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1.
L. I. Markova N. G. Korobochkina T. N. Serdyukova V. G. Kharchenko 《Chemistry of Heterocyclic Compounds》2000,36(9):1032-1038
We have worked out the optimal conditions for synthesis of 2,4-diaryl-5-oxo-5,6,7,8-tetrahydrochromenylium and -thiochromenylium salts based on triketones of the 2-(1,3-diaryl-3-oxopropyl)cyclohexane-1,3-dione series. For the first time, along with 5-oxo-substituted salts, we have obtained 5-thioxo-5,6,7,8-tetrahydrothiochromenylium salts. A necessary condition for the formation of the latter on treatment with acids and S-nucleophiles is the presence of electron-donor groups on the aryl substituents of the indicated triketones. 相似文献
2.
Abstract New N-substituted 4-arylidene-isoquinoline-1,3-dione derivatives were obtained as one geometrical isomer by aldol condensation of the appropriate aldehyde and the corresponding N-substituted homophthalimides. The structural elucidation of compounds 3a–h was established by infrared and NMR spectroscopy including 1 H, 13 C, CH CORR, and distortionless enhancement by polarization transfer measurements. Compounds 3d–h were evaluated for their antibacterial activity against some strains of bacteria using the disc diffusion method and microdilution tests. 相似文献
3.
Dimethylsulfonium acetic acid betaine (1) and thiolanium acetic acid betaine (4) react with 4-nitrophenyldiazonium tetrafluoroborate (2) in aceticacid solution to give the formazyl compounds3 and5. Reaction of dimethylsulfonium- and thiolanium-trifluoroacetyl-methylide (9 and11, resp.) with compound2 leads to the phenylhydrazones10 and13, whereas trimethylammonium-trifluoroacetyl-methylide (14) reacts with formation of the formazane derivative15.
Herrn Prof. Dr. Dr. h. c.K. Kratzl, Universität Wien, mit besten Wünschen zur Vollendung des 70. Lebensjahres gewidmet. 相似文献
4.
The condensation of 2-aminoacetophenone with RFCO2Et (RF = CF3, CF2H, CF2CF2H) in the presence of LiH in THF or ButOK in ButOH affords either 2-polyfluoroalkyl-4-quinolones or 1-(2-polyfluoroacylaminophenyl)-3-polyfluoroalkylpropane-1,3-diones, depending on the ratio of the initial reactants. The latter are hydrolyzed in an acidic medium to produce 2-polyfluoroalkyl-4-quinolones. N-Methyl-2-trifluoromethyl-4-quinolone was synthesized from 2-aminoacetophenone, CF3CO2Et, and MeI in the presence of ButOK. 相似文献
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6.
Sandeep Nigam Y. C. Joshi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(7):1583-1586
Synthesis of 2,4-disubstituted 1,5-benzothiazepines 3a-3i is reported by the condensation of 2-aminothiophenol 1 with 1,3-diones in pyridine. The structures of the compounds have been established by elemental, IR, 1 H NMR, 13 C NMR, and mass spectral analyses. 相似文献
7.
Mohamed G. Kassem S. A. Shams El-Dine Farid S. G. Soliman Manal N. S. Saudi 《Monatshefte für Chemie / Chemical Monthly》1990,121(8-9):671-675
Summary Approaches leading to 5,6-dihydro-5,6-diphenyl-2-substituted-pyrrolo[3,4-d][1,2,3]-triazol-4(2H,4H)-ones (10) are described. The first approach consists of cyclodehydrating 3(or 4)-hydroxyimino-1,5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrrolidin-2-ones (4,7) with boiling acetic anhydride. The second approach involves cyclization of 3(or 4)-acetoxyimino-1,5-diphenyl-4(or 3)-(4-substituted phenylhydrazono)pyrrolidin-2-ones (8,9) with elimination of acetic acid upon treatment with sodium hydroxide.Part of the work has been presented at the 8th International Congress of Heterocyclic Chemistry (August 1981), Graz, Austria 相似文献
8.
T. G. Nikolaeva Yu. M. Shchekotikhin A. S. Ponomarev A. P. Kriven'ko 《Chemistry of Heterocyclic Compounds》2000,36(4):403-409
The conditions for the formation of N-substituted decahydroacridine-1,8-diones from -R-methylenebiscyclohexane-1,3-diones and 5,5-dimethyl-3-(N-methylamino)-2-cyclohexen-1-one in ethanol, isopropanol, and DMSO have been studied. Methods have been developed for preparation of 1,8-dioxo-10-methyldecahydroacridines which contain furyl and 5-nitrofuryl substituents at the 9 position.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 475–481, April, 2000. 相似文献
9.
Oleg I. Zhukov Boris I. Drevko 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1):663-666
3-Thia(selena)pentane-1,5-diones react with Lewis acids by heteroatom. In these reactions soft Lewis acids such as tin tetrachloride and antimony pentachloride form adducts but hard Lewis acid such as phosphorus pentachloride oxidizes chalcogen atom of 3-thia(selena)-pentane-1,5-dione. Carbon analogues of these diketones form pyrylium salts in the reactions with these Lewis acids. 相似文献
10.
Andrzej Piasecki 《Monatshefte für Chemie / Chemical Monthly》1986,117(11):1287-1293
2-(2-Alkoxyethyl)-1,3-dioxanes (1) were prepared by ap-toluenesulfonic acid-catalyzed, one-step reaction of propenal with a mixture of aliphatic alcohol and trimethylene glycol in good yields. The transacetalization reaction of 1,1,3-trialkoxypropanes (3) with ethylene glycol or propylene-(1,2)glycol afforded good yields of pure 2-(2-alkoxyethyl)-1,3-dioxolanes (5 or6), respectively. This reaction proceeds through an intermediate 1,3-dialkoxy-1-(2-hydroxyalkoxy)-propane.
Ein- oder Zweistufensynthese von 2-(2-Alkoxyethyl)-1,3-dioxacyclanen
Zusammenfassung In der durchp-Toluolsulfonsäure — katalysierten, direkten Reaktion von Propenal mit einem Gemisch von aliphatischem Alkohol und Trimethylenglykol wurden die entsprechenden 2-(2-Alkoxyethyl)-1,3-dioxane (1) in guten Ausbeuten erhalten. Die Umacetalisierung von 1,1,3-Trialkoxypropanen (3) mit Ethylenglykol oder 1,2-Propylenglykol lieferte 2-(2-Alkoxyethyl)-1,3-dioxolane (5 oder6) in guten Ausbeuten. Die Umacetalisierungsreaktion von 1,1,3-Trialkoxypropanen verläuft über 1,3-Dialkoxy-1-(2-hydroxyalkoxy)-propane als Zwischenprodukte.相似文献
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12.
S. G. Dzhavakhishvili N. Yu. Gorobets V. N. Chernenko V. I. Musatov S. M. Desenko 《Russian Chemical Bulletin》2008,57(2):422-427
An efficient method for the synthesis of novel 3-(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)-diones from various 2-dimethylaminomethylidenecyclohexane-1,3-diones, (1,3-thiazol-2-yl)acetonitriles, and dimethylformamide
dimethyl acetal was developed. These transformations proceeded through intermediate 2-[2-(4-aryl-1,3-thiazol-2-yl)-2-cyanoethenyl]-3-oxocyclohex-1-en-1-olates.
They were isolated as piperidinium salts and used in further heterocyclization reactions with aromatic amines, giving novel
1-aryl-3-(1,3-thiazol-2-yl)-7,8-dihydroquinoline-2,5(1H,6H)-diones. These compounds were also obtained by preparative three-step “one pot” synthesis under controlled microwave irradiation.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 412–417, February, 2008. 相似文献
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14.
T. I. Yaroshenko A. S. Nakhmanovich L. I. Larina V. N. Elokhina S. V. Amosova 《Chemistry of Heterocyclic Compounds》2008,44(9):1129-1134
Interaction of benzimidazole-2-thione with propargyl bromide under found conditions permitted the direct synthesis of 2-(2-propynylsulfanyl)-3H-1,3-benzimidazolium
bromide, the base 2-(2-propynylsulfanyl)-1H-1,3-benzimidazole, stable crystalline 2-(1,2-propadienylsulfanyl)-1H-1,3-benzimidazole,
and 3-methyl[1,3]thiazolo[3,2-a][1,3]benzimidazole. The reaction of benzimidazole-2-thione with 1,3-dibromopropyne in chloroform
or absolute methanol gave 2-(3-bromo-2-propynylsulfanyl)-3H-1,3-benzimidazolium bromide, and in absolute methanole in the
presence of a twofold excess of sodium methoxide the reaction proceeded stereo-and regioselectively to give 3-[(Z)-bromomethylidene][1,3]thiazolo[3,2-a][1,3]benzimidazole.
Presented to Academician B. A. Trofimov on his 70th jubilee.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, 1399–1405, September, 2008. 相似文献
15.
V. N. Britsun A. N. Borisevich L. S. Samoylenko A. N. Chernega M. O. Lozynskii 《Russian Chemical Bulletin》2005,54(3):770-773
Oxalylation of 3-oxo-N-phenyl-3-R-propanethioamides in aprotic solvents in the temperature range from −40°C to +20°C results in 4-acyl-5-phenylamino-2,3-dihydrothiophene-2,3-diones and 2-(2-oxo-2-R-ethylidene)-3-phenyl-1,3-thiazolidine-4,5-diones, while in the presence of potassium carbonate, potassium 4-acyl-2,3-dioxo-1-phenyl-2,3-dihydro-1H-pyrrole-5-thiolates are formed.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 757-760, March, 2005. 相似文献
16.
V. G. Arseniev E. P. Olekhnovich O. Ya. Borbulevych O. V. Shishkin Yu. A. Zhdanov V. I. Minkin L. P. Olekhnovich 《Russian Chemical Bulletin》1999,48(3):516-524
The chemistry and the regioselectivity of alcoholysis, aminolysis, and hydrolysis of symmetrical trimethinecyanine carbenium
ions in 4-[3-(2,2-diorganyl-6-phenyl-4H-1,3-dioxen-4-ylidene) prop-1-enyl]-2,2-diorganyl-6-phenyl-1,3-dioxenium perchlorates (4a,b) were investigated. The structures of trimethinecyanine 4,5:4′,5′-bisannelated at the methine chain (3) and of a product of the reaction of nonannelated trimethinecyanine with the methoxide anion were established by X-ray diffraction
analysis,1H NMR spectroscopy, and quantum-chemical calculations (PM3). The nucleophile attacks the mesomeric π-conjugated system of
the trimethinecyanine cation selectivily at the C(6) atom of one of the dioxenium fragrments, the second dioxenium ring being
deactivated. Alcoholysis affords products of addition of the methoxy group to trimethinecyamines. In the course of aminolysis
and hydrolysis, the dioxenium ring that is subjected to the attack eliminates acetone to form 1,3-dioxenylidenepropenylic
derivatives of 1,3-enaminoketones and 1,3-ketoenols, respectively.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 521–529, March. 1999. 相似文献
17.
The synthesis of some substituted 4-hydroxy-2,5,6,7-tetrahydro-pyrano[2,3-c]pyrrole-2,5-diones (5) and 4-hydroxy-1,2,6,7-tetrahydro-5H-pyrrolo[3,4-b]pyridine-2,5-diones (6) by reacting 1,5-diaryl-pyrrolidine-2,4-diones (1) and 1,5-diaryl-1,5-dihydro-4-amino-2H-pyrrol-2-ones (3) with bis-2,4,6-trichlorophenyl malonates (4) is described.Dedicated to Prof. Dr. Dr. h. c.O. Kratky, Graz, on the occasion of his 80th birthday. 相似文献
18.
L. I. Zakharkin S. V. Sokolovskaya L. K. Moldovanova V. V. Guseva 《Russian Chemical Bulletin》1994,43(10):1698-1699
6-(4-n-Hexyloxyphenyl)- and 6-(4-n-decyloxyphenyl)-2-pyrones, which possess smectic and nematic mesomorphism, were synthesized.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1793–1794, October, 1994. 相似文献
19.
S. Z. Vatsadze M. L. Kostochka V. P. Lezina V. G. Vinokurov P. M. Klodt N. V. Zyk 《Russian Chemical Bulletin》2005,54(1):257-258
1,5-Dicarbonyl derivatives of piperidine and tropane were studied in the heterocyclization with hydroxylamine hydrochloride. All the 5,6,7,8-tetrahydro-1,6-naphthyridines obtained exhibit a pronounced analgesic effect.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 251–253, January, 2005. 相似文献
20.
Shubhangi C. Joshi Kunjbihari N. Trivedi 《Monatshefte für Chemie / Chemical Monthly》1992,123(6-7):557-564
Summary The Claisen rearrangement of 7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 a) gave 7-hydroxy-8-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (3 a) and 2,3-dihydro-2,6-diphenyl-3-methyl-(7H)furo[2,3-h]-1-benzopyran-7-one (7 a). 2-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 b) afforded4 b and7 b. 8-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (12) gave only the alkali soluble product 7-hydroxy-8-methyl-6-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (13).3 a,4 b, and13 were further cyclized in acidic medium to9 a,10 b, and14 followed by dehydrogenation.This paper is dedicated to Dr. F. M. Dean, Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool, U. K., on his retirement 相似文献