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龙舌兰属植物中甾族皂甙元的研究——Ⅱ.剑麻中甾族皂甙元的分离和鉴定 总被引:1,自引:0,他引:1
从海南岛栽培的剑麻叶中分离出10个已知的甾族化合物,即新替告皂甙元酮(II,Neo-tigogenone)、β-谷甾醇(V,β-Sitosterol)、新替告皂甙元(VI_a,Neotigogenin)、替告皂甙元(VI_b,Tigogenin)、剑麻皂甙元(VII_a,Sisalagenin)、海柯皂甙元(VII_b,Hecogenin)、5α-娠烷-3β、20β-二醇(IX,5a-Pregnan-3β,20β-diol)、洛柯皂甙元(X,Rockogenin)、12-表洛柯皂甙元(XI,12-Epirockogenin)和绿莲皂甙元(XVI,Chlorogenin)以及两个新的三羟基甾族皂甙元,即海南皂甙元(Hainangenin)和红光皂甙元(Hongguanggenin),根据质谱和核磁共振谱,这两个新皂甙元的结构初步分别定为3β,6α,23β-三羟基-5α,25R-螺甾烷(XVIII_a)和3β,6α,23α-三羟基-5α,25R-螺甾烷(XVIII_b),两者为C_(23)位的差向异构体。 相似文献
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本文报导以胆甾醇为原料经五步反应合成了4α—甲基—5α—胆甾烷与4β—甲基—5α—胆甾烷的混合物。其关键反应是利用胆甾—4—烯—3,6—二酮和重氮甲烷反应而引入4—甲基。 相似文献
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报导了17α-羟基-16β-甲基-4,9(11)孕甾二烯-3,20-二缩酮(1)用70%醋酸进行的水解反应. 结果得相应的3,20-二酮化合物(2). 当用98%醋酸处理(1)不能获得(2). 而是重排成17α-羟基-16β, 17β-二甲基-D-高孕甾二烯二酮(3). 当化合物(1)和(2)与含有CaCl2的70%醋酸反应获得16β, 17β-二甲-D-高-4,9(11), 15-孕甾三烯-3,17-二酮, 其得率取决于CaCl2的浓度和反应时间. 相似文献
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小花金挖耳地上部分萜类成分研究 总被引:3,自引:0,他引:3
本文首次报道对小花金挖耳地上部分化学成分的研究工作,采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、中压柱色谱和薄层制备色谱方法进行分离纯化,从中分离得到8个化合物:(1R,2S,4S,5R)-2,5-二羟基-p-薄荷烷(1),(1S,2S,4R,5S)-2,5-二羟基-p-薄荷烷(2),(3R,4R,6S)-3,6-二羟基-p-1-薄荷烯(3),5αH-桉烷-4(15),11(13)-二烯-12,8β-内酯(4),5α-羟基-桉烷-4(15),11(13)-二烯-12,8β-内酯(5),2α-羟基-5αH-桉烷-4(15),11(13)-二烯-12,8β-内酯(6),4β-羟基-1α,10βH-伪愈创木烷-11(13)-烯-12,8α-内酯(7),4-羰基-1α,10βH-伪愈创木烷-11(13)-烯-12,8α-内酯(8),利用波谱数据和理化性质鉴定了它们的结构.化合物1-3首次从天名精属植物中分离得到. 相似文献
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Madureira AM Ascenso JR Valdeira L Duarte A Frade JP Freitas G Ferreira MJ 《Natural product research》2003,17(5):375-380
A phytochemical reinvestigation of the whole plant of Euphorbia segetalis yielded five tetracyclic triterpenes: 3beta-hydroxy-cycloart-25-en-24-one (1), cycloart-25-ene-3beta,24-diol (2), cycloart-23-ene-3beta,25-diol (3), lanosta-7,9(11),24-trien-3beta-ol (4) and lanosta-7,9(11),24(31)-trien-3beta-ol (5). beta-acetoxy-cycloart-25-en-24-one (1a) and glutinol (6), lupenone (7), dammaranodienol (9), cycloartenol acetate (10), 24-methylenecycloartanol acetate (11) and beta-sitosterol (12), isolated previously, were evaluated for their antiviral activities against Herpes simplex virus (HSV) and African swine fever virus (ASFV). Lupenone exhibited strong viral plaque inhibitory effect against HSV-1 and HSV-2. The in vitro antifungal and antibacterial activities of la, cycloart-23-ene-3beta,25-diol, 3-acetate (3a) and 6-12 were also investigated. 相似文献
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N. F. Samoshina L. N. Atopkina V. L. Novikov V. A. Denisenko N. I. Uvarova 《Chemistry of Natural Compounds》1982,18(5):564-571
The catalytic rearrangement of 20(S),24(R)-epoxydammarane-3,12β,25-triol 3-mono and 3,12-di(α-D-glucose 1,2-orthoacetate)s leads to the formation of the corresponding 12-mono- and 12,25-diglucosides. The anomalous regioselectivity of the catalytic rearrangements of orthoesters of 20(S),24(R)-epoxydammarane-3,12β,25-triols is evidently due to the influence of strong intramolecular hydrogen bonds. Details of the IR, PMR, and13C NMR spectra, and also the physicochemical constants, of the newly obtained compounds are given. 相似文献
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A new oxylipin, (8E,12Z)-10,11-dihydroxyoctadeca-8,12-dienoic acid (1), a new steroid, 3β,4α-dihydroxy-26-methoxyergosta-7,24(28)-dien-6-one (2), and four known steroids, episterol (3), (22E,24R)-ergosta-7,22-dien-3β,5α,6α-triol (4), (22E,24R)-ergosta-5,22-dien-3β-ol (5), and (22E,24R)-ergosta-4,6,8(14),22-tetraen-3-one (6), were isolated from the cultures of Aspergillus flavus, an endophytic fungus isolated from the marine red alga Corallina officinalis. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. 1 and 2 exhibited low activity to inhibit acetylcholinesterase and no activity against plant pathogenic fungi Colletotrichum lagenarium and Fusarium oxysporum. 相似文献
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Wang XL Hay AE Matheeussen A Gupta MP Hostettmann K 《Magnetic resonance in chemistry : MRC》2011,49(4):184-189
Phytochemical investigation of dichloromethane (DCM) extract from the stems of Paragonia pyramidata var. pyramidata L. Rich. (Bur.) resulted in the isolation and characterization of two new triterpenoids 3β,19β-dihydroxylup-12, 20(29)-diene-28-oic acid (1) and 3β,19β-dihydroxylup-12-en-28-oic acid (2), three known triterpenoids lupeol (3), spinosic acid A (4) and oleanolic acid (5), together with four known steroids (20R)-22E-24-ethylcholesta-4,22-dien-3-one (6), (20R)-24-ethylcholest-4-en-3-one (7), stigmasterol (8) and β-sitosterol (9). HREIMS, GC-MS and NMR experiments including HSQC, HMBC, COSY and NOESY were used for the determination of the structures and NMR spectral assignments. This is the first report about the chemical constituents for this plant. 相似文献
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Raymond Zelnik Ema Rabenhorst Akhtar Haider Jürgen Lauterwein Hugo Wyler 《Helvetica chimica acta》1983,66(3):780-788
Dehydration of abiet-8-ene-7β, 13β-diol (ibozol, 1 ) leads to abieta-7,9(11)-dien-13β-ol ( 2 ) which aromatizes slowly to the known abieta-8,11,13-triene ( 3 ). Photosensitized oxygenation of the heteroannular diene 2 yields a mixture from which three compounds were identified; abiet-7-ene-9α, 11α, 13β-triol ( 4 ), abieta-8,11,13-trien-7-one ( 5 ), and abieta-8,11,13-trien-7α-ol ( 6 ). 相似文献
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The condensation of 20(S),24(R)-epoxydammarane-3β,12β,25-triol with α-acetobromoglucose in the presence of silver oxide, silver zeolite, and silver oxide with 4 Å molecular sieves has been studied. It has been established that the reaction takes place nonregioselectively and leads to a mixture of acetylated mono-, di-, and triglucosides with a predominance of the 3-O-mono- and 3,12-di-O-glucosides. The structures of the newly obtained 3-O-mono- and 3,12-di-O-glucosides have been established on the basis of the results of IR and1H and13C NMR spectroscopy. 相似文献
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Theodor W. Güntert Horst H. A. Linde Mohamed S. Ragab Sigrid Spengel 《Helvetica chimica acta》1977,60(2):334-339
Synthesis of a steroidal 17 β-pyrrolinone We describe the synthesis of 4′-(3 β-hydroxy-androst-5-ene-17 β-yl)-3′-pyrrolin-2′-one (6) starting from 3β-acetoxy-21-hydroxy-pregn-5-ene-20-one (1). 相似文献
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López-Pérez JL Erazo S Delporte C Negrete R Muñoz O García R Backhouse N San Feliciano A 《Magnetic resonance in chemistry : MRC》2005,43(11):943-947
Two new dammarane triterpenoids, 20R,21-epoxydammar-24-ene-3,23-dione and 20R,21-epoxy-3beta-hydroxydammar-24-ene-23-one have been isolated from the aerial parts of Kageneckia angustifolia D. Don, Rosaceae, along with the previously reported triterpenoids oleanolic acid and 3beta-(beta-D-glucosyloxy)-16alpha,23alpha-epoxycucurbita-5,24-dien-11-one and the phenolic prunasin. The structures of these compounds were established by MS, 1D- and 2D-NMR experiments, and the structure of the new compounds were confirmed by X-ray diffraction analysis. 相似文献
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Microbial metabolism of the diterpene sclareol ( 1 ) was studied. Screening studies have shown a number of microorganisms capable of metabolizing 1 . Preparative-scale fermentation with Septomyxa affinis ATCC 6737 has resulted in the production of three fungal metabolites that have been characterized by 2D-NMR techniques and chemical reactions. These metabolites have been identified as 8α,13β-dihydroxylabd-14-en-3-one ( 2 ), labd-14-ene-3β.8α,13β-triol ( 4 ), and labd-14-ene-2α,8α,13β-triol ( 6 ). 相似文献
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Dou DQ Chen YJ Liang LH Pang FG Shimizu N Takeda T 《Chemical & pharmaceutical bulletin》2001,49(4):442-446
Six new minor saponins, together with known ginsenosides, were isolated from the leaves of Panax ginseng. The new saponins were named as ginsenoside-Rh5, -Rh6, -Rh7 -Rh8, -Rh9 and -Rg7, and their structures were elucidated on the basis of chemical and physicochemical evidence to be as follows: ginsenoside-Rh5: 3beta,6alpha,12beta,24zeta-tetrahydroxy-dammar-20(22),25-diene 6-O-beta-D-glucopyranoside (1), -Rh6: 3beta,6alpha12beta,20(S)-tetrahydroxy-25-hydroperoxy-dammar-23-ene 20-O-beta-D-glucopyranoside (2), -Rh7: 3beta,7beta,12beta,20(S)-tetrahydroxy-dammar-5,24-diene 20-O-beta-D-glucopyranoside (3), -Rh8: 3beta,6alpha,20(S)-trihydroxy-dammar-24-ene-12-one 20-O-beta-D-glucopyranoside (4), -Rh9: 3beta,6alpha,20(S)-trihydroxy-12beta,23-epoxy-dammar-24-ene 20-O-beta-D-glucopyranoside (5) and -Rg7: 3-O-beta-D-glucopyranosyl 3beta,12beta,20(S),24(R)-tetrahydroxy-dammar-25-ene 20-O-beta-D-glucopyranoside (6). 相似文献