An Efficient Synthetic Method of Nordihydroguaiaretic Acid（NDGA）

Nordihydroguaiaretic acid(NDGA)has been synthesized in nine steps from piperonal using Stobbe condensation as the key step with high yield.By this approach,five relative natural products were obtained.     

A Direct and Efficient Synthetic Method for Nitriles from Ketones

Cyclic cyano derivatives 3 were obtained by the reaction of Me₃SiCN / ZnI₂ with the cyclic ketones 2 which gave the trimethylsilyloxy nitriles 4. They were directly transformed to cyano derivatives 3 (70–80% yield) by the reductive reagent Me₃SiCl-NaI in acetonitrile in the presence of H₂O.     

An Efficient Synthetic Method for 2-Methoxy-L,2-dihydro-3H-indol-3-ones

An efficient method for synthesis of 2-methoxy-l,2-dihydro-3H-indol-3-ones using two successive oxidations of indoles is described.     

布帕伐醌的改进合成方法

布帕伐醌是一种治疗牛泰勒焦虫病的药物,其传统的合成工艺存在产率低、污染严重以及成本过高的问题。本文在目前布帕伐醌的合成工艺上进行了优化,以1,4-萘醌作为起始原料,经过4步转化合成得到布帕伐醌,反应总收率达到62%,产品纯度可达99%以上,该方法在布帕伐醌的大规模生产上具有很好的应用前景。     

An Improved Synthetic Method of Saquinavir

IntroductionThe human immunodeficiency virus(HIV)is thecausative agent of acquired immunodeficiency syndrome(AIDS).Since HIV protease is essential for the repli-cation and maturation of HIV,the inactivation of HIVprotease by either mutation or chemical in…     

一种有效的从五氟氯乙烷合成五氟碘乙烷的方法

本文发展了一种有效的从五氟氯乙烷合成五氟碘乙烷的方法。仔细考察了五氟氯乙烷亚磺化脱氯的条件,由此生成的五氟乙基亚磺酸盐无须纯化,可以直接进行碘化,能以中等收率生成相应的五氟碘乙烷。     

An Efficient Solvent-free Synthetic Technique of 4,4’-Diaminotriarylmethane Leuco Materials

An efficient, versatile and solvent-free synthetic technique of diaminotriarylmethanes was reached by treating N,N-dimethylaniline with some arylaldehydes over zirconium(IV) oxide chloride (ZrOCl2•8H2O), in which ZrOCl2•8H2O has good activity, easy availability, recovery as well as reusability.     

正戊醛合成方法的改进

正戊醛合成方法的改进刘瑞蓝，南志祥，郭治安（西北大学化学系西安７１００６９）关键词正戊醛，一步氧化法，共沸蒸馏，精馏醛类化合物的使用相当广泛，尤其在香料工业中越来越受到人们重视，但由于易氧化与易聚合，在加热条件下合成难度大，产率低，我们在过去研究工作...     

A Novel Sesquiterpenoid from Glechoma longituba

Glechoma longituba (NaKai) Kupr. as a folk medicine, widely distribute in China. The whole plant has been used for treatment of urosealith and urinary tract infection1. It was previously reported1, 2 that some compounds, such as glechomafuran, ursolic aci…     

A New Eudesmanolide and a New Aromatic Derivative from Carpesium cernuun

Carpesium cernuun L. has long been used as chinese folk medicine for its anti-inflammatory, pain-relief, and detoxication properties1. Up to now, no phytochemical studies of Carpesium cernuun has been carried out. Here we report the structure elucidation of a new eudesmanolide 1 and a new aromatic derivative 2, which were obtained from this plant. Compound 1 was isolated as colorless gum, [(]+128.4 (c 0.43, CHCl3). Its EIMS revealed a molecular ion peak m/z 248. Together with the support …     

对烷氧基苯甲醛合成方法的改进

对烷氧基苯甲醛合成方法的改进董恒山杨世琰＊殷元骐（中国科学院兰州化学物理研究所兰州７３００００）关键词对烷氧基苯甲醛，Ｗｉｌｉａｍｓｏｎ醚合成，Ｃａｎｎｉｚｚａｒｏ反应１９９６－０４－１８收稿，１９９６－０８－０９修回对烷氧基苯甲醛是合成液晶材料和有...     

A New and Efficient Synthetic Method and Antibacterial Activities of Oxazolidinone Analogues

A series of novel oxazolidinone analogues were prepared by a new and efficient synthetic method and their antibacterial activities were determined. These compounds wer echaracterized by LC-MS and ^1H NMR.     

An Efficient Synthetic Method to Nonnatural α- and β-Tryptophan Analogues via Friedel-Crafts Alkylation of Indoles with Nitroacrylates

The Friedel-Crafts alkylation of indoles with nitroacrylates could provide α- and β-tryptophan nitro-precursors, respectively, in moderate to good yields under Lewis acid catalysis. The diastereoselectivities of the reaction were enhanced by using 2-substituted indoles. The alkylation products could be easily transformed to nonnatural tryptophan derivatives.     

An Efficient Synthetic Method and Single Crystal Structure of a 2:3 Adduct of Cyclohexyl Isocyanide and Dimethyl Acetylenedicarboxylate

An efficient synthetic method and single crystal structure of a 2:3 adduct of cyclohexyl isocyanide and dimethyl acetylenedicarboxylate are described.     

Four New Eudesmane Sesquiterpenoid Lactones from Chloranthus serratus

Four new eudesmane sesquiterpenoids endowed with an α,β‐unsaturated γ‐lactone five‐membered ring, serralactones A–D ( 1 – 4 , resp.), along with seven known sesquiterpenoids, were isolated from the whole plant Chloranthus serratus. Their structures and relative configurations were established on the basis of extensive spectroscopic analyses.     

An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines

Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment. In addition, sulfonamides are also useful in herbicides and pesticides. Herein, we communicate an efficient strategy for the preparation of sulfonamides via NH₄I‐mediated amination of sodium sulfinates. This new method provides a general and environmentally friendly access to sulfonamide compounds and tolerates a wide range of functional groups.     

An Efficient Synthetic Strategy for Construction of Functionalized Pentacyclic Skeleton of ecteinascidin-saframycin Alkaloids

Ecteinascidin 743 (Et 743, 1) is an extremely potent antitumor alkaloid isolated from the marine tunicate Ecteinascidia turbinate. It is currently undergoing phase Ⅱ/Ⅲ clinical trials1. In view of its novel structure, the lack of availability and unique mechanism of action, Et 743 has attracted extensive synthetic studies during the past decade, culminating in the first stereoselective total synthesis by E. J. Corey and co-workers in 1996 and another total synthesis by Fukuyama and co-work…