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1.
Deoxyribozyme-based logic gates 总被引:14,自引:0,他引:14
Stojanovic MN Mitchell TE Stefanovic D 《Journal of the American Chemical Society》2002,124(14):3555-3561
We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout. 相似文献
2.
Andréasson J Straight SD Kodis G Park CD Hambourger M Gervaldo M Albinsson B Moore TA Moore AL Gust D 《Journal of the American Chemical Society》2006,128(50):16259-16265
One molecule acts as both an AND and an XOR Boolean logic gate that share the same two photonic inputs. The molecule comprises a half-adder, adding two binary digits with only light as inputs and outputs, and consists of three covalently linked photochromic moieties, a spiropyran and two quinoline-derived dihydroindolizines. The AND function is based on the absorption properties of the molecule, whereas the XOR function is based on an off-on-off response of the fluorescence to the inputs that results from interchromophore excited-state quenching interactions. The half-adder is simple to operate and can be cycled many times. 相似文献
3.
Andréasson J Kodis G Terazono Y Liddell PA Bandyopadhyay S Mitchell RH Moore TA Moore AL Gust D 《Journal of the American Chemical Society》2004,126(49):15926-15927
A molecule-based binary half-adder with optical inputs and outputs has been demonstrated. The half-adder consists of two photochromic organic molecules in solution and a third-harmonic-generating crystal. One substance acts as an AND Boolean logic gate and the other as an XOR gate. Inputs are laser pulses at 1064 or 532 nm that initiate photoisomerization reactions. Outputs are the optical absorbance of a fullerene radical anion (AND gate) and fluorescence of a porphyrin (XOR gate). The system carries out binary addition based on the laser input pulses. Half-adders in combination are capable of carrying out all mathematical operations necessary for digital computing. 相似文献
4.
Stojanovic MN Semova S Kolpashchikov D Macdonald J Morgan C Stefanovic D 《Journal of the American Chemical Society》2005,127(19):6914-6915
A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage. 相似文献
5.
This work demonstrates two DNA-based logic circuits that behave as a half-adder and a half-subtractor. A half-adder is composed of an AND gate and an XOR gate, whereas a half-subtractor consists of an INH gate and an XOR gate. The proposed designs are inspired by molecular beacons. 相似文献
6.
A new redox molecule-based half-adder with tetrathiafulvalene (TTF) was reported for the first time. This half-adder employs electrochemical and chemical oxidations (NOPF6) as input signals and absorbances at 350 and 435 nm as output signals. It is interesting to note that this new molecule-based half-adder shows reset capability by making use of the unique redox behaviors of TTF. 相似文献