Syntheses based on 2-ethoxycarbonylmethyl-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5(5H)-one

2-Ethoxycarbonylmethyl-7-methyl-1,3,4-thiadiazolo[3,2-a]pyrimidin-5(5H)-one containing the active methylene group reacts easily with carbon disulfide and phenyl isothiocyanate in the presence of sodium hydride. Further alkylation of the reaction product by alkyl halides results in the formation of the corresponding 1,3,4-thiadiazolo[3,2-a]pyrimidine derivatives containing a ketene dithioacetal fragment. Deceased. Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2371–2373, November, 1998.     

One-Pot Synthesis of 4-Hydroxy-3-phenyl-2H-pyrano[3,2-b]benzofuran-2-one Derivatives

Novel 4-hydroxy-3-phenyl-2H-pyrano[3,2-b]benzofuran-2-ones (15a–d), were synthesized in a one-step procedure by the reaction of substituted benzofuran-3-ones 12a–d and (chlorocarbonyl)phenyl ketene.