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1.
M. Judith Percino Víctor M. Chapela Enrique Pérez-Gutiérrez Margarita Cerón Guillermo Soriano 《Chemical Papers》2011,65(1):42-51
The Knoevenagel condensation between aldehydes and substrates with active methylene groups was applied to synthesise a series
of 3-(4-substituted phenyl)-2-arylacrylonitriles (aryl = phenyl or pyridyl). Chloro-, fluoro-, or dimethylamino-substituted
aryls and a cyano group attached to the double bond of acrylonitrile were studied. Previous studies showed that the condensation
products were E isomers. The compounds synthesised were: 3-(4-chlorophenyl)-2-phenylacrylonitrile, 3-(4-chlorophenyl)-2-(pyridin-2-yl)acrylonitrile,
3-(4-chlorophenyl)-2-(pyridin-3-yl)acrylonitrile, 3-(4-chlorophenyl)-2-(pyridin-4-yl)acrylonitrile, 3-(4-fluorophenyl)-2-phenylacrylonitrile,
3-(4-fluorophenyl)-2-(pyridin-2-yl)acrylonitrile, 3-(4-fluorophenyl)-2-(pyridin-3-yl)acrylonitrile, 3-(4-fluorophenyl)-2-(pyridin-4-yl)acrylonitrile,
3-(4-dimethylaminophenyl)-2-phenylacrylonitrile, 3-(4-dimethylaminophenyl)-2-(pyridin-2-yl)acrylonitrile, 3-(4-dimethylaminophenyl)-2-(pyridin-3-yl)acrylonitrile,
and 3-(4-dimethylaminophenyl)-2-(pyridin-4-yl)acrylonitrile. Structures were confirmed by IR, MS, and NMR spectral data. Molar
absorption coefficient, absorbance, and fluorescence emission spectra were compared in order to evaluate the effects of substituents
on phenyl and the position of nitrogen in pyridine moiety on the electronic properties of acrylonitrile derivatives prepared. 相似文献
2.
Rita Vaickelionienė Vytautas Mickevičius Gema Mikulskienė Maryna Stasevych Olena Komarovska-Porokhnyavets Volodymyr Novikov 《Research on Chemical Intermediates》2011,37(8):1009-1027
N′-(4-Oxo-1,4-dihydronaphthalen-1-ylidene)-1-phenyl-5-oxopyrrolidine-3-carbohydrazides and N′-(3-methyl-4-oxo-1,4-dihydronaphthalen-1-ylidene)-1-phenyl-5-oxopyrrolidine-3-carbohydrazides were synthesized by reactions
of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with 1,4-naphthoquinone or 2-methyl-1,4-naphthoquinone. The alkylated analogues
of the above products were obtained using ethyl iodide. The interaction of 5-oxo-1-phenylpyrrolidine-3-carbohydrazides with
2,3-dichloro-1,4-naphthoquinone was followed by formation of N′-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-1-phenyl-5-oxopyrrolidine-3-carbohydrazides. All these compounds were characterized
using 1H, 13C NMR, IR and mass spectra. Some of the new compounds were tested for the antimicrobial and antifungal activity. 相似文献
3.
Ingrida Tumosien? Zigmuntas Jonas Beresnevi?ius 《Monatshefte für Chemie / Chemical Monthly》2009,43(9):1523-1528
Abstract
Reaction of 3,3′-[(4-alkoxyphenyl)imino]bis(propanoic acid hydrazides) with CS2 in alkaline solution and subsequent acidification gave 5,5′-[[(4-alkoxyphenyl)imino]diethane-2,1-diyl]bis(1,3,4-oxadiazole-2(3H)-thiones). The same dihydrazides on reaction with phenyl isocyanates or phenyl isothiocyanates were converted to bis[N′-(phenylaminocarbonyl)propanoic acid hydrazides] and bis[N′-(phenylaminocarbonothioyl)propanoic acid hydrazides], which underwent cyclization in alkaline medium to produce 5,5′-[[(4-alkoxyphenyl)imino]diethane-2,1-diyl]bis(4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-ones) and their 3-thio analogues, whereas in sulfuric acid or POCl3 5,5′-[[(4-alkoxyphenyl)imino]diethane-2,1-diyl]bis(N-phenyl-1,3,4-oxadiazol-2-amines) and 5,5′-[[(4-alkoxyphenyl)imino]diethane-2,1-diyl]bis(N-phenyl-1,3,4-thiadiazol-2-amines) were obtained. 相似文献4.
Summary. The reaction of alkoxycarbonyl- and cyanomethylene(triphenyl)phosphoranes with 3,3-diphenylindan-1,2-dione in dry benzene
at room temperature for about 5 h led to the formation of a mixture of (E)- and (Z)-diastereomers. On the other hand, treatment of the dione with acetylmethylene(triphenyl)phosphorane afforded a mixture of
(E)-3,3-diphenyl-1-(2-oxo-2-methylethylidene)indan-2-one and unexpected product (E)-3-(3,3-diphenyl-2-oxoindan-1-ylidene)-4-(triphenyl-λ5-phosphanylidene)hexane-2,5-dione, whereas with benzoylmethylene(triphenyl)phosphorane gave a mixture of (E)-3,3-diphenyl-1-(2-oxo-2-phenylethylidene)indan-2-one, [(2R
*,3S
*)-3-benzoyl-8,8-diphenyl-3,8-dihydro-2H-indeno{2,1-b}furan-2-yl]phenylmethanone and 1,4-diphenyl-2-(3,3-diphenyl-2-hydroxy-3H-inden-1-yl)but-2-ene-1,4-dione. The reaction mechanisms are considered and structural assignments of the new compounds are
based on spectroscopic evidence. The molecular structures of the two diastereomers and the unexpected product were elucidated
by X-ray crystallography. 相似文献
5.
The reaction of alkoxycarbonyl- and cyanomethylene(triphenyl)phosphoranes with 3,3-diphenylindan-1,2-dione in dry benzene
at room temperature for about 5 h led to the formation of a mixture of (E)- and (Z)-diastereomers. On the other hand, treatment of the dione with acetylmethylene(triphenyl)phosphorane afforded a mixture of
(E)-3,3-diphenyl-1-(2-oxo-2-methylethylidene)indan-2-one and unexpected product (E)-3-(3,3-diphenyl-2-oxoindan-1-ylidene)-4-(triphenyl-λ5-phosphanylidene)hexane-2,5-dione, whereas with benzoylmethylene(triphenyl)phosphorane gave a mixture of (E)-3,3-diphenyl-1-(2-oxo-2-phenylethylidene)indan-2-one, [(2R
*,3S
*)-3-benzoyl-8,8-diphenyl-3,8-dihydro-2H-indeno{2,1-b}furan-2-yl]phenylmethanone and 1,4-diphenyl-2-(3,3-diphenyl-2-hydroxy-3H-inden-1-yl)but-2-ene-1,4-dione. The reaction mechanisms are considered and structural assignments of the new compounds are
based on spectroscopic evidence. The molecular structures of the two diastereomers and the unexpected product were elucidated
by X-ray crystallography. 相似文献
6.
I. V. Dyachenko V. D. Dyachenko E. B. Rusanov 《Russian Journal of Organic Chemistry》2007,43(1):83-89
Knoevenagel condensation of N-hetaryl-substituted cyanoacetamides with aldehydes gave the corresponding (E)-N-hetaryl-2-cyanoacrylamides which were converted into (E)-N-alkyl-N-hetaryl-2-cyanoacrylamides and 6-amino-2-oxo-4-phenyl-1-(pyridin-2-yl)-1,2-dihydropyridine-3,5-dicarbonitriles. The structure
of (E)-N-(pyridin-2-yl)-2-cyano-3-phenylprop-2-enamide was determined by X-ray analysis.
Original Russian Text ? I.V. Dyachenko, V.D. Dyachenko, E.B. Rusanov, 2007, published in Zhurnal Organicheskoi Khimii, 2007,
Vol. 43, No. 1, pp. 81–86. 相似文献
7.
A. V. Velikorodov A. K. Kuanchalieva O. L. Titova 《Russian Journal of Organic Chemistry》2010,46(7):1060-1065
Oximation of indoles having a methoxycarbonylamino group on C5 and an acyl group on C3 with hydroxylamine hydrochloride in the presence of pyridine gave the corresponding oximes. The reduction of the 3-C=O group
with sodium tetrahydridoborate in the presence of sodium hydroxide was accompanied by removal of the methoxycarbonyl group
at the pyrrole nitrogen atom with formation of racemic alcohols. 1,4-Addition of 1-(pyridin-3-yl)butane-1,3-dione to dimethyl
1,4-benzoquinone diimine N,N′-dicarboxylate in dioxane in the presence of sodium methoxide, followed by heating in boiling 22% hydrochloric acid, afforded
methyl 2-methyl-5-(methoxycarbonylamino)-3-(pyridin-3-ylcarbonyl)-1H-indole-1-carboxylate. 3-(Dimethylamino)-1-(4-methyl-1,2,5-oxadiazol-3-yl)prop-2-en-1-one reacted with N,N′-bis(methoxycarbonyl)- and N,N′-bis(phenylsulfonyl)-1,4-benzoquinone diimines in methylene chloride and acetic acid, respectively, in the presence of BF3 · Et2O to produce indoles having a 1,2,5-oxadiazolylcarbonyl group on C3. 相似文献
8.
L. V. Batog V. Yu. Rozhkov E. V. Shatunova M. I. Struchkova 《Russian Chemical Bulletin》2008,57(1):165-169
Methods for the synthesis of 4-amino-4′-R-3,3′-(NNO)-azoxy-1,2,5-oxadiazoles (amino-azoxyfurazans) with 4-nitro-1,2,3-triazol-1-yl
and 1,2,3-triazolo[4,5-c]furazan-5-yl substituents (R) by cycloaddition of morpholinonitroethylene to 4′-amino-4-azido-3,3′-(ONN)-azoxyfurazan or
oxidative condensation of 3-R-4-aminofurazans with 4-trifluoroacetylamino-3-nitrosofurazan were elaborated. Related polycyclic
azo derivatives were also synthesized.
For preliminary communication, see Ref. 1.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 159–163, January, 2008. 相似文献
9.
Matthew L. Milling Jermaine Cooley Dmitriy V. Liskin Edward J. Valente 《Structural chemistry》2009,20(6):969-973
Abstract
Oxidation of 1,4-bis(4′-oxo-2′,2′-dimethylpent-2-yl)benzene with hypochlorite produces 1,4-bis(3′-carboxy-2′-methylbut-2-yl)benzene and 3-(4′-carboxyphenyl)-3,3-dimethylpropanoic acid. Cyclization of this mixture forms 3,3,7,7-tetramethyl-1,2,3,5,6,7-hexahydro-s-indacen-1,5-dione, 3,3,7,7-tetramethyl-1,2,3,5,6,7-hexahydro-as-indacen-1,5-dione (5) and 6-carboxy-3,3-dimethyl-1-indanone (6). Ketoacid (6) is converted to the arylpyran pseudoacid 7-carboxy-3-hydroxy-4,4-dimethylisobenzopyran-1-one (7). In the crystal structure of (7), carboxylic acid and the pseudoacid groups each form complementary dimer hydrogen bonds linking the molecules in chains. Contact O···O distances reflect their differing energetics, with pseudoacyl O···O at 2.78(1)Å and carboxylic O···O at 2.62(1)Å. 相似文献10.
V. V. Shchepin D. V. Uzun Yu. G. Stepanyan P. S. Silaichev M. I. Vakhrin 《Russian Journal of Organic Chemistry》2007,43(7):995-997
Zinc enolates derived from 1-aryl-2,2-dibromoalkanones reacted with tetramethyl 2,2′-(1,4-phenylenedimethylidene)dimalonate, dimethyl 3,3′-(1,4-phenylene)bis(2-cyanoacrylate), and 2,2′-(1,4-phenylenedimethylidene)bis(malononitrile) to give, respectively, tetramethyl 3,3′-(1,4-phenylene)bis(2-alkyl-2-aroylcyclopropane-1,1-dicarboxylates), dimethyl 3,3′-(1,4-phenylene)bis(2-alkyl-2-aroyl-1-cyanocyclopropane-1-carboxylates), and 3,3′-(1,4-phenylene)bis(2-alkyl-2-aroylcyclopropane-1,1-dicarbonitriles) as a single stereoisomer. 相似文献
11.
Armando Castillo Paulina Ceballos Pilar Santos Margarita Cern Perumal Venkatesan Enrique Prez-Gutirrez Martha Sosa-Rivadeneyra Subbiah Thamotharan Maxime A. Siegler María Judith Percino 《Molecules (Basel, Switzerland)》2021,26(6)
The compounds I (Z)-2-(phenyl)-3-(2,4,5-trimethoxyphenyl)acrylonitrile with one side (2,4,5-MeO-), one symmetrical (2Z,2′Z)-2,2′-(1,4-phenylene)bis(3-(2,4,5-trimethoxyphenyl)acrylonitrile), II (both sides with (2,4,5-MeO-), and three positional isomers with pyridine (Z)-2-(pyridin-2- 3, or 4-yl)-3-(2,4,5-trimethoxyphenyl)acrylonitrile, III–V were synthetized and characterized by UV-Vis, fluorescence, IR, H1-NMR, and EI mass spectrometry as well as single crystal X-ray diffraction (SCXRD). The optical properties were strongly influenced by the solvent (hyperchromic and hypochromic shift), which were compared with the solid state. According to the solvatochromism theory, the excited-state (μe) and ground-state (μg) dipole moments were calculated based on the variation of Stokes shift with the solvent’s relative permittivity, refractive index, and polarity parameters. SCXRD analyses revealed that the compounds I and II crystallized in the monoclinic system with the space group, P21/n and P21/c, respectively, and with Z = 4 and 2. III, IV, and V crystallized in space groups: orthorhombic, Pbca; triclinic, P-1; and monoclinic, P21 with Z = 1, 2, and 2, respectively. The intermolecular interactions for compounds I–V were investigated using the CCDC Mercury software and their energies were quantified using PIXEL. The density of states (DOS), molecular electrostatic potential surfaces (MEPS), and natural bond orbitals (NBO) of the compounds were determined to evaluate the photophysical properties. 相似文献
12.
Ruthenium complexes( 1 – 3 ) have been synthesized using pincer-type ligands L1 = (E)-2-((2-phenyl-2-(pyridin-2-yl)hydrazono)methyl)pyridine, L2 = (E)-2-(1-phenyl-2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)pyridine, L3 = (E)-2-(phenyl(2-phenyl-2-(pyridin-2-yl)hydrazono) methyl)pyridine. The molecular structures of all the complexes 1 , 2 and 3 were determined by using single crystal X-ray diffraction. These complexes showed excellent catalytic activities such as transfer hydrogenation and alcohol oxidation. Theoretical calculations have been performed to understand the electronic properties of all the complexes using B3LYP as a function and LANL2DZ as a basis set. 相似文献
13.
Wael A. El-Sayed Mohamed I. Hegab Hala E. M. Tolan Adel A.-H. Abdel-Rahman 《Monatshefte für Chemie / Chemical Monthly》2008,139(9):1055-1060
A series of new N- and S-substituted 1,3,4-oxadiazole derivatives were synthesized. 5-Pyridin-3-yl-3-[2-(5-thioxo-4,5-dihydro-l,3,4-thiadiazol-2-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione and 5-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)methyl]-N-phenyl-1,3,4-thiadiazol-2-amine were formed by cyclization of 3-(5-pyridin-3-yl-2-thioxo-1,3,4-oxadiazol-3(2H)-ylpropanimidohydrazide and 2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)thio]thiosemicarbazide with CS2 and H2SO4. On the other hand, a number of new bicyclic 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were synthesized. 6-Pyridin-3-ylbis[1,2,4]‐triazolo[3,4-b:4′,3′-d][1,3,4]thiadiazole-3(2H)-thione was synthesized by reaction of 6-(hydrazino)-3-pyridine-3-yl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole with CS2/KOH/EtOH. The structures of the newly synthesized compounds were elucidated by the spectral and analytical data IR, Mass, and 1H NMR spectra.
Correspondence: Adel A.-H. Abdel-Rahman, Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam,
Egypt; Wael A. El-Sayed, National Research Centre, Department of Photochemistry, Cairo, Egypt. 相似文献
14.
█tl="American"█The synthesis of the three N,N′-di(4-coumaroyl)tetramines, i.e., of (E,E)-N-{3-[(2-aminoethyl)amino]propyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(ethane-1,2-diyl)bis[prop-2-enamide] ( 1a ), (E,E)-N-{4-[(2-aminoethyl)amino]butyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(ethane-1,2-diyl)bis[prop-2-enamide] ( 1b ), and (E,E)-N-{6-[(2-aminoethyl)amino]hexyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(ethane-1,2-diyl)bis[prop-2-enamide] ( 1c ), is described. It proceeds through stepwise construction of the symmetric polyamine backbone including protection and deprotection steps of the amino functions. Their behavior on TLC in comparison with that of 1,4-di(4-coumaroyl)spermine (=(E,E)-N-{4-[(3-aminopropyl)amino]butyl}-3,3′-bis(4-hydroxyphenyl)-N,N′-(propane-1,3-diyl)bis[prop-2-enamide]; 2 ) is discussed. 相似文献
15.
Natalia Fridman Moshe Kapon Yana Sheynin Menahem Kaftory 《Journal of inclusion phenomena and macrocyclic chemistry》2006,54(3-4):153-157
1,3-Benzenediamine,N,N′-bis(4,6-dichloro-1,3,5-triazine-2-yl) and 1,3,5-Triazine,2,2′-[2-methyl-1,3-phenylenebis(oxy)] bis(4,6-dichloro) were synthesized as host molecules. The inclusion compound of 1,3-Benzenediamine,N,N′-bis(4,6-dichloro-1,3,5-triazine-2-yl) crystallizes in the monoclinic crystal system in space group C2/c. The host molecule occupies the space group 2-fold special position and packed in the crystal lattice in such a manner as to leave channels running along the c axis of a rectangular cross-section. It crystallizes with two molecules of acetone that are hydrogen bonded to the amino nitrogen atoms. Molecules of 1,3,5-Triazine,2,2′-[2-methyl-1,3-phenylene bis(oxy)]bis(4,6-dichloro) are packed in the crystal in such a manner as to leave channels of a trapezoid cross-section that are running along the a axis. Guest molecules such as metanol, ethanol, and ethyl acetate can be used to fill the channels. The crystal structures of two inclusion compounds are described. 相似文献
16.
A. V. Gutov E. B. Rusanov L. V. Chepeleva S. G. Garasevich A. B. Ryabitskii A. N. Chernega 《Russian Journal of General Chemistry》2009,79(7):1513-1518
Alkylation of 1,4-bis[2-(pyridin-4-yl)ethenyl]benzene with alkyl p-toluenesulfonates and dimethyl sulfate gave new viologen analogs, 1-alkyl-4-(2-{4-[2-(1-alkylpyridinium-4-yl)ethenyl]phenyl}ethenyl)-pyridinium
bis(p-toluenesulfonates) and sulfate. Their derivatives with tetrafluoroborate and tetraphenylborate ions were also obtained. Spectral
properties of the synthesized compounds were examined, and their structure was determined by X-ray analysis. 相似文献
17.
Masoud Salavati-Niasari Noshin Mir 《Journal of inclusion phenomena and macrocyclic chemistry》2007,59(3-4):223-230
New square-planar bis(macrocyclic)dicopper(II) complexes containing phenylene bridges between 16-membered pentaaza macrocyclic
subunits have been synthesized via in-situ one pot template condensation reaction (IOPTCR) of aromatic nitrogen-nitrogen linker (R = 1,4-phenylenediamine; benzidine;
4,4′-diaminodiphenylmethane; 4,4′-diaminodiphenylether; 4,4′-diaminodiphenylsulfone), formaldehyde, bis(1,3-diaminopropane)copper(II)
perchlorate and 1,3-dibromopropane in a 1:4:2:2 molar ratio results in the formation of new series of binuclear copper(II)
complexes; 1-phenyl- (1); 1,1′-phenyl- (2); 1,1′-diphenylmethan- (3); 1,1′-diphenylether- (4); 1,1′-diphenylsulfone- (5) bis(1,3,7,11,15-pentaazacyclohexadecane)copper(II)), {[Cu([16]aneN5)]2R}(ClO4)4″. The formation of the macrocyclic framework and the mode of bonding of the complexes have been confirmed by data obtained
from elemental analyses, UV-visible, FT-IR, 1H-NMR, electronic spectral studies, conductivity and magnetic susceptibility measurements. These bis(macrocyclic) complexes
catalyzed efficiently the selective oxidation of tetrahydrofuran into tetrahydrofuran-2-one and a small amount of tetrahydrofuran-2-ol
and 4-hydroxybutyraldehyde using dil. H2O2 as the oxidant. 相似文献
18.
Thermal decomposition of 2,4,6-trimethylphenyl and (+)-2′-methoxy-1,1′-binaphthalen-2-yl (4-methylphenylsulfonyl)azidimidocarbonates
in the presence of norbornene, methyl acrylate, and camphene was studied. (+)-2′-Methoxy-1,1′-binaphthalen-2-yl (4-methylphenylsulfonyl)azidimidocarbonate
reacted with norbornene to give (+)-exo-2′-methoxy-1,1′-binaphthalen-2-yl N-(4-methylphenylsulfonyl)-3-azatricyclo-[3.2.1.02,4]octane-3-carboximidoate, while in the reaction with methyl acrylate a mixture of stereoisomeric methyl 1-[(2′-methoxy-1,1′-binaphthalen-2-yloxy)(4-methylphenylsulfonylimino)methyl]aziridine-2-carboxylates
was obtained. The reaction of 2,4,6-trimethylphenyl (4-methylphenylsulfonyl)azidimidocarbonate with (−)-camphene involved
insertion of intermediate nitrene into the exocyclic double bond with formation of 2,4,6-trimethylphenyl N-(3,3-dimethylbicyclo[2.2.1]heptan-2-ylidenemethyl)-N′-(4-methylphenylsulfonyl)-imidocarbamate as a 3: 1 mixture of E,E and E,Z diastereoisomers in good yield.
Published in Russian in Zhurnal Organicheskoi Khimii, 2008, Vol. 44, No. 10, pp. 1495–1500.
The text was submitted by the authors in English. 相似文献
19.
Schiff base derivatives have gained great importance due to revealing a great number of biological properties. Schiff bases were synthesized by treatment of 4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one ( 1 ) with various aldehydes in methanol at reflux. In addition, diamine was reacted with an aldehyde to yield the corresponding Schiff bases. The structures of synthesized Schiff bases were elucidated by spectroscopic methods such as microanalysis, 1H-NMR, 13C-NMR, and FTIR. Antioxidant activities of synthesized Schiff bases were carried out using different antioxidant assays such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH•) scavenging, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, and reducing power activity. (E)-4-((1H-indol-3-yl)methyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one ( 3 ), (E)-1,5-dimethyl-4-((2-methyl-1H-indol-3-yl)methyleneamino)-2-phenyl-1H-pyrazol-3(2H)-one ( 5 ), (E)-1,5-dimethyl-2-phenyl-4-(thiophen-2-ylmethyleneamino)-1H-pyrazol-3(2H)-one ( 7 ), (E)-1,5-dimethyl-2-phenyl-4-(quinolin-2-ylmethyleneamino)-1H-pyrazol-3(2H)-one ( 9 ), (1S,2S,N1,N2)-N1,N2-bis((1H-indol-3-yl)methylene)cyclohexane-1,2-diamine ( 11 ), and (1S,2S,N1,N2)-N1,N2-bis((2-methyl-1H-indol-3-yl)methylene)cyclohexane-1,2-diamine ( 12 ) were synthesized in high yields. Compound 5 displayed a good ABTS•+ activity. Compound 3 revealed the outstanding activity in all assays. Compound 7 has the best-reducing power ability in comparison to other synthesized compounds. Although compounds 5, 11, 12 are new, compounds 3, 7, 9 are known. Due to revealing a good antioxidant activity, the synthesized compounds ( 3, 5, 7 ) have the potential to be used as synthetic antioxidant agents. 相似文献
20.
Simonov A. Yu. Lakatosh S. A. Luzikov Yu. N. Reznikova M. I. Preobrazhenskaya M. N. 《Russian Chemical Bulletin》2010,59(7):1442-1450
A dialkylaminomethylation reaction (the Mannich reaction) of 3,4-bis(indol-l-yl)-maleimides and 3-(indol-l-yl)-4-(indolin-l-yl)maleimides
leads to mono- and di(dimethyl-amino) derivatives at position 3 of one or two indole rings. A series of 3,4-bis(indol-l-yl)-maleimides
and 3-(indol-l-yl)-4-(indolin-l-yl)maleimides containing ω-hydroxyalkyloxy-methyl substituents at position 3 of the indole
ring was obtained by the reaction of iodomethyl-ates of these compounds with ethylene glycol and other 6h,ω-alkanediols. The
reaction of quaternary salts of bis(3-dimethylaminomethylindol-l-yl)maleimides with 6h,ω-alkanediols resulted in the isolation
of 3,4-bis(3-ω-hydroxyalkyloxymethylindol-l-yl)maleimides. Upon heating iodomethylate of 3-(3-dimethylaminoindol-l-yl)-4-(indolin-l-yl)maleimide
in pyridine, 5,6-dihydro-10-methyl-H-indolo[l′,7a′,7′:4,5,6]pyrrolo[3′,4′:2,3]-[l,4]diazepino[l,7-a]-indole-l,3(2H)-dione was obtained due to the intramolecular alkylation and formation of the bond between position 2 of the
indole and position 7 of the indoline rings. 相似文献