水溶性卟啉及金属卟啉在DNA中的研究进展

近年来, 卟啉及金属卟啉与DNA的相互作用已成为研究的热点. 通过对卟啉及金属卟啉与DNA相互作用的研究将有助于更深地认识DNA本身的结构和功能, 有助于卟啉及金属卟啉在医学上的应用, 对认识很多疾病的治病机制和药物的设计也起到非常重要的作用. 本文阐述了卟啉及金属卟啉与DNA相互作用的方式和影响因素, 并将水溶性卟啉及金属卟啉分为三类: 具有吡啶基或铵基的阳离子型卟啉及金属卟啉, 具有磺酸基或羧基的阴离子型卟啉及金属卟啉, 以及非离子型的卟啉及金属卟啉. 重点论述了这三类水溶性卟啉及金属卟啉与DNA之间的相互作用, 以及这三类水溶性卟啉及金属卟啉在DNA中的应用研究进展.     

含氟潤滑油

近代的高速飞行及火箭导弹技术要求能在高温、低溫、高压及高速下工作的液压油及润滑油。适合于以上条件的液压油及潤滑油须具备以下的性能: 1.不燃性 2.稳定性——高低温、水解及氧化稳定性等 3.优良润滑性 4.保持流体状态 5.不腐蚀性 6.优良绝缘性能及介电性能     

微处理器及其在电化学和电化学分析上的应用

一、微处理器及微型电子计算机1.微处理器及微型电子计算机简介2.微型电子计算机的组件(1)存储器(2)输入/输出及终端(3)海量存储设备3.微处理器所用的数字系统及数字逻辑(1)数字系统(2)二进制数字的加减乘除及负数运算     

碳氢化合物的活化及氧化理论研究*

通过理论方法研究碳氢化合物的活化及氧化,可以对不同催化剂及氧化剂的反应机理形成深刻认识,从而指导设计合成更加高效的碳氢化合物活化及氧化催化剂。本文总结了近几年在碳氢化合物的活化及氧化领域的一些新进展,涉及的底物包括从甲烷到碳原子数等于6的烃类,而催化剂及氧化剂包括有机金属化合物和无机化合物（如分子筛催化剂、金属团簇和金属氧化物等）。文章底物的碳原子数为依据进行分类编排,对每一类底物的活化及氧化介绍不同催化剂及氧化剂的反应过程,着重比较了各类催化剂及氧化剂的异同。     

农林高校无机及分析化学基础课教学改革探索与实践

化学课程为农林专业不可或缺的基础课,无机及分析化学是化学课程的必要基础。无机及分析化学的教学质量对促进化学类课程质量提高,进而促进农林专业课程的提升甚为重要。本文分析比较了当前无机及分析化学线上线下教学方法,探讨了浙江农林大学无机及分析化学教学中存在的一些不足,提出无机及分析化学加强教学内容设计、交叉融合化学课程及专业课,缩小个体差异、满足学生个性化需求,改进教学模式、加强课程思政建设等解决方案。并在无机及分析化学教学中实践,教学效果得到明显改善,学生的学习效率、学习能力及化学思维能力明显提升。     

ZnO、Ag和ZnO-Ag超微粒子的制备和表面性质研究,显影抑制机理研究

有机分子与金属及半导体之间的界面相互作用及界面间的电子转移反应是现代物理化及材料科学研究的重要课题.     

欧盟化学品分类及标签法案即将出台

随着欧盟即将对欧盟的化学物质及制剂贸易商实施《化学品注册、评估及许可法规》（简称REACH法规）,有关化学品分类及标签方法的法规将会出台。新法规将与联合国的全球化学品分类及标签协调制度一致。欧委会已通过一项关于化学物质和混合剂分类、标签及包装的法规议案,并已纳入了联合国认可的分类准则及标签规则。     

1993年及以后将在我国召开的国际会议

1.国际生漆会议1993年5月2～5日在福州举行.主题为:漆及其成分的化学;漆酶的化学;漆和漆酶的改进;有关物质的农业化学;栽培、收获及其它方法的改进;其工业中的计算机辅助;漆及其成分在涂料、医药及其它(如高分子掺合物及复合物)方面的应用;漆酶的生物化学;漆的历史及分布;桐油、乌臼油及其它真漆材料的化学及工艺;从树液浓缩制漆过程的物理化学及树液或漆的流变学.     

石油分子表征与分子层次模型构建:前沿及挑战

石油资源的绿色、高效及高值化利用需要从分子层次认识石油分子的组成及转化规律,并构建分子层次的精细化过程模型,由此诞生了分子管理技术路线.石油分子组成及转化过程的高度复杂性使得石油分子管理技术开发面临巨大的挑战.本文阐述了石油分子管理的沿革及内涵,总结了石油分子组成表征及石油加工分子模型的进展及所面临的挑战,并对未来的发展方向进行了展望.     

脂肪族聚碳酸酯——二氧化碳共聚物的性能及应用

介绍了由二氧化碳与环氧化的共聚合成的脂肪族聚碳酸酯的性能及应用。包括其合成进展，结构及物性、生物降解能力、热降解机理及热稳定性的提高，共混改性及应用，以及在其它方面的一些应用等。     

正常组织和胰腺癌组织中差异表达蛋白的鉴定

采用双向凝胶电泳和生物质谱技术, 对12对胰腺癌组织和癌旁组织样品、3个胰腺良性疾病样品、3个正常胰腺组织样品的蛋白质进行了分离和鉴定, 获得了重复性较好的双向凝胶电泳图谱; 鉴定了胰腺癌和癌旁组织的差异表达蛋白质, 发现了30个差异表达蛋白质; 应用MALDI-TOF-MS/MS技术对差异表达蛋白质进行鉴定, 共有24个蛋白质得到鉴定, 其中15个蛋白质在胰腺癌组织中表达上调, 9个蛋白质表达下调. 这些蛋白质与胰腺癌的发生相关, 可能成为胰腺癌的分子标志物和药物治疗的靶蛋白.     

聚金属氧酸盐在阿尔兹海默症治疗中的新进展

从聚金属氧酸盐(POMs)对β-淀粉样蛋白(Aβ)聚集的调控作用、 水解及光动力治疗等方面介绍其在阿尔兹海默症(AD)治疗中的最新研究进展, 为进一步研究POMs抗AD药物活性提供了参考.     

Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive age-related neurodegenerative disease recognized as the most common form of dementia among elderly people. Due to the fact that the exact pathogenesis of AD still remains to be fully elucidated, the treatment is only symptomatic and available drugs are not able to modify AD progression. Considering the increase in life expectancy worldwide, AD rates are predicted to increase enormously, and thus the search for new AD drugs is urgently needed. Due to their complex nitrogen-containing structures, alkaloids are considered to be promising candidates for use in the treatment of AD. Since the introduction of galanthamine as an antidementia drug in 2001, Amaryllidaceae alkaloids (AAs) and further isoquinoline alkaloids (IAs) have been one of the most studied groups of alkaloids. In the last few years, several compounds of new structure types have been isolated and evaluated for their biological activity connected with AD. The present review aims to comprehensively summarize recent progress on AAs and IAs since 2010 up to June 2021 as potential drugs for the treatment of AD.     

质谱技术在中药研究中的应用进展

中药是中华传统医学的瑰宝,在我国已广泛应用于疾病预防和治疗中,但其存在化学成分复杂、作用机制不明确等问题,制约了中药现代化及国际化的发展进程。质谱技术具有高灵敏度、高选择性、高稳定性及高通量的特点,特别适合于中药复杂成分及其代谢物的定性定量分析。该文综述了近年来质谱技术在中药成分鉴定及质量控制、中药代谢组学及中药药代动力学研究方面的典型应用,并对存在的问题及改进方法进行了展望。     

Graphite Carbon Nitride and Its Composites for Medicine and Health Applications

With the progress of science and technology and the improvement of people‘s living standards, the performance of traditional materials can no longer fully meet the needs of social development. Graphitic phase carbon nitride (g-C₃N₄), as a new type of nanomaterial, has good properties. Its unique graphite like structure and stable thermodynamic characteristics have led an increasing number of researchers to explore its diverse functions and use this as a basis to develop related energy and products for applications in various fields. Among them, applications in the field of medicine health have become popular in recent years. Therefore, this review summarizes the synthesis methods of g-C₃N₄ and its composites, as well as their applications in food, medicine, environmental monitoring and disease treatment, in the hope of providing references and basis for further expanding the applications of g-C₃N₄ in large health areas.     

中医中药在肿瘤治疗中的应用

肿瘤学系一门研究肿瘤发生、发展、防治及临床表现的学科。在近代,肿瘤学已经经历了一百年;然而,与其它学科相比,肿瘤学仍是一门年轻的学科。近几年来,应用中药防治肿瘤无论是在科研方面,还是在临床方面均取得了一定的进步和发展,并逐渐被越来越多中外学者青睐。对于中药来防治肿瘤,有很好的发展前景,本文结合实践从以下几个方面谈谈中药在肿瘤治疗中的应用。     

Treatment of Alzheimer's disease with small-molecule photosensitizers

Alzheimer’s disease is a neurodegenerative disease that signals for excess β-amyloid(Aβ) aggregation.Although people have made great attempts to control the aggregation of Aβ, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer’s disease, this pape...     

Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a rare but progressive and currently incurable disease, which is characterized by vascular remodeling in association with muscularization of the arterioles, medial thickening and plexiform lesion formation. Despite our advanced understanding of the pathogenesis of PAH and the recent therapeutic advances, PAH still remains a fatal disease. In addition, the susceptibility to PAH has not yet been adequately explained. Much evidence points to the involvement of epigenetic changes in the pathogenesis of a number of human diseases including cancer, peripheral hypertension and asthma. The knowledge gained from the epigenetic study of various human diseases can also be applied to PAH. Thus, the pursuit of novel therapeutic targets via understanding the epigenetic alterations involved in the pathogenesis of PAH, such as DNA methylation, histone modification and microRNA, might be an attractive therapeutic avenue for the development of a novel and more effective treatment. This review provides a general overview of the current advances in epigenetics associated with PAH, and discusses the potential for improved treatment through understanding the role of epigenetics in the development of PAH.     

Potential of Ramalin and Its Derivatives for the Treatment of Alzheimer’s Disease

The pathogenesis of Alzheimer’s disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, Ramalina terebrata), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.     

An Overview of Peptide-Based Molecules as Potential Drug Candidates for Multiple Sclerosis

Multiple sclerosis (MS) belongs to demyelinating diseases, which are progressive and highly debilitating pathologies that imply a high burden both on individual patients and on society. Currently, several treatment strategies differ in the route of administration, adverse events, and possible risks. Side effects associated with multiple sclerosis medications range from mild symptoms, such as flu-like or irritation at the injection site, to serious ones, such as progressive multifocal leukoencephalopathy and other life-threatening events. Moreover, the agents so far available have proved incapable of fully preventing disease progression, mostly during the phases that consist of continuous, accumulating disability. Thus, new treatment strategies, able to halt or even reverse disease progression and specific for targeting solely the pathways that contribute to the disease pathogenesis, are highly desirable. Here, we provide an overview of the recent literature about peptide-based systems tested on experimental autoimmune encephalitis (EAE) models. Since peptides are considered a unique therapeutic niche and important elements in the pharmaceutical landscape, they could open up new therapeutic opportunities for the treatment of MS.