibrational modes of aniline are characterised. The shifts in
a
(NH2) and
s
(NH2) reveal hydrogen bonding between the NH2 group of aniline and the cyanide group of the host lattice to be stronger than in Hofmann-type aniline clathrates. However, the out of plane deformation mode of aniline indicates absence of hydrogen bonding between ammonia and the -cloud of the aniline ring. The related aniline clathrates with bridging Cd(CN)4 M(NH3)2Cd(CN)4· 2C6H5NH2 (M=Zn or Cd), exhibit similar behaviour. 相似文献
16.
Dong Qing LIU Ya Qing FENG Hao Hui GU Wen Liang XU 《中国化学快报》2006,17(6):747-750
It is well known that calixarenes are extremely versatile classes of macrocyclic receptor able to complex various metal ions as well as to selectively recognize both neutral and charged inorganic or organic species in solution. It is unable to get a clear… 相似文献
17.
5,10, 15-Triphenyl-20-{2- [α- (adenine-9 ) acetylamino]} phenyl porphyrin ( 1 ), 5,10, 15-triphenyl-20-{2-[α-(cytosine-1)acetylamino]} phenyl porphyrin (2), 5, 10, 15-triphenyl-20-{4-[α-(cytosine-1)ethoxy]} phenyl porphyrin (3) and their zinc complexes Zn-1, Zn-2 and Zn-3 have been prepared and characterized by ^1H NMR spectra, elemental analyses, electronic absorption spectra and mass spectra (FAB). Intramolecular π-π interactions and intramolecular metal-~ interaction for 1, 2, Zn-1,and Zn-2 have been investigated by several methods. ^1H NMR studies demonstrate that the porphyrin π-system in 1 and 2 is parallel to the adenine and the cytosine aromatic ring, respectively. The electronic absorption spectral properties of free porphyrin derivatives and their zinc complexes have been compared with those of H2TPP and ZnTPP. The results show that the UV-vis spectra of 1 and 2 are the same as that of H2TPP,whereas the spectra of their zinc complexes show 7 nm red shifts of the Soret bands compared to that of ZnTPP. The emission spectra of Zn-1 and Zn-2 are independent of excitation wavelength. From combination of the evidence of absorption and emission spectra it is suggested the existence of intramolecular metal-π interaction in Zn-1 and Zn-2. The results of conformational analysis agreed quite nicely with that of experiments, thus it was further to validate the experimental conclusions. 相似文献
18.
Ai-You Hao Ji-Mao Lin Lin-Hui Tong 《Journal of inclusion phenomena and macrocyclic chemistry》1999,34(4):445-454
Mono-3-deoxy-(N-benzoyl-ethylenediamino)--CD, mono-3-deoxy-(N-benzylidene-ethylenediamino)--CD and mono-3-deoxy-(N-salicylidene-ethylenediamino)--CD, each having a flexible chain that bonds the aryl moiety on the secondary side of -CD, were prepared. The reaction processes might involve the formation of mono-(2,3-manno-epoxide)--CD as an intermediate under our reaction conditions. Further experiments showed that the aryl moiety which was bonded as a functional group on the primary side of -CD or on the secondary side of -CD with or without an ethylenediamino chain show remarkably different complexation properties in the complexation with small molecular guests such as alkanes, cycloketones etc. 相似文献
19.
Synthesis and Characterization of Novel Mercapto-end Ferrocenyl Derivatives with Schiff Base Linkage
HaiFengSONG MiaoCHEN YongMinLIANG LingSHI GuoShengHUANG 《中国化学快报》2004,15(9):1087-1090
Novel ferrocenyl derivatives of p-(10-mercaptodecyloxy)benzal 4-ferrocenylaniline have been prepared and characterized by element analysis,HNMR,and FAB=MS,Cyclic voltammetry has been used to characterize the self-assembled monolayers formed from the compounds on the gold electrodes. 相似文献
20.
《合成通讯》2013,43(9):1203-1208
Abstract A new and efficient solid‐state method for the preparation of thiohydantoins is reported. With this method, twelve thiohydantoin compounds have been synthesized in good to excellent yields (81–92%). In addition, this method has the advantages of high yields, a cleaner reaction, simple methodology, and short reaction times. 相似文献