共查询到20条相似文献,搜索用时 15 毫秒
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Dongfei Liu Cristina Rodríguez Bernuz Jin Fan Wei Li Alexandra Correia Jouni Hirvonen Hélder A. Santos 《Advanced functional materials》2017,27(9)
An advanced approach that can prepare narrowly size distributed nanomaterials with ultrahigh mass fraction of therapeutics, superior colloidal stability, minimal off‐target effects, as well as precisely controlled drug‐release profiles, is strongly desirable. Here, an optimal nano‐in‐nano vector, consisting of a drug (sorafenib, SFN, or itraconazole, ICZ) nanocrystal core and a polymer (folic acid conjugated spermine‐functionalized acetalated dextran, ADS‐FA) shell on a 1:1 ratio (HSFN@ADS‐FA or ICZ@ADS‐FA) is successfully fabricated. With the help of computational fluid dynamics, the concentration and velocity field are computed in the microfluidic domain, as well as the mixing time between the solvent and nonsolvent for nanovector precursors. The favorable features of both polymer nanoparticles and drug nanocrystals are inherited by the obtained nano‐in‐nano vector, showing ultrahigh drug‐loading degree, biodegradability, pH‐responsive fast dissolution, high stability in serum, and ease of surface functionalization. Furthermore, the half‐maximal inhibitory concentration value of the nano‐in‐nano HSFN@ADS‐FA is ≈54 times lower than the conventional nanovector (LSFN@ADS‐FA) with a low drug‐loading degree. Overall, this nano‐in‐nano vector merges the best of polymeric nanoparticles and drug nanocrystals. 相似文献
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Cancer Treatment: Biocompatible,Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo (Adv. Funct. Mater. 17/2014) 下载免费PDF全文
Quan Zhang Xiaoling Wang Pei‐Zhou Li Kim Truc Nguyen Xiao‐Jun Wang Zhong Luo Huacheng Zhang Nguan Soon Tan Yanli Zhao 《Advanced functional materials》2014,24(17):2413-2413
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Drug Delivery: Virus‐Inspired Mimics Based on Dendritic Lipopeptides for Efficient Tumor‐Specific Infection and Systemic Drug Delivery (Adv. Funct. Mater. 33/2015) 下载免费PDF全文
Zhijun Zhang Xiao Zhang Xianghui Xu Yunkun Li Yachao Li Dan Zhong Yiyan He Zhongwei Gu 《Advanced functional materials》2015,25(33):5241-5241
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Drug Delivery: ATP‐Responsive Aptamer‐Based Metal–Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs (Adv. Funct. Mater. 37/2017) 下载免费PDF全文
Wei‐Hai Chen Xu Yu Wei‐Ching Liao Yang Sung Sohn Alessandro Cecconello Anna Kozell Rachel Nechushtai Itamar Willner 《Advanced functional materials》2017,27(37)
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Sarah J. Leung Xenia M. Kachur Michael C. Bobnick Marek Romanowski 《Advanced functional materials》2011,21(6):1010-1010
Biodegradable, spectrally tunable plasmon resonant nanocapsules are created via the deposition of gold onto the surface of 100 nm diameter thermosensitive liposomes. These nanocapsules exhibit selective release of encapsulated contents upon illumination with light of a wavelength matching their distinct resonance bands. In this study, 760 and 1210 nm laser illumination elicits complete release from gold‐coated liposomes with a corresponding resonance, while causing minimal release from liposomes with an unmatching resonance. Spectrally selective release is accomplished through the use of multiple, low‐intensity laser pulses delivered over a period of minutes, ensuring that illumination affects the gold‐coated liposomes without heating the surrounding media. The use of pulsed illumination to achieve spectral selectivity is validated experimentally and through modeling of the heat equation. The result of this illumination scheme for selective release using multiple wavelengths of light is a biologically safe mechanism for realizing drug delivery, microfluidic, and sensor applications. 相似文献
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Drug Delivery: On‐Chip Fabrication of Paclitaxel‐Loaded Chitosan Nanoparticles for Cancer Therapeutics (Adv. Funct. Mater. 4/2014) 下载免费PDF全文
Fatemeh Sadat Majedi Mohammad Mahdi Hasani‐Sadrabadi Jules John VanDersarl Nassir Mokarram Shahirar Hojjati‐Emami Erfan Dashtimoghadam Shahin Bonakdar Mohammad Ali Shokrgozar Arnaud Bertsch Philippe Renaud 《Advanced functional materials》2014,24(4):418-418
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Drug Delivery: Polylactide‐block‐Polypeptide‐block‐Polylactide Copolymer Nanoparticles with Tunable Cleavage and Controlled Drug Release (Adv. Funct. Mater. 26/2014) 下载免费PDF全文
Robert Dorresteijn Nils Billecke Mischa Schwendy Sabine Pütz Mischa Bonn Sapun H. Parekh Markus Klapper Klaus Müllen 《Advanced functional materials》2014,24(26):4025-4025
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Drug Delivery: Remotely Controlled Red Blood Cell Carriers for Cancer Targeting and Near‐Infrared Light‐Triggered Drug Release in Combined Photothermal–Chemotherapy (Adv. Funct. Mater. 16/2015) 下载免费PDF全文
Xiaoqi Sun Chao Wang Min Gao Aiyan Hu Zhuang Liu 《Advanced functional materials》2015,25(16):2480-2480
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Drug Delivery: Gel–Liposome‐Mediated Co‐Delivery of Anticancer Membrane‐Associated Proteins and Small‐Molecule Drugs for Enhanced Therapeutic Efficacy (Adv. Funct. Mater. 16/2014) 下载免费PDF全文
Tianyue Jiang Ran Mo Adriano Bellotti Jianping Zhou Zhen Gu 《Advanced functional materials》2014,24(16):2258-2258
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Drug Delivery: Dendron‐Based Micelles for Topical Delivery of Endoxifen: A Potential Chemo‐Preventive Medicine for Breast Cancer (Adv. Funct. Mater. 17/2014) 下载免费PDF全文
Yang Yang Ryan M. Pearson Oukseub Lee Chan‐Woo Lee Robert T. Chatterton Jr. Seema A. Khan Seungpyo Hong 《Advanced functional materials》2014,24(17):2441-2441
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Drug Delivery: Plant‐Based Hollow Microcapsules for Oral Delivery Applications: Toward Optimized Loading and Controlled Release (Adv. Funct. Mater. 31/2017) 下载免费PDF全文
Michael G. Potroz Raghavendra C. Mundargi Jurriaan J. Gillissen Ee‐Lin Tan Sigalit Meker Jae H. Park Haram Jung Soohyun Park Daeho Cho Sa‐Ik Bang Nam‐Joon Cho 《Advanced functional materials》2017,27(31)
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Hydrogels: Supertough Hybrid Hydrogels Consisting of a Polymer Double‐Network and Mesoporous Silica Microrods for Mechanically Stimulated On‐Demand Drug Delivery (Adv. Funct. Mater. 42/2017) 下载免费PDF全文
Suji Choi Young jin Choi Moon‐Sun Jang Jung Hee Lee Ji Hoon Jeong Jaeyun Kim 《Advanced functional materials》2017,27(42)
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Sensors: 6‐Mercaptopurine‐Induced Fluorescence Quenching of Monolayer MoS2 Nanodots: Applications to Glutathione Sensing,Cellular Imaging,and Glutathione‐Stimulated Drug Delivery (Adv. Funct. Mater. 41/2017) 下载免费PDF全文
Shih‐Chiang Chen Chang‐Yu Lin Tian‐Lu Cheng Wei‐Lung Tseng 《Advanced functional materials》2017,27(41)