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1.
S. K. Petkevich A. S. Kishkentaeva O. G. Ryazantsev E. A. Dikusar N. A. Zhukovskaya A. V. Kletskov N. G. Kozlov G. A. Atazhanova S. M. Adekenov V. I. Potkin S. G. Pashkevich A. A. Denisov V. A. Kul’chitskii 《Russian Journal of Organic Chemistry》2014,50(9):1351-1356
Esters derived from 5-phenyl-, 5-(4-methylphenyl)-, and 5-(2,5-dimethylphenyl)-1,2-oxazole-3-carboxylic and 4,5-dichloro-1,2-thiazole-3-carboxylic acids and some natural alcohols (L-menthol, grosshemin), thymol, and synthetic analogs of the latter (4-tert-butylphenol, 4-tert-octylphenol, 2-tert-butyl-4-methylphenol) were synthesized by reactions of the corresponding alcohols with acid chlorides. 相似文献
2.
Yu. I. Gorak N. D. Obushak V. S. Matiichuk R. Z. Lytvyn 《Russian Journal of Organic Chemistry》2009,45(4):541-550
Arylation of furan-2-carboxylic acid or its methyl ester with arenediazonium chlorides in the presence of copper(II) chloride gave the corresponding 5-arylfuran-2-carboxylic acids or methyl 5-arylfuran-2-carboxylates. 5-Arylfuran-2-carbonyl chlorides reacted with potassium thiocyanate and then with 5-methyl-1,2-oxazol-3-amine to give 5-aryl-N-[3-(2-oxopropyl)-1,2,4-thiadiazol-5-yl]furan-2-carboxamides as a result of recyclization of intermediate isoxazolylthiourea derivatives. The reactions of 5-arylfuran-2-carbonyl chlorides with 5-(2-furyl)-1H-tetrazole involved opening of the tetrazole ring with elimination of nitrogen molecule and led to the formation of 2-(5-arylfuran-2-yl)-5-(2-furyl)-1,3,4-oxadiazoles. 3-Substituted 6-(5-arylfuran-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles were obtained by condensation of 5-arylfuran-2-carboxylic acids with 5-substituted 4-amino-4H-1,2,4-triazole-3-thiols in phosphoryl chloride. 相似文献
3.
Potassium 2-methylthio-5-bromopyrimidine-4-carboxylate was condensed with thiophenoxide ion containing various electron releasing groups to produce 2-methylthio-5-arylthiopyrimidine 4-carboxylic acids. Some of these acids were cyclized through their acid chlorides with anhydrous aluminum chloride to their corresponding 10H-[1]benzothiopyrano[3.2—d]pyrimidin-10-ones. 相似文献
4.
The anhydride of cis-4-cyclohexene-1,2-dicarboxylic acid was condensed with phenanthrene, acenaphthene and fluorene in the presence of anhydrous aluminium chloride to give the corresponding 2-(aroyl) cyclohex-4-ene-1-carboxylic acids. These keto acids when subjected to Wolf-Kishner reduction yielded the corresponding 2-(aryl) cyclohex-4-ene-1-carboxylic acids, which were then converted into their respective acid chlorides by refluxing with thionyl chloride in benzene. The acid chlorides in turn were cyclised by anhydrous aluminium chloride in carbon disulphide to give the corresponding cyclic ketones. These cyclic ketones were then reduced by Wolf-Kishner method to furnish the desired hydrocarbons, 2,3-cyclohex-2′-ene-5,6-substituted cyclohexanes. 相似文献
5.
V. M. Tormyshev T. V. Mikhalina O. Yu. Rogozhnikova T. I. Troitskaya D. V. Trukhin 《Russian Journal of Organic Chemistry》2006,42(7):1031-1035
Reaction of ethyl isocyanoacetic acid with sodium hydride in anhydrous benzene, followed by treatment with carboxylic acid chlorides or N-(acyloxy)pyrrolidine-2,5-diones, gives 5-substituted oxazole-4-carboxylic acid esters. The procedure is applicable to derivatives of various carboxylic acids, including saturated aliphatic, α,β-unsaturated, alicyclic, aromatic, heterocyclic, and N-Boc-protected amino acids. 相似文献
6.
V. I. Potkin S. K. Petkevich A. V. Kletskov E. A. Dikusar Yu. S. Zubenko N. A. Zhukovskaya V. V. Kazbanov S. G. Pashkevich 《Russian Journal of Organic Chemistry》2013,49(10):1523-1533
Acylation of benzene and toluene with 5-phenyl- and 5-(p-tolyl)isoxazole-3-carbonyl chlorides gave 5-phenyl(or p-tolyl)isoxazol-3-yl phenyl(or p-tolyl)ketones which were reduced to the corresponding alcohols with sodium tetrahydridoborate in propan-2-ol. Selective reduction of the carboxy group in 4,5-dichloroisothiazole-3-carboxylic acid was achieved by the action of BH3, and the aldehyde group in 4-formyl-2-methoxyphenyl 5-arylisoxazole-3-carboxylates and 4,5-dichloroisothiazole-3-carboxylates was reduced to hydroxymethyl group with sodium triacetoxyhydridoborate in benzene. Acylation of the resulting hydroxymethyl derivatives with 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carbonyl chlorides afforded the corresponding esters containing two azole fragments in their molecules. 相似文献
7.
Richard Cremlyn Frederick J. Swinbourne Stephen Graham John M. Lynch 《Phosphorus, sulfur, and silicon and the related elements》2013,188(1-4):121-134
Abstract Diphenylmethane (1) and dibenzyl (17) reacted with chlorosulphonic acid to give the corresponding p,p′-disulphonyl chlorides (2,18). However, attempted chlorosulfonations of α-chloro-, αα′-dichlorodiphenylmethane, stilbene and 1,4-diphenylbutadiene were unsuccessful. Diphenylacetic acid reacted with chlorosulfonic acid to give a mixture of 4,4′-dichlorosulfonyl-benzophenone (40) and α-chlorodiphenylmethane-4,4′-disulfonyl chloride (39). Benzilic acid (41) afforded 9-chlorofluorene-2,7-disulfonyl chloride (42), which with amines gave 3 different products according to the reaction conditions. Fluorene (53) and the 9-carboxylic acid (43) have been treated with chlorosulfonic acid. The various sulfonyl chlorides were converted into 43 derivatives for biocidal evaluation. Mechanistic interpretations for the reactions are included. 相似文献
8.
The arylhydrazides of 1,2,3,4-tetrahydroacridine-9-carboxylic and 2,3-pentamethylene-quinoline-4-carboxylic acids were obtained by the reaction of the hydrochlorides of the acid chlorides of these acids with arylhydrazines. Their properties and biological activity were investigated.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 546–547, April, 1972. 相似文献
9.
Jia-Yuh Sheu Yeh-Long Chen Kuo-Chang Fang Tai-Chi Wang Cherng-Chyi Tzeng Chien-Fang Peng 《Journal of heterocyclic chemistry》1998,35(4):955-964
Alkylation of 6,7-difluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester with substituted-benzyl chlorides gave 1-(substituted-benzyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl esters. Their treatment with piperazine or N-methylpiperazine in pyridine yielded 1-(substituted-benzyl)-6-fluoro-1,4-dihydro-4-oxo-7-(l-piperazinyl)quinoline-3-carboxylic acid ethyl esters which were hydrolyzed with aqueous sodium hydroxide and then acidified with hydrochloric acid afforded the desired 1-(substituted-benzyl)-6-fluoro-1,4-dihydro-4-oxo-7-(1-iperazinyl)quinoline-3-carboxylic acids. The 6,8-difluoro analogs were prepared similarly using 6,7,8-trifluoro-4-hydroxyquinoline-3-carboxylic acid ethyl ester as a starting material. Some of these quinolones demonstrated fairly good antibacterial activities. Among them, 6-fluoro-1-(4-fluorophenylmethyl)-1,4-dihydro-7-(1-iperazinyl)-4-oxoquinoline-3-carboxylic acid ( 7d ) and 6,8-difluoro-1-(3-fluorophenylmethyl)-1,4-dihydro-7-(1-piperazinyl)-4-oxoquinoline-3-carboxylic acid ( 8c ) are two of the best. 相似文献
10.
Saponification of the appropriate 3-carbethoxy-α-pyrones gives α-pyrone-3-carboxylic acid and its homologs, further converted via their acid chlorides to the substituted amides of the acids. 相似文献
11.
Aghekyan A. A. Mkryan G. G. Tsatinyan A. S. Gasparyan G. V. 《Russian Journal of General Chemistry》2019,89(5):1051-1054
Russian Journal of General Chemistry - 1-Arylcyclopentane-1-carboxylic acids were synthesized by alkaline hydrolysis of the corresponding nitriles. Reactions of the acid chlorides with... 相似文献
12.
E. G. Mamedov 《Russian Journal of Applied Chemistry》2005,78(9):1552-1554
Acetylenic esters of polychlorobicyclo[2.2.1]hept-2-ene-5-carboxylic acids were prepared from the corresponding acid chlorides and acetylenic alcohols. 相似文献
13.
Konstantina Koriatopoulou 《Tetrahedron》2008,64(42):10009-10013
A novel four-step synthesis to the pyrrolo[2,1-c][1,4]benzodiazocine ring system is described. 1H-Pyrrole-2-carbaldehyde was alkylated with ethyl or methyl bromoacetate and the resulting ethyl or methyl (2-formyl-1H-pyrrol-1-yl)acetates oxidised with potassium permanganate to the corresponding 1-[(2-ethoxy or methoxy)-2-oxoethyl]-1H-pyrrole-2-carboxylic acids. The latter was converted into their acid chlorides by reaction with thionyl chloride and without isolation transformed into the respective methyl 2-({[1-(2-ethoxy or methoxy-2-oxoethyl)-1H-pyrrol-2-yl]carbonyl}amino)benzoates by reaction with methyl anthranilate. Dieckmann condensation of methyl 2-({[1-(2-methoxy-2-oxoethyl)-1H-pyrrol-2-yl]carbonyl}amino)benzoate provided the pyrrolo[2,1-c][1,4]benzodiazocine. 相似文献
14.
M. Vivekananda Bhatt Shaker H. El Ashry M. Balakrishnan 《Journal of Chemical Sciences》1979,88(6):421-437
Pseudo acid chlorides derived from levulinic acid ando-benzoyl-benzoic acid, solvolyse in aqueous acetone, aqueous dioxane and aqueous dimethylformamide by aS
Nl process. Their reaction pattern is distinct from that of typical normal acid chlorides, viz.,p-benzoylbenzoyl chloride and fluorene-9-one-1-carboxylic acid chloride, which solvolyse by aS
N2 pathway. No evidence for tautomerism could be obtained either between the normal and pseudo forms of the acid chlorides
or the derived ion pairs. 相似文献
15.
By condensation of the chlorides of the three 9-oxo-fluorene-2-, -3-, and -4-carboxylic acids with 4-bromo-1,2-xylene on one side, and of the chlorides of o-bromobenzoic acid, 2-bromo-4-methyl-benzoic acid and 2-bromo-4,5-dimethyl-benzoic acid with fluorene, 2-methylfluorene and 3-methylfluorene on the other side, followed by direct or indirect cyclisation and by final reduction, several new methyl derivatives of the indenofluorenes I, II and IV are synthesized. 相似文献
16.
H. R. Kricheldorf Sven A. Thomsen 《Journal of polymer science. Part A, Polymer chemistry》1991,29(12):1751-1757
Tristrimethylsilyl-3-amino-4-hydroxybenzoic acid was condensed with various aromatic acetoxy carboxylic acid chlorides in Marlotherms-S® at 20–350°C. Under these conditions formation of an amide group, ring closure to benzoxazole groups and polycondensation occur step by step in a “one-pot procedure”. The crude polyesters were hydrolyzed to yield pure 2-(hydroxyaryl) benzoxazole-5-carboxylic acids which were acetylated and polycondensed. The pure polyesters obtained in this way were characterized by viscosity and DSC measurements, WAXS-powder patterns, and thermogravimetric analyses. The polyester of 2-(4-hydrophenyl) benzoxazole-5-carboxylic acid has a degree of crystallinity > 90% and a short term in thermostability in air up to 500°C. 相似文献
17.
Anastasiya V. Agafonova Mikhail S. Novikov Alexander F. Khlebnikov 《Molecules (Basel, Switzerland)》2023,28(1)
Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with N-, O-, or S-nucleophiles mediated by an ortho-substituted pyridine. With readily available chloroisoxazoles and a nucleophile, 2-picoline can be used as an inexpensive base. When a high yield of the acylation product is important, the reagent 2-(trimethylsilyl)pyridine/ethyl chloroformate is more suitable for the acylation with 2H-azirine-2-carbonyl chlorides. 相似文献
18.
4-Acyl-pyrazole-3-carboxylic acids (1) were synthesized via the reaction of 4-acyl-2,3-furandiones (F) with hydrazone (1-benzylidene-2-(2,5-dimethyl-phenyl)-hydrazine) by heating under solid phase and their acid chlorides (2) were obtained. Then these derivatives were easily converted into the corresponding derivatives such as ester, amide, ureide, pyrazolo-pyridazine, etc. Totally 62 new compounds were synthesized. The structures of these new synthesized compounds were determined by spectroscopic methods and the in vitro antibacterial activity of newly synthesized compounds were carried out against some gram-positive and gram-negative bacteria by well diffusion method (zone inhibition). Our results have showed that these new synthesized compounds have much potent of antibacterial activity owing to containing of pyrazole and/or pyridazine, chromone, oxazine, furane, and pyrrole rings. Some of the new pyrazole derivatives exhibited higher activities than reference drugs against the representative bacteria. 相似文献
19.
Isomeric half eater acid chlorides derived from 1,2-and 1-3-carboxylic acids give rise to the same oxonium salt with Lewis acids. 相似文献
20.
Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques. 相似文献