共查询到19条相似文献,搜索用时 93 毫秒
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含硅二烃基锡(Ⅳ)邻菲咯啉配合物的合成及结构表征 总被引:2,自引:0,他引:2
1980年,Crowe等人首次报道了六配位有机锡(Ⅳ)配合物R2SnX2L2(R=烷基或苯基;X=F,C l,Br,I或NCS;L为含O或N的有机配体)对P388淋巴白血病细胞有抑制活性[1]。以后人们合成许多二烃基锡配合物,并对基作了广泛的研究[2,3]。结果表明,二烃基锡化合物的抗肿瘤活性主要取决于烃基,混合二烃基锡化合物毒性较高,使它们的应用受到一定的限制。在药物分子中,某个碳原子被硅取代,称为硅药(Sila-drug),其特点是能降低毒性,有时也能提高药效[6]。因此,开展对含硅有机锡化合物进行研究,对于探讨分子中引入硅原子后对有机锡化合物性质的影响有一定的… 相似文献
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芳香异羟肟酸二烃基锡配合物的合成、表征及其抗癌活性的研究 总被引:1,自引:0,他引:1
合成了9个R_2SnL_2型(R=乙基、正丁基和苯基;HL=苯甲酰异羟肟酸,对羟基苯甲酰异羟肟酸和水杨酰异羟肟酸)和6个[R_2SnL]_2O型(R=乙基、正丁基;HL同上)二烃基锡新配合物。测定了它们的分子量、红外光谱和核磁共振谱,着重研究了这些配合物的体外抗癌活性。结果表明,这二类配合物对人白血病HL-60,艾氏腹水和S-180癌细胞有很好的抑制能力。初步探讨了结构-抗癌活性间的关系。 相似文献
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合成了11个含硅二烃基锡的水杨醛缩氨基硫脲席夫碱配合物R(Me3SiCH2)SnL(R=Me3SiCH2或Ph,Cy;H2L=水杨醛缩氨基硫脲席夫碱),并通过1H NMR、13C NMR、IR、元素分析和X射线单晶衍射对目标化合物结构进行了表征。结果表明,水杨醛缩氨基硫脲席夫碱作为三齿双阴离子配体,通过酚氧、亚胺氮和硫醇硫与锡(Ⅳ)配位,形成了中心锡原子为五配位的五元杂环与六元杂环的并联结构。生物活性试验的初步结果显示,该类化合物对人体乳腺癌细胞MDA-MB-231和MCF-7具有较好的体外抗癌活性。 相似文献
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合成了12个二烃基锡糖基羧酸酯。利用元素分析,IR和^1H NMR表征这些化合物的组成和结构。 相似文献
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Six mononuclear complexes [M(L1)2(H2O)4] (M = Co(II), 1a and M = Mn(II), 1b), [Cu(L1)2(H2O)2] (1c), [Cu(L1)2(H2O)(Py)2] (1d), [Cu(L3)(H2O)Cl] · H2O (3a) and [Co(Sal)(H2O)(Py)3] · 2ClO4 · H2O (3b) of phenoxyacetic acid derivatives and Schiff base were determined by single crystal X-ray diffraction. The Co(II) (1a) and Mn(II) (1b) complexes are isomorphous. X-ray crystal structural analyses reveal that these coordination complexes form polymeric structure via formation of different types of hydrogen bonding and π-stacking interactions in solid. Thermal analysis along with the powder X-ray diffraction data of these complexes shows the importance of the coordinated and/or crystal water molecules in stabilizing the MOF structure. Complexes 1a, 1c, 3a show marginal catalytic activity in the oxidation of olefins to epoxides in the presence of i-butyraldehyde and molecular oxygen. 相似文献
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《Journal of Coordination Chemistry》2012,65(15):1693-1701
Six diorganotin esters of Schiff-base ligands formulated as [R2SnLY]2, where L1 is C6H5CON2C(CH3)CO2 with Y?=?CH3CH2OH, R?=?mClC6H4CH2 (1), oFC6H4CH2 (2), pFC6H4CH2 (3) and L2 is 2-HOC6H4CON2C(CH3)CO2 with Y?=?CH3OH, R?=?oFC6H4CH2 (4), pFC6H4CH2 (5), mClC6H4CH2 (6) have been prepared and characterized by elemental analysis, IR, 1H and 119Sn NMR spectra. The crystal structures of complexes 1 and 4 have been determined by X-ray single crystal diffraction. The structure analyses reveal that the Sn atom in both 1 and 4 is seven-coordinate in distorted pentagonal bipyramid geometries with a planar SnO4N unit and two apical aryl carbon atoms, thus forming a dimeric molecule, which sits on a crystallographic center of symmetry. Intramolecular or intradimeric hydrogen bonds contribute to the stability and compactness of the crystal structures. 相似文献
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A simple synthesis of a new amino acid derivative 5,6-bis(trimethylsilyl)indanylglycine via cobalt mediated [2 + 2 + 2] cycloaddition strategy is described. Co-trimerization of diyne building block containing amino acid moiety with bis(trimethylsilyl)acetylene in presence of CpCo(CO)2 catalyst afforded the silylated indane-based α-amino acid (AAA) derivative. Electrophilic aromatic substitution reaction, ipso to the trimethylsilyl group gave highly functionalised indane-based AAA derivatives. 相似文献
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苯氧乙酸类化合物的合成研究 总被引:2,自引:0,他引:2
二苯醚型苯氧基乙(丙)酸类除草剂是一类用于禾本科杂草的除草剂,具有选择性强,内吸迅速,对环境危害小和使用安全等优点,被广泛应用于农林业生产。为了寻找更高效、低毒和低残留的除草剂,本文以相应结构的取代羟基二苯醚为骨架,以氯代乙酸乙酯为原料,经亲核取代反应制得此类化合物。在反应过程中为提高产率,加入了相转移催化剂;由于羟基二苯醚类化合物在空气中容易被氧化,在反应过程中采用氮气保护,得到了较纯产物,产率较高。共合成了苯氧基苯氧基乙酸乙酯类化合物5个,目标物的合成路线如下: 相似文献
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N. E. Galanin L. A. Yakubov G. P. Shaposhnikov 《Russian Journal of General Chemistry》2008,78(9):1802-1807
3-Heptyloxyphenol was obtained by reaction of resorcinol with 1-bromoheptane. Further alkylation with monochloroacetc acid resulted in the synthesis of [3-(heptyloxy)phenoxy]acetic acid. Heating of the latter with phthalimide in the presence of zinc acetate afforded zinc complexes of meso-[(3-heptyloxy)phenoxy] tetrabenzoporphyrins whose demetalization gave free porphyrin bases. Spectral properties of the synthesized compounds were studied. 相似文献
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Gamil A. Guirgis Mohammad A. Qtaitat Y. A. Pentin C. M. Whang J. F. Sullivan J. R. Durig Peter Klaeboe 《Fresenius' Journal of Analytical Chemistry》1995,352(5):499-507
The Raman (50 to 3200 cm–1) and infrared (50 to 3500 cm–1) spectra of chlorodimethylmethoxysilane, Cl(CH3)2SiOCH3, in the vapor and solid phases have been recorded. Raman spectra of the liquid including depolarization ratios have also been recorded. Optimized geometries and conformational stabilities have been obtained from ab initio calculations utilizing the RHF/3–21G* and RHF/6–31G* basis sets. The calculations from both of these basis sets indicated the gauche conformer to be significantly more stable than the trans conformer. Since the gauche has twice the multiplicity of the trans form it is unlikely that the trans conformer will be detected in the fluid phases at room temperature. This is supported by the fact that no infrared or Raman bands were found to vanish in the spectra of the crystalline solid. The vibrational frequencies have been calculated using appropriate scaling factors, and the vibrational spectra are interpreted in detail. The results have been compared with those obtained for some related molecules.Dedicated to Professor Dr. H. Kriegsmann on the occasion of his 70th birthdayFor part XX, see J Raman Spectrosc 26:in press (1995)Analytical R/D Department, Organic Products Division, Miles Inc., Bushy Park Plant. Charleston, SC 9411, USAChemistry Department, Mu'tah University, P.O.Box 7, Mu'tah-Karak, JordanDepartment of Chemistry, Moscow State University, Moscow, B-234, RussiaDepartment of Ceramic Engineering, Inha University, Nam-Ku, Incheon 160, KoreaDepartment of Chemistry, University of Oslo, P.O.Box 1033, 0315 Oslo, Norway 相似文献
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I. L. Baranov L. V. Tabulina L. S. Stanovaya T. G. Rusal’skaya 《Russian Journal of Electrochemistry》2006,42(4):320-325
Variations in electrophysical properties of anodic silicon oxide at the surface of semiconductor silicon are studied as a function of the composition of electrolytic solutions containing orthophosphoric acid and the conditions of reaching the final formation potential. The optimum conditions for the formation of anodic SiO2 coatings that include phosphorus-containing admixtures are determined, the coatings being intended for application as diffusates in nanoelectronics. 相似文献