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1.
B. P. Chelobanov P. P. Laktionov M. V. Khar"kova E. Yu. Rykova D. V. Pyshnyi I. A. Pyshnaya V. N. Silnikov V. V. Vlassov 《Russian Chemical Bulletin》2002,51(7):1204-1211
Interactions between oligodeoxyribonucleotides (ODN) with different sequences and cell proteins were examined using the affinity modification by [32P]-labeled reactive oligonucleotide derivatives. 3"-Terminal ribouridine oxidized with sodium periodate, 4-[(N-2-chloroethyl-N-methyl)amino]benzylamine, and the maleimide residue were used as reactive groups. All the compounds used are specific reagents. The set of the discovered nucleic acid-binding (NA-binding) proteins depends on the chemical properties of the affinity reagent. The presence of the hydrophobic group at the 5"-terminus of the ODN molecule is the key factor determining the variety of the discovered NA-binding proteins. The cells of different origin (A431, HeLa, KB, MCF-7, Hap-2, K562, Cos-7, NIH/3T3, human-lung primary epithelial cells, and porcine kidney primary cells) are characterized by the same set of NA-binding proteins whose affinity modifications depends on the conditions of incubation of oligonucleotides with the cells. Treatments of cells disturbing the integrity of the cellular membrane (scrapping, treatment with trypsin, or cell permeabilization with streptolysin O or saponin), disrupt interactions between NA-binding proteins from native cells and ODN. 相似文献
2.
N-(3-Azido-2-nitroxypropyl)-N-alkylnitramines andN-(2,3-diazidopropyl)-N-alkylnitramines were prepared by nitration and azidation ofN-alkyl-N-(2-hydroxy-3-chloropropyl)sulfamates andN-(3-azido-2-hydroxypropyl)-N-alkylsulfamates.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 206–208, January, 1999. 相似文献
3.
A. G. Mustafin A. R. Gimadieva I. N. Khalilov L. V. Spirikhin A. A. Fatykhov R. A. Nurushev I. B. Abdrakhmanov G. A. Tolstikov 《Russian Chemical Bulletin》1998,47(1):188-190
The effect ofmeta-substituents in the aromatic ring on the route of Claisen rearrangement ofN-(pent-3-en-2-yl)-3-fluoro(or 3-trifluoromethyl, 3,4-difluoro)anilines induced by ZnCl2 was investigated. The formation of two possibleortho-alkenylated reaction products was observed. The ratio of these isomers depends on the nature of the acid catalyst.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 188–190, January, 1998. 相似文献
4.
Gubskaya V. P. Konovalova N. P. Nuretdinov I. A. Fazleeva G. M. Berezhnaya L. Sh. Sibgatullina F. G. Karaseva I. P. 《Russian Chemical Bulletin》2002,51(9):1723-1726
New fullerenopyrrolidines were synthesized by the three-component reactions of fullerene C60, N-methylglycine, and aromatic aldehydes, viz., N,N-bis(2-chloroethyl)-4-aminobenzaldehyde, N-(2-chloroethyl)-N-methyl-4-aminobenzaldehyde, indole-3-carbaldehyde, 4-phenylbenzaldehyde, and anthracene-9-carbaldehyde. The structures of the resulting compounds were established by spectroscopic methods. 相似文献
5.
N-[2(3)-Hydroxyalkylj-4-thiazolidinones have been synthesized by the reaction of 2(3)-vinyloxyalkylamines with mercaptoacetic acid in 24–69 % yield. The structure of the compounds obtained was supported by (R and1H NMR spectroscopic data.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 677–679, March, 1996. 相似文献
6.
Shubhangi C. Joshi Kunjbihari N. Trivedi 《Monatshefte für Chemie / Chemical Monthly》1992,123(6-7):557-564
Summary The Claisen rearrangement of 7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 a) gave 7-hydroxy-8-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (3 a) and 2,3-dihydro-2,6-diphenyl-3-methyl-(7H)furo[2,3-h]-1-benzopyran-7-one (7 a). 2-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (2 b) afforded4 b and7 b. 8-Methyl-7-(3-phenyl-2-propenyloxy)-3-phenyl-(4H)-1-benzopyran-4-one (12) gave only the alkali soluble product 7-hydroxy-8-methyl-6-(1-phenyl-2-propenyl)-3-phenyl-(4H)-1-benzopyran-4-one (13).3 a,4 b, and13 were further cyclized in acidic medium to9 a,10 b, and14 followed by dehydrogenation.This paper is dedicated to Dr. F. M. Dean, Department of Organic Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool, U. K., on his retirement 相似文献
7.
《Journal of Molecular Structure》2001,560(1-3)
The molecular structure of the endogenous plant hormone (auxin) conjugate, N-(indol-3-ylacetyl)-
-glutamic acid, is deduced by comparison with N2-(indol-3-ylacetyl)glutamine (IAA-Gln), N2-(indol-3-ylacetyl)asparagine (IAA-Asn) and N-(indol-3-ylacetyl)-
-aspartic acid using X-ray structure analysis, 1H-NMR spectroscopy (NOE measurements) and molecular modelling. The significance of the overall molecular shape, and of the resulting amphiphilic properties, of the compounds studied are discussed in terms of possible implications for trafficking between cell compartments. Both in the solid state and in solution, the molecules are in the hair-pin (folded) conformation in which the side chain is folded over the indole ring. While extended conformations can be detected by molecular dynamics simulations, they are so short-lived that any major influence on the biological properties of the compounds studied is unlikely. 相似文献
8.
2-Hydroxy-4-oxo-4-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-but-2-enoic acid methyl ester (1) was synthesized by the reaction of pentafluoroacetophenone with dimethyl oxalate in the presence of sodium methylate. Subsequently, reactions of compound 1 with aniline, o-phenylenediamine, and o-aminophenol were investigated. In addition, the thermal cyclization of ester 1 was studied and led to the formation of 5,6,8-trifluoro-7-methoxy-4-oxo-4H-chromene-2-carboxylic acid methyl ester (6) due to nucleophilic substitution of the 3-fluoro group. Hydrolysis of compound 1 and subsequent cyclization by treatment with SOCl2 gave 5-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-furan-2,3-dione (3). Thermal decarbonylation of compound 3 under mild conditions resulted in the formation of 3-(2,3,5,6-tetrafluoro-4-methoxyphenyl)-propene-1,3-dione (4) which dimerized to pyranone 5. 相似文献
9.
V. P. Kislyi E. B. Danilova E. P. Zakharov V. V. Semenov 《Russian Chemical Bulletin》2004,53(3):622-625
The reactions of N-substituted cyanoacetamides with EtONO in the presence of an equimolar amount of EtONa afforded the corresponding sodium salts of hydroxyimino derivatives in 70—95% yields. The latter were transformed into 4-amino-5-(4-bromobenzoyl)isoxazole-3-carboxamides in 30—57% yields using the known method. 相似文献
10.
V. A. Tartakovsky A. S. Ermakov D. B. Vinogradov P. V. Bulatov 《Russian Chemical Bulletin》1998,47(4):652-655
Nitration ofN-3-chloroalkoxy-2-hydroxypropyl-N-alkylsulfamates gave the correspondingN-3-chloroalkoxy-2-nitroxypropyl-N-alkylnitramines. Azidation of the latter resulted inN-azido-3-azidoalkoxypropyl-N-alkylnitramines.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 673–676, April, 1998. 相似文献
11.
The geometric parameters, the charge distribution, and the energetics of N-methyl-2-(N-ethylanilino)-3-(indol-1-yl)-and N-methyl-2-(N-ethylanilino)-3-(indol-3-yl)maleimides and their conjugated acids were studied by density functional theory calculations
at the B3LYP/6-31G(d) level. The mechanism of the tandem hydride transfer/cyclization sequence, which occurs after protonation
of N-methyl-2-(N-ethylanilino)-3-(indol-1-yl)-and N-methyl-2-(N-ethylanilino)-3-(indol-3-yl)maleimides, was analyzed. The investigation of the potential energy surface for the tandem hydride
transfer/cyclization of the iminium cation that formed upon protonation revealed that the hydride transfer followed by intramolecular
cyclization at position 7 of the indole fragment in N-methyl-2-(N-ethylanilino)-3-(indol-1-yl)maleimide is the preferable process, unlike alternative intramolecular cyclization involving
the cationic center at the C(2) atom of the indole fragment and the benzene ring of the N-ethylaniline fragment of the indoleninium cation in N-methyl-2-(N-ethylanilino)-3-(indol-3-yl)maleimide. A study of the key intermediates of the assumed reaction mechanism demonstrated that
these intermediates are actually stationary points on the potential energy surface (minima and transition states).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2069–2073, December, 2006. 相似文献
12.
G. Veinberg R. Bokaldere K. Dikovskaya M. Vorona I. Kanepe I. Shestakova E. Yashchenko E. Lukevics 《Chemistry of Heterocyclic Compounds》2003,39(5):587-593
A series of 1,3,4-trisubstituted and 3,4-disubstituted 2-azetidinones were synthesized in order to study the relation between their structure and biological characteristics. Study of the cytotoxic activity of these compounds revealed an anticancer effect in (3S,4S)-1-(4-methoxyphenyl)-3-methyl-2-azetidinones containing 2-acetoxybenzoyloxymethyl and 2,2-dicyanovinyl substituents at position 4 in vitro with respect to a wide range of monolayer cultures of cancer cells. 相似文献
13.
14.
Reactions of N-pyrrolylpotassium with fluorinated electrophiles yielded N-substituted pyrroles containing polyfluoroalkyl, polyfluoroalkenyl, polyfluoroalkylsulfonyl, and polyfluoroaryl substituents.
N-Polyfluoro-substituted pyrroles did not isomerize at ≥100 °C; they were found to be reactive in [4+2] cycloaddition reactions
with perfluorobut-2-yne.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1890–1895, August, 2005. 相似文献
15.
K. A. Frolov V. V. Dotsenko S. G. Krivokolysko V. P. Litvinov 《Russian Chemical Bulletin》2005,54(5):1335-1336
Multicomponent cyclocondensation of Meldrum's acid, 2-chlorobenzaldehyde, and N-(4-bromophenyl)-3-amino-3-thioxopropanamide in the presence of N-methylmorpholine afforded N-methylmorpholinium 3-[N-(4-bromophenyl)carbamoyl]-4-(2-chlorophenyl)-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolate in 65% yield. When treated with
dilute HCl, the thiolate easily transformed into N-(4-bromophenyl)-4-(2-chlorophenyl)-2-oxo-6-thioxopiperidine-5-carboxamide, which reacted with alkyl halides to give products
of regioselective S-alkylation in high yields.
Dedicated to Academician N. K. Kochetkov on the occasion of his 90th birthday.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 5, pp. 1297–1298, May, 2005. 相似文献
16.
通过低温量热和热分析方法,测定了N-对甲基苯基-N′-(2-吡啶基)脲(以下简称NPMPN′2PU)的低温热容和热力学性质.通过对NPMPN′2PU进行低温量热,得到了NPMPN′2PU在80~370 K 温区的热容曲线,热容曲线光滑,没有任何热异常现象,由此实验热容数据计算出NPMPN′2PU在这段温区内的热力学数据.从DSC实验结果发现, NPMPN′2PU熔化峰值出现在173.86 ℃,熔化焓为204.45 kJ•mol-1.紧接熔化峰后NPMPN′2PU开始分解,分解峰只有一个,分解峰值温度为226.11 ℃.TG和DTG的实验结果表明,NPMPN′2PU失重的峰值为227.2 ℃,这些结果与DSC实验结果吻合. 相似文献
17.
A new method for the synthesis of N-substituted 2-(4-oxo-4,5,6,7-tetrahydroindol-3-yl)acetic acids was developed. Alkylation of cyclic 1,3-diketones with 3,5,5,5-tetrachloropentan-2-one affords 1,4-diketones, which undergo cyclization with different primary amines into N-substituted 3-(2,2,2-trichloroethyl)-4,5,6,7-tetrahydroindol-4-ones. Acid hydrolysis of the latter gives the corresponding indol-3-ylacetic acids. The structures of the compounds obtained were confirmed by 1H and 13C NMR data. 相似文献
18.
M. G. Voronkov N. F. Lazareva G. G. Efremova V. P. Baryshok 《Russian Chemical Bulletin》1995,44(2):375-377
The reactions of aminoalkylethoxysilanes and 2,2-dimethyl-1,3-dioxa-6-aza-2-silacyclooctane with 2-(chlormethyl)thiophene and its 5-chloroderivative lead to the correspondingN-(2-thenyl) derivatives. TheN-methyl-N-(2-thenyl)aminomethyltriethoxysilane and 5-chlorothyenyl derivative formed are converted by triethanolamine into silatranes.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 2, pp. 384–386, February, 1995. 相似文献
19.
1-(N-alkylnitraminomethyl)-3-nitroureas were prepared by nitration of condensation products of urea with formaldehyde andN-alkylsulfamate.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2041–2042, November, 1994. 相似文献
20.
N. Ya. Grigorieva 《Russian Chemical Bulletin》2005,54(4):1046-1047
High (Z)-stereoselectivity of olefination of methyl α-phenylthioalkyl and methyl α-phenylthioalkenyl ketones with methyl trimethylsilylacetate
decreases in the case of ketones containing a higher alkyl-substituent in place of the methyl group.
Dedicated to Corresponding Member of the Russian Academy of Sciences E. P. Serebryakov on the occasion of his 70th birthday.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 1020–1021, April, 2005. 相似文献