共查询到20条相似文献,搜索用时 31 毫秒
1.
A series of novel chiral C2-symmetric bis (oxazoline) ligands have been synthesized.The copper and magnesium complexes,prepared in situ from copper(Ⅱ)-triflate of magnesium triflate with the new enantiopure oxazoline ligands,were evaluated as chiral catalysts in the enantioselective Diels-Alder reaction of cyclopentadiene with N-crotenoyl-oxazolidin-2-one.Primary results showed that diastereoselectivity up to 94% and enantioselectivity up to 68% ee for endo products were observed respectively with these ligands. 相似文献
2.
3.
Fraile JM García JI Gissibl A Mayoral JA Pires E Reiser O Roldán M Villalba I 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(31):8830-8839
A thorough experimental and theoretical study of the enantioselective cyclopropanation of alkenes catalyzed by chiral bis(oxazoline)- and azabis(oxazoline)-copper complexes, which comprise a new family of ligands that lack C2 symmetry, has been conducted. Surprisingly high enantioselectivities were observed with some of these ligands, which were rationalized on the basis of molecular modeling studies. The course of the asymmetric induction in connection with ligand symmetry and the implications for supported enantioselective catalysts are discussed. 相似文献
4.
The common use of NHC complexes in transition‐metal mediated C–C coupling and metathesis reactions in recent decades has established N‐heterocyclic carbenes as a new class of ligand for catalysis. The field of asymmetric catalysis with complexes bearing NHC‐containing chiral ligands is dominated by mixed carbene/oxazoline or carbene/phosphane chelating ligands. In contrast, applications of complexes with chiral, chelating bis(NHC) ligands are rare. In the present work new chiral iridium(I) bis(NHC) complexes and their application in the asymmetric transfer hydrogenation of ketones are described. A series of chiral bis(azolium) salts have been prepared following a synthetic pathway, starting from L ‐valinol and the modular buildup allows the structural variation of the ligand precursors. The iridium complexes were formed via a one‐pot transmetallation procedure. The prepared complexes were applied as catalysts in the asymmetric transfer hydrogenation of various prochiral ketones, affording the corresponding chiral alcohols in high yields and moderate to good enantioselectivities of up to 68%. The enantioselectivities of the catalysts were strongly affected by the various, terminal N‐substituents of the chelating bis(NHC) ligands. The results presented in this work indicate the potential of bis‐carbenes as stereodirecting ligands for asymmetric catalysis and are offering a base for further developments. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
5.
Benaglia M Benincori T Mussini P Pilati T Rizzo S Sannicolò F 《The Journal of organic chemistry》2005,70(19):7488-7495
[structure: see text] The role played by the electronic properties and the steric features of bis(oxazoline) ligands in the Cu(I)-catalyzed cyclopropanation of styrene effected with ethyl diazoacetate was investigated. Two pairs of new bis(oxazolines) displaying flexible and atropisomeric 3,3'-bithiophene backbones were synthesized and structurally and electronically characterized. For the first time, the electrochemical oxidative potential was used as a reliable index of the electronic density on the nitrogen atom of the chelating groups of new and, for comparative purposes, of already known bis(oxazolines). The Cu(I) complexes of the new ligands were prepared, and their enantioselection ability and catalytic efficiency were tested. This investigation suggests that steric factors and catalyst geometrical features are clearly more important than any consideration of the electronic properties of the chiral ligands. 相似文献
6.
The phosphine oxide-linked bis(oxazoline) ligands were designed and synthesized in two ways. One is the coupling of Grignard reagent derived from 2-(2-bromophenyl)oxazoline with phenylphosphonic dichloride, another route is the condensation of bis(2-formylphenyl)(phenyl)phosphine oxide with chiral amino alcohols followed by NBS oxidation. These new bis(oxazoline) ligands were applied in Pd-catalyzed asymmetric allylic alkylation reactions and good yields and enantioselectivities were obtained with diphenyl substituted ligand (up to 95% ee). 相似文献
7.
《Tetrahedron: Asymmetry》1999,10(16):3095-3098
The use of sterically congested C2-symmetrical bis(oxazoline) ligands with methylene and ethylene spacers between the oxazoline rings results in the reversal of the enantioselection for aldol reactions catalyzed by bis(oxazoline)–Cu(II) complexes. 相似文献
8.
9.
In recent years, C2-symmetric chiral bis (oxazoline) ligand-metal complexes have received a great of attention through their use in various catalytic processes[1-2]. Since the early 1990s, many impressive enantioselective carbon-carbon bond forming reactions, aziridination reactions, hydrosilylations, oxidations and reductions have been recorded using bis (oxazoline)-metal complexes with wide structural diversity[3-4]. The latest review is intended to focus on the recent developments of bis(oxazoline) ligand-metal catalyzed asymmetric reactions and their applications in organic synthesis. Herein we intend to report the synthesis of a new type of chiral bis(oxazoline), 1,3-bis(oxazolinyl)benzene. Application of their asymmetric catalysis is under working. 相似文献
10.
《Tetrahedron letters》2004,45(36):6765-6768
Azabis(oxazoline)-Cu complexes are more stable than their analogues based on bis(oxazoline) ligands. This increased stability leads to improved recoverability (up to eight times) when these systems are used in an ionic liquid medium. The solution of the chiral catalyst can even be reused in different enantioselective cyclopropanation reactions and still lead to high enantiomeric excess (>90%). 相似文献
11.
A series of chiral C2-symmetric bis(oxazoline) ligands containing dibenzo[a,c]cycloheptadiene units were synthesized. The copper complexes, prepared in situ from copper (I)-triflate and the new enantiopure oxazoline ligands, were assessed as chiral catalysts in the enantioselective cyclopropanation of styrene with diazoacetate. Enantioselectivities up to 82 and 62%, respectively, for trans- and cis-2-phenylcyclopropanecarboxylate were observed. 相似文献
12.
13.
Michael Seitz 《Tetrahedron》2006,62(42):9973-9980
Highly modular N,Y,Z,Y,N-ligands (Y=N, O, S; Z=N, NO, OH, OMe) have been prepared using bis(oxazoline) building blocks either as nucleophiles or as electrophiles in coupling reactions with central aromatic units. This way, a great variety of pentadentate bis(oxazoline) ligands in diastereo- and enantiomerically pure form become readily available, which are useful for the construction of helical metal complexes with predetermined chirality. 相似文献
14.
Anthracene- and pyrene-tagged bis(oxazoline) ligands have been prepared and immobilized on charcoal, fullerene, and single-walled carbon nanotubes through π–π interactions. The corresponding copper complexes have been evaluated for their propensity to promote heterogeneous asymmetric Henry and ene reactions. The best results, in terms of activity, selectivity, and stability toward the recycling procedure have been obtained with the pyrene/SWCNT system, as the first example demonstrating the usefulness of such reversible interactions for the asymmetric formation of new C–C bonds. 相似文献
15.
The scaffold rigidity of bis(oxazoline) ligands was rationally tuned on the basis of literature information. Diphenylsulfide-linked bis(oxazoline) ligands with a flexible scaffold were efficiently synthesized to test our hypothesis. The improved enantioselectivity in palladium-catalyzed asymmetric allylic alkylation reaction was achieved as we expected. 相似文献
16.
Mansur B. Ibrahim Imran Malik S. M. Shakil Hussain Atif Fazal Mohammed Fettouhi Bassam El Ali 《Transition Metal Chemistry》2016,41(7):739-749
Palladium–bis(oxazoline) complexes (Pd-BOX-A and Pd-BOX-B) were synthesized and characterized by 1H, 13C NMR, IR and elemental analysis. The molecular structures of the complexes were confirmed by single-crystal X-ray analysis. In both cases, the palladium center is coordinated by the nitrogen atoms of the two oxazoline rings and two chloride ligands in a distorted square planar geometry. Despite the fact that the bis(oxazoline) ligand is achiral, the asymmetrical substitution on the phenyl spacer and the rigid backbone of the complex Pd-BOX-A induce inherent chirality and the compound crystallizes as a racemic mixture. Both complexes were found to be highly effective catalysts for Suzuki–Miyaura, Mizoroki–Heck and Sonogashira cross-coupling reactions. They also show excellent catalytic activities toward carbonylative coupling reactions. 相似文献
17.
《Journal of Coordination Chemistry》2012,65(3):432-448
New bis(oxazoline) ligands and their palladium complexes were synthesized and characterized. X-ray crystal structures of the two new complexes showed distorted square planar geometry with the palladium ion bonded to nitrogens of two bidentate heterocycles in addition to two bromides and two acetate ions for Pd-BOX-1 and Pd-BOX-2, respectively. The complexes adopt a chair structure with a rigid curvature inducing an inherent chirality. The complexes were effective catalysts for Suzuki–Miyaura, Mizoroki–Heck, and copper-free Sonogashira coupling reactions in aqueous dimethylformamide and under aerobic conditions. The reaction conditions were optimized for best solvent, base, and temperature. The substrate scope of the new catalytic system was evaluated for coupling reactions of a variety of aryl halides with aryl boronic acids, alkenes, and alkynes. 相似文献
18.
Heteroleptic [Bis(oxazoline)](dipyrrinato)zinc(II) Complexes: Bright and Circularly Polarized Luminescence from an Originally Achiral Dipyrrinato Ligand
下载免费PDF全文
![点击此处可从《Angewandte Chemie (International ed. in English)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Dr. Julius F. Kögel Dr. Shinpei Kusaka Dr. Ryota Sakamoto Toshiki Iwashima Mizuho Tsuchiya Ryojun Toyoda Ryota Matsuoka Dr. Takamasa Tsukamoto Dr. Junpei Yuasa Prof. Dr. Yasutaka Kitagawa Prof. Dr. Tsuyoshi Kawai Prof. Dr. Hiroshi Nishihara 《Angewandte Chemie (International ed. in English)》2016,55(4):1377-1381
Heteroleptic zinc(II) complexes synthesized using achiral dipyrrinato and chiral bis(oxazoline) ligands show bright fluorescence with quantum efficiencies of up to 0.70. The fluorescence originates from the 1π–π* photoexcited state localized exclusively on the dipyrrinato ligand. Furthermore, the luminescence is circularly polarized despite the achirality of the dipyrrinato ligand. Single‐crystal X‐ray structure analysis discloses that the chiral bis(oxazoline) ligand undergoes intramolecular π–π stacking with the dipyrrinato ligand, inducing axial chirality in the dipyrrinato moiety. 相似文献
19.
A series of new C(2)-symmetric fluoren-9-ylidene malonate-derived bis(oxazoline) ligands were synthesized from fluoren-9-ylidene malonate and enantiomerically pure amino alcohols via a convenient route. Their asymmetric catalytic properties in the Friedel-Crafts reactions of indoles with arylidene malonates were evaluated, and the Cu(OTf)2 complex of a fluoren-9-ylidene malonate-derived bis(oxazoline) bearing a phenyl group showed moderate to good enantioselectivity (up to 88% ee). 相似文献
20.
The electronic effect of diphenylamine-linked bis(oxazoline) ligands was tuned through introduction of electron-withdrawing
bromo and nitro substituents onto the 4 and 4′ position. The variation of the NH bond acidity was determined by the different
chemical shifts of NH. The catalytic activity and enantioselectivity of the modified ligands were tested in the asymmetric
Friedel-Crafts alkylation of indole with β-nitrostyrene. The effect of ligand skeleton rigidity was also investigated through
the synthesis of iminodibenzyl-linked bis(oxazoline) ligands and evaluation of their catalytic activity in Friedel-Crafts
alkylation. 相似文献