Transmission properties of bone conducted sound: measurements in cadaver heads

In the past, only a few investigations have measured vibration at the cochlea with bone conduction stimulation: dry skulls were used in those investigations. In this paper, the transmission properties of bone conducted sound in human head are presented, measured as the three-dimensional vibration at the cochlear promontory in six intact cadaver heads. The stimulation was provided at 27 positions on the skull surface and two close to the cochlea; mechanical point impedance was measured at all positions. Cochlear promontory vibration levels in the three perpendicular directions were normally within 5 dB. With the stimulation applied on the ipsilateral side, the response decreased, and the accumulated phase increased, with distance between the cochlea and the excitation position. No significant changes were obtained when the excitations were on the contralateral side. In terms of vibration level, the best stimulation position is on the mastoid close to the cochlea; the worst is at the midline of the skull. The transcranial transmission was close to 0 dB for frequencies up to 700 Hz; above it decreased at 12 dB/decade. Wave transmission at the skull-base was found to be nondispersive at frequencies above 2 kHz whereas it altered with frequency at the cranial vault.     

Acoustic method for calibration of audiometric bone vibrators

The standard method for the calibration of audiometric bone vibrators requires the use of an artificial mastoid, a device that converts vibratory energy to an electrical analog. The mechanical input impedance of the device is designed to represent the average mechanical impedance of the human head. For calibration purposes, it is not necessary that the coupling device represent the impedance of the head. It is only necessary that it provides a repeatable measurement of the output of the vibrator that can be related to the normal threshold of hearing at each test frequency. In addition to the mechanical output that serves as the stimulus for the hearing test, bone vibrators produce an acoustic signal that is proportional to the mechanical force delivered to the head. By determining the transfer function relating the acoustic sound pressure to the mechanical force, the acoustic signal can serve as a proxy for the vibratory stimulus. This article describes the design and validation of an acoustic coupler for the calibration of audiometric bone vibrators.     

A piezoelectric bone-conduction bending hearing actuator

A prototype of a novel bone-conduction hearing actuator based on a piezoelectric bending actuator is presented. The device lies flat against the skull which would allow it to form the basis of a subcutaneous bone-anchored hearing aid. The actuator excites bending in bone through a local bending moment rather than the application of a point force as with conventional bone-anchored hearing aids. Through measurements of the cochlear velocity created by the actuator in embalmed human heads, the device is shown to exhibit high efficiency, making it a possible alternative to present-day electromagnetic bone-vibration actuators.     

Dynamic properties of the human head

Driving point mechanical impedance measurements were used to determine the dynamic response of the human head to sinusoidal vibration in the frequency range between 30 Hz and 5000 Hz at excitation levels of 0·98 m/s² and 3·4 m/s2. Because of the low excitation levels, the weight of the head was sufficient to couple the head to the vibration source.At 20 Hz the impedance magnitude was about 790 N-s/m but increased at approximately 6dB/octave to a peak near 3500 N-s/m at 70–90 Hz. Between 100 Hz and 2000 Hz impedance decreased by about two orders of magnitude while the apparent mass decreased by three orders of magnitude indicating good vibration isolation at higher frequencies. The impedance response contains the information for modelling the head as a dynamic system.The response of the head to vibration can be simulated by a two degree-of-freedom, mass-excited system consisting of a series connection of a small driving mass, a damper, a spring and damper in parallel and a large final mass. Parameter values, derived by computer techniques, suggest that the large mass represents the total head, the small mass the tissue in contact with the vibration input and the spring the skull stiffness.     

Binaural measurement of bone conduction click evoked otoacoustic emissions in adults and infants

Transient evoked otoacoustic emissions (TEOAEs) are usually evoked with air conduction (AC) stimuli. Only a few reports exist about OAEs where stimuli have been delivered using bone conduction (BC) by placing a bone conductor on the forehead or the mastoid. The aims of the present study were to improve the test performance of BC-TEOAEs by using a nonlinear stimulation protocol and to find out, whether this technique can be applied in newborn hearing screening. BC-TEOAEs were measured binaurally in ten normal hearing adults and in ten infants. For measurements in infants, miniaturized probes without loudspeakers were constructed to allow a complete insertion of the probe in the infant's ear canal. It could be shown that robust and valid BC-TEOAEs can be elicited using a nonlinear stimulation protocol. Findings in adults indicated that BC-TEOAEs can be measured with properties similar to AC-TEOAEs. However, mean BC-TEOAE levels were reduced by 0.8-3.7 dB depending on frequency. In view of test time, this is compensated by performing binaural recordings. Measurements in infants indicated that the screening performance of BC-TEOAEs and AC-TEOAEs may be comparable. Further studies have to investigate, whether BC-TEOAEs are more robust than AC-TEOAEs against small conductive hearing loss.     

Acoustic mechanisms that determine the ear-canal sound pressures generated by earphones

In clinical measurements of hearing sensitivity, a given earphone is assumed to produce essentially the same sound-pressure level in all ears. However, recent measurements [Voss et al., Ear and Hearing (in press)] show that with some middle-ear pathologies, ear-canal sound pressures can deviate by as much as 35 dB from the normal-ear value; the deviations depend on the earphone, the middle-ear pathology, and frequency. These pressure variations cause errors in the results of hearing tests. Models developed here identify acoustic mechanisms that cause pressure variations in certain pathological conditions. The models combine measurement-based Thévenin equivalents for insert and supra-aural earphones with lumped-element models for both the normal ear and ears with pathologies that alter the ear's impedance (mastoid bowl, tympanostomy tube, tympanic-membrane perforation, and a "high-impedance" ear). Comparison of the earphones' Thévenin impedances to the ear's input impedance with these middle-ear conditions shows that neither class of earphone acts as an ideal pressure source; with some middle-ear pathologies, the ear's input impedance deviates substantially from normal and thereby causes abnormal ear-canal pressure levels. In general, for the three conditions that make the ear's impedance magnitude lower than normal, the model predicts a reduced ear-canal pressure (as much as 35 dB), with a greater pressure reduction with an insert earphone than with a supra-aural earphone. In contrast, the model predicts that ear-canal pressure levels increase only a few dB when the ear has an increased impedance magnitude; the compliance of the air-space between the tympanic membrane and the earphone determines an upper limit on the effect of the middle-ear's impedance increase. Acoustic leaks at the earphone-to-ear connection can also cause uncontrolled pressure variations during hearing tests. From measurements at the supra-aural earphone-to-ear connection, we conclude that it is unusual for the connection between the earphone cushion and the pinna to seal effectively for frequencies below 250 Hz. The models developed here explain the measured pressure variations with several pathologic ears. Understanding these mechanisms should inform the design of more accurate audiometric systems which might include a microphone that monitors the ear-canal pressure and corrects deviations from normal.     

骨导振子佩戴位置对重放声的影响

骨导振子佩戴位置会影响骨传导声重放的性能,但已有研究还不够全面和完善.针对11名双耳听力正常的受试者,采取不同的骨导振子佩戴位置,对骨传导声重放在听力阈值、主观音质评价和语言清晰度3个方面进行了研究.实验结果表明不同的佩戴位置会影响骨传导声重放性能,髁骨位置在3个实验都表现最好,髁骨的听力阈值比乳突位置平均低8.7 d...     

Acoustics of the human middle-ear air space

The impedance of the middle-ear air space was measured on three human cadaver ears with complete mastoid air-cell systems. Below 500 Hz, the impedance is approximately compliance-like, and at higher frequencies (500-6000 Hz) the impedance magnitude has several (five to nine) extrema. Mechanisms for these extrema are identified and described through circuit models of the middle-ear air space. The measurements demonstrate that the middle-ear air space impedance can affect the middle-ear impedance at the tympanic membrane by as much as 10 dB at frequencies greater than 1000 Hz. Thus, variations in the middle-ear air space impedance that result from variations in anatomy of the middle-ear air space can contribute to inter-ear variations in both impedance measurements and otoacoustic emissions, when measured at the tympanic membrane.     

Hand-arm vibration part III: A distributed parameter dynamic model of the human hand-arm system

An anatomically analogous distributed parameter dynamic model of the human arm is proposed and quantitatively validated. Distributed mass and stiffness parameters have been obtained by representing each long bone of the arm as a flexural beam. A distributed damping parameter was introduced by allowing the beam stiffness to be a complex quantity. Hand properties were modelled as a lumped parameter damped spring-mass system. Mechanical driving point impedance techniques were used to verify the model. A dual beam model of the forearm was first proposed, and its frequency response was compared with impedance data collected on the forearm. After having established the validity of the forearm model, it was then extended to include the upper arm. The frequency response of the whole-arm model was then compared with impedance data on the whole arm collected by a previous investigator. It is concluded that the beam model of the human arm adequately represented its dynamic behavior as measured by mechanical driving point impedance techniques. The amount of information concerning the dynamic behavior of the arm yielded by the distributed parameter model is found to be vastly greater than that yielded by lumped parameter models.     

Ultrasonic effects on titanium tanning of leather

The effects of ultrasound on titanium tanning of leather were investigated. Either 20 or 40 kHz ultrasound was applied to the titanium tanning of pigskins. Five different treatment conditions were carried out and the effects were examined, such as leather shrinkage temperature (T(s)), titanium content and titanium distribution in the leather. Overall heat loading was carefully controlled. Results showed that 20 kHz ultrasound effectively improves titanium agent penetration into the hide and increases the leather's shrinkage temperature. Doubling the frequency to 40 kHz produced negligible enhancements. An impressive 105.6 degrees C T(s) was achieved using 20 kHz ultrasound pretreatment of the tanning liquor followed by 20 kHz ultrasound in the tanning mixture (liquor plus pigskins) in a special salt-free medium. Finally, using a unique ultrasonic tanning drum with 26.5 kHz ultrasound, the T(s) reached a record level of 106.5 degrees C, a value not achieved in conventional (no ultrasound) titanium tanning. The ultrasonic effects on titanium tanning of leather are judged to make a superior mineral tanned leather.     

Child and adult vibrotactile thresholds for sinusoidal and pulsatile stimuli

Three experiments were performed to obtain vibrotactile sensitivity thresholds from hearing children and adults, and from deaf children. An adaptive two-interval forced-choice procedure was used to obtain estimates of the 70.7% point on the psychometric sensitivity curve. When hearing children of 5-6 and 9-10 years of age and adults were tested with sinusoids and haversine pulse stimuli, at 10, 100, 160, and 250 Hz or pps, respectively, only the 10-Hz stimulus resulted in an age effect. For this stimulus, young children were significantly less sensitive than adults. When sinusoids were again tested at 20, 40, 80, and 160 Hz, a small overall effect of age was observed with a significant effect only at 20 Hz. Two prelingually profoundly deaf children were tested with haversine pulse trains at 10, 50, 100, 160, and 250 pps. Both children were at least as sensitive to the tactile stimulation as were the hearing children and adults. Pulsatile stimulation, compared to sinusoidal stimulation, exhibited relatively flat threshold versus frequency functions. The present results, demonstrating no age effect for pulsatile stimulation and similar performance for deaf and hearing children, suggest that pulsatile stimulation would be appropriate in vibrotactile speech communication aids for the deaf.     

Accuracy of a pulse-echo boundary tomogram

An ultrasonic tomogram was developed with a view to providing the outline of a cross section of the ulna in vivo. The construction and design of the instrument was undertaken to obtain a resolution as close as possible to theoretical limits. The apparatus was constructed to be used in conjunction with a system for assessing bone mineral content using a conventional clinical x-ray set. It had been expected that the information from the two instruments would make it possible to obtain a precise spatial plot of bone density. It was thought that the tomograph would respond only to reflections at the bone--soft tissue interface, where there is a large change in acoustic impedance, but in vivo trials have shown that other soft tissue interfaces give rise to reflection, which makes the performance unsatisfactory. However, some interesting results have been obtained from solid objects in water, which have shown that there is a limitation on the accuracy of the plot depending on the angle of incidence of the ultrasonic beam and not dependent on errors of mechanical or electronic origin. Some theory is put forward to account for irregularities in plots for these objects.     

真人头部骨导效应实验和分析

利用耳声发射原理,借鉴三间隔范式分离方法,提出对骨导振子施加扫频音,以快速准确获取全频段刺激频率耳声发射(SFOAE)信号的方法,以此研究真人头部的骨导效应,将测得的耳声信号和骨导振子激励信号之间的相对关系定义为耳声相关骨传导响应函数(OAR-BCRF)。10名听力正常的受试者的OAR-BCRF实验结果表明,不同刺激强度下测量的OAR-BCRF的包络形状差异不大,仅幅度随着刺激强度的增加而整体增大;乳突和下颌骨髁突两个不同刺激位置下的OAR-BCRF包络整体趋势相似,但在不同频段存在差异,下颌骨髁突处的经颅传输要低于乳突。受试者的平均OAR-BCRF数据显示,在2~6 kHz之间,同侧OAR-BCRF的幅度最大相差13 dB,而对侧OAR-BCRF最大相差19 dB。实验也发现同侧与对侧的OAR-BCRF包络相似且双侧骨传导的隔离度不高。本文的OAR-BCRF研究有效地探讨了真人头部的骨导传输的生理特性,可为经颅衰减和骨传导空间声定位等相关研究提供基础。      

Factors contributing to bone conduction: the outer ear

The ear canal sound pressure and the malleus umbo velocity with bone conduction (BC) stimulation were measured in nine ears from five cadaver heads in the frequency range 0.1 to 10 kHz. The measurements were conducted with both open and occluded ear canals, before and after resection of the lower jaw, in a canal with the cartilage and soft tissues removed, and with the tympanic membrane (TM) removed. The sound pressure was about 10 dB greater in an intact ear canal than when the cartilage part of the canal had been removed. The occlusion effect was close to 20 dB for the low frequencies in an intact ear canal; this effect diminished with sectioning of the canal. At higher frequencies, the resonance properties of the ear canal determined the effect of occluding the ear canal. Sectioning of the lower jaw did not significantly alter the sound pressure in the ear canal. The sound radiated from the TM into the ear canal was investigated in four temporal bone specimens; this sound is significantly lower than the sound pressure in an intact ear canal with BC stimulation. The malleus umbo velocity with air conduction stimulation was investigated in nine temporal bone specimens and compared with the umbo velocity obtained with BC stimulation in the cadaver heads. The results show that for a normal open ear canal, the sound pressure in the ear canal with BC stimulation is not significant for BC hearing. At threshold levels and for frequencies below 2 kHz, the sound in the ear canal caused by BC stimulation is about 10 dB lower than air conduction hearing thresholds; this difference increases at higher frequencies. However, with the ear canal occluded, BC hearing is dominated by the sound pressure in the outer ear canal for frequencies between 0.4 and 1.2 kHz.     

Continuous optical coherence tomography monitoring of nanoparticles accumulation in biological tissues

In this study, dynamics of nanoparticles penetrating and accumulating in biotissue (healthy skin) was investigated in vivo by the noninvasive method of optical coherence tomography (OCT). Gold nanoshells and titanium dioxide nanoparticles were studied. The processes of the nanoparticles penetration and accumulation in biotissue are accompanied by the changes in optical properties of skin which affect the OCT images. The continuous OCT monitoring of the process of the nanoparticles penetration into skin showed that these changes appeared in 30 min after application of nanoparticles on the surface; the time of accumulation of maximal nanoparticles concentration in skin was observed in period of 1.5–3 h after application. Numerical processing of the OCT signal exhibited the increase in contrast between upper and lower parts of dermis and contrast decay of the hair follicle border during 60–150 min. The transmission electron microscopy technique confirmed accumulation of the both types of nanoparticles in biotissue. The novelty of this study is presentation of OCT ability to in vivo monitor dynamics of nanoparticles penetration and their re-distribution within living tissues.     

Skin effect under the conditions of ferromagnetic and spin-wave resonance

An expression for the electromagnetic field penetration depth in a metallic magnetic layer is derived taking into account the complexity of the high-frequency permeability under the conditions of ferromagnetic and spin-wave resonance. The frequency dependences of the skin depth and its dependences on the magnitude and type of spin pinning are determined from a numerical analysis of the solutions of the motion equation for magnetization. Some features of the dependences associated with the nature of the spin-wave spectrum are revealed.     

Some considerations on biomaterials and bone

Osteoinduction is a property not traditionally attributed to Calcium Phosphate ceramics. Histologic, SEM and X-ray microanalyses of a biopsy of pulmonary alveolar microlithiasis allow to discredit this opinion. Bone, even lamellar type, was ectopically formed on microliths undergoing osteoclastic erosion. The SEM and X-ray microanalyses of coral granules implanted in humans indicate an osteoconductive property for both Calcium and Phosphorus. Analysis of in vitro allows to propose an enhancement of the osteocapability of coral. Lamellar bone formation in the near absence of loads undermines the opinion which sees a correlation between lamellar bone and mechanical loads. Analysis of the bone surrounding an uncemented titanium hip prosthesis highlights that both remodeled and newly formed bone have lamellae oriented parallel to prosthesis surfaces, i.e. orthogonal to loads, as opposed to that of lamellar bone of osteons which are oriented parallel to loads. Analysis of longitudinal sections of cortical bone under polarized light points out that lamellae are displaced parallel to the cement line surface both in the conic end of osteons and in Volkman's canals with thick wall, i.e. undergoing sloped load directions. In conclusion, there may be a relationship between lamellae formation and gravity.     

Effects of normal and pathologic eardrum impedance on sound pressure in the aided ear canal: a computer simulation

Reported herein are results of computer simulations of aided sound spectra in ears with normal and pathologic eardrum impedance. The computer technique used in this study has been reported elsewhere [D. P. Egolf, D. R. Tree, and L. L. Feth, J. Acoust. Soc. Am. 63, 264-271 (1978)]. Consequently, to develop reader confidence in the computer scheme, its application to real ears was first tested. This was accomplished by (1) comparing computed spectral data with in-the-ear measurements and (2) comparing real ear minus 2-cc coupler data-both computer generated--with an idealized difference curve published elsewhere [R. M. Sachs and M. D. Burkhard, unpublished rep. no. 20022-1, Industrial Research Products, Inc., Elk Grove Village, IL (1972)]. Results indicate that the wide variation in eardrum impedance among normals evidenced in other studies produces a corresponding wide variation in aided spectrum shape. Likewise, simulations utilizing two sets of pathologic eardrum impedance data obtained from the literature show that aided sound spectra in such ears are likely to be significantly different from those occurring in normal ears. These findings suggest, as others have concluded, that there may be a substantial variation in spectrum shape among individuals wearing identically the same hearing aid--even if those individuals have normal hearing. In conclusion, questions are raised about the use of real-ear simulators and the need for a comprehensive computer-based model of an entire hearing aid.     

Auditory Hopf Amplification Revealed by an Energy Method

We report on the auditory Hopf amplification contributed by the electrical energy of the hair cell during its bundle deflecting. An energy method to calculate the active force is adopted according to the electrical energy consumption of the hair cell. After some experimental data was analyzed and simulated, we find that the electrical energy determines the value of the active force and enlarges the mechanical response of the hair bundle.This amplification is controlled by the cell voltage and makes the sensor a Hopf vibrator with hearing nonlinear characteristics. A velocity-dependent active force derived previously from the force-gating channel operation strongly reinforces our conclusion.     

Measurement of sun and heat protecting properties of human skin through addition of titanium dioxide nanoparticles

Based on the developed mathematical model of skin with the addition of titanium dioxide (TiO₂) nanoparticles 62 and 122 nm in diameter, the absorbed energy density distribution in the skin depth is obtained for the skin irradiated by UV radiation at wavelengths of 310 and 400 nm. It is found that high reflective and scattering properties of the corneal layer of the skin treated by photoprotective preparations based on nanoparticles prevent the penetration of the UV radiation into inner skin layers. It is shown that the majority of the radiation energy is captured or reflected in a thin surface skin layer containing nanoparticles. A decrease in the thermal load on the tissue is observed.