4-苯基-2-对甲氧基苯基-1,5-苯并硫氮杂卓-α,α-二甲基-β-内酰胺的合成及晶体结构

合成了标题化合物并测定了其晶体结构。该化合物的化学式为C26H25NO2S, Mr = 415.53。晶体为三斜晶系,P 空间群,晶胞参数为:a = 9.299(3), b = 10.134(3), c = 12.455(4) ? a = 98.457(5), b = 106.143(5), g = 103.843(5), V = 1065.7(6) 3, Z = 2, Dc = 1.295 g/cm3, F(000) = 440, m = 0.175 mm-1, R = 0.0406, wR = 0.1064。晶体结构显示,化合物中七员环呈类椅式构象,b-内酰胺环近似梯形。     

2-氨基-3-氰基-7,7-二甲基-4-苯基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃的合成和晶体结构

标题化合物C18H18N2O2是由亚苄基丙二睛和5,5-二甲基-1,3-环己酮在乙二醇中反应2小时得到,结构通过单晶X-射线衍射法确定,其晶体属单斜晶系,空间群P21/c,Mr=294.34,a = 11.3070(1), b= 9.4750(1),c = 14.919(2) ,β= 99.34(1)埃琕 = 1577.1(3) 3,Z = 4,Dc=1.240Mgm-3,μ=0.082mm-1,F(000)=624, 最终的偏离因子为R=0.0381,wR=0.0961,在分子结构中存在3个环:苯环(A)、吡喃环(B)及与吡喃环稠合的六员环(C)。A与B、A与C及B与C之间的两面角分别为 92.5°、85.7°和8.2°。     

Synthesis, Crystal Structure and Herbicidal Activity of O,O'-Diethyl-N-[2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yloxy)-benzoxyl]-1-amino-benzyl phosphonate

The crystal structure of the title compound (C25H28N5O5P,Mr= 509.49) has been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 13.0726(4), b = 13.4513(4), c = 15.103(1) (A),β = 93.650(1)°, V= 2650.29(14) (A)3, Z= 4, Dc =1.277 g/cm3, F(000) = 1072, μ(MoKα) = 0.147 mm-1, the final R = 0.0748 and wR = 0.1956 for 3186 observed reflections (Ⅰ＞ 2σ(Ⅰ)). The fused triazolopyrimidine system ring is coplanar, the dihedral angles between the triazolopyrimidine and C(1)-C(3)-C(5) phenyl, the triazolopyrimidine and C(17)-C(19)-C(21) phenyl, and the two phenyl rings are 66.87, 58.79 and 80.11°, respectively.contribute to the stability of the structure and result in a three-dimensional framework. The preliminary bioassay indicates that the title compound exhibits moderate herbicidal activity against dicotyledonous plants (Brassica campestris L) at the concentration of 100 mg/L.     

Synthesis and Crystal Structure of 13-Phenyl-1,10- dithia-4,7-dioxa-13-aza-15-Crown-5

1　ＩＮＴＲＯＤＵＣＴＩＯＮＣｒｏｗｎａｎｄａｚａｃｒｏｗｎｅｔｈｅｒｈａｖｅｂｅｅｎｕｓｅｄｗｉｄｅｌｙａｓｈｏｓｔｓｆｏｒｒｅｃｏｇｎｉｚｉｎｇｇｕｅｓｔｍｅｔａｌｉｏｎｓ.[1～ 4] Ｔｈｉａｃｒｏｗｎｅｔｈｅｒｓｉｎｃｏｒｐｏｒａｔｉｎｇｏｎｌｙｓｕｌｆｕｒａｔｏｍｓｉｎｒｉｎｇａｌｓｏｈａｖｅｂｅｅｎｓｔｕｄｉｅｄａｓｅｘｔｒａｃｔｉｎｇｒｅａｇｅｎｔｓｆｏｒｓｏｍｅｓｏｆｔｍｅｔａｌｉｏｎｓ.[5] Ｏｎ ｌｙｆｅｗｓｔｕｄｉｅｓｏｎｍｉｘｅｄ ｄｏｎｏｒｃｒｏｗｎｅｔｈｅｒｃｏｎｔａｉｎ ｉｎｇ…     

2,6-二甲基-4-苯基-1,4-二氢吡啶-3,5-二甲酸乙酯的合成和晶体结构

标题化合物C1 9H2 3NO4由苯甲醛、尿素、乙酰乙酸乙酯在微波辐射下干反应而得。结构通过单晶X 射线衍射法测定 ,其晶体属单斜晶系 ,空间群P2 1 /c ,a =9.745(2 ) ,b =7.388(2 ) ,c =2 4 .354(5) ,β =92 .60 (3)°,V =1 751 .6(6) 3,Z =4,Mr=32 9.38,Dc=1 2 4 9g/cm3,μ(MoKα) =0 .0 87mm- 1 ,F(0 0 0 ) =70 4。晶体结构用直接法解出 ,经全矩阵最小二乘法对原子参数进行修正 ,最终的偏离因子为R =0 .0 4 1 6,wR =0 .1 1 75。在晶体结构中 ,二氢吡啶环与苯环之间的二面角为 92 .1 4°。     

手性3,5-二甲基-2-芳基-2-吗啉醇盐酸盐的合成及其晶体结构

以(S)-2-氨基丙醇为手性源与α-溴-3-氯苯丙酮反应, (R)-2-氨基丙醇为手性源与6-甲氧基-2-(2-溴丙酰基)萘反应, 分别合成了手性纯化合物(2R,3R,5S)-3,5-二甲基-2-(3-氯苯基)-2-吗啉醇盐酸盐(4a)和(2S,3S,5R)-3,5-二甲基-2-(6-甲氧基-2-萘基)-2-吗啉醇盐酸盐(4b), 利用X射线单晶衍射仪测定了两化合物的晶体结构和两化合物的空间结构, 并初步分析两化合物空间结构, 化合物4a晶体属正交晶系, 空间群为P2₁2₁2, 晶胞参数为: a＝0.8718(2) nm, b＝0.7883(2) nm, c＝2.0247(6) nm, Z＝4, V＝1.3915(7) nm³, D_c＝1.328 g/cm³, F(000)＝584, R₁＝0.0399, wR₂＝0.0797, S＝1.042. 化合物4b晶体属正交晶系, 空间群为P2₁2₁2₁, 晶胞参数为: a＝0.71035 (9) nm, b＝0.77703(10) nm, c＝2.9820(4) nm, Z＝4, V＝1.6318(4) nm³, D_c＝1.318 g/cm³, F(000)＝688, R₁＝0.0520, wR₂＝0.1108, S＝0.994.     

Synthesis and Crystal Structure of Cis 2-（6-Chloro-3-pyridylmethylamino）-4-chlorophenyl- 5,5-dimethyl- 1,3,2-dioxaphosphinane 2-Oxides

1 INTRODUCTION Neonicotinioid insecticides as nicotinic acetyl-choline receptor inhibitors have attracted increasingattention because of its safety, low toxicity, wide andhigh activities[1, . A lot of new insecticides such as 2]imidacloprid, acetamiprd and nitenpyram have beencommercialized. It is found that most biologicallyactive nicotinic compounds contain 3-aminomethyl-pyridine moiety[3]. Due to their wide biological acti-vities, organic phosphorus heterocyclic compoundsplay an import…     

Synthesis and Crystal Structure of 1-(1''''- t- Butyl-5''''-methyl-4-pyrazolyl-carbonyl)- 3,5-dimethyl-1H-yl-pyrazole

1 INTRODUCTION Pyrazole and its derivatives represent one of the most active classes of compounds possessing a wide spectrum of biological activities. During the past years considerable evidence has been accumulated to demonstrate the efficacy of pyra- …     

Synthesis and Crystal Structure of N-（1-Phenyl-3-methyl-4-benzal-pyrazolone-5）-furoic Hydrazide

1 INTRODUCTION In recent years, investigations on the com- pounds containing hydrazide or hydrazone moieties have been increased considerably because of their potentially biological activities, especially as poten- tial inhibitors for many enzymes[1～5]. The presence of weak molecular interactions such as hydrogen- bonding controls the conformational and structural features which are important to the drug action[6, 7]. We have synthesized the photochromic compounds of pyrazolone thiosemi…     

3-邻氯苯基-3-(5,5二甲基-3-羟基-2-环己烯-1-酮-2-基)丙酸乙酯的合成和晶体结构

标题化合物C19H23O4Cl（4）是由邻氯苯甲醛（1）与5，5-二甲基-1，3-环己二酮（2）、2，2-二甲基-1，3-二氧六环-4，6-二酮（3）在乙醇中反应而得。结构通过单晶X-射线衍射分析确定，其晶体属于单斜晶系，空间群晶体结构用直接法解出，使用全矩阵最小二乘法对原子参数进行修正，最后的偏离因子R＝0．034，Rw＝0．042。在晶体结构中存在一个共轭的烯醇结构。单晶X-射线分析表明；平面1（C（1）～C（6）、Cl）和平面2（C（8）～C（10）、C（12）、C（13））之间的两面角为97．11°，原子C（7）呈变形的四面体构型。     

2-(N-环己胺)-6-三氟甲氧基苯并噻唑的合成及其晶体结构

以利鲁唑为原料,与硫酸肼经回流反应制得2-肼基-6-三氟甲氧基苯并噻唑(2); 2经氯化亚砜氯代制得2-氯-6-三氟甲氧基苯并噻唑(3);3与环己胺经取代反应合成了新化合物2-(N-环己胺)-6-三氟甲氧基苯并噻唑(4),其结构经¹H NMR, IR,元素分析和X-射线单晶衍射表征。4 (CCDC：1 440 686)属三斜晶系,P-1空间群,晶胞参数a=10.617(3) , b=13.607(4) , c=16.619(5) , V=2 201.8 ³, Dc=1.422 g·cm^-3, Z=6, R₁=0.082 0, wR₂=0.235 1。     

Synthesis and Crystal Structure of 1-Phenyl-2-acetoxy-2-methyl-1-propanone

1-Phenyl-2-acetoxy-2-methyl-propanone, a new α-hydroxy ketone derivative, was synthesized by Friedel-Crafts acylation and characterized by FT-IR, 1H NMR, MS spectra and single-crystal X-ray diffraction measurements. The data are as follows: monoclinic, space group P21/c, Z = 4, C12H14O3, Mr = 206.24, a = 8.9430(2), b =15.2680(4), c = 8.2550(2) , β = 91.9650(5)o, V = 1126.60(5) 3, Dc = 1.216 g/cm3, μ(MoKα) = 0.087 mm1, F(000) = 440, R = 0.0725 and wR = 0.1379 for 1282 observed reflections with I > 2σ(I). The structure was solved by direct methods and refined by full-matrix least-squares refinement on F2 methods. The benzene ring in the structure is almost coplanar with the adjacent carbonyl groups and t-carbonyl atom. Meanwhile, the long chain is approximately perpendicular to the plane. X-ray analysis reveals that the crystal structure involves two weak intramolecular C–H···O hydrogen bonds.     

Crystal Structure of 4—（4—chlorophenyl）—7,7—dimethyl—2,5—dioxo—1,2,3,4,5,6,7,8—octahydroquinoline

1 INTRODUCTION Since the discovery of the pharmacological effects of 1,4-dihydropridines(1,4-DHPs) as calcium channel blocks[1], a great deal of work has been directed towards synthesis of the novel 1,4-DHPs acting as calcium antagonists[2, 3]. In fact, it is well-established that slightly modified structures on the DHP exhibit a calcium agents effect[4, 5] ; however, two fused rings have been less well-studied. By refluxing equivalent amounts of dimedone, aromatic aldehyde Meldrum抯 …     

A Facile Synthesis and Crystal Structure of 1-Amino-3-(2''-methylphenyl)isoquinolin Hydrochloride

The title compound(C16H15ClN2)has been synthesized by a facile self-condensation of ο-tolunitrile promoted by potassium tert-butanolate in DMPU,and its structure was characterized by 1H NMR,13C NMR,IR,UV,HRMS and X-ray single-crystal diffraction.The crystal belongs to orthorhombic.space group Pna21 with a=19.560(3),b=7.8500(14),c=18.428(3)(A),Dc=1.271g/cm3,Z=8,λ=0.71073(A),μ(MoKα)=0.257 mm-1,Mr=270.75,V=2829.5(8)(A)3,Hack parameter=0.12(12),F(000)=1136,the final R=0.0571 and wR=0.1445 for 2701 observed reflections with I＞2σ(I).The intermolecular N-H…Cl hydrogen bonds link the molecules into a one-dimensional chain running along axis a.     

Synthesis and Crystal Structure of 5,7-Dimethoxy-2-phenylquinolin-4-yl Phenyloxy （N-L-Alanine ethyl ester） Phosphoramidate

5,7-Dimethoxy-2-phenylquinolin-4-yl phenyloxy （N-L-alanine ethyl ester） phosphoramidate （C28H29N2O7P, Mr = 536.17） has been synthesized by a facial phosphorylated reaction, and its structure was determined by IR, NMR, HR MS and X-ray single-crystal diffraction. The crystal belongs to triclinic, space group P1^-, with a = 11.375（2）, b = 11.591（2）, c = 11.638（2） A^°, α= 109.46（3）, β= 104.58（3）, γ= 100.48（3）°, V = 1339.6（5）A^°^3, Z = 2, Dc = 1.330 g/cm^3,μ = 0.152 mm^-1, F（000） = 564, the final R = 0.0654 and wR = 0.1546. In the crystal structure, the title compound is constructed by a centrosymmetric dimmer unit composed of a pair of π-π stacking diastereoisomers. The compound has a noteworthy feature in the framework, and such units are linked by two equal intermolecular P=O…H-N hydrogen bonds.     

4-(4-N,N-二甲胺基)苯基-7,7-二甲基-5-氧代-3,4,5,6,7,8-六氢香豆素酮的合成和晶体结构

标题化合物C19H23NO3由4-N,N-二甲胺基苯甲醛、5,5-二甲基-1,3-环己二酮、麦氏酸在乙二醇中于80℃反应2.5小时而得。结构通过单晶X-射线衍射法确定,其晶体属单斜晶系, C19H23NO3,空间群P21, a = 9.364(2), b = 5.974(1), c = 15.731(3)?, b = 102.87(3)°, V = 857.9(3)?3, Z = 2, Dc = 1.213Mg/m3, μ(MoKa) = 0.082mm-1, F(000)=336。晶体结构用直接法解出,经用全矩阵最小二乘法对原子参数进行修正,最终的偏离因子为R=0.0521, wR=0.1392。在分子结构中,存在3个平面, C(10)~C(15)构成平面1,C(5)-C6)-C(8)-C(9)-O(2)构成平面2,C(1)-C(2)- C(4)-C(5)-C(9)构成平面3,平面1与平面2的最小二乘面的两面角为88.77°,平面1与平面3的最小二乘面的两面角为86.58°,平面2与平面3的最小二乘面的两面角为1.86°.     

Synthesis and Crystal Structure of 1,4-Bis(2-hydroxymethylphenyl)-1,4-dioxabutane

1 INTRODUCTION Macrocyclic ligands and their metal complexes have received much attention due to their applications in ion transport, ion separation and as models in biomimic researches[1~7]. The synthetic methods of macrocyclic ligands and their metal complexes are mainly divided into three kinds[8]. The first one is synthesizing free ligand, then forming the metal complexes; the second is template synthesis; and the third is synthesizing the end-off or side-off precursor ligand, then c…     

Synthesis and Crystal Structure of 2-Benzylsulefnyl-3-cyano-5,7-dimethyl-pyrazolo[1,5-a]pyrimidine

1 INTRODUCTION The pyrazolo[1,5-a]pyrimidines are the active compositions in many pesticides and medicines. A new class of KDR (tyrosine kinase VEGFR-2) ki- nase inhibitors is discovered and found to have affi- nity for the human CRF-1 (Corticotrophin re…     

Stereoselective Synthesis and Crystal Structure Analysis of N-Naphthy1-2-deoxy-α-d-ribopyranosylamine

A new compound N-naphthy1-2-deoxy-α-D-ribopyranosylamine was synthesized and structurally determined.It crystallizes in the orthorhombic system,space group P212121 with a =8.361(2),b=12.432(3),C=12.791(4)A,Z=4,V=1329.6(6)A3,DC=1.295 g/cm3,F(000)= 552,C15H17NO3 and Mr=259.30.All the active hydrogen atoms arc involved in the formation of hydrogen bonds in the molecule.     

Synthesis and Crystal Structure of 2-Benzylsulfnyl-3-cyano-5,7-dimethyl-pyrazolo[1,5-a]pyrimidine

The title compound, C16H14N4S, has been synthesized by the reaction of pentane-2,4-dione with 5-amino-3-benzylthio-4-cyano-l-H-pyrazole in ethanol, and its crystal structure was determined by X-ray diffraction method. The crystal is of monoclinic, space group P21/n with a=8.699(3), b=23.139(9), c=7.536(3) A, β= 92.400(8)°, V= 1515.5(10) A3, Z=4,Mr=294037, Dc= 1.290 g/cm3, λ=0.71073 A,μ(MoKo)=0.212 mm-1 and F(000)=616. The structure was refined to R=0.0533 and wR=0.1141 for 2672 unique reflections with Rint= 0.06.distance of 3.875 A and the angle of 164.8°.