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1.
E. G. Mamedov 《Russian Journal of Applied Chemistry》2004,77(8):1316-1320
A procedure was developed for preparing acetylenic esters of bicyclo[2.2.1]hept-5-ene-2-carboxylic acid. The structures of the compounds were confirmed by IR and 1H NMR spectroscopy. The Kovats indices of the compounds were determined, and their boiling points were estimated by gas-liquid chromatography. The protective properties of the esters against acid corrosion of steel were studied.Translated from Zhurnal Prikladnoi Khimii, Vol. 77, No. 8, 2004, pp. 1331–1335.Original Russian Text Copyright © 2004 by Mamedov. 相似文献
2.
Arthur A. Santilli Stephen V. Wanser Dong H. Kim Anthony C. Scotese 《Journal of heterocyclic chemistry》1975,12(2):311-316
Dieckmann ring closure reactions of 4-[(2-cyanoethyl)substituted amino]-2-phenyl-5-pyrimidinecarboxylates (Ha-f) afforded several 5,6,7,8-tetrahydro-5-oxo-2-phenylpyrido[2,3-d]pyrimidine-6- carbonitriles (IIIa-f). The open-chain intermediates (IIa-f) were prepared by dechloroamination of 5-carbethoxy-4-chloro-2-phenylpyrimidine (1a) with several 3-substituted amino- propionitriles. Alkylation of the sodium salt of 5,6,7,8-tetrahydro-8-methyl-5-oxo-2-phenyl-pyrido[2,3-d]pyrimidine-6- carbonitrile (IIIa) with methyl iodide in DMF resulted in methylation at C-6 to afford IV. Tosylation of IIIa in pyridine gave the corresponding tosyl ester (V) of the enolic form. Oxidative dehydrogenation at the 6,7-position resulted when IIIa reacted with thionyl chloride, affording 5,8-dihydro-8-methyl-5-oxo-2-phenylpyrido[2,3-d]pyrimidine-6- carbonitrile (VII). Dechloroamination of la or 5-carbethoxy-4-chloro-2-methylthiopyrimidine (Ib) with ethyl 3-ethylaminopropionate followed by Dieckmann cyclization of the resulting open-chain intermediates gave the corresponding ethyl 5,6,7,8-tetrahydro-5-oxopyrido[2,3-d]pyrimidine-6-carboxylates IX'a and IX'b, respectively. These exist predominately in the enol form and undergo alkylation and oxidation reactions similar to IIIa. 相似文献
3.
C. D. Weis 《Journal of heterocyclic chemistry》1978,15(1):29-30
Oxidation of 3-hydroxy-6-methyl-2-hydroxymethylpyridine with manganese dioxide yielded the corresponding aldehyde, the condensation of which with diethyl bromomalonate furnished hydroxydihydrofuro[3,2-b]pyridinediearboxylie acid ester. Saponification of the diester with concentrated hydrochloric acid afforded the hydrochloride of 5-methylfuro[3,2-b]pyrjdine car-boxylic acid. 相似文献
4.
Cross coupling protocols were applied for the synthesis of 3-(4-heteroaryl-phenyl)-8-oxabicyclo[3.2.1]oct-2-ene-2-carboxylic acid methyl esters. Stille conditions produced the corresponding products in reasonable yields. Samarium iodide reduction of the resulting coupling products produced the 2β-carbomethoxy-3α-aryl-8-oxabicyclo[3.2.1]octane diastereoisomers as the major, and the 2β-carbomethoxy-3β-aryl-8-oxabicyclo[3.2.1]octane diastereoisomer as the minor products. Both diastereomers manifested inhibition of the dopamine (DAT) and serotonin (SERT) transporters, with some selectivity for SERT inhibition. 相似文献
5.
The crystal structure of a novel ferrocene derivative with potential flame-retardant/smoke-suppressant activity, 1,4,5,6,7,7-hexachloro-2-endo-ferrocenyl-hydroxymethyl-3-endo-hydroxymethyl-5-norbornene, has been determined. Some of the carbon–carbon bonds within the chlorendic residue are unusually long, and there is no interaction between the hydroxyl groups and the iron atom. There is evidence of intramolecular hydrogen bonding between the two hydroxyl groups. 相似文献
6.
Dorokhov V. A. Voronkova V. A. Komkov A. V. Baranin S. V. Vasil’ev L. S. 《Russian Chemical Bulletin》2010,59(5):1035-1040
A reaction of alkyl 2-(diaminomethylidene)-3-oxoalkanoates with arylisocyanates leads to the formation of the corresponding
ureas, which upon the action of Na alkoxides cyclize to 1-aryl-6-R-cytosine-5-carboxylates. The latter reacting with arylisocyanates
according to the similar scheme give rise to 3,6-diaryl-5-methylpyrimido[4,5-d]pyrimidine-2,4,7(1H,3H,6H)-triones. 相似文献
7.
Hyun-Nam Cho Kil-Yeong Choi Sam-Kwon Choi 《Journal of polymer science. Part A, Polymer chemistry》1985,23(3):623-634
The anionic polymerization of a bridged bicyclic lactam, 2-azabicyclo[2,2,1]heptan-3-one (ABHO), was carried out in bulk and in solution under various reaction conditions. In general bulk polymerization of ABHO was superior to solution polymerization in conversion and degree of polymerization. The resulting polymer exhibited good thermal stability at temperatures up to 300°C. The melting point and decomposition temperature of this polyamide, poly(cyclopentane-1,3-diyliminocarbonyl), were about 307 and 335°C, respectively. Copolymerization of ABHO with 2-pyrrolidone was also made at 30°C and a varying weight percentage of ABHO with potassium pyrrolidonate as catalyst and CS2 as activator. Copolyamides that contained 15 w % of ABHO decomposed at a temperature higher than the melting point by almost 30°C. Thus the thermal stability of copolymers compared with that of nylon-4, was greatly improved. Moisture sorptions of homopolymers and copolymers were always larger than those of other polyamides (nylon 4 and 6) at any relative humidity. Tenacity and elongation at the break of melt-spun fibers obtained from copolyamides that contained 15 w % of ABHO without the drawing and annealing process were 1.25 g/den and 13.1%, respectively. 相似文献
8.
二氯二茂钛可与醇、酚、酸等反应生成相应的烃氧基或酰氧基二茂钛。当钛一氧键中氧的未共用电子与π键发生共轭,或与氧相连的取代基上带有强吸电子基团时,这类化合物较稳定,所以近年来合成了一系列芳氧基和一些卤素取代的酰氧基二茂钛,二氯二茂钛及其衍生物,能引发某些烯类的聚合。 相似文献
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11.
Syntheses of Boc-protected 4-amino- and 5-amino-pyrrole-2-carboxylic acid methyl esters have been achieved and the structures of these compounds have been fully characterized by detailed NMR studies. 相似文献
12.
all-endo-3-amino-5-hydroxybicyclo[2.2.2]octane-2-carboxylic acid (13) and all-endo-5-amino-6-(hydroxymethyl)bicyclo[2.2.2]octan-2-ol (10) were prepared via dihydro-1,3-oxazine or g-lactone intermediates by the stereoselective functionalization of an N-protected derivative of endo-3-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acid (2). Ring closure of b-amino ester 4 resulted in tricyclic pyrimidinones 15 and 16. The structures, stereochemistry and relative configurations of the synthesized compounds were determined by IR and NMR. 相似文献
13.
14.
Spiro[4.n]-2-aza-alkan-carboxylic acids represent bulky proline analogues with increased lipophilicity. They are readily available from cyclic nitriles via alkylation with bromoacetaldehyde acetals, reduction to the corresponding amine, cyclisation to the imine and subsequent Strecker synthesis. 相似文献
15.
Yue-He Tan Zhao-Yang Wang Ji Qi Jin-Feng Xiong Mei-Xiang Lv 《Research on Chemical Intermediates》2012,38(3-5):925-936
Using K2CO3 as a base and CH3CN as solvent, different kinds of N-[5-alkoxy-2(5H)-furanonyl] amino acids were reacted with propargyl bromide via substitution reaction at 40?°C to give 16 N-[5-alkoxy-2(5H)-furanonyl] amino acid propargyl esters with the yields of 44?C85% (mostly over 74%). The structures of all newly synthesized compounds were elucidated and confirmed by FTIR, UV, 1H NMR, 13C NMR, MS, and elemental analysis. The rapid, efficient, and brief synthesis of the series propargyl esters with multiple bioactive units, will afford not only a basis for the activity test of potential drug molecules, but also an important synthetic strategy for 2(5H)-furanone derivatives with polyfunctional groups. 相似文献
16.
G. D. Krapivin L. A. Badovskaya V. G. Kul'nevich 《Chemistry of Heterocyclic Compounds》1975,11(9):1018-1019
5-Nitrofuran-2-carboxylic acid was obtained in quantitative yield by oxidation of 5-nitrofurfural with hydrogen peroxide and decomposition of the intermediate 5-nitrofurfural α-hydroxyhydroperoxide. The mechanism of the reaction is discussed. 相似文献
17.
The title compound was prepared from 4-tert-butyl cyclohexanone in high yield by a simple three step procedure. 相似文献
18.
The optimum route for the synthesis of methyl esters of N-[(4-substituted amino)-5-cyano-2-methylthiopyrimidin-6-yl]amino acids (which are starting materials for preparing the methyl esters of the corresponding 5-amino-4-(substituted amino)pyrrolo[2,3-d]pyrimidine-6-carboxylic acids) is via subsequent reactions of 4,6-dichloro-2-methylthiopyrimidine-5-carbonitrile with amines and methyl glycinate. In some examples, the reaction of methyl N-(4-chloro-2-methylthio-6-pyrimidinyl)aminoacetate with amines occurs to give the corresponding acid amides. The previously unknown synthesized derivatives of pyrimidin-6-yl amino acids and 4,5-diaminopyrrolo[2,3-d]pyrimidine- 6-carboxylic acids possess fungicidal properties.Vilnius University, Vilnius 2006, Lithuania. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No 7, pp. 955–961, July, 2000. 相似文献
19.
Esráa S. Abu-Sheaib Jalal A. Zahra Mustafa M. El-Abadelah Roland Boese 《Monatshefte für Chemie / Chemical Monthly》2008,139(9):1061-1066
Cyclocondensation reaction of ethyl 7,8-diamino-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate with 1-methylisatin produced a separable mixture of the corresponding indolo[3,2-b]- and [2,3-b]pyrido[2,3-f]quinoxaline-3-carboxylates, of which the latter isomer predominates. On the other hand, interaction with 1H-isatin or 5-chloroisatin gave the respective indolo[2,3-b]pyrido[2,3-f]quinoxaline-3-carboxylates as the sole regiospecific products. The structures of these new pentacyclic derivatives are based on microanalytical, spectral (IR, MS, and NMR) and X-ray crystal structure data. 相似文献
20.
Márta Palkó Elvira Sándor Pál Sohár Ferenc Fül?p 《Monatshefte für Chemie / Chemical Monthly》2005,4(5):2051-2058
All-endo-3-amino-5-hydroxybicyclo[2.2.1]heptane-2-carboxylic acid and two epimers of 3-amino-6-hydroxybicyclo[2.2.1]heptane-2-carboxylic
acid were prepared via 1,3-oxazine or γ-lactone intermediates by the stereoselective functionalization of endo-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxylic acid derivatives. Their structures were proved by IR and NMR spectroscopy, with
the use of HMQC, HMBC, DEPT, and DIFFNOE techniques. 相似文献