肿瘤治疗的重离子束物理性质研究

重离子在肿瘤治疗方面的优势主要是由于其优越的物理性质，因此，研究其与生物体相互作用也就成为肿瘤治疗中的基本课题，介绍一些研究结果来解决人们关心的问题.The advance of tumor therapy with heavy ions beam is due to the physics quality of heavy ions.So,the investigation of heavy ions action with biological materials will be a basic task. In the paper, the investigated results show a picture to resolve some problems which attract people＇s attention.     

C离子束放射治疗肿瘤的进展

重离子(C离子)用于肿瘤放射治疗具有物理学和生物学两方面的优势, 被誉为面向21世纪最佳放疗用射线。 综合论述了世界各国重离子束治癌的发展历史, 在日本国立放射医学综合研究所(NIRS)提供的临床试验数据基础上分析了C离子束治疗的适应症以及对正常组织的放射损伤。 此外, 通过分析潜在患者人数和治疗相关硬件与软件设备, 对C离子束治癌的运用前景做了初步评估。Heavy ions (carbon ions) were considered currently as the best radiation in radiotherapy for their two superiorities in the physical and biological properties. This paper firstly put the focus on the history of development of heavy ion radiotherapy in the world, then a comprehensive analysis of the indications and radiation damages of normal tissues in clinical trails of heavy ion therapy was made based on the published data by NIRS. Moreover, the prospect of using carbon ions in radiotherapy was estimated by analyzing the potential patients’ number, its related instruments and etc.     

重离子束治癌

本文回顾了辐射治癌的历史发展和国内外动态，讨论了重离子束与常规辐射相比在肿瘤治疗上的优势，提出了为治疗应用的重离子束的主要参数以及兰州重离子研究装置（HIRFL）拟建的冷却储存环（CSR）上建立治疗实验室的初步考虑。     

中国科学院近代物理研究所重离子束治癌进展

介绍了中国科学院近代物理研究所在重离子束治癌研究和治疗装置研制方面的最新进展, 以及中国科学院近代物理研究所重离子束治癌的发展规划。     

重离子束定点诱变育种初探

介绍了在兰州重离子加速器上采用 75 Me V/u16O8+离子进行了贯穿与定点注入的实验 ,以及不同注入部位的种子在实验室萌发的根尖细胞染色体的微核率和畸变率与大田培育结果随剂量的变化情况 .经过 3年 5代 (南繁加代 )的系统选育 ,筛选出增产、矮杆、抗 (锈 )病、抗干热风和早熟等 9个稳定突变系.Penetration and site chosen implantation of spring wheat seeds at HIRFL with 75 MeV/u 16 O 8+ ions were caried out. The seeds, of which the different sites ware implanted by the ions were germinated in room. The frequency of micronuclei and chromosome aberration in their root tip cells was observed. The results of their cultivation in the field were different. Through selection of three year five generations (adding a generation in southern China each year), nine stable...     

重离子束用于肿瘤放射治疗的基础理论

通过与低传能线密度辐射治疗对比分析建立了重离子束肿瘤放射治疗的基础理论,提出了一些提高重离子束放射治疗疗效和减少对正常组织损伤的技术措施,旨在为已开展的重离子治癌临床研究提供理论依据． The basic theory of tumor radiotherapy with heavy ion beam was introduced in contrast to low LET irradiation therapy. Some useful methods are also suggested to improve the curative effect of heavy ion therapy and to spare the normal tissue around the tumor.     

利用超分次技术进行肿瘤治疗的探讨

以人类肝癌细胞SMMC-7721和正常肝细胞L02为研究对象，以这两种细胞0．3Gy时超敏感性的存活数据为基础，从理论上探讨了γ射线照射时，用超分次技术治疗肝癌的可能性。经过计算发现:如果目标肿瘤和周围的正常组织超敏感性的存活差异提高到3％，即可利用超分次技术对肿瘤进行治疗。应用超分次进行分次照射时，照射的结果与分次的间隔时间有关。对这一现象的机理进行了一定的探讨，发现时间间隔与细胞G2期的长短可能存在一定的相关性。Based on the survival data of human hepatoma SMMC-7721 and normal liver L02 cells irradiated with γ-rays at 0.3 Gy and 2 Gy, the possibility of uhra-fractionated radiotherapy is discussed in this paper. According to calculations, it is found that if the difference in cell survival between target tumor and adjacent normal tissue is up to 3%, radiotherapy using HRS would be realized through uhra-fractionation. Furthermore, the low-dose response is time-dependent. After analyzing this phenomenon, it was pointed that there would be a correlation between fractionation interval and the duration of cell G2 phase.     

重离子束辐照育种研究进展及发展趋势

相对于低能离子束生物学, 中能重离子束对植物的诱变效应介绍较少。 从机理上综述了中能重离子束辐照诱变技术的优点, 简要介绍了粮食作物、 经济作物及模式植物的重离子束辐照育种的现状, 最后从转基因、 分子辅助标记及航天育种等方面对重离子束辐照育种的发展趋势进行了展望。 In recent years, the intermediate energy heavy ion biology has been concerned rarely comparing to that of the low energy ions. In this paper, we summarized the advantage of a new mutation breeding method mediated by intermediate energy heavy ion irradiations. Meanwhile, the present state of this mutation technique in applications of the breeding in grain crops, cash crops and model plants were introduced. And the preview of the heavy ion irradiations in gene transfer, molecular marker assisted selection and spaceflight mutation breeding operations were also presented.     

质子与重离子肿瘤治疗的进展

简要介绍了质子与重离子肿瘤治疗的历史和现状.现在,全世界有质子治疗中心23家,治疗肿瘤患者总数为39 612人;重离子治疗设备有3台,治疗肿瘤患者4 511人（包括He离子治疗2 054例病人）.     

重离子束对北里链霉菌的诱变效应

考察不同剂量重离子束对北里链霉菌的致死及诱变效应, 可确定最有利于筛选高产菌株的重离子束辐照剂量。 利用不同剂量的重离子束辐照北里链霉菌孢子, 统计了存活率、 致死率、 正负突变率。 结果发现, 在5 Gy重离子辐照时北里链霉菌出现较高致死率, 其后随剂量升高, 致死率变化较平缓。 各辐照剂量下正负突变率相比较, 40 Gy时正突变率最高, 负突变率相对较低, 存活率为0.92%。 因此确定40 Gy是对北里链霉菌高产菌株筛选最有利的辐照剂量。 To define the optimum dose of heavy ion beams for selecting high productive strains, we should study mortality and mutation effects of Streptomyces kitasatoensis irradiated by heavy ion beams in diffe rent doses. In this research, spores of Streptomyces kitasatoensis were irradiated by heavy ion beams with different doses. And survival rate, mortality rate, positive mutation and negative mutation were analyzed statistically. The results showed that high mortality rate appeared from 5 Gy and then the mortality rate curve became gently. Compared the positive and negative mutations in different doses, highest positive mutation was obtained in 40 Gy, while the negative mutation was lower in this dose, and the survival rate was 0.92%. So we defined that optimum dose of heavy ions radiation for Streptomyces kitasatoensis selection was 40 Gy in this experiment.     

重离子束适形放射治疗技术

重离子束适形放射治疗技术主要包括束流配送系统和治疗计划系统等 .前者是实现重离子束适形放射治疗的硬件设施 ,后者为适形治疗的软件支撑系统 ,两者缺一不可 .鉴于重离子束与物质相互作用在物理学及生物学效应上表现出的特殊性,重离子束治癌中特别引入了面向生物学效应的适形治疗和束流的正电子断层在线监控技术. The conformal radiotherapy techniques mainly include the two systems that are beam delivery and treatment planning. The formal is the hardware basis while the later is the software supplement for heavy ion conformal therapy, they are dependent on each other to realize the cancer conformal therapy with heavy ion beam. Because of the specificities of interaction between heavy ion and target on both physics and biological effects, the heavy ion cancer therapy especially involves...     

SSC-LINAC重离子RFQ动力学模拟与研究

采用多粒子跟踪程序BEAMPATH 对SSC-LINAC 重离子RFQ 直线加速器进行动力学模拟,分别对RFQ 的接受度、高频特性、束流稳定性、空间电荷效应等进行了分析。该RFQ具有很大的纵向接受度,有利于束流在RFQ中的传输;高频特性研究表明,翼间电压设定在理论值以上时,该RFQ都能保持较好的束流特性;束流稳定性分析结果表明,该RFQ具有很大的束流失配容忍度;空间电荷效应研究表明,当束流强度低于0.5 mA时,束流传输不受影响。综合研究结果表明,53.667 MHz重离子RFQ具有较好的动力学特性,满足SSC-LINAC直线加速器的设计要求。The RFQ beam dynamics of a heavy ion linac was investigated in this paper and the BEAMPATH code was employed in this study. The main research was focused on the beam performances depending on longitudinal acceptance, RF properties, beam instability and space charge effect. The RFQ has large longitudinal acceptance in design, which brings the beam performances well. In the RF parameter study, the beam can keep good transmission in the acceleration even the vane voltage is larger than the theoretical value. It is also shown that the RFQ has a large robustness for the mismatch of the input beam by the analysis of the beam instability.Furthermore, the beam evolution is independent on the space charge effect when the beam current is less than 0.5 emA. The preliminary analysis of the beam dynamics shows that the 53.667 MHz heavy ion RFQ has a promising performance, which meets the requirements of SSC-LINAC.     

重离子的束内散射

本文在Bjorken和Mtingwa束内散射理论的基础上进一步推导出了束内散射率的普遍表达式,并将该表达式应用于HIRFL—CSR的磁铁结构(lattice),计算并得到了束流横向发射度和纵向动量散度随时间变化的规律,结果表明,束内散射不会成为CSRlattice设计的障碍.     

重离子束治癌的最新进展和思考

简要叙述了近年来重离子束治癌的最新进展,特别是美国、日本、德国和欧洲一些国家的动态,并对此作了一些简短的评论．根据国际动向和我国国情,提出了几点思考. Newest progress in cancer therapy with heavy ion beam are briefly described in the paper, especially, the trends in United States, Japan, Germany and some European countries in recent years. Furthermore, some brief reviews for the trends are presented. According to the international trends and the potential of our country, our several considerations are proposed.     

Aluminum Ion Beam Treatment of Zirconium Ceramics

Russian Physics Journal - The paper presents the radiation and thermal treatment of zirconium ceramics with high-energy Al ion beams generated at an accelerating voltage of 1.5 kV, which modifies...     

重离子束治癌中深度剂量分布优化

针对兰州重离子研究装置所加速的120MeV/u ¹²C离子束,利用模拟退火优化算法进行了Bragg峰展宽的剂量优化.取相同的展宽区域(30mm),4种不同的步长(2,1,0.5,0.25mm)进行Bragg峰展宽模拟.对所得到的剂量平均值,均方差,入射口剂量,峰坪比等优化结果的参数做了比较.讨论了重离子束治癌临床上最优的Bragg峰展宽模型的选取.