Paeoniflorigenone,a new monoterpene from paeony roots

Paeoniflorigenone (1), a new monoterpene which produces a neuromuscular-blocking effect in mice, was isolated from paeony roots and its structure was elucidated.     

Three new monoterpenoids from the fruit of Genipa americana

Three new monoterpenoids, called genipacetal, genipamide, and genipaol, were isolated from the fruit of Genipa americana L. (Rubiaceae), along with the four known iridoids genipin, gardendiol, deacetyl asperulosidic acid methyl ester, and shanzhiside. Their chemical structures were determined on the basis of spectroscopic data.     

Constituents of the roots of Cynanchum bungei Decne. Isolation and structures of four new glucosides, bungeiside-A, -B, -C, and -D.

Four new glucosides, bungeiside-A, -B, -C, and -D, were isolated from the roots of Cynanchum bungei Decne. The structures of the new compounds were determined by chemical and spectroscopic methods, including two-dimensional nuclear magnetic resonance (2D NMR) techniques, especially 1H-detected heteronuclear multiple-bond multiple-quantum coherence.     

Four new prostanoids: Claviridenone-A, -B, -C,and -D from the okinawan soft coral Clavularia viridis

The structures of four new prostanoids named claviridenone-a, -b, -c, and -d, which were isolated from the Okinawan soft coral Clavularia viridis, were elucidated as $\text{1}$, $\text{2}$, $\text{3}$, and $\text{4}$, respectively.     

Glaucolide-A and -B,new germacranolide-type sesquiterpene lactones from Vernonia (compositae)

The structures of two new germacranolides, glaucolide-A (1a) and -B (1b), isolated from more than 25 species of Vernonia from the Western Hemisphere, have been established by a series of chemical transformations, and spectral and X-ray crystallographic studies.     

Isolation and total syntheses of two new alkaloids, dubiusamines-A, and -B, from Pandanus dubius

Chemical investigation of the crude base of Pandanus dubius led to the isolation of two new alkaloids, dubiusamine-A (1) and dubiusamine-B (2). The structures of the two alkaloids including their absolute configuration were unambiguously confirmed by 1D and 2D NMR analysis and asymmetric total synthesis.     

Longifoside-A and -B: two new cerebrosides from Mentha longifolia (Lamiaceae)

Two new N-acyl-glycosphingosines (cerebrosides) named longifoside-A {6'-tetracosenamide, N-[3,4-dihydroxy-1-(hydroxymethyl)-2-(beta-D-glucopyranosyl) heptadecyl]-(6'E)} and B {6'-tetracosenamide, N-[3-hydroxy-1-(hydroxymethyl)-2-(beta-D-glucopyranosyl)-4Z-heptadecenyl]-(6'E)} have been obtained from the methanolic extract of Mentha longifolia belonging to the family Lamiaceae. Both the cerebrosides were purified as their acetate-derivatives: 6'-tetracosenamide, N-[3,4-diacetoxy-1-(acetoxymethyl)-2-(tetraacetoxy-beta-D-glucopyranosyl) heptadecyl]-(6'E) and 6'-tetracosenamide, N-[3-acetoxy-1-(acetoxymethyl)-2-(tetraacetoxy-beta-D-glucopyranosyl)-4Z-heptadecenyl]-(6'E). They were characterized with the aid of 1D and sophisticated 2D-NMR spectroscopic techniques.     

Two novel aromatic glycosides,pueroside-A and -B,from puerariae radix

Two novel aromatic glycosides were obtained from Puerariae Radix and their chemical structures were characterized.     

Peagol and peagoldione, two new strigolactone-like metabolites isolated from pea root exudates

Two new strigolactone-like metabolites, named peagol and peagoldione, with germinative activity for root parasitic plants, were isolated from pea root exudates and were characterized by spectroscopic methods. Peagol was more active on Orobanche foetida and Phelipanche aegyptiaca seeds, while peagoldione was active on P. aegyptiaca only. Low activity was found on Orobanche crenata and Orobanche minor. Stimulatory activity of peagol on O. foetida seeds is most relevant as this species does not respond to the synthetic strigolactone analogue GR24, usually used as Orobanche germination standard.     

Sinodielides E-H,four new guaianolides,from the root of Sinodielsia yunnanensis

Four new guaianolides, sinodielides E-H (1-4), were isolated from the root of Sinodielsia yunnanensis WOLFF. Their structures were established by spectral evidence.     

Five new steroidal glycosides,pregnedioside-A, -B,and their three monoacetates,from an Okinawan soft coral of Alcyonium sp.

Five new pregnene-type steroidal glycosides, named pregnedioside -a ($\text{1}$), 4′-O-acetyl-pregnedioside-a ($\text{2}$), 3′-O-acetyl-pregnedioside-a ($\text{3}$), pregnedioside-b ($\text{5}$), and 4′-O-acetyl-pregnedioside-b ($\text{6}$), were isolated from an Okinawan soft coral of Alcyonium sp. and their structures were elucidated. These are rare examples of steroidal gylcosides from soft coral.     

Two novel sesquiterpene lactones,cytotoxic vernolide-A and -B,from Vernonia cinerea

Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED(50)=0.02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively).     

A new sesquiterpene and other constituents from Saussurea lappa root

Five sesquiterpenes, dehydrocostus lactone (1), santamarine (5), beta-cyclocostunolide (6), 4alpha-hydroxy-4beta-methyldihydrocostol (7) and 10alpha-hydroxyl-artemisinic acid (9), along with four other compounds, beta-sitosterol (2), daucosterol (3), 5-hydroxymethyl-furaldehyde (4), and trans-syingin (8), were isolated and identified from the roots of Saussurea lappa (Compositae). Based on previous reports and our study, sesquiterpene derivatives are common and characteristic constituents of the genus Saussurea. Among the nine compounds obtained, 9 is a new sesquiterpene. It is an artemisinic acid derivative, whose structural skeleton has not been reported for Saussurea species before, but artemisinic acid is a common compound in another Compositae species, Artemisia annua. Dehydrocostus lactone (1) is present in high-content and is a possible bioprecursor of 10alpha-hydroxyartemisinic acid (9).     

利用甘油醛进行白三烯B4中1-C～6-C及11-C～20-C片断的手性合成

本文报道由D-甘露醇和L-抗坏血酸为手性源, 通过D(+)-和L(-)-甘油醛分别合成白三烯B4中1-C～6-C片断5-(S)-苯甲酰氧基-6-氧代-己酸乙酯及11-C～20-C片断-2-(R)-叔丁基-二苯基硅氧基-癸-4-(z)-烯醛的新合成方法。     

Antifungal activity of bicyclic monoterpenoids and terpenesulfides

A total of 33 compounds including bicyclic monoterpenes, oxides, allyl alcohols, and S-containing pinane and carane derivatives were screened for antifungal activity against mycelial and yeast-like fungi. The structure–activity relationship was studied. The most active antimycotics were found.