RING ENLARGEMENT OF N-HETEROCYCLES

ＲＩＮＧＥＮＬＡＲＧＥＭＥＮＴＯＦＮ－ＨＥＴＥＲＯＣＹＣＬＥＳ￥ＪｉａｎＷｅｉＺＨＡＮＧ；ＪｉＹｕＧＵＯ；ＸｉａｏＴｉａｎＬＩＡＮＧ（ＩｎｓｔｉｔｕｔｅｏｆＭａｔｅｒｉａＭｅｄｉｃａ．ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＭｅｄｉｃａｌＳｃｉｅｎｃｅｓ．ａ...     

STRUCTURE OF 1-EPICRASSICAUDINE

ＳＴＲＵＣＴＵＲＥＯＦ１－ＥＰＩＣＲＡＳＳＩＣＡＵＤＩＮＥ￥ＦｅｎｇＰｅｎｇＷＡＮＧ；ＸｕｅＰｉｎｇＤＡＩ；ＪｉａｎＺｈｏｎｇＷＡＮＧａｎｄＲｏｎｇＺＨＡＮＧ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙｏｆＭｅｄｉｃｉｎａｌＮａｔｕｒａｌＰｒｏｄｕｃ...     

Crystal Structure of Taxinine A

ＣｒｙｓｔａｌＳｔｒｕｃｔｕｒｅｏｆＴａｘｉｎｉｎｅＡＷＵＮａｎ；ＬＵＹａｎｇ；ＺＨＥＮＧＱｉ－Ｔａｉ；ＦＡＮＧＷｅｉ－Ｓｈｕｏ；ＴＯＮＧＸｉａｏ－Ｊｉｅ；ＦＡＮＧＱｉ－Ｃｈｅｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＭａｔｅｒｉａＭｅｄｉｃａ，ＣｈｉｎｅｓｅＡｃ...     

Study on a New Type of All-Solid-StateReference Electrode

ＳｔｕｄｙｏｎａＮｅｗＴｙｐｅｏｆＡｌｌ－Ｓｏｌｉｄ－ＳｔａｔｅＲｅｆｅｒｅｎｃｅＥｌｅｃｔｒｏｄｅＣｈａｏＬｕｎＨＵＡＮＧ；ＪｕＪｉｅＲＥＮ；ＤａＦｅｎｇＸＵ（ＤｅｐａｒｔｍｅｎｔｏｆＰｈａｒｍａｃｙ，ＨｅｂｅｉＭｅｄｉｃａｌＵｎｉｖｅｒｓｉｔｙ，...     

TERMINAL-GROUP EFFECT ON COAGGREGATION

ＴＥＲＭＩＮＡＬ－ＧＲＯＵＰＥＦＦＥＣＴＯＮＣＯＡＧＧＲＥＧＡＴＩＯＮ￥ＧｕｏＺｈｅｎＪＩ；ＸｉＬｉｎＣＵＩ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆ－ＯｒｇａｎｉｃＣｈｅｍｉｓｔｒｙ．ＡｃａｄｅｍｉａＳｉｎｉｃａ，３５４ＦｅｎｇｌｉｎＬｕ．Ｓｈａｎｇ...     

RING ENLARGEMENT OF SECURININE

ＲＩＮＧＥＮＬＡＲＧＥＭＥＮＴＯＦＳＥＣＵＲＩＮＩＮＥＪｉａｎＷｅｉＺＨＡＮＧ；ＸｉａｏＴｉａｎＬＩＡＮＧ；ＬｉＹｕＧＵＯ（ＩｎｓｔｉｔｕｔｅｏｆＭａｔｅｒｉａＭｅｄｉｃａ．ＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＭｅｄｉｃａｌＳｃｉｅｎｃｅｓ．ａｎｄＰｅｋ...     

An AM1 Study on the Mechanism of Uridine Phospborolysis

ＡｎＡＭ１ＳｔｕｄｙｏｎｔｈｅＭｅｃｈａｎｉｓｍｏｆＵｒｉｄｉｎｅＰｈｏｓｐｂｏｒｏｌｙｓｉｓＳｈａｎＲｏｎｇＺＨＡＯ；ＱｉｎＭｉＷＡＮＧ；ＫａｉＸｉａｎＣＨＥＮ；Ｓｕｏ－ＢａｏＲＯＮＧ，Ｒｕ－ＹｕｎＪＩ（ＳｈａｎｇｈａｉＩｎｓｔｉｔｕｔｅｏｆＭａｔ...     

AN AB INITIO SORBIE-MURREL POTENTIAL ENERGY SURFACE OF CARBON DISULFIDE

ＡＮＡＢＩＮＩＴＩＯＳＯＲＢＩＥ－ＭＵＲＲＥＬＰＯＴＥＮＴＩＡＬＥＮＥＲＧＹＳＵＲＦＡＣＥＯＦＣＡＲＢＯＮＤＩＳＵＬＦＩＤＥ￥ＹｕＢｉｎＷＡＮＧ；ＸｉｎＪｉＨＯＮＧ；ＺｈｅｎＹｉＷＥＮ（ＩｎｓｔｉｔｕｔｅｏｆＭｏｄｅｒｎＰｈｙｓｉｃｓ，Ｎｏｒｔｈｗｅ...     

DIOXANE-WATER MIXTURE SEPARATION BY PERVAPORATION

ＤＩＯＸＡＮＥ－ＷＡＴＥＲＭＩＸＴＵＲＥＳＥＰＡＲＡＴＩＯＮＢＹＰＥＲＶＡＰＯＲＡＴＩＯＮ￥ＧｕｉＢａｏＺＨＡＮＧ；ＫｅＤａＺＨＡＮＧ；ＪｉＰｉｎｇＸＵ（ＣｈａｎｇｃｈｕｎＩｎｓｔｉｔｕｔｅｏｆＡｐｐｌｉｅｄＣｈｅｍｉｓｔｒｙ，ＡｃａｄｅｍｉａＳｉｎ...     

SYNTHESIS OF LIQUID CRYSTALS CONTAINING THE AZA-15-CROWN-5 UNIT

ＳＹＮＴＨＥＳＩＳＯＦＬＩＱＵＩＤＣＲＹＳＴＡＬＳＣＯＮＴＡＩＮＩＮＧＴＨＥＡＺＡ－１５－ＣＲＯＷＮ－５ＵＮＩＴ￥ＷｅｉＺＨＡＯ；ＭｉｎｇＧｕｔＸＩＥ；ＱｉｎｇＪＩＡＮＧ（ＤｅｐａｒｔｍｅｎｔｏｆＣｈｅｍｉｓｔｒｙ，ＳｉｃｈｕａｎＵｎｉｖｅｒｓｉｔｙ...     

μ‐Oxo‐Dinuclear‐Iron(III)‐Catalyzed O‐Selective Acylation of Aliphatic and Aromatic Amino Alcohols and Transesterification of Tertiary Alcohols

A highly chemoselective and reactive μ‐oxo‐dinuclear iron(III) salen catalyst for transesterification was developed. The developed iron complex catalyzed acylation of aliphatic amino alcohols with nearly perfect O‐selectivity, even when using activated esters, for which chemoselectivity is more difficult to control. In addition, O‐selective transesterification of aromatic amino alcohols was achieved for the first time. The high activity of the iron complex enabled the use of sterically congested tertiary alcohols, including unprecedented tert‐butanol.     

Palladium on carbon–bromobenzene mediated esterification and transesterification

A series of carboxylic acids were converted into their corresponding esters using the Pd/C catalyzed hydrogenation conditions in the presence of catalytic bromobenzene in alcohols and the method could also be applicable for the transesterification of esters. Good to excellent yields were obtained for different aliphatic or aromatic starting materials. The success of this esterification relies on the in situ generation of hydrobromic acid (HBr) from bromobenzene which provides a mild and acidic reaction environment. The palladium catalyst exhibits a remarkable activity and is reusable for up-to three consecutive cycles.     

二元羧酸半酯与环氧化合物反应动力学研究

用于印制电路板 ( PCB)的传统的热固化或光固化阻焊油墨是利用屏印的方法把图案印刷在覆铜板上 ,然后固化 .通过这种方法得到的图案不够精细 ,应用上也受到一定限制 .为此 ,近年来国际上研制出一类新型的阻焊油墨——碱液显影型阻焊油墨 [1～ 3] .它是通过曝光、显影及后固化等步骤形成精确的图案 ,可用于制备高密度的电路板 .通常 ,碱水显影型阻焊油墨由碱溶性光敏树脂 (组分 A)、环氧化合物 (组分 B)、光引发剂、热固化剂和稀释剂组成 .组分 A由二元羧酸与含有光聚合性双键的线性酚醛型环氧化合物通过半酯化反应得到 ,羧基的引入使其具…     

不同溶剂中酶催化合成油酸酯研究初探

对几种非水溶剂中脂肪酶催化合成油酸酯 (油酸乙酯、油酸正辛酯和油酸油酯 )进行了初步考察。结果表明 ,在环己烷、正庚烷和甲苯等有机溶剂中 ,上述酯化反应都有很高的转化率 ;在所考察的实验条件下 ,超临界CO2 中反应的转化率略比上述有机溶剂中的低 ,但该结果已初步显示以超临界CO2 替代有机溶剂合成油酸酯具有很大的应用潜力。     

Bismuth(III) Triflate: A Safe and Easily Handled Precursor for Triflic Acid: Application to the Esterification Reaction

A series of carboxylic acids were converted into their corresponding methyl esters using bismuth(III) triflate as a catalyst in methanol. Good to excellent yields were obtained for different aliphatic or aromatic starting materials. In the reaction, bismuth triflate acts as a precursor that, upon hydrolysis, liberates sufficient triflic acid to catalyze the esterification.     

Silica sulfuric acid-catalyzed expeditious environment-friendly hydrolysis of carboxylic acid esters under microwave irradiation

Silica sulfuric acid was found to be an efficient, recoverable, reusable and environment-friendly catalyst for the fast hydrolysis of various carboxylic acid esters in high conversions and selectivities under microwave irradiation conditions. This protocol has the advantages of no corrosion, no environmental pollution, high reaction rate, high yield, and simple work-up procedure.     

有机相中固定化脂肪酶催化合成植物甾醇酯

酶法合成植物甾醇酯具有反应条件温和、产物纯度和产量高等优点,但非水相酶催化的活性和稳定性普遍较低.本文以大孔树脂固定化脂肪酶为催化剂,并在催化过程中添加乳糖的类似物,构建了有机相高效合成植物甾醇酯的工艺过程.以酯化率为考察指标,对脂肪酶和反应溶剂进行筛选,对酯化条件进行优化,同时考察了糖的种类及添加量对酶催化性能的影响.结果表明,大孔树脂NKA吸附固定化的褶皱假丝酵母(Candida rugosa)脂肪酶(NKA-CRL)为最适宜的催化剂,以正己烷为反应介质,在酸醇摩尔比为2和添加酶蛋白质量7.5%的海藻糖的条件下,40°C反应10 h,酯化率达到96.6%.连续6次催化后,植物甾醇的酯化率仍维持在85.0%以上.     

Nanocrystalline copper(II) oxide catalyzed aza-Michael reaction and insertion of α-diazo compounds into N-H bonds of amines

Nanocrystalline copper(II) oxide efficiently catalyzed the conjugate addition of aliphatic amines to α,β-unsaturated compounds to produce β-amino compounds with excellent yields under mild reaction conditions. Similarly, Glycine esters are obtained in good yields by the insertion of α-diazoacetate into N-H bonds of amines. The catalyst is used for three cycles with minimal loss of activity.     

Effective esterification of carboxylic acids using (6-oxo-6H-pyridazin-1-yl)phosphoric acid diethyl ester as novel coupling agents

(6-Oxo-6H-pyridazin-1-yl)phosphoric acid diethyl esters (3) are efficient and selective coupling agents for equimolar esterification of carboxylic acids and alcohols. Esterification of aliphatic and aromatic carboxylic acids with aliphatic and aromatic alcohols using 3 afforded the corresponding esters chemoselectively in good to excellent yield.     

磷钨杂多酸季铵盐催化脂肪酸甲酯环氧化

以钨酸钠、磷酸、过氧化氢H2O2和氯代十六烷基吡啶为原料制备了磷钨杂多酸季铵盐相转移催化剂.实验发现,采用乙酸乙酯溶解氯代十六烷基吡啶制备的催化剂呈颗粒状析出于油水界面,简单过滤即可分离.该催化剂与H2O2作用体系呈均相,反应速率显著加快.H2O2耗尽并降温后,催化剂以固体颗粒形式沉淀,回收率达90%,重复使用六次活性基本不变.采用FT-IR表征了反应前后催化剂结构的变化.以二氯乙烷为溶剂考察了反应条件对脂肪酸甲酯环氧化反应和H2O2利用率的影响.实验结果表明,在反应时间2.5h,催化剂0.3g,分步加入30%H2O23.5g(30.88mmol),反应温度65℃,二氯乙烷20mL,脂肪酸甲酯5.0g(双键22.84mmol)时,产品环氧值可达5.78%,双键环氧化选择性81.9%,H2O2利用率达86%.