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De Feng XU Xiao Juan GUO Zhao Hui XU Shao Shun LI School of Pharmacy Shanghai Jiaotong University Shanghai 《中国化学快报》2006,(7)
Shikonin 1 was a key component isolated from the traditional Chinese herbal medicine, Zicao(Lithospermum erythrorhizon Sieb.et Zucc), which possesses multiple biological activities1. There have been many synthetic routes to shikonin, however, all these ro… 相似文献
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《中国化学快报》1998,(4)
Chrysotricine1wasisolatedfromtheChineseherbmedicineHedyotiSChrysotricha'anditssthectUrehasbeenestablishedasanew0-carbolinealkaloidwitha2,5-trans-substitutedtetrahydrofuranylgrouPatitsl-positionbyX-raydiffractionandspectralanalysis.PharmaceuticalstUdiesshowedpotentialantitUmoractivity.Theinterestingbiologicalactivityandthechemistryof6-carb0linesmict[JIehaveattiactedconsiderableattentioninrecentyears.InordertostUdythisstrUctUre-activityrelationshiPfurther,wewereillterestedinthedevelopmento… 相似文献
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Trichodiene (1), a sesquiterpene hydrocarbon, was isolated from the extract of mycelium of Trichothecium roseum. The structure of trichodiene (1) was elucidated by Nozoe and Machida in 1970 via degradation and spectroscopy.1 Trichodiene (1) has been shown to be the biogenetic precursor of the trichothecane family of sesquiterpenoids as characterized by the cytotoxic fungal metabolite (-)-trichodermin (2).2,3 The structure and absolute stereochemistry of (-)-trichodermin (2) were determined by X-ray diffraction and, therefore, the structure and absolute stereochemistry of trichodiene (1) are now firmly established.4 We wish to report a total synthesis of (±)-trichodiene (1) via previously reported lactone 3.5,6 相似文献
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Cheng Lu ZHANG? Ying Ge MA Chun Li SUN Ye Hong QIU Department of Chemistry Liaoning Normal University Dalian 《中国化学快报》2005,(6)
(±)-13-Hydroxy-8 (14)-abietene, a rare alicyclic diterpene possessing an isopropyl group and a hydroxy group at the C-13 position, was isolated from Solidago missouriensis nutt1. Many diterpenes exhibit significant bioactivities, such as antibacterial. As a part of our synthetic studies on the naturally-occurring diterpenes, we are attemping the synthesis of the rare natural compound. To our knowledge no total synthetic work has been reported yet. In order to study the further relationship b… 相似文献
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Yi SHEN Ling XIANG Yong DENG Yu Guo ZHONG Department of Medicinal Chemistry West China School of Pharmacy Sichuan University Chengdu 《中国化学快报》2006,(4)
A convenient synthesis of cis-(±) isomer 1 and trans-(±) isomer 2 of lamivudine starting from benzoyloxyacetaldehyde and l,4-dithiane-2,5-diol is described. The key steps include chlorination of oxathiolane lactol 5 by SOCl2/DMF, followed by coupling with silylated N4-acetylcytosine and deprotection. The overall yield was 42.6 % and 20.1 %, respectively. 相似文献
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Dr. Donghui Ma Dr. Yangbin Liu Prof. Dr. Zhang Wang 《Angewandte Chemie (International ed. in English)》2017,56(27):7886-7889
A biomimetic total synthesis of racemic homodimericin A was achieved in seven steps, including two cascade reactions. Aqueous buffer solutions are found to help both the oxidative dimerization cascade and the intramolecular Diels–Alder cascade. This synthetic sequence validates key steps in the biogenetic proposal of homodimericin A. 相似文献
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Cheng Lu ZHANG Ping Yan BIE Xuan Jia PENG Xin Fu PAN* Department of Chemistry National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 《中国化学快报》2002,13(10)
Most diterpenoids exhibit significant bioactivities, such as antidermatophytic, antibact- erial, and antioxidant. Although a large number of aromatic tricyclic diterpenoids have been isolated, there are a few of them having ethyl substituent. The synthesis of this type diterpenoids has been seldom reported. In order to further study the relationship between the structure and bioactivities of the diterpenoid, we extended the diterpene synthesis1,2,3. It is desirable to report herein the syn… 相似文献
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对四种天然二聚二苯乙烯类化合物Shegansu B (1), Gnetuhainin F (1a), Maackin A (2)以及Cassigarol E (3)的全合成进行了研究. 以3,5-二羟基苯甲酸(4)为起始原料, 经六步反应制得异丹叶大黄素(13)和白皮杉醇(14), 在HRP/H2O2酶催化氧化体系中, 13和14分别进行自身的氧化偶联得到各自的二聚产物. 首次完成了1a, (±)-2和(±)-3的全合成, 并以较文献报道为高的氧化偶联产率合成了(±)-1. 相似文献
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Guang Xing WANG Jing Xin ZHANG Shu Feng CHEN Xiao Tian LIANG* Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 《中国化学快报》2001,(3)
Chrysotricine 1 was isolated from the Chinese herb medicine Hedyotis Chrysotricha and was shown to possess antitumor activity1. Its structure has been elucidated as a novel zwitterionic (-carboline alkaloid containing a 2,2,5-trisubstituted tetrahydrofuranyl group. The (-carboline compounds have attracted considerable attraction in recent years because of their promising and intriguing biological activities2. Recently, we have established the absolute configuration of chrysotricine by the fir… 相似文献
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A convenient total synthesis of (±) thaicanine (5) is described from 2-benzyloxy-3,4-dimethoxyphenylethylamine (1). 相似文献
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Benxiang Zhang Dr. Xiaoqing Wang Chao Cheng Dr. Deqian Sun Prof. Dr. Chaozhong Li 《Angewandte Chemie (International ed. in English)》2017,56(26):7484-7487
The first total synthesis of the hexacyclic indole alkaloid (±)-corymine is described. Starting from the readily available N-protected tryptamine, the title compound was achieved in 21 steps in 3.4 % overall yield. Key steps of the synthesis include: a) the addition of a malonate to a 3-bromooxindole to afford 3,3-disubstituted oxindole, b) the formation of a 12-membered cyclic enol ether by intramolecular O-propargylation, immediately followed by propargyl Claisen rearrangement to provide the α-allenyl ketone stereospecifically, c) DMDO oxidation to install a hydroxy group in a highly stereoselective manner, and d) the SmI2-mediated reductive C−O bond cleavage to remove the α-keto carboxyl group. 相似文献
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In 1972 we proposed1 structure 3 for flavipucine, an antibiotic from an Aspergillus flavipes strain. Later we reported2 a novel reaction of 6-methyl-4-hydroxy-2-pyridone with α keto aldehydes which provided 1a from isobutylglyoxal and it was stated that we believed 1a would serve as a key intermediate in the total synthesis of flavipucine 3. 相似文献
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Wen-Hua Ji Qian-Shan Gao Yun-Liang Lin Hong-Mei Gao Xiao Wang Yan-Ling Geng 《合成通讯》2014,44(4):540-546
An efficient formal synthesis of (±)-glabridin was accomplished in 10 steps from resorcinol using Raney Ni to reduce carbon–carbon double bonds in α,β-unsaturated carbonyl compound as the key step.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献
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Dr. Hongsoo Lee Dr. Taek Kang Prof. Dr. Hee-Yoon Lee 《Angewandte Chemie (International ed. in English)》2017,56(28):8254-8257
The first total synthesis of waihoensene, a tetracyclic diterpene containing an angular triquinane and a six-membered ring, with four contiguous quaternary carbon atoms, was achieved through the tandem cycloaddition reaction of an allenyl diazo substrate containing a six-membered ring via trimethylenemethane (TMM) diyl intermediate. 相似文献
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《中国化学快报》1998,(4)
Hinesollanditsrelatedspiro[4.5]decenesesquiterpeneagarospir0l2wereisolatedfromavarietyofplants.Althoughmanmethodshavebeendevelopedfortheirsynthesis,fewofthemgivesatisfactoryresults,especiallywithcontrolofstereochendstryatthespirocenteraswellinC2andC1O.Inl985,YangreportedthattWonewspiro[4.5]decenesesquiterpenes,whichhaveunusualbiologicalactivity,wereis0latedfromAquilariasinensiS(Lour.)Gilgandnamedbadrixinicacid3andbairnuxinal4l.InordertostUdytheirsmictUre-activityrelati0nshiPfurther,wehave… 相似文献