共查询到20条相似文献,搜索用时 31 毫秒
1.
G. V. Pshenichnii Samekh Khamo V. A. Mashenkov L. S. Stanishevskii 《Chemistry of Heterocyclic Compounds》1991,27(1):104-107
The stereomeric 1-benzyl-3-hydroxy-3-methyl-6e-(2-bemyloxyphenyl)-4-piperidones on debenzylation and subsequent reaction with formaldehyde are converted into cis- and trans-1,3,4-10b-tetrahydro-3-hydroxy-3-methyl-2-oxopyrido-[1,2-c][1,3]benzoxazines.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 124–127, January, 1991. 相似文献
2.
Gordon W. Gribble Erin T. Pelkey Wendy M. Simon Hernando A. Trujillo 《Tetrahedron》2000,56(52):10133-10140
The unsymmetrical mesoionic münchnones 13 (3-benzyl-2-methyl-4-phenyl-1,3-oxazolium-5-olate) and 14 (3-benzyl-4-methyl-2-phenyl-1,3-oxazolium-5-olate) react with the N-protected 2- and 3-nitroindoles 1 (ethyl 2-nitroindole-1-carboxylate), 6 (3-nitro-1-(phenylsulfonyl)indole), and 17 (ethyl 3-nitroindole-1-carboxylate) in refluxing THF to afford in good to excellent yields the pyrrolo[3,4-b]indoles 15 (2-benzyl-1-methyl-3-phenyl-4-carboethoxy-2,4-dihydropyrrolo[3,4-b]indole), 16 (2-benzyl-3-methyl-1-phenyl-4-carboethoxy-2,4-dihydropyrrolo[3,4-b]indole), 18 (2-benzyl-1-methyl-3-phenyl-4-(phenylsulfonyl)-2,4-dihydropyrrolo[3,4-b]indole), and 19 (2-benzyl-3-methyl-1-phenyl-4-(phenylsulfonyl)-2,4-dihydropyrrolo[3,4-b]indole). In several cases the regiochemistry, which is opposite to that predicted by FMO theory, is very high and leads essentially to a single pyrrolo[3,4-b]indole; e.g., 6+13→19 in 74% yield. 相似文献
3.
G. G. Danagulyan L. G. Sahakyan G. A. Panosyan 《Chemistry of Heterocyclic Compounds》2000,36(2):185-189
The condensation of substituted 2-benzyl-4-hydrazinopyrimidines with phenylpyruvic acid gave the corresponding hydrazones, which cyclize upon the action of POCl, to give derivatives of pyrimido[6,1-c][1,2,4]-triazine. The substituted 2-benzylpyrimidinylhydrazides of some carboxylic acids react with POCl, to give 1,2,4-triazolo[4,3-c]pyrimidines. The reaction of 7-benzyl-5-methyl-l-phenyl-1,2,4-triazolo[2,3-c]pyrimidine with sodium ethylate leads to rearrangement and formation of 7-benzyl-5-methyl-2-phenyl-1,2,4-triazolo[2,3-c]pyrimidine.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 225–229, February, 2000. 相似文献
4.
G. G. Danagulyan L. G. Saakyan G. A. Panosyan G. A. Bulakhov P. B. Terent'ev M. G. Zalinyan 《Chemistry of Heterocyclic Compounds》1993,29(11):1332-1334
Refluxing 4-allyl-7-benzyl-5-methyl-1,2,4-triazolo[4,3-c]pyrimidine in an alcohol solution of sodium ethylate causes a Dimroth rearrangement together with a prototropic isomerization of the allyl fragment to give 7-benzyl-5-methyl-4-propenyl-1,2,4-triazolo[2,3-c]pyrimidine.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1545–1547, November, 1993 相似文献
5.
G. G. Danagulyan L. G. Saakyan M. G. Zalinyan 《Chemistry of Heterocyclic Compounds》1992,28(2):186-188
The Dimroth rearrangement of 7-benzyl-5-methyl-1,2,4-triazolo[4,3-c]pyrimidine to 7-benzyl-5-methyl-1,2,4-triazolo[2,3-c]pyrimidine was realized by the action of sodium ethoxide and other nucleophilic agents. The rearrangement was investigated by the dynamic PMR spectroscopic method.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 225–227, February, 1992. 相似文献
6.
Reactions of 6-Amino-5-Cyano-3-Methyl-1,4-Diphenyl-1H 4H-Pyrano[2,3-C]Pyrazole and its Methanimidate
Reaction of 6-amino-5-cyano-3-methyl-1,4-diphenyl- 1H,4H-pyrano[2,3-c]pyrazole 1 with triethyl orthoformate in acetic anhydride gave its methanimidate 2, which reacts with primary aliphatic and aromatic amines to give 4,6-dihydro-3-methyl-1,4-diphenyl-6- (alkyl)pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine-5(lH)- imine 3 and the starting compound 1 , respectively. Treatment of 1 with o-aminophenol gave 5-(2-benzoxalyl)- 1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazol- 6-amine 9. 相似文献
7.
Vasile-Nicolae Bercean Valentin Badea Călin Deleanu Alina Nicolescu 《Central European Journal of Chemistry》2012,10(2):373-379
1H-1-Alkyl-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles (2aa-ad) were obtained by regioselective alkylation of 1H-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles (2a). 1H-1-Alkyl-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles 2aa and 2ab were also prepared by coupling phenyldiazonium chloride with 1H-1-alkyl-6-methyl-3-phenyl-pyrazolo[5,1-c][1,2,4]triazoles 1aa and 1ab. The new compounds were characterized by IR, UV-VIS, 1H-NMR, 13C-NMR, and 15N-NMR spectroscopy and their structures and actual tautomeric forms were established unequivocally.
相似文献
8.
S. V. Volkov A. N. Levov A. T. Soldatenkov N. M. Kolyadina O. E. Volkova V. N. Khrustalev 《Chemistry of Heterocyclic Compounds》2007,43(9):1181-1188
The 4-nitro derivatives and an oxidation by-product, 9-hydroxy-2-methyl-3-oxo-9-phenyl-2,3-dihydro-9H-indeno[2,1-c]pyridine
were obtained by the nitration of N-alkyl-9-phenyl-2,3-dihydro-1H-indeno-[2,1-c]pyridines with sodium nitrite in acetic acid.
Their molecular structures were studied by X-ray structural analysis. The product of [2+3] cycloaddition, 5-methyl-3,7-diphenyl-3a,
4,5,6-tetrahydroindeno[2,1-c]isoxazolo[5,4-d]pyridine, was obtained by the interaction of 2-chloro-1-hydroxy-2-phenylazomethine
with 2-methyl-9-phenyl-2,3-dihydro-1H-indeno[2,1-c]pyridine.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1390–1399, September, 2007. 相似文献
9.
The selective reduction of α,β-unsaturated ketones and CC double bonds of pyrazolo[3,4-c][1]benzothiepins with sodium borohydride was studied. The reduction of 1-methyl-2-phenyl-1,2,3,10-tetrahydro-4H-pyrazolo[3,4-c][1]benzot (1) with sodium borohydride in refluxing methanol gave 1-methyl-2-phenyl-1,2,3,10-tetrahydro-4H-pyrazolo[3,4-c][1]benzothiepin-3-one (2). The mechanism of this unusual reaction in which the heterocyclic ketone was reduced to the corresponding methylene grouping with such a reagent was elucidated by the isolation of the following intermediates: 1-methyl-2-phenyl-1,2,3,3a, 10, 10a-hexahydro-4H-pyrazolo[3,4-c][1]benzothiepin-3,4-dione (6) and 1-methyl-2-phenyl-1,2,3,3a,10,10a-hexahydro-4H-pyrazolo[3,4-c][1]benzothiepin-3-one (4). 相似文献
10.
Huisgen reaction of nitrile oxides and nitrile imines leading to isoxazoline and pyrazole-4,6-diones
Huisgen reaction of nitrile oxides and nitrile imines generated in situ in the presence of N-benzylmaleimide afforded regiospecifically
the corresponding cis-3-aryl-5-benzyl-3a,4,6,6atetrahydro-4H, 6H-pyrrolo[3,4-d]isoxazoline-4,6-diones and cis-3-aryl-5-benzyl-1-(2′,4′-dibromophenyl)-3a,
4,6,6a-tetrahydro-1H,5H-pyrrolo[3,4-c]pyrazole-4,6-diones in good yield.
Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 935–939, June, 2006. 相似文献
11.
2-Amino or 2-hydrazino derivatives of pyridine or pyridinopyrazole were obtained by amination or hydrazination of 2-chloro-3-cyano-4-methoxy-6-methylpyridine. Acid hydrolysis of these derivatives leads to heterocyclization with formation of 4-amino-1H-furo[3,4-c]pyridines or pyrazolo[3,4-b]pyridine. The possibility to synthesize 4-arylamino-1H-furo[3,4-c]-pyridines from 4-chloro-6-methyl-1H-furo[3,4-c]-pyridine has been shown.V. S. Pustovoit All-Russian Oil-Bearing Crops Research Institute, Krasnodar 350038, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–66, January, 1999. 相似文献
12.
Stewart W. Schneller Jiann-Kuan Luo Ramachandra S. Hosmane Rainer H. DÚrrfeld 《Journal of heterocyclic chemistry》1984,21(4):1153-1155
The synthesis of 1-methyl- ( 1a ) and 1-benzyl-6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one ( 1b ) from the appropriate N-alkylaminoacetaldehyde is described. These provide examples of a synthetic procedure that can be used to prepare 1-substituted 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-ones wherein the N-1 substituent is regiospecifically placed. 相似文献
13.
Isaka K Nagatsu A Ondognii P Zevgeegiin O Gombosurengyin P Davgiin K Kojima K Ogihara Y 《Chemical & pharmaceutical bulletin》2001,49(9):1072-1076
Nine novel prenyl-dihydrofurocoumarin-type sesquiterpenoid derivatives, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-hydroxy-2R*,3R*-dimethyl-2-[4-methyl-5- (4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2R*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadienyl]-furo[3,2-c]coumarin, 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4,8-dimethyl-3(E),7-nonadien-6-onyl]-furo-[3,2-c]coumarin, and 2,3-dihydro-7-methoxy-2S*,3R*-dimethyl-2-[4-methyl-5-(4-methyl-2-furyl)-3(E)-pentenyl]-furo[3,2-c]coumarin, were isolated from the roots of Ferula ferulaeoides [corrected]. The structures were established by comprehensive spectral analysis. The biosynthetic pathway leading to these prenyl-furocoumarin-type sesquiterpenoids is proposed based on their structures. 相似文献
14.
The reaction of methyl 2-bromo-6-(trifluoromethyl)-3-pyridinecarboxylate ( 1 ) with methanesulfonamide gave methyl 2-[(methylsulfonyl)amino]-6-(trifluoromethyl)-3-pyridine-carboxylate ( 2 ). Alkylation of compound 2 with methyl iodide followed by cyclization of the resulting methyl 2-[methyl(methylsulfonyl)amino]-6-(trifluoromethyl)-3-pyridinecarboxylate ( 3 ) yielded 1-methyl-7-(trifluoromethyl)-1H-pyrido[2,3-c][1,2]thiazin-4(3H)-one 2,2-dioxide ( 4 ). The reaction of compound 4 with α,2,4-trichlorotoluene, methyl bromopropionate, methyl iodide, 3-trifluoromethylphenyl isocyanate, phenyl isocyanate and 2,4-dichloro-5-(2-propynyloxy)phenyl isothiocyanate gave, respectively, 4-[(2,4-dichlorophenyl)methoxy]-1-methyl-7-(trifluoromethyl)-1H-pyrido[2,3-c][1,2]thiazine 2,2-dioxide ( 5 ), methyl 2-[[1-methyl-2,2-dioxido-7-(trifluoromethyl)-1H-pyrido[2,3-c][1,2]thiazin-4-yl]oxy]propanoate ( 6 ), 1,3,3-trimethyl-7-(trifluoromethyl)-1H-pyrido[2,3-c][1,2]thiazin-4(3H)-one 2,2-dioxide ( 7 ), 4-hydroxy-1-methyl-7-(trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]-1H-pyrido[2,3-c][1,2]thiazine-3-carboxamide 2,2-dioxide ( 8 ), 4-hydroxy-1-methyl-7-(trifluoromethyl)-N-phenyl-1H-pyrido[2,3-c][1,2]thiazine-3-carboxamide 2,2-dioxide ( 9 ) and N-[2,4-dichloro-5-(2-propynyloxy)phenyl]-4-hydroxy-1-methyl-7-(trifluoromethyl)-1H-pyrido[2,3-c][1,2] thiazine-3-carboxamide 2,2-dioxide ( 10 ). 相似文献
15.
A. E. Kretov A. P. Momsenko A. S. Bespalyi Yu. A. Levin 《Chemistry of Heterocyclic Compounds》1973,9(5):592-594
1-Oxo-3-thioxo-5-hydroxy-2-acyl-2,3-dihydro-1H-1,3-thiazino[6,5-c]quinolines were obtained for the first time by condensation of 2-hydroxy-3-mercaptoquinoline-4-carboxylic acid with acyl isothiocyanates. Alkyl and acyl isothiocyanates react with 1-methyl-2-oxo-3-mercapto-1, 2-dihydroquinoline-4-carboxylic acid to give 1,5-dioxo-3-thioxo-2-alkyl (acyl)6-methyl-2, 3,5,6-tetrahydro-1H-1,3-thiazino [6,5-c] quinolines.See [1] for communication I.Deceased.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 641–643, May, 1973. 相似文献
16.
P. S. Silaichev V. O. Filimonov P. A. Slepukhin A. N. Maslivets 《Russian Journal of Organic Chemistry》2012,48(10):1329-1332
Methyl 1-aryl-3-cinnamoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 4-benzylamino- and 4-arylaminopent-3-en-2-ones to give 1-aryl-7-benzyl- and 1,7-diaryl-9-acetyl-4-cinnamoyl-3-hydroxy-8-methyl-1,7-diazaspiro[4.4]nona-3,8-diene-2,6-diones. The crystalline and molecular structures of 9-acetyl-4-cinnamoyl-3-hydroxy-1-(4-methoxyphenyl)-8-methyl-7-phenyl-1,7-diazaspiro[4.4]nona-3,8-diene-2,6-dione were studied by X-ray analysis. 相似文献
17.
18.
(±)-1-Benzyl-3α-hydroxy-4β-methylamino-2-oxopyrrolidine (15) and its cis-isomer (16) were synthesised from 1-benzyl-4-ethoxycarbonyl-2,3-dioxopyrrolidine (2) in several steps. The former (15) was converted to 3-benzyl-6-methyl-2-oxo-3,6-diazabicyclo[3.1.0]hexane (17) with a mixture of triphenylphosphine, carbon tetrachloride and triethylamine. 相似文献
19.
Bulygina L. A. Khrushcheva N. S. Peregudov A. S. Sokolov V. I. 《Russian Chemical Bulletin》2016,65(10):2479-2484
Russian Chemical Bulletin - A new (C,N,N)-pincer cyclopalladate unsymmetrical complex of 3-benzyl-7-methyl-3,7-diazabicyclo[3.3.1]nonane (3-benzyl-7-methylbispidine) was synthesized and... 相似文献
20.
L. N. Zhukauskaite A. P. Stankevichyus A. N. Kost 《Chemistry of Heterocyclic Compounds》1978,14(1):49-54
Ammonolysis of the methyl esters of trans--(3-cyano-2-pyridyl)acrylic (I) and trans--(6-methyl-3-cyano-2-pyridyl)acrylic (II) acids gave the amides of these acids. The addition of bromine, diazomethane, and hydrogen to the double bond of cis- and trans-acids I and II is described. Hydrogenation of the methyl esters of trans-acids I and II over Raneynickel at room temperature and atmospheric pressure occurs with intramolecular cyclization to two-ring lactams — 7-oxo-5, 6,8,9-tetrahydropyrid[3,2-c]azepine and 2-methyl-7-oxo-5,6,8,9-tetrahydropyrid[3,2-c]azepine. Under the conditons of acid hydrolysis of acids I and II the elements of water add to the nitrile group with intramolecular cyclization to give, respectively, 3-carboxymethyl-1-oxo-2,3-dihydrofuro [4,3-b]pyridine and 5-methyl-3-carboxymethyl-1-oxo-2,3-dihydrofuro[4,3-b]pyridine, whereas refluxing these acids with aqueous sodium hydroxide gives two-ring lactams — 3-carboxymethyl-1-oxo-2, 3-dihydropyrrolo[4,3-b]pyridine and its 5-methyl homolog. The structures of the compounds were confirmed by the UV, IR, PMR, and mass spectra.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 63–69, January, 1978. 相似文献