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将ε-聚赖氨酸(EPL)抗菌肽接枝到明胶上,合成ε-聚赖氨酸改性明胶(GEL-E)后,以GEL-E、羧甲基壳聚糖(CMC)和氧化硫酸软骨素(OCS)为原料,制备了一种具有可注射性、自愈合性及抗菌性的多功能快速凝胶化水凝胶——GEL-E/CMC/OCS水凝胶.该水凝胶具有较高的储能模量、弹性形变性能、自愈合性能、可注射性能以及抗菌性能.将甘草酸二钾(DG)载入水凝胶,赋予水凝胶抗炎特性以及促伤口愈合能力.初步评价了水凝胶的释药行为.结果表明,药物释放可达100%.同时,评价了载药后水凝胶的细胞相容性以及促细胞迁移能力,发现水凝胶对细胞的毒性很低,且可以促进细胞迁移.研究结果表明,该水凝胶具有良好的力学性能、生物相容性以及促细胞迁移能力,在促进伤口愈合领域具有广阔的应用前景. 相似文献
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胶原蛋白基水凝胶是较为理想的创面修复敷料材料之一,但其对伤口的炎症调节作用仍需要强化。本研究以胶原蛋白为基质材料,复配硫酸软骨素A (CSA)和硫酸软骨素C (CSC)后,通过与醛基化聚乙二醇交联制备水凝胶。通过扫描电镜观察到该水凝胶孔隙致密均一,综合溶胀实验结果显示出良好的吸水率,利于后期应用于伤口时吸收组织渗液。细胞毒性实验及使用激光共聚焦荧光显微镜观察细胞在水凝胶上的生长情况,实验表明水凝胶有利于巨噬细胞和成纤维细胞的增殖。水凝胶的溶血率低于1.5%,同时凝血指数(BCI)明显降低、扫描电镜观察血细胞凝集效果良好。这些结果都表明胶原蛋白基硫酸软骨素复合水凝胶具备作为止血抗炎敷料的潜力。 相似文献
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两性离子水凝胶是一类含有两性离子聚合物的凝胶材料,其分子结构中的阴阳离子基团能与水分子紧密结合,形成致密的水合层。这种静电诱导水合作用使得两性离子水凝胶具有极低的生物黏附性,能有效抵抗非特异性蛋白、细胞、细菌等的黏附,具有极低的免疫原性。这些特性使得两性离子水凝胶在生物医用领域有广阔的应用前景。本综述首先介绍了两性离子水凝胶的结构及性质,然后概述了其分类和制备方法,并进一步总结了其在组织工程、药物载体、创伤敷料、生物传感器、医疗器械水凝胶涂层等生物医学领域中的应用。最后展望了两性离子水凝胶未来的发展方向。 相似文献
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抗菌生物材料因其能够有效抑制细菌感染而被公认为是重要的抗生素替代品。其中抗菌水凝胶因制备工艺简单,结构多样,具有易负载和可控药物释放性、良好的生物相容性和抗菌性等多种特殊功能而受到越来越多的关注。壳聚糖及其衍生物具有高抗菌性、低毒性、生物相容性和降解性等优点被广泛用作抗菌水凝胶材料。本文根据壳聚糖基抗菌水凝胶的性能和抗菌机理,综述了近年来在固有抗菌水凝胶、光响应性抗菌水凝胶、荧光抗菌水凝胶、负载抗菌药物水凝胶和协同抗菌水凝胶等方面的研究进展,探讨了壳聚糖基抗菌水凝胶目前所面临的挑战,并对其未来发展作了展望。 相似文献
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Ferrocene(Fc)-containing imidazolium type ionic liquids(ILs) and corresponding poly(ionic liquid)(PIL) membranes with tunable antibacterial activity based on electrochemical redox reaction and host-guest chemistry were developed. The effect of Fc moiety on the antimicrobial activities against both Staphylococcus aureus(S. aureus) and Escherichia coli(E. coli) was studied by minimum inhibitory concentration(MIC). The presence of Fc groups highly enhanced the antibacterial efficiency of Fccontaining ILs because of the generation of reactive oxygen species(ROS). The electrochemical oxidation of Fc to Fc+and the formation of inclusion complexes between Fc and β-CD via host-guest interactions decreased the antibacterial activities of ILs and PIL membranes. The antibacterial activities may be recovered in some extent upon the electrochemical reduction of Fc+to Fc or the exclusion of the Fc out of the cavity of β-CD. Furthermore, all the Fc-containing PIL membranes showed relatively low hemolysis activities and none cytotoxicity toward human cells, indicating clinical feasibility in topical applications. 相似文献
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Sakey Ravindra Kokkarachedu Varaprasad V. Rajinikanth Antoine F. Mulaba-Bafubiandi Koduri Venkata Surya Ramam 《高分子科学杂志,A辑:纯化学与应用化学》2013,50(12):1230-1240
Design of silver nanoparticles containing poly(N-isopropylarclamide) (PNIPAAm) hydrogels were prepared by free-radical polymerization of N-isopropylarclamide as an environmentally sensitive monomer and MBA as a crosslinker in an aqueous medium. The embedded silver nanocomposite hydrogels (AgNCH) structure were characterized by, UV-Vis, FTIR, DLS, TEM and X-ray analysis. Curcumin loading and release characteristics were performed for PNIPAAm hydrogel, silver ions loaded hydrogels as well as silver nanocomposite hydrogels. These curcumin loaded silver nanocomposite hydrogels exhibit excellent antibacterial action on Escherichia coli (E. coli). Therefore, the present study clearly provides novel antimicrobial hydrogels which are potentially useful in biomedical applications. 相似文献
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以H2O2为氧化剂,研究了离子液体为催化剂和溶剂,环己烯氧化生成反-1,2-环己二醇的反应。 考察了不同咪唑型离子液体、反应时间、反应温度和H2O2用量等对产率和选择性的影响, 实验结果表明,在7种咪唑型离子液体催化体系中,阳离子为咪唑环上含有1或2个羧基,阴离子为[PF6]的离子液体催化效果较好。 反应温度为100 ℃,n(H2O2)∶n(Cyclohexene)=1.1∶1,反应5 h时,离子液体c(0.60 g,2.1 mmol)催化生成的反-1,2-环己二醇的产率和选择性分别为95%和97%,而离子液体f(0.20 g,0.6 mmol)催化生成的反-1,2-环己二醇的产率和选择性分别为84%和90%,从离子液体的用量来看,含2个羧基的离子液体f的催化效率更高。 相似文献
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Deepak Chand Dr. Jiaheng Zhang Prof. Dr. Jean'ne M Shreeve 《Chemistry (Weinheim an der Bergstrasse, Germany)》2015,21(38):13297-13301
Hydrazine and its derivatives are used as fuels in rocket propellant systems; however, due to high vapor pressure, toxicity, and carcinogenicity, handling of such compounds is extremely hazardous. Hypergolic ionic liquids have shown great promise to become viable replacements for hydrazines as fuels. Borohydride‐containing ionic liquids have now been synthesized using a more efficient synthetic pathway that does not require liquid ammonia and halide precursors. Among the eight new compounds, 1‐allyl‐3‐n‐butyl‐imidazolium borohydride ( 1 ) and 1, 3‐diallylimidazolium borohydride ( 5 ) exhibit very short ignition‐delay times (ID) of 8 and 3 ms, respectively. The hydrolytic stability of borohydride compounds has been greatly improved by attaching long‐chain alkyl substituents to the imidazole ring. 1,3‐Di‐(n‐octyl)‐imidazolium borohydride ( 3 ) is a water stable borohydride‐containing ionic liquid. 1,3‐Di‐(n‐butyl)‐imidazolium borohydride ( 2 ) is a unique example of a borohydride liquid crystal. These ionic liquids have some unusual advantages, including negligible vapor pressures, good ignition delay (ID) times, and reduced synthetic and storage costs, thereby showing good application potential as environmentally friendly fuels in bipropellant formulations. In addition, they also have potential applications in the form of reducing agents and hydrogen storage materials. 相似文献
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Huadong Tang Jianbin Tang Shijie Ding Maciej Radosz Youqing Shen 《Journal of polymer science. Part A, Polymer chemistry》2005,43(7):1432-1443
Polymeric forms of ionic liquids have many potential applications because of their high thermal stability and ionic nature. Two ionic liquid monomers, 1‐(4‐vinylbenzyl)‐3‐butyl imidazolium tetrafluoroborate (VBIT) and 1‐(4‐vinylbenzyl)‐3‐ butyl imidazolium hexafluorophosphate (VBIH), were synthesized through the quaternization of N‐butylimidazole with 4‐vinylbenzylchloride and a subsequent anion‐ exchange reaction with sodium tetrafluoroborate or potassium hexafluorophosphate. Copper‐mediated atom transfer radical polymerization was used to polymerize VBIT and VBIH. The effects of various initiator/catalyst systems, monomer concentrations, solvent polarities, and reaction temperatures on the polymerization were examined. The polymerization was well controlled and exhibited living characteristics when CuBr/1,1,4,7,10,10‐hexamethyltriethylenetetramine or CuBr/2,2′‐bipyridine was used as the catalyst and ethyl 2‐bromoisobutyrate was used as the initiator. Characterizations by thermogravimetric analysis, differential scanning calorimetry, and X‐ray diffraction showed that the resulting VBIT polymer, poly[1‐(4‐vinylbenzyl)‐3‐butyl imidazolium tetrafluoroborate] (PVBIT), was amorphous and had excellent thermal stability, with a glass‐transition temperature of 84 °C. The polymerized ionic liquids could absorb CO2 as ionic liquids: PVBIT absorbed 0.30% (w/w) CO2 at room temperature and 0.78 atm. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 1432–1443, 2005 相似文献
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Rabia Hassan Farzana Nazir Mah Roosh Arshemah Qaisar Uzma Habib Abdulrahim A. Sajini Mudassir Iqbal 《Molecules (Basel, Switzerland)》2022,27(19)
Ionic liquids (ILs) have emerged as active pharmaceutical ingredients because of their excellent antibacterial and biological activities. Herein, we used the green-chemistry-synthesis procedure, also known as the metathesis method, to develop three series of ionic liquids using 1-methyl-3-butyl imidazolium, butyl pyridinium, and diethyldibutylammonium as cations, and bromide (Br−), methanesulfonate (CH3SO3−), bis(trifluoromethanesulfonyl)imide (NTf2−), dichloroacetate (CHCl2CO2−), tetrafluoroborate (BF4−), and hydrogen sulfate (HSO4−) as anions. Spectroscopic methods were used to validate the structures of the lab-synthesized ILs. We performed an agar well diffusion assay by using pathogenic bacteria that cause various infections (Escherichia coli; Enterobacter aerogenes; Klebsiella pneumoniae; Proteus vulgaris; Pseudomonas aeruginosa; Streptococcus pneumoniae; Streptococcus pyogenes) to scrutinize the in vitro antibacterial activity of the ILs. It was established that the nature and unique combination of the cations and anions were responsible for the antibacterial activity of the ILs. Among the tested ionic liquids, the imidazolium cation and NTf2− and HSO4− anions exhibited the highest antibacterial activity. The antibacterial potential was further investigated by in silico studies, and it was observed that bis(trifluoromethanesulfonyl)imide (NTf2−) containing imidazolium and pyridinium ionic liquids showed the maximum inhibition against the targeted bacterial strains and could be utilized in antibiotics. These antibacterial activities float the ILs as a promising alternative to the existing antibiotics and antiseptics. 相似文献
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Cedric Maton Nils De Vos Bart I. Roman Evert Vanecht Dr. Neil R. Brooks Prof. Dr. Koen Binnemans Stijn Schaltin Prof. Dr. Jan Fransaer Prof. Dr. Christian V. Stevens 《Chemphyschem》2012,13(13):3146-3157
A versatile and efficient method to synthesize tetrasubstituted imidazoles via a one‐pot modified Debus–Radziszewski reaction and their subsequent transformation into the corresponding imidazolium ionic liquids is reported. The tetrasubstituted imidazoles were also synthesized by means of a continuous flow process. This straightforward synthetic procedure allows for a fast and selective synthesis of tetrasubstituted imidazoles on a large scale. The completely substituted imidazolium dicyanamide and bis(trifluoromethylsulfonyl)imide salts were obtained via a metathesis reaction of the imidazolium iodide salts. The melting points and viscosities are of the same order of magnitude as for their non‐substituted analogues. In addition to the superior chemical stability of these novel ionic liquids, which allows them to be applied in strong alkaline media, the improved thermal and electrochemical stabilities of these compounds compared with conventional imidazolium ionic liquids is also demonstrated by thermogravimetrical analysis (TGA) and cyclic voltammetry (CV). Although increased substitution of the ionic liquids does not further increase thermal stability, a definite increase in cathodic stability is observable. 相似文献
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通过氧化偶联聚合方法成功地制备出一种基于烷氧磺酸盐功能化的聚乙撑二氧噻吩水凝胶, 揭示了零维单体胶束向二维纳米片层及三维水凝胶的转变过程, 发现通过改变反应温度或初始单体浓度, 可以诱导水凝胶网络结构单元的维度变化, 即由零维纳米粒子向二维纳米片层进行转化. 提出了一种导电高分子水凝胶的合成方法, 即采用一种氧化剂与一种多价金属盐的混合物作为引发剂, 其中前者用于诱导单体聚合, 后者则充当离子交联试剂, 并发现可以通过引入不同金属离子来改变凝胶的形貌. 此外, 导电高分子水凝胶具有良好的电化学电容, 并具有选择性吸附与可控脱附某些染料分子的特性. 相似文献
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Molecular dynamics (MD) simulations have been performed for prototype models of polymer electrolytes in which the salt is an ionic liquid based on 1-alkyl-3-methylimidazolium cations and the polymer is poly(ethylene oxide), PEO. The MD simulations were performed by combining the previously proposed models for pure ionic liquids and polymer electrolytes containing simple inorganic ions. A systematic investigation of ionic liquid concentration, temperature, and the 1-alkyl- chain length, [1,3-dimethylimidazolium]PF6, and [1-butyl-3-methylimidazolium]PF6, effects on resulting equilibrium structure is provided. It is shown that the ionic liquid is dispersed in the polymeric matrix, but ionic pairs remain in the polymer electrolyte. Imidazolium cations are coordinated by both the anions and the oxygen atoms of PEO chains. Probability density maps of occurrences of nearest neighbors around imidazolium cations give a detailed physical picture of the environment experienced by cations. Conformational changes on PEO chains upon addition of the ionic liquid are identified. The equilibrium structure of simulated systems is also analyzed in reciprocal space by using the static structure factor, S(k). Calculated S(k) display a low wave-vector peak, indicating that spatial correlation in an extended-range order prevail in the ionic liquid polymer electrolytes. Long-range correlations are assigned to nonuniform distribution of ionic species within the simulation box. 相似文献
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《Mendeleev Communications》2023,33(3):425-427
The spectral characteristics of ethylene absorbed by ionic liquids (ILs) containing silver ions were studied by in situ ATR-FTIR spectroscopy at high pressure. Three different states of ethylene were observed based on the band shift of out-of-plane bending vibrations (ωCH2) due to van der Waals interactions, hydrogen bonds, and π-complex formation with silver ions. Thus, ethylene can be used as an IR-sensitive probe molecule for characterizing interactions with ILs and other substances. 相似文献