一种新的手性多齿配体的合成

反-二苯乙烯;叔丁基二甲基氯硅烷;(1R;2R)-二苯基乙二醇;手性多齿配体     

一种新的具有C_2对称轴的含N,O的手性多齿配体的合成

以(1R,2R)-1,2-二苯基乙二醇和2-甲氧基-4,6-二氯-1,3,5-三嗪为原料,经保护、取代和去保护反应合成了一种新的手性多齿配体——2-甲氧基-4,6-二[(1R,2R)-1,2-二苯基-2-羟基乙氧基]-1,3,5-三嗪,其结构经1HNMR,13CNMR,IR及LC-MS表征。     

手性多齿配体的合成及其在二乙基锌对苯甲醛不对称加成反应中的应用

以(1R,2R)-1,2-二苯基乙二醇和2,4,6-三氯-1,3,5-三嗪为原料,经保护、取代、去保护等反应合成了3个新的手性多齿配体,并将其应用于二乙基锌对苯甲醛不对称加成反应中。结果表明,2,4-二(4-吗啉基)-6-((1R,2R)-1,2-二苯基-2-羟基乙氧基)-1,3,5-三嗪在此反应中的效果最好,所得产物ee值为32%。     

新型C2轴对称吡啶羧酸酯手性多齿配体的合成

以L-(+)-酒石酸和吡啶甲酸为原料,经酯化,缩合、还原、DCC-DMAP催化酯化等反应合成了3个新型手性多齿配体--(4R,5R)-1,3-二氧戊环-2-苯基-4,5-二吡啶羧酸酯(5a～5c),其结构经1H NMR,13C NMR,IR和MS表征,并通过高斯软件HF/6-31G模拟了5a可能的分子结构.     

含吡啶基的C2轴对称手性配体的合成

以L-酒石酸、2-吡啶甲酸、烟酸、异烟酸为原料,通过酯化、缩合、还原等反应合成了5个C2轴对称含吡啶基的手性多齿配体:(4S,5S)-1,3-二氧戊环-2,2-二甲基-4,5-二吡啶酰胺(5a～5e),其结构经1H NMR,13C NMR和MS表征。合成方法具有条件温和、反应时间较短、产率较高等优点。     

手性1,2-二苯基乙二醇衍生物的合成及催化性能研究

合成了3种含吡啶环的手性1,2-二苯基乙二醇衍生物,并通过1HNMR、13CNMR、LCMS和IR的结构表征。将3种衍生物用于催化苯甲醛与二乙基锌的不对称加成反应的结果表明,其中的(1R,2R)-2-(2-吡啶甲氧基)-1,2-二苯基乙醇具有较好的催化活性,获得了78%的收率和56%e.e.。     

新型手性Schiff碱的合成

从手性联萘酚出发,经四步反应合成了一种水杨醛类衍生物(4); 4与(1S,2R)-(+)-2-氨基-1,2-二苯基乙醇反应合成了一种新型手性Schiff碱(6); 6经NaBH4还原制得其类似物.其结构经1H NMR和IR表征.     

一种新的手性三齿膦配体的合成及其应用

自从１９６６年第一个不对称催化反应［１］问世以来，研究最为广泛、深入的是不对称催化氢化反应．由于手性配体是手性催化剂产生不对称诱导和控制的源泉，因此，人们对手性配体研究得较为深入，已经出现了上千种不同结构的手性膦配体，其中手性双膦配体较多，而三齿膦配...     

磺酰胺型多齿配体的合成

有机金属配合物涉及了许多重要的生命过程,配体和配合物的合成及性质研究都越来越受到人们的重视。磺酰胺类化合物,磺酰胺中氨基氢的酸性可与酚类化合物相比拟,对金属离子有较强的配位能力,并且比酚试剂不易氧化,还可改变磺酰胺的空间体积和亲脂性。本文报道一类新的磺酰胺型多齿配体的合成,并证明它们能与金属离子形成配合物。     

功能性多吡啶配体的合成

经过多步反应,合成了10个新的多吡啶配体,其中,有带强吸附性的基团(磷酸基、羧基),有对pH敏感及具有平面大共轭体系的联多吡啶配体及其中间体,用光谱鉴定了它们的结构.     

新型多齿手性氨基醇的合成和结构表征

以L-苯甘氨酸和N,N-二甲基苯胺为原料,合成了2种新型多齿手性氨基醇S-1,1,2-三苯基-2-[(2-二甲氨基-5-溴-1-苯基)甲氨基]-1-乙醇和S-2-苯基-2-[(2-二甲氨基-5-溴-1-苯基)甲氨基]-1-乙醇;利用红外光谱仪、核磁共振谱仪及质谱仪表征了合成产物的结构.     

Synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes containing a chiral tetradentate ligand

A series of novel dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1′R,2R,2′R)-N¹,N¹′-(1,2-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), and mono-carboxylic acid derivatives as ligands have been designed, synthesized, and characterized. In vitro cytotoxicity evaluation of synthesized complexes against human HepG-2, A549, HCT-116, and MCF-7 cancer cell lines has been conducted by MTT assays. All compounds showed antitumor activity to HepG-2 and HCT-116 cell lines. Compound L2 exhibited better cytotoxicity than that of carboplatin against HepG-2 and A549 cell lines and also showed comparable activity against HCT-116 cell line.     

Synthesis and applications in Henry reactions of novel chiral thiazoline tridentate ligands

Several novel chiral tridentate ligands containing thiazoline were efficiently synthesized from commercially available l=cysteine in high yield. These ligands were subsequently applied to the asymmetric Henry reaction of nitromethane and various aldehydes. It was found that the structures of the thiazoline ligands had a significant influence on the enantioselectivity. It was shown that the optimal catalyst for this reaction was a ligand complexed with CuCl, which was formed from chiral thiazoline with chiral aminoalcohol. At ?20°C, with 10 mol% of this ligand, a product with (S)‐configuration was isolated in 93% yield and 98% enantiomeric excess. Copyright © 2015 John Wiley & Sons, Ltd.     

HPLC enantioresolution of (R,S)-baclofen using three newly synthesized dichloro-s-triazine reagents having amines and five others having amino acids as chiral auxiliaries

Enantioresolution of (R,S)-baclofen was accomplished using a newly synthesized set of three chiral derivatizing reagents (CDRs) having amines [(S)-(-)-α,4-dimethylbenzylamine, (-)-cis-myrtanylamine and (R)-(-)-1-cyclohexylethylamine] as chiral auxiliaries in cyanuric chloride and another set of five CDRs having amino acids (L-Leu, D-Phg, L-Val, L-Met and L-Ala) as chiral auxiliaries. These eight CDRs were used for synthesis of diastereomers of (R,S)-baclofen under microwave irradiation. The diastereomers were separated on a reversed-phase C(18) column using mixtures of methanol with aqueous trifluoroacetic acid with UV detection at 230 nm. Chromatographic data obtained for the two sets of diastereomers were compared among themselves and among the two groups. The method was validated for limit of detection, linearity, accuracy and precision.     

Theoretical study of the conformations of triosmium clusters with a chiral carane ligand

A theoretical study has been performed to investigate the conformations of triosmium clusters with a chiral carane ligand . The potential curves of internal rotation have been determined for organic ligands rotating around the S-C bond in the cluster complexes. The structures of possible conformers are analyzed along with reasons for their stability. The rotation barrier relative to the S-C bond is 439.8 kJ/mole, which hinders free rotation of ligands.Original Russian Text Copyright © 2004 by V. A. Potemkin V. A. Maksakov, and V. P. KirinTranslated from Zhurnal Strukturnoi Khimii, Vol. 45, No. 3, pp. 430–434, May–June, 2004.     

手性亚砜法合成粉 虫性信息素

5-氯-2-戊酮(2)经四步反应制得(R)-(+)-4-甲基-3-戊烯基对甲苯基亚砜(6), 化合物6与乙醛进行不对称加成反应得手性醇(7), 7经兰尼镍还原性脱硫反应即合成出目标产物粉 虫性信息素(1), 其光学纯度可达45%。     

Synthesis and fluorescent properties of novel chiral 1,2-diaminocyclohexane substituted ligands and their complexes

A series of novel chiral 1,2-diaminocyclohexane derivatives bearing heterocyclic units were synthesized via improved methods under ultrasonic irradiation. The photophysical properties of compounds were studied in ethanol, methanol, and chloroform. The sensitivity of these amines toward Cu²⁺, Cd²⁺, and Ni²⁺ was studied by the UV–vis and fluorescent methods. The π-electron structure of thiophene and bithiophene containing sensors is the most active toward all above mentioned metal ions and is highly selective for Ni²⁺ and Cd²⁺.     

用(R)-(+)-缩水甘油的亲核开环反应制备手性连二醇

以D-甘露醇为原料合成(R)-(+)-缩水甘油1。该环氧化合物的亲核开环反应为高立体选择性地(93%-96%e.e.)制备各种手性连二醇提供了一条简便途径。     

Synthesis of a novel macrocyclic ligand containing bipyridine units

The 6-hydroxymethyl-6'-tetrahydropyranyloxymethyl-2, 2'-bipyridine (2) was synthesized by the reaction of 6,6'-dihy-droxymethyl-2, 2'-bipyridine (1) with 3, 4-dihydropyran (DHP). 6-Tetrahydropyranyloxymethyl-6'-iodomethyl-2, 2'-bipyridine (5) was obtained from mesylate and iodizating reaction of compound 2. The coupling of 2 and 5 followed by hydrolysis gave bis(6'-hydroxymethyl-2,2'-bipyridme-6-methyl)ether (7) .The macrocydic ligand 8 was obtained by treating 7 and 6,6'-dibromomethyl-2,2'-bipyridine. The synthetic conditions of the intermediate 2 and macocyclic ligand 8 were discussed.