手性2-噁唑烷酮的无溶剂合成法

手性2-噁唑烷酮的无溶剂合成法;手性氨基醇;脲;手性噁唑烷酮     

3-丙酰基-2,5-二芳基-1,3,4-噁唑啉类化合物的合成

3-丙酰基-2;5-二芳基-1;3;4-噁唑啉类化合物的合成;噁唑啉;衍生物;合成;结构表征     

二氧化碳合成杂环噁唑烷酮的研究进展（英文）

二氧化碳捕获和利用(CCU)是目前降低大气中二氧化碳浓度的最好方法之一,而且具有很好的发展前景。在此基础上人们探究了以CO₂为碳源合成有机化合物的方法。噁唑烷酮分子通常被应用于合成一些药物,并且在有机合成中也具有重要的意义,其合成方法近年来层出不穷,以二氧化碳为碳源的方法更是吸引了诸多研究工作者。早期人们利用二氧化碳和氮丙啶进行环加成反应,使用碱金属、Cr、Al等金属催化剂来提高反应的收率。考虑到成本和绿色合成的原则,选用廉价易得的离子液体或者不使用催化剂的方法更适合大规模的生产。除此之外,二氧化碳还可以和2-氨基醇等化合物在不同反应条件下得到优良甚至极好的产率。因此,本工作对近几年通过二氧化碳分别和氮丙啶、2-氨基醇、不饱和胺以及1, 2-二卤代烃反应合成噁唑烷酮的方法进行了总结和概述。     

5-芳氧甲基-2-噁唑烷酮的合成及表征

环氧氯丙烷;氯甲基噁唑烷酮;合成;芳氧甲基噁唑烷酮     

一种有效合成3-芳基-4-氟烷基-2-噁唑烷酮的方法

报道了一种方便有效地合成3-芳基-4-氟烷基-2-噁唑烷酮的方法.用芳基胺作为起始原料通过与氯甲酸烯丙基酯反应以95.8%～99.5%的收率得到芳基氨基甲酸烯丙基酯.芳基氨基甲酸烯丙基酯与氟烷基碘在乙腈和水的混合液中由连二亚硫酸钠引发在室温下发生自由基加成反应得到氟烷基化的加成产物.加成产物在碱性条件下发生分子内的N-环合反应得到3-芳基-4-氟烷基-2-噁唑烷酮.整个反应都在室温下进行,并且没有用到光气合成了3-芳基-4-氟烷基-2-噁唑烷酮,该方法具有原料易得,条件温和,绿色环保的优点.     

噁唑烷酮环氧树脂的研究进展

含噁唑烷酮结构的树脂具有优良的耐热性、电性能及物理机械性能等。将噁唑烷酮环引入环氧树脂,可提高固化物的玻璃化转变温度、粘结性、介电性和阻燃性等。本文综述了噁唑烷酮环氧树脂的一般合成方法,探讨了原料配比、反应温度、催化剂种类及用量对噁唑烷酮环氧树脂合成过程的影响,分析了固化剂与噁唑烷酮环氧树脂固化产物性能之间的联系,对噁唑烷酮环氧树脂在绝缘材料、涂料、粘合剂、印刷电路板以及高性能树脂基体等领域的应用情况进行了详细介绍,并对其发展前景予以展望。     

含噁唑烷酮基团丙烯酰单体在纤维素纤维表面的接枝反应

饮用水的水质状况与人体健康的关系十分密切,但是当前世界上的清洁水资源越来越紧缺．水的处理和净化成为人类健康的重要保障,研制一种经济、简便、实用的水处理的材料具有巨大社会效益和经济效益．     

鳗鲡肌肉冻干粉中呋喃唑酮代谢物3-氨基-2-(噁)唑烷酮残留标准物质的研制

建立了鳗鲡肌肉冻干粉中3-氨基-2-噁唑烷酮(AOZ)残留分析标准物质的研制和定值方法。以约0.16mg/L呋喃唑酮对鳗鲡进行药浴给药,使呋喃唑酮在鱼体中代谢,从而使鳗鲡肌肉中含有一定浓度的呋喃唑酮代谢物AOZ。经冻干、真空包装及辐照等处理后获得1批400个独立包装的肌肉冻干粉样本。经过均匀性与稳定性检验,由11家实验室采用同位素稀释液相色谱-串联质谱法进行协同定值,并进行了不确定度评估,已被国家质检总局批准确为国家二级标准物质。     

(S)-4-苄基-2-噁唑烷酮的合成工艺改进

以L-苯丙氨酸为原料,经还原和关环反应合成了(S)-4-苄基-2-噁唑烷酮,总收率66%,其结构经1HNMR,13C NMR和HR-MS表征。     

5-(3′-芳基-5′-噁唑烷酮基甲氧基)-3(2H)哒嗪酮类化合物的合成及生物活性

5-(3′-芳基-5′-噁唑烷酮基甲氧基)-3(2H)哒嗪酮类化合物的合成及生物活性;芳基噁唑烷酮基甲氧基哒嗪酮;合成;生物活性     

Stereoselective synthesis of 4-hydroxymethyl-1,3-oxazolidin-2-one derivatives from novel 2-hydroxymethylaziridines

A stereoselective and simple method for the synthesis of trans-2-hydroxymethyl-N-alkyl-1,3-oxazolidin-2-ones is described. The synthesis involved the reduction of trans-aziridine-2-carboxylates with LiAlH₄, followed by a ring opening and a cyclization reaction in the presence of methyl chloroformate to afford the target trans-oxazolidinones in completely regio- and stereoselective process. A plausible reaction mechanism has been proposed involving an S_N1 pathway and a detailed computational study of this mechanistic process has been carried out using theoretical calculations.     

Enzymatic Synthesis and Characterization of Novel Polycarbonates Derived from 5-Allyloxy-1, 3-dioxan-2-one and 5, 5-Dimethyl-1, 3-dioxan-2-one

Aliphatic polycarbonates and their copolymers have been used in drug controlled release system and other biomedical applications due to their good biocompatibility, favorable mechanical properties and some elasticity1, such as poly(1, 3-dioxan-2-one)2 and…     

无溶剂条件下硒酚对末端环氧化合物的开环反应及其在1,3-噁唑烷-2-酮衍生物合成中的应用

Regioselective ring-opening reactions of 1,2-epoxides with ArSeH catalyzed by Ti（O^tPr）4 under solvent-free conditions were investigated. A variety of β-hydroxyselenides were obtained in excellent yields of 90%-97% and regioselectivities by a simple, atom economic and environment-friendly procedure. Several N-tosyl- 1,3-oxazolidin-2-ones were prepared starting from the corresponding 1,2-epoxides and ArSeH by a one-pot three-step procedure.     

Efficient synthesis of new chiral 1,2-benzothiazin-3-one 1,1-dioxide derivatives via lateral lithiation of 3-N-mesitylenesulfonyl-1,3-oxazolidin-2-ones

Chiral 3-N-mesitylenesulfonyl-1,3-oxazolidin-2-ones 4a-e derived from (l)- and (d)-amino acids 1a-e undergo lateral lithiation with lithium diisopropylamide and TMEDA in anhydrous THF to provide new optically-active 1,2-benzothiazin-3-one 1,1-dioxide derivatives 5a-e with yields ranging from 63% to 79%.     

4-二甲氨基吡啶催化的1,3-二酮与3-丁炔-2-酮的苯环化反应

在4-二甲氨基吡啶(DMAP)催化下, 1,3-二酮与3-丁炔-2-酮可以区域选择性地合成四取代的苯, 该方法具有反应条件温和和操作简单等优点, 产物的结构通过IR, 1H NMR, 13C NMR, HRMS确证.     

Syntheses and Crystal Structures of Cobalt(II) Chloride Complexes of 1,3-Bis(pyridyl-4-ylthio)propan-2-one

1 INTRODUCTION Widespread interest of metal-organic coordination compounds has been stirred by their intriguing struc- tural topologies and promising properties[1]. Al- though structural motifs of coordination compounds are mainly defined by metal ions’ coordination pre- ferences and chemical structures of organic ligands including the molecular angle, length and relative orientation of the donor groups[2], numerous other factors such as solvent systems, concentration, coun- terions and e…     

Synthesis and characterization of N-3-phenyl-2-propenoyl amino acids

Three N-3-phenyl-2-propenoyl amino acids were synthesized through interaction between 3-phenyl-2-propenoyl chloride and amino acids in alkaline with a high Yield.Structure of the products were identified by elemental analysis,IR and NMR spectroscopy.     

Baylis-Hillman Reactions of Sulfonyl Aldimines or Aryl Aldehydes with 3-Methylpenta-3,4-dien-2-one or 3-Benzylpenta-3,4-dien-2-one

The attempted Baylis-Hillman reactions of sulfonyl aldimines or aryl aldehydes with 3-methylpenta-3,4-dien-2-one or 3-benzylpenta-3,4-dien-2-one gave the corresponding Baylis-Hillman adducts in moderate yields in DMSO under the catalysis of DBU or PMe3, respectively. Moderate diastereoselectivities were observed in the reaction of 3-benzylpenta-3,4-dien-2-one with N-arylmethylidene-1-naphthalenesulfonamides catalyzed by chiral catalyst cinchona alkaloid derivative TQO {4-（3-ethyl-4-oxa-1-azatricyclo[4.4.0.0^3,8]dec-5-yl）quinolin-6-ol}.     

合成3-苯甲酰胺基-6-甲基-2-吡喃酮衍生物的新方法

以马尿酸、原甲酸三乙酯和乙酰乙酸乙酯或乙酰丙酮为原料,合成了两个3-苯甲酰胺基-6-甲基-2-吡喃酮衍生物(总产率66％)和一个新化合物——3-苯甲酰胺基-5-羟乙基-6-甲基-2-吡喃酮(总产率42％),其结构经1H NMR和13C NMR表征.