ScCoSb: der bisher valenzelektronenärmste Vertreter der ternären Übergangsmetallantimonide MM'Sb mit M–M-Bindungen

ScCoSb: the Most Valence-Electron-Poor Ternary Transition Metal Antimonide MM'Sb with M–M Bonding The antimonide ScCo_1–xSb was prepared by arc-melting the elements. ScCoSb crystallizes in the TiNiSi structure type, occurring as a drilling. The lattice parameters are a = 680.62(6) pm, b = 425.65(5) pm, c = 737.77(8) pm, V = 213.74 10⁶ pm³ (space group Pnma, Z = 4). Besides strong Sc–Sb-, Co–Sb-, and Sc–Co bonding, Sc–Sc bonds stabilize the structure to a small extent. The results of Extended Hückel calculations point to metallic properties of ScCoSb, which are confirmed by measurements of the electrical resistivity as a function of temperature.     

Semisynthese. Chemie mit den Molekülen der Natur

In Semisynthesis complex molecules have to be manipulated in a chemoselective, regioselective, and stereoselective fashion, necessitating smart protective group operations and innovative synthesis development. Key are always easily accessible and suitable starting materials, especially intermediates which can be produced by biotechnological processes. An extensive synthetic construction of drug candidates carries high innovative and intellectual property protection potential, hence multistep semi‐ and even total syntheses are an integral part of modern industrial research and drug development. Not a long time ago, the complexity such realized would have been inconceivable, which profoundly illustrates the progress synthesis methodology has made. Semisynthesis always aims more toward focussed application, and hence its scientific contribution mostly cater to the elucidation of molecular correlations. Especially the study of cellular processes and their quantification will be stimulated in the future. Thereby semisynthesis will continue to bridge the key future areas of synthesis research and chemical biology.