共查询到20条相似文献,搜索用时 15 毫秒
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IsoflavonoidsarebiologicallyimportantnaturalproductsoccurringmainlyinspeciesoftheLeguminosaefamilyandhaveshownawidespectrumofbiologicalactivitiesincludingestrogenic,anticancer,insecticidal,pisciadalandantifungalproperty'.Theseisoflavonoidphytoestrogensarerichinsomeplantdietsuchassoybean'.Animalexperimentshadshownthatsoybeandietinhibitradiation-andchemical-inducedtumorofthemammary',skin',andlivers.AstudyconductedbyBarnesetal.6suggestedthatsoybeanisoflavonesmayberesponsiblefortheanticarcinogeni… 相似文献
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Propyl O-(α-L-rhamncpyranosyl)-(1→3)-[2,4-di-O-(2s-methylbutyryl)-α-L-rham-nopyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside (1), the tetrasac-charide moiety of Tricolorin A, was synthesized in total 23 steps with a longest linear sequence of 10 steps, and overall yield of 3.7% from D-Glucose. The isomerization of the dioxolane-type berzyli-dene in the presence of NIS/AgOTf was observed. Tetrasaccharide 1 exhibited no activity against the cultured P388 cell as Tricolorin A did. 相似文献
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YAO Jun-hua 《分析测试学报》2007,(Z1)
2-[[(2′-氰基联苯基)-4-基]甲基]氨基-3-硝基苯甲酸乙酯是生产抗高血压药坎地沙坦酯的中间产物[1],由3-硝基邻苯二甲酸为起始原料,经酯化、卤代、Curtius重排、与2-氰基-4′-溴甲基联苯缩合4步反应制得,合成路线见文献[2-3]。在生产过程中,每一步反应带来的副产物都影响到最终 相似文献
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2-Thioxo-1,2-dihydropyridine derivatives 2a, 2b were reacted with methyl iodide to give 2-methylthiopyridines 3a, 3b, which were reacted with hydrazine hydrate to produce 3-aminopyrazolo[5,4-b]pyridines 4a, 4b. Compounds 4a, 4b were diazotized to afford the corresponding diazonium salts 5a, 5b, which were reacted with some active methylene compounds 6a-6h to give the corresponding pyrido[2′,3′ : 3,4]pyrazole[5,1-c][1,2,4]triazines 7-14. 相似文献
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合成了18个含有1H-1,2,4-三唑的咪唑[2,1-b]-1,3,4-噻二唑以及S-三唑[3,4-b]-1,3,4-噻二唑的稠杂环衍生物,经元素分析及谱学表征,探讨2,5,6-三取代咪唑[2,1-b]-1,3,4-噻二唑的可能生成机制.对大肠杆菌、绿脓杆菌、枯草杆菌等初步抑菌试验证明,多数化合物表现了较好的抑菌活性. 相似文献
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YU Chen-Xia ZHU Xiao-Tong YAO Chang-Sheng TU Shu-Jiang 《结构化学》2007,26(5):533-536
The title compound (C16H14BrNO) has been synthesized by the reaction of p-tolylamine, Meldrum’s acid and 4-bromo-benzaldehyde, and its structure was characterized by IR, 1H NMR and X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 7.6850(11), b = 8.3004(11), c = 21.301(3) , β = 95.110(2)°, V = 1353.4(3) 3, Mr = 316.19, Z = 4, Dc = 1.552 g/cm3, μ(MoKα) = 3.028 mm-1, F(000) = 640, the final R = 0.0345 and wR = 0.0768. X-ray analysis reveals that the atoms of C(1), C(2), C(3), C(4), C(5) and N(1) form a six-membered ring of boat conformation. 相似文献
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α-{3-[2-hydroxy-3-(N-methyl-N-hydroxyethylamino)propoxy]propyl}-ω-butylpolydimethylsiloxanes Ⅲ with various moleculax weights were prepared by epoxy addition of α-[3-(2,3-epoxy-propoxy)propyl]-ω-butylpolydimethylsiloxanes Ⅱ and Nmethylmonoethanolamine.At each step.the outcome compounds were characterized through FT-IR and NMR spectra,the results showed that each step was successfully carried out and objective products were achieved. 相似文献
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1-[2-(2,4-二氯苯氧)乙酰基]-5-氨基-1H-吡唑衍生物的合成与生物活性 总被引:8,自引:0,他引:8
为寻求高效低毒的农药,设计、合成了一系列新的1-[2-(2,4-二氯苯氧)乙酰基]-5-氨基-1H-吡唑衍生物3a~3j和4a~4d.元素分析,1H NMR,IR和MS证实了它们的结构.初步的生物活性测试结果表明,在10 mg/L浓度下,化合物3a~3j和4a~4d对油菜的根茎均有很好的抑制作用,对油菜的根的抑制率为90.0%~98.7%;于100 mg/L浓度下,对稗草的根抑制率为84.0%~100%. 相似文献
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对(4R-cis)-6-[2-[2-(4-氟苯基)-5-(1-异丙基)-3-苯基-4-[苯胺(羰基)]-^1H-吡咯-1-基]乙基]-2,2-二甲基-1,3-二氧己环-4-乙酸叔丁酯的傅里叶变换离子回旋共振质谱(FT-ICR-MS)、核磁共振氢谱(^1H-NMR)、碳谱(^13C-NMR)以及^1H同核位移相关谱(^1H-^1HCOSY)、检出^1H的异核多量子相干谱(HMQC)和^1H检测的异核多键相关谱(HMBC)报道并进行解析。确定了^1H谱、^13C谱中各谱峰的归属,研究了其六元环部分的立体构象,并就空间效应对其化学位移的影响做了初步的探讨。 相似文献
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提出了制备头孢类抗生素的中间体α-(2-氨基噻唑-4-基)-α[(叔-丁氧基羰基)异丙氧亚胺基]-乙酸(ATIA)的反相高效液相色谱测定方法,采用SpherigelTM C18色谱柱(250 mm×4.6 mm,5μm),以0.05 g·L-1四丁基溴化铵的甲醇-水(6+4)溶液为流动相,流速为1 mL·min-1,柱温30℃,检测波长260 nm,以外标法定量.在0.001~1.0 mg范围内,ATIA的质量与峰面积呈线性关系,回归方程为A=31 475.6m+1 786.7,相关系数为0.999 7,以质量为0.06 mgATIA按方法测定6次,算得其相对标准偏差为3.7%,检出限(3S)为0.6μg,回收率的试验结果在98.8%~104.0%之间. 相似文献
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Chun Xia Tan Ruo Fei Feng Xiao Xia Peng 《中国化学快报》2007,18(5):505-508
By the condensation of 2,6-bis(4-amino-5-mercapto-[1,2,4]-triazoles-2)pyridine with aromatic acid in the presence of phosphorus oxychloride. Compounds of 2,6-bis(6-aryl-[1,2,4]-triazolo[3,4-b][1,3,4]-thiadiazole-3-yl)pyridines were synthesized. Their structures were confirmed by IR, ^1H NMR spectroscopies and elemental analysis. Their electrochemical behavior and cyclic voltammogram also were be studied. The results showed that they have high ionization potentials and good affinity. 相似文献
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通过3-取代-4-氨基-5-巯基-1,2,4-三唑(3a~3m)和2-溴-2-(1H–1,2,4-三唑-1-基)-4′-氯代苯乙酮(2)的缩合反应,合成了13个新型3-取代-6-(4-氯苯基)-7-(1H-1,2,4-三唑-1-基)-1',2',4'-三唑[3,4-b]-1",3",4"-噻二嗪衍生物4a~4m.化合物结构经元素分析,1HNMR,IR和MS进行了表征.抗菌试验表明所合成的化合物对细菌表现出中等程度的抑制活性. 相似文献
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稠杂环化合物的研究(Ⅷ)——3-(α-萘亚甲基)-6-烷基/芳基均三唑并[3,4-b]-1,3,4-噻二唑的合成及生物活性研究 总被引:2,自引:0,他引:2
合成了15个新的3-(α-萘亚甲基)-6-烷基/芳基均三唑并[3,4-b]-1,3,4-噻二唑,经EA、JR、~1H NMR和MS确定其组成和结构,并对其代表物4b、4d、4f和4g的抗菌、除草、植物生长调节活性进行了初步观察。 相似文献
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The title compound2-p-methyloxyphenyl-3a-(2-phenyl-1,2,3-triazole-4-yl)-3,4- dihydro-1,2,4-oxa-diazolo[4,5-d][1,5] benzothiazepine (C31H25N5O2S, Mr = 531.63) has been syn- thesized and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to triclinic, space group P1 with a = 10.888(2), b = 15.115(3), c = 16.702(3), α = 99.90(3), β = 95.21(3), γ = 100.41(3)o, V = 2642.1(9) nm3, Dc = 1.336 g/cm3, Z = 4, F(000) = 1112, μ = 0.162 mm-1 ,λ(MoKα) = 0.071073 nm, R = 0.0357 and wR = 0.1126 for 10620 observed reflections with I > 2σ(I). X-ray analysis reveals that the molecular backbone consists of a tricyclic system with the central seven- membered ring in a twisted boat-like conformation. 相似文献