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1.
Jia Rong LI Shu Ling MA 《中国化学快报》2005,16(11):1424-1426
2H-3, 1-Benzoxazine heterocyclic compounds are a series of potent nonsteroidal pro- gesterone receptor agonists1-3 and have many other applications such as carbonaceous electrode, plant growth regulating and anti-stress activities4-6, etc.. Comparing to other benzoxazine series, such as 1, 4-benzoxazine, 2H-1, 3-benzoxazine, etc., little attentions have been paid for this series of compounds. There is only one method for the preparation of 2H-3, 1-benzoxazine, e.g. cyclocondensation of o-amin… 相似文献
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Jing Shan SHEN* Li Jun LEI Hai Fang MAO Jian Feng LI Ru Yun JI Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai Shanghai Jahwa Fine Chemicals Co. Ltd Shanghai 《中国化学快报》2001,(11)
Searching for new analgesic is still of great interesting for the researchers. Opioids have been a hot topic for their powerful pain relieving properties and their potential for recreational abuse1,2. In the previous paper3 we have reported the synthesis of 2- substituted hexahydro-1H-1, 4-diazepine analogues. In order to get more selective k-opioid receptor agonists, which can elicit ana lgesia while lacking serious side effects, a series of 5-substituted hexahydro-1H-1, 4-diazepine analo… 相似文献
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I. Yu. Bagryanskaya Yu. V. Gatilov S. A. Osadchii A. A. Martynov M. M. Shakirov E. E. Shul'ts G. A. Tolstikov 《Chemistry of Natural Compounds》2005,41(6):657-662
Oximation of oreoselone to produce a mixture the E- and Z-oximes was investigated. The crystal and molecular structures of
oreoselone Z-oxime and the Beckmann rearrangement product of oreoselone E- or Z-oximes and PCl5, 7-(1-chloro-2-methylpropoxy)-2-oxo-2H-1-benzopyran-6-carbonitrile, were established by XSA. Hydrolysis of the latter produced
7-hydroxy-2-oxo-2H-1-benzopyran-6-carbonitrile.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 541–545, November–December, 2005. 相似文献
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Xue Qin Hai Bo Yu Hong Dai Zhen Fang Qin Xin Zhang Gui Fang Bing Ting Ting Wang Jian Xin Fang 《中国化学快报》2010,21(3):283-286
<正>Eleven new imine derivatives 6 containing 1H-1,2,4-triazole and thiazole rings were synthesized by the condensation of 5-((1H- 1,2,4-triazol-1-yl)methyl)-4-tert-butylthiazol-2-amine with various substituted benzaldehydes.The structures of the title compounds were characterized by ~1H NMR,MS and elemental analysis.The plant-growth regulatory activities of these compounds were evaluated.The primary bioassay results indicated that these target compounds exhibited promising plant-growth regulatory activities. 相似文献
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N'-(4-fluorobenzylidene)-2-(1H-1,2,4-triazole-1-yl)acetohydrazide was synthesized by the reaction of 4-fluorobenzaldehyde with 2-(1H-1,2,4-triazole-1-yl) acetohydrazide. The structure was confirmed via elemental analysis, MS,1H NMR, IR, and X-ray diffraction. It crystallized in a monoclinic system with space group P2 ( 1 ), a =0.4905(1) nm, b=0.8160(2) nm, c=1.4105(3) nm,β=93.33(3)°,Z=2, V=0.5636(2) nm3, Dc =1.457 Mg/m3,μ=0.112 mm-1 , F(000) =256, and final R1 =0. 0685. Several intermolecular hydrogen-bond interactions existed in the crystal structure, facilitating the stabilization of the compound. 相似文献
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A novel biscalixarene with two kinds of calix[4]arene derivative units connected by four bridging chains, was facilely' synthesized by "1 + 1" condensation mode in high yield. The element analyses, ESI-MS, ^1H NMR and ^1H-^1H COSY spectrum showed that the calix[4]arene units of compound 4 were in cone conformations and compound 4 possessed biscalixarene-tube structure. 2007 Fa Fu Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 相似文献
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Eighteen novel triazole compounds containing 1,3,4-oxadiazole groups were synthesized from 2-(1H-1,2,4-triazol-1-yl)acetohydrazide and carbon disulfide by several step reactions. The target compounds were characterized by elemental analysis, 1H NMR, 13C NMR, IR, MS, and X-ray crystallography. The results of preliminary biological tests show that all the compounds exhibit certain fungicidal activities. 相似文献
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M. Z. Krimer O. M. Radul L. N. Margolin I. V. Feofanova L Ya Bogel'fer V. V. Negrebetskii 《Russian Chemical Bulletin》1992,41(10):1787-1789
The kinetics of rearrangement of 2,4-dichlorophenyl(1H-1,2,4-triazol-1-ylmethyl)ketone enol acetate into 2,4-dichlorophenyl(5-acetyl-1H-1,2,4-triazol-l-ylmethyl)ketone were investigated by1H NMR spectroscopy. It was shown that this rearrangement is a first-order reaction. The rate constant was measured in the 129–156°C range and the activation parameters of the reaction were determined. A hypothesis concerning the intramolecular character of the observed rearrangement was drawn based on the kinetic data.Institute of Chemistry, Academy of Sciences of the Moldovian Republic, 277014 Kishinev. All-Union Scientific-Research Institute of Chemical Agents for the Protection of Plants, Moscow. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 10, pp. 2284–2287, October, 1992. 相似文献
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Nazariy T. Pokhodylo Vasyl S. Matiychuk 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):1895-1901
Abstract 1-Aryl-1H-1,2,3-triazole-4-carbonyl chlorides were selected as starting materials for the Boulton–Katritzky rearrangement. When 3-amino-5-methylisoxazole was acylated by 1-aryl-1H-1,2,3-triazole-4-carbonyl chlorides, 1-aryl-5-methyl-N-(5-methylisoxazol-3-yl)-1H-1,2,3-triazole-4-carboxamides 5 were obtained and no further rearrangement occurred. On the other hand, when 1-aryl-1H-1,2,3-triazole-4-carbonyl chlorides were first converted into isothiocyanates by the reaction with KSCN and then were allowed to react with 3-amino-5-methylisoxazole 4 in one pot, intermediate thioureas were formed and spontaneously transformed in statu nascendi into 1,2,4-thiadiazole derivatives 6. GRAPHICAL ABSTRACT 相似文献
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V. N. Britsun A. N. Esipenko V. V. Pirozhenko M. O. Lozinskii 《Chemistry of Heterocyclic Compounds》2005,41(10):1334-1338
We have established that the products of aminolysis of 2-aryl-5-R-5,6-dihydro-7H-[1,2,4]triazolo-[5,1-b][1,3]thiazin-7-ones
in boiling ethanol are 3-R-3-(5-aryl-4H-1,2,4-triazol-3-ylsulfanyl)-propanamides, and at 180°C–210°C (depending on the structure
of the substituent R): 3-phenyl-4,5-dihydro-1H-1,2,4-triazoline-5-thione and 3-arylacrylamides or 3-(3-aryl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)propanamides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1587–1592, October, 2005. 相似文献
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3-嘧啶胺基或三嗪胺基甲酰基-4-羟基-2H-1,2-苯并噻嗪-1,1-二氧化物的合成及活性 总被引:1,自引:0,他引:1
通过3-乙氧甲酰基-4-羟基-2-氢(甲基)-2H-1,2-苯并噻嗪-1,1-二氧化物与取代嘧啶胺或均三嗪胺的胺解反应,合成了标题化合物。生物活性测定结果表明多数化合物具有较好的除草活性,部分化合物显示好的植物生长调节活性和抗炎免疫活性。 相似文献
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2H-1,2,4-噻二唑并[2,3-a]嘧啶衍生物的合成及除草活性研究(Ⅲ) 总被引:2,自引:3,他引:2
合成了10个新的2-乙氧甲酰亚胺基-2H-1,2,4-噻二唑并[2,3,-a]嘧啶类化 合物,结构经IR,^1H NMR,MS和元素分析确证,除草活性测定结果表明,部分目标 化合物具有良好的除草性且选择性较好,对双子叶植物安全。 相似文献
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XU Liang-zhong ZHU Chong-yi YU Chen-long LI Kai SI Guo-dong 《高等学校化学研究》2005,21(6):673-676
The title compound, 2-( 4-fluorophenyl ) -2-oxo-1-( 1H-1, 2,4-triazol-1-yl ) ethyl morpholine-4-carbodithioate, was synthesized and its structure was confirmed by means of IR, MS, 1 H NMR and elemental analysis. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound possesses some biological activities. 相似文献
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YE Xiao-qin ZHANG Li-xue ** ZHANG An-jiang CHEN Xian-xing ZHANG Zi-yi . Department of Chemistry Wenzhou Teachers'''' College Wenzhou P. R. China . Chemistry Teaching Research Section Wenzhou Medical College Wenzhou P. R. China. Department of Chemistry Lanzhou University Lanzhou P. R. China 《高等学校化学研究》2002,18(4):393-396
IntroductionAmongst various heterocycles 3 ,6 -disubstituted- 7H- 1 ,2 ,4- triazolo[3 ,4- b][1 ,3 ,4]thiadiazines have received considerable attentionduring the lasttwo decades as potentially biologicalactive agents[1,2 ] . A literature survey indicated thatthis kind of N - bridged heterocycles displayed awide spectrum of biological properties,such asantimicrobial[3] ,antibacterial,antifungal[4 ] ,antiinflammatory[5] ,diuretic[6 ] ,anthelmintic,andanalgesic[7] . They can also be used as the p… 相似文献
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1-X-1-Oxo-1,2-dihydro-4H-3,1-benzoxaphosphorins (X = CH2Cl, Ph, and OH) were obtained by reacting ortho-(butoxymethoxymethyl)phenylmagnesium bromide with derivatives of chloromethylphosphonic and chloromethylphosphinic acids, followed by intramolecular alkylation. X-Ray diffraction was used to study the molecular and crystalline structure of one of these compounds (with X = OH).Institute of Physiologically Active Substances, Russian Academy of Sciences, 142432 Chernogolovka. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 9, pp. 2174–2180, September, 1992. 相似文献