Multicomponent synthesis of benzoxazinones via tandem Ugi/Mitsunobu reactions: an unexpected cine-substitution

A short (2 steps) synthesis of diverse benzoxazinones by coupling the Ugi multicomponent reaction with an intramolecular Mitsunobu substitution is reported. The cyclization step proceeds via an unexpected cine substitution.     

Recent advances in the development of polycyclic skeletons via Ugi reaction cascades

Isocyanide-based multicomponent reactions are among the most powerful synthetic tools available. Particularly, the isocyanide-based Ugi reaction can allow rapid preparation of \(\alpha \)-aminoacyl amide derivatives and polyazaheterocycles with extensive pharmaceutical applications. Moreover, bridged polyazaheterocycles, including one or more quaternary carbon centers, can be constructed via the Ugi cascade reaction in a few steps. This review will emphasize synthesis and bioactivities of bridged compounds with quaternary centers constructed through Ugi cascade reactions.     

Synthesis of some new triamide derivatives via Ugi five-component reaction in aqueous solution

Triamide derivatives have been synthesized in good yields in a novel, one-pot, five-component, and efficient process by the reaction of Z-oxazolone, water, primary amines, aldehydes, isocyanides, in the presence of catalytic amount of KAl(SO₄)₂·12H₂O (alum) as a non-toxic, reusable, inexpensive, and easily available reagent via Ugi reaction in aqueous solution.     

Efficient conversion of light from sparse laser arrays into single-lobed far field using phase structures

An efficient beam-combining technique based on aperture filling is introduced to direct virtually all the energy of a mutually coherent laser array to the far-field main lobe. A comparison between this method and the Dammann grating method for beam superposition reveals the connection between the two and suggests specific applications for each.     

Efficient coupling of light into and out of a photonic crystal waveguide via surface modes

In this paper, we show how the coupling of light into a photonic crystal waveguide can be greatly enhanced by creating a periodic modulation in the dielectric structure surrounding the entrance of the waveguide. In this way, surface modes supported by the system can funnel the light that impinges onto the surface into the interior of the waveguide. Moreover, we also demonstrate that the shape and direction of the beam that emerges from the structure can be tailored by constructing a periodic corrugation near the exit side of the waveguide.     

Low-energy nuclear reactions in crystal structures

Results of studying low-energy nuclear reactions at the HELIS facility (LPI) are presented. Investigations of yields from DD reactions in deuterated crystal structures at deuteron energies of 10 to 25 keV show a considerable enhancement effect. It is shown that exposure of the deuterated targets to the Н⁺ (proton) and Ne⁺ beams with energies from 10 to 25 keV and an X-ray beam with the energy of 20 to 30 keV stimulates DD reaction yields. For the CVD diamond target, it is shown that its orientation with respect to the deuteron beam affects the neutron yield. The D⁺ beam is shown to cause much higher heat release in the TiD_x target than the Н⁺ and Ne⁺ beams, and this heat release depends on the deuterium concentration in the target and the current density of the deuteron beam.     

Self-assembly via adsorbate-driven dislocation reactions

Deposition of S onto a monolayer of Ag/Ru(0001) transforms the herringbone pattern of the clean Ag film into a strikingly regular array of 2D-vacancy islands [Nature (London) 397, 238 (1999)]]. Time-resolved scanning tunneling microscopy reveals that this nanometer-scale restructuring occurs by a cooperative mechanism involving the sequential formation of triangular regions with fcc and hcp stacking. Using a 2D Frenkel-Kontorova model, we can simulate the creation of these triangular building blocks via basic dislocation motions and reactions.     

Efficient broadband simulations for thin optical structures

The thickness of the layers comprising optical structures is usually very thin. When modelling such thin features using a traditional numerical method, for instance the transmission-line modelling (TLM) method, a very small space step is often used to properly discretize the material geometry. This consequently results in large memory storage and longer run time. In this paper a new technique embedding thin structures between TLM nodes is investigated. The key features of this technique are the acquisition of the formulations in the frequency domain and the utilisation of digital filter theory and an inverse Z transform to change the formulations to the time domain. This technique has been successfully applied to calculate the reflection and transmission coefficients of optical structures incorporating thin layers, including antireflection coatings and fibre Bragg grating structures.     

Efficient autofocus method for sequential automatic capturing of high-magnification microscopic images

This letter presents an autofocus （AF） method to position a high-magnification microscope lens that automatically captures hundreds of images from a single moving slide. These images are taken by a mobile clinic unit in a rural location, and are later automatically processed and revised by a remote specialist. This process requires high focus precision to enable image processing techniques to achieve proper results. Low focusing times are also required for the system to be operative. We propose a novel method that combines two focus measures with an adapted searching scheme to cope with both constraints.     

Biomimetic, hierarchical structures on polymer surfaces by sequential imprinting

Thermal nanoimprint lithography (NIL) is based on the thermo-mechanical deformation of a polymer film above the glass transition temperature (T_g) and at an applied pressure. Sequential imprinting extends the process of thermal NIL to create hierarchical structures by carrying out secondary and tertiary imprintings at temperatures below the T_g of a polymer. In this work, we demonstrate the use of sequential imprinting technique to fabricate two- and three-level hierarchical structures on polystyrene (PS) and poly(methyl methacrylate) (PMMA) films over a temperature range of 70-130 °C, with the aim to mimic the hierarchical structures found in biological systems. By mimicking the hierarchical structure in a plant leaf, the water contact angle of PS film was increased from 95° to 128°, while the water contact angle of PMMA film was increased from 71° to 104°, without any chemical treatment.     

Synthesis of novel isoquinolinone and 1,2-dihydroisoquinoline scaffolds via Ugi reaction and ring opening reaction of furans

Combining the Ugi reaction with ring opening reaction of furans for the synthesis of novel isoquinolinone and 1,2-dihydroisoquinoline scaffolds has been developed. The isoquinolinone and 1,2-dihydroisoquinoline derivatives with unsaturated carbonyl moiety may open up many opportunities for further functionalizations.     

Efficient sampling of protein structures by model hopping

We introduce a novel simulation method, model hopping, that enhances sampling of low-energy configurations in complex systems. The approach is illustrated for a protein-folding problem. Thermodynamic quantities of proteins with up to 46 residues are evaluated from all-atom simulations with this method.     

Efficient Network Dismantling via Node Explosive Percolation

The network dismantling problem asks the minimum separate node set of a graph whose removal will break the graph into connected components with the size not larger than the one percentage of the original graph.This problem has attracted much attention recently and a lot of algorithms have been proposed. However, most of the network dismantling algorithms mainly focus on which nodes are included in the minimum separate set but overlook how to order them for removal, which will lead to low general efficiency during the dismantling process. In this paper,we reformulate the network dismantling problem by taking the order of nodes' removal into consideration. An efficient dismantling sequence will break the network quickly during the dismantling processes. We take the belief-propagation guided decimation(BPD) dismantling algorithm, a state-of-the-art algorithm, as an example, and employ the node explosive percolation(NEP) algorithm to reorder the early part of the dismantling sequence given by the BPD. The proposed method is denoted as the NEP-BPD algorithm(NBA) here. The numerical results on Erd¨os-R′enyi graphs,random-regular graphs, scale-free graphs, and some real networks show the high general efficiency of NBA during the entire dismantling process. In addition, numerical computations on random graph ensembles with the size from 2~(10) to2~(19) exhibit that the NBA is in the same complexity class with the BPD algorithm. It is clear that the NEP method we used to improve the general efficiency could also be applied to other dismantling algorithms, such as Min-Sum algorithm,equal graph partitioning algorithm and so on.     

Efficient multiqubit entanglement via a spin bus

We propose an experimentally feasible architecture with controllable long-range couplings built up from local exchange interactions. The scheme consists of a spin bus, with strong, always-on interactions, coupled dynamically to external qubits of the Loss and DiVincenzo type. Long-range correlations are enabled by a spectral gap occurring in a finite-size chain. The bus can also form a hub for multiqubit entangling operations. We show how multiqubit gates may be used to efficiently generate W states (an important entanglement resource). The spin bus therefore provides a route for scalable solid-state quantum computation, using currently available experimental resources.     

Condensed phase combustion travelling waves with sequential exothermic or endothermic reactions

The one-dimensional propagation of a combustion wave through a premixed solid fuel for two-stage kinetics is studied. We re-examine the analysis of a single reaction travelling-wave and extend it to the case of two-stage reactions. We derive an expression for the travelling wave speed in the limit of large activation energy for both reactions. The analysis shows that when both reactions are exothermic, the wave structure is similar to the single reaction case. However, when the second reaction is endothermic, the wave structure can be significantly different from single reaction case. In particular, as might be expected, a travelling wave does not necessarily exist in this case. We establish conditions in the limiting large activation energy limit for the non-existence, and for monotonicity of the temperature profile in the travelling wave.     

Some methods of electron-beam entry into a dense gas

A system is considered of pumping a laser with an electron beam that moves relative to the active medium. The problem of planar two-dimensional gas flow through a bounded heat-releasing medium, a problem analogous to that of rectilinear motion of a beam with constant velocity, is solved analytically. It is proposed to admit an electron beam into a dense gas through aerodynamic ports. The effect of perturbations induced by the beam passage on the flow of gas in an aerodynamic port with a rarefaction wave is analyzed.Translated from Trudy Ordena Lenina Fizicheskogo Institute im. P. N. Lebedeva AN SSSR, Vol. 145, pp. 160–171, 1984.     

Evolution of reactions on surfaces exhibiting defect structures

This paper considers the time and spatial dependent behavior of an active surface exposed to two reactants which may diffuse on the surface, desorb, and also react. The surface is assumed to contain defect structures corresponding to either inherent lattice faults or foreign material on the surface. A number of case studies are examined corresponding to different assumptions about the desorption and kinetic characteristics of the defect sites. The surface concentration profiles are examined to gain physical insight into the competing surface processes. The net effect of surface defects on chemical production rates was examined by integrating the local production rate over a test region on the surface. Of special interest was the study of the poisoning effect of the product species on the diffusion and reaction of the reactants. The reaction-diffusion equations of the models were solved by the alternating direction collocation technique which shows promise for providing an efficient numerical procedure capable of handling practical large scale problems.