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1.
YANG Feng-ying SU Yan-fang ZHANG Xiao TU Guang-zhong GAO Xiu-mei ZHANG Bo-li 《高等学校化学研究》2010,26(5):746-748
A new spirostanol sulfonate, spirost-5,25(27)-dien-1β,3β-diol 1-sulfonate(1), was isolated from the rhi-zomes of Helleborus thibetanus(Ranunculaceae), and the structure was identified on the basis of a detailed spectros-copic analyses, including 2D NMR spectrometry, IR and HRESI-MS. 相似文献
2.
Lanying Liu Fuqin Guan Yu Chen Fan Wang Pengxu Chen Min Yin Bi Wang Linwei Li Qizhi Wang Yonghua Gu Xu Feng 《Molecules (Basel, Switzerland)》2022,27(18)
Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-β-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3–7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes. 相似文献
3.
Two new steroidal glycosides, parquisoside A ( 1 ) and B ( 2 ) were isolated from the aerial parts of Cestrum parqui (family Solanaceae). Their common aglycone is a new steroid of the spirostane series, which we name parquigenin. It has the structure (3β,24S,25S)‐spirost‐5‐ene‐3,24‐diol, i.e. a (24S,25S)‐24‐hydroxydiosgenin. The structures of parquisosides A and B were elucidated as (3β,24S,25S)‐spirost‐5‐ene‐3,24‐diol 3‐O‐{[α‐L ‐rhamnopyranosyl‐(1→2)]‐β‐D ‐glucopyranosyl‐(1→4)‐α‐L ‐rhamnopyranosyl‐(1→4)}‐β‐D ‐glucopyranoside ( 1 ) and (3β,24S,25S)‐spirost‐5‐ene‐3,24‐diol 3‐O‐{[α‐L ‐rhamnopyranosyl)‐(1→4)‐α‐L ‐rhamnopyranosyl‐(1→2)]‐β‐D ‐glucopyranosyl‐(1→4)‐α‐L ‐rhamnopyranosyl‐(1→4)}‐β‐D ‐glucopyranoside ( 2 ), respectively, on the basis of detailed spectroscopic studies and chemical analysis. The crude extract of Cestrum parqui showed inhibition of carrageenin‐induced edema. 相似文献
4.
Atta‐ur‐Rahman Shama Nasim Irfan Baig Ilkay Orhan Bilge Sener Filiz Ayanoglu M.Iqbal Choudhary 《Helvetica chimica acta》2003,86(10):3354-3362
Five new di‐ and triglycosides, irigenin 7‐[O‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranoside] ( 1 ), 6‐hydroxygenistein 4′‐[O‐β‐D ‐glucopyranosyl‐(1→6)‐β‐D ‐glucopyranoside] ( 2 ), nigricin 4′‐[O‐β‐D ‐glucopyanosyl‐(1→6)‐β‐D ‐glucopyranoside] ( 3 ), nigricin 4′‐[O‐β‐D ‐glucopyanosyl‐(1→2)‐O‐[α‐L ‐rhamnopyranosyl‐(1→6)]‐β‐D ‐glucopyranoside] ( 4 ), and 7‐{4′‐{[2″‐O‐(4′′′′‐acetyl‐2′′′′‐methoxyphenyl)‐β‐D ‐glucopyranosyl]oxy}‐3′‐(β‐D ‐glucopyranosyloxy)phenyl]‐9‐methoxy‐8H‐1,3‐dioxolo[4,5‐g]‐[1 benzopyran‐8‐one‐] ( 5 ), along with a known compound, nigricin 4′‐(β‐D ‐glucopyranoside) ( 6 ), were isolated from the rhizomes of Iris germanica. The structures of these compounds were established by spectroscopic methods, including 2D NMR spectroscopic techniques. 相似文献
5.
Phytochemical analyses were carried out on the rhizomes of Clintonia udensis (Liliaceae) with particular attention paid to the steroidal glycoside constituents, resulting in the isolation of three new polyhydroxylated spirostanol glycosides, named clintonioside A ( 1 ), B ( 2 ), and C ( 3 ). On the basis of their spectroscopic data, including 2D‐NMR spectroscopy, in combination with acetylation and hydrolytic cleavage, the structures of 1 – 3 were determined to be (1β,3β,23S,24S,25R)‐1,23,24‐trihydroxyspirost‐5‐en‐3‐yl O‐β‐D ‐glucopyranosyl‐(1→4)‐O‐[α‐L ‐rhamnopyranosyl‐(1→2)]‐β‐D ‐glucopyranoside ( 1 ), (1β,3β,23S,24S)‐3,21,23,24‐tetrahydroxyspirosta‐5,25(27)‐dien‐1‐yl O‐α‐L ‐rhamnopyranosyl‐(1→2)‐O‐[β‐D ‐xylopyranosyl‐(1→3)]‐β‐D ‐glucopyranoside ( 2 ), and (1β,3β,23S,24S)‐21‐(acetyloxy)‐24‐[(6‐deoxy‐β‐D ‐gulopyranosyl)oxy]‐3,23‐dihydroxyspirosta‐5,25(27)‐dien‐1‐yl O‐α‐L ‐rhamnopyranosyl‐(1→2)‐O‐[β‐D ‐xylopyranosyl‐(1→3)]‐β‐D ‐glucopyranoside ( 3 ). 相似文献
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Five new sesquiterpenoids, namely, 8β‐(angeloyloxy)‐4β,6α,15‐trihydroxy‐14‐oxoguaia‐9,11(13)‐dien‐12‐oic acid 12,6‐lactone ( 1 ), 4β,6α,15‐trihydroxy‐8β‐(isobutyryloxy)‐14‐oxoguaia‐9,11(13)‐dien‐12‐oic acid 12,6‐lactone ( 2 ), 11,12,13‐trinorguai‐6‐ene‐4β,10β‐diol ( 3 ), (1(10)E,4E,8Z)‐8‐(angeloyloxy)‐6α,15‐dihydroxy‐14‐oxogermacra‐(1(10),4,8,11(13)‐tetraen‐12‐oic acid 12,6‐lactone ( 9 ), and (1(10)E,4β)‐8β‐(angeloyloxy)‐6α,14,15‐trihydroxygermacra‐1(10),11(13)‐dien‐12‐oic acid 12,6‐lactone ( 11 ), and three new artifacts, (1(10)E,4Z)‐8β‐(angeloyloxy)‐9α‐ethoxy‐6α,15‐dihydroxy‐14‐oxogermacra‐1(10),4,11(13)‐trien‐12‐oic acid 12,6‐lactone ( 6 ), (1(10)E,4Z)‐8β‐(angeloyloxy)‐9α,13‐diethoxy‐6α,15‐dihydroxy‐14‐oxogermacra‐1(10),4‐dien‐12‐oic acid 12,6‐lactone ( 7 ), and (1(10)E,4Z)‐8β‐(angeloyloxy)‐9α‐ethoxy‐6α,15‐dihydroxy‐13‐methoxy‐14‐oxogermacra‐1(10),4‐dien‐12‐oic acid 12,6‐lactone ( 8 ), together with the three known sesquiterpenoids 4, 5 , and 10 , were isolated from the aerial parts of Siegesbeckia orientalis L. Their structures were established by spectral methods, especially 1D‐ and 2D‐NMR spectral methods. 相似文献
9.
`Dimeric' coumarin glycoside 1 and `trimeric' coumarin fucosides 2 and 3 were isolated from Daphne oleoides. Their structures were established by means of different spectroscopic techniques, including 2D‐NMR spectroscopy. 相似文献
10.
A new triterpenoid glycoside(1) and seven known triterpenoid glycosides, pseudoginsenoside RT2(2), yesanchinoside R2(3), vinaginsenoside R13(4), vinaginsenoside R8(5), notoginsenoside E(6), 6'-O-acetylginsenoside Re(7), 6"-O-acetylginsenoside Rb1(8), were isolated from the rhizomes of Panacis majoris. The new triterpenoid glycoside was elucidated as 3-O-[β-D-glucopyranosyl-(1→2)-β-D-(6'-O-ethyl)-glucuronopyranosyl]-oleanolic acid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2-8 were obtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate (ADP)-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibited moderate antiplatelet aggregation activity induced by arachidonic acid(AA). 相似文献
11.
ChuanChunZOU ShuJieHOU PingShengLEI XiaoTianLIANG 《中国化学快报》2003,14(4):361-364
Two spirostanol saponins(gracillin and dioscin)which have the typical sugar moieties were synthesized facilely by a general approach. 相似文献
12.
Pnar Akbay Jürg Gertsch Ihsan als Jrg Heilmann Oliver Zerbe Otto Sticher 《Helvetica chimica acta》2002,85(7):1930-1942
Two novel and three new sterol glycosides were isolated from the MeOH extract of the aerial parts of Ajuga salicifolia (L.) Schreber . The structures of the compounds were elucidated as (3R,16S,17S,20R,22S,23S, 24S,25S)‐16,23 : 16,27 : 22,25‐triepoxy‐3‐(β‐D ‐glucopyranosyloxy)coprostigmast‐7‐en‐17‐ol ( 1 ), (3R,16S,17S, 20R,22S,23S,24S,25S)‐16,23 : 16,27 : 22,25‐triepoxy‐3‐{[β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐glucopyranosyl]oxy}coprostigmast‐7‐en‐17‐ol ( 2 ), (3R,16S,17R,20S,22R,24S,25S)‐22,25‐epoxy‐3,27‐bis(β‐D ‐glucopyranosyloxy)coprostigmast‐7‐en‐16‐ol ( 3 ), (3R,16S,17R,20S,22R,24S,25S)‐22,25‐epoxy‐3‐{[β‐D ‐glucopyranosyl‐(1→2)‐β‐D ‐glucopyranosyl]oxy}‐27‐(β‐D ‐glucopyranosyloxy)coprostigmast‐7‐en‐16‐ol ( 4 ), and (3R,16R,17S,20R,22S,23S, 24S,25S)‐22,25‐epoxy‐3‐(β‐D ‐glucopyranosyloxy)coprostigmast‐7‐ene‐16,17,23,27‐tetrol 27‐acetate ( 5 ) by means of 1D and 2D NMR spectroscopy and HR‐MALDI mass spectrometry. The novel compounds, which consist of three additional ring systems at the coprostigmastane skeleton, were named ajugasalicioside A ( 1 ) and B ( 2 ), and the new compounds C ( 3 ), D ( 4 ) and E ( 5 ). In our cytotoxicity assays (HeLa cells, Jurkat T cells, and peripheral mononuclear blood cells), ajugasaliciosides A–D specifically inhibited the viability and growth of Jurkat T‐leukemia cells at concentrations below 10 μM . Ajugasalicioside A ( 1 ; (IC50=6 μM ) and C ( 3 ; IC50=3 μM ) were the most active compounds. Ajugasalicioside A ( 1 ) induced cell‐cell contact, inhibited Jurkat T cell proliferation, and up‐regulated mRNA levels of the cell‐cycle regulator cyclin D1, which might be an indication for cell differentiation. Furthermore, 1 down‐regulated the mRNA levels of the NF‐κB subunit p65 in a concentration‐dependent manner. These effects were not found for ajugasalicioside B ( 2 ), which has an additional glucose unit, and the onset of cytotoxicity of 2 (IC50=10 μM ) was delayed by 24 h. 相似文献
13.
Four novel glycosides, bambusicolasides III–VI ( 1 – 4 ), were isolated from the aphid Pseudoregma bambusicola T. The structures of 1 – 4 were elucidated by spectral evidence including FAB-MS and C.H-COSY, HMBC, and NOE difference experiments, and by hydrolysis. In vitro tests with these compounds showed little cytotoxic activity against human KB cells (< 10%). 相似文献
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Li‐Rong Sun Jian Yan Lu Lu Sheng‐Ji Pei Zhong‐Rong Li Lin Zhou Xian‐Min Zhang Ming‐Hua Qiu 《Helvetica chimica acta》2007,90(7):1313-1318
Cimicifine A ( 1 ), the first cycloartane triterpene alkaloid, was isolated from the rhizomes of Cimicifuga foetida, together with the known compound cimicifugoside H‐1 ( 2 ). Their chemical structures were established by extensive NMR and MS analyses and by comparison with literature. 相似文献
16.
Chemical examination of the underground parts of Tupistra chinensis led to the isolation of two new 5beta-spirostane type steroidal sapogenins, tupichigenin B (1) and C (2), together with two known steroidal sapogenins, ranmogenin A (3) and delta25(27)-pentrogenin (4). The structures of 1 and 2 were established as spirost-25(27)-ene-1beta,3beta,4beta,5beta,6b eta-pentaol and 1beta,2beta,3beta,4beta,5beta-pentahydroxyspi rost-25(27)-en-6-one, respectively, on the basis of detailed analysis of their physical and spectral data. 相似文献
17.
Hyoung-Geun Kim Seon Min Oh Na Woo Kim Ji Heon Shim Youn Hee Nam Trong Nguyen Nguyen Min-Ho Lee Dae Young Lee Tong Ho Kang Nam-In Baek 《Molecules (Basel, Switzerland)》2021,26(22)
The extract from Cnidium officinale rhizomes was shown in a prior experiment to markedly recover otic hair cells in zebrafish damaged by neomycin. The current study was brought about to identify the principal metabolite. Column chromatography using octadecyl SiO2 and SiO2 was performed to isolate the major metabolites from the active fraction. The chemical structures were resolved on the basis of spectroscopic data, including NMR, IR, MS, and circular dichroism (CD) data. The isolated phthalide glycosides were assessed for their recovery effect on damaged otic hair cells in neomycin-treated zebrafish. Three new phthalide glycosides were isolated, and their chemical structures, including stereochemical characteristics, were determined. Two glycosides (0.1 μM) showed a recovery effect (p < 0.01) on otic hair cells in zebrafish affected by neomycin ototoxicity. Repeated column chromatography led to the isolation of three new phthalide glycosides, named ligusticosides C (1), D (2), and E (3). Ligusticoside C and ligusticoside E recovered damaged otic hair cells in zebrafish. 相似文献
18.
黑龙骨中两个新强心苷的结构鉴定 总被引:1,自引:0,他引:1
系统研究黑龙骨Periploca forrestii Schltr.中的化学成分, 利用各种色谱技术进行分离, 得到2个新类型的强心苷,黑龙骨苷甲和乙. 并通过化学和光谱方法(MS, 1H, 13C NMR和2D NMR)鉴定其结构为: 5β-羟基-8,14β-环氧-强心 甾- 20(22)-烯-3-O-β-D-磁麻吡喃糖苷(1)和5β-羟基-8,14β-环氧-强心甾-20(22)-烯-3-O-β-D-葡萄吡喃糖基-(1→4)-β-D-磁麻吡喃糖苷(2). 相似文献
19.
从富宁藤中得到的两类新的强心苷以及它们之间的可能的生源转化途径 总被引:1,自引:0,他引:1
Five novel cardiac glycosides with two types of unusual aglycone [funingenin A (2a) and B], named funingenosides E-I (2-6), together with a known compound, funingenoside B (1), were isolated from the aerial part of Parepigynumfuningense Tsiang et P. T. Li (Apocynaceae). The structures of 2-6 were elucidated by means of MS, IR, NMR spectral analyses and chemical degradation. The possible biogenetic pathway of the two types of cardiac glycosides was also discussed. 相似文献
20.
Qing-Wei Tan Jian-Cheng Ni Jian-Ting Shi Jian-Xuan Zhu Qi-Jian Chen 《Molecules (Basel, Switzerland)》2020,25(23)
Phytochemistry investigations on Ailanthus altissima (Mill.) Swingle, a Simaroubaceae plant that is recognized as a traditional herbal medicine, have afforded various natural products, among which C20 quassinoid is the most attractive for their significant and diverse pharmacological and biological activities. Our continuous study has led to the isolation of two novel quassinoid glycosides, named chuglycosides J and K, together with fourteen known lignans from the samara of A. altissima. The new structures were elucidated based on comprehensive spectra data analysis. All of the compounds were evaluated for their anti-tobacco mosaic virus activity, among which chuglycosides J and K exhibited inhibitory effects against the virus multiplication with half maximal inhibitory concentration (IC50) values of 56.21 ± 1.86 and 137.74 ± 3.57 μM, respectively. 相似文献