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O. J. Scherer 《Nachrichten aus der Chemie》1987,35(10):1062-1062
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Indenestrol A (IA) is a metabolite of diethylstilbestrol (DES), and indenestrol B (IB) is an analog of IA. IA was simply obtained from E,E-dienestrol in the presence of dilute sulfuric acid, and a mixture of IA and IB was formed by thermal cyclization of E,E-dienestrol. In order to elucidate the effects of optically active IA and IB on microtubule assembly, the IA and IB enantiomers were separated to greater than 99% purity by high-pressure liquid chromatography using a chiral column. The di(4-bromobenzoate) of (-)-IB was analyzed by X-ray crystallography and its absolute structure was determined as C(3)-S. The (+)-, (-)-, and (+/-)-indenestrols A and B were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins from porcine brain. (+/-)-IB is more active than (+/-)-IA, and the order of inhibitory activity of the enantiomers on microtubule assembly was (+)-IB greater than (+)-IA greater than (-)-IA greater than (-)-IB. 相似文献
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Nicolas Braun 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》1995,107(4):541-541
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《Journal of organometallic chemistry》1987,326(1):C51
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Karl Deres 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》1993,105(4):657-657
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A. L. Weiss 《Nachrichten aus der Chemie》1987,35(3):276-276
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