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1.
The acetylation and chloroacetylation of 5-nitro- and 5-ethoxycarbonyl-substituted 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones proceeds regioselectively at the N3 atom of the heterocycle whereas the acetylation of the 5-aryloxy-substituted analog results in a mixture of N1- and N3-acetylated regioisomers. 相似文献
2.
V. D. Dyachenko E. N. Karpov I. A. Feskov 《Russian Journal of General Chemistry》2013,83(9):1716-1723
New 4-alkyl-6-amino-N 3,N 5-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides have been prepared via enantioselective reaction of 3-amino-N-aryl-3-thioxopropanamides with N-aryl-2-cyanoacetamide and aliphatic aldehydes. The prepared products can be regioselectively alkylated at sulfur atom. 相似文献
3.
N-Phenylurea reacted with benzoylacetone derivatives (I) to give 1,4-diaryl-6-methyl-2-(1H)pyrimidinones (II) in addition to low yields of 1,6-diaryl-4-methyl-2-(1H)pyrimidinones (IV), while N-phenylthiourea afforded only 1,6-diaryl-4-methyl-2-(1H)pyrimidinethiones (III) in good yields. Further 1,6-diaryl-4-methyl-2-(1H)- pyrimidinethiones (III) were successfully converted in satisfactory yields into the corresponding 2-(1H)-pyrimidinones (IV) by the treatment with methyl iodide in the presence of sodium methoxide in methanol at room temperature. 相似文献
4.
V. N. Britsun A. N. Borisevich V. B. Pirozhenko M. O. Lozinskii 《Russian Journal of Organic Chemistry》2007,43(2):276-279
Direction of a reaction between 3-oxo-3-R1-N-R2-propanethioamides and 2-amino-5-R-pyridines in acetic acid depends on the structure of initial thioamides: at R1 = Me, R2 = Ar, Et 2-methyl-7-R-4H-pyrido[1,2-a]-pyrimidine-4-thiones are obtained, and at R1 = Ar, R2 = Me form 1-methyl-5-(N-methylaminothiocarbonyl)-4,6-diaryl-1,2-dihydropyridine-2-thiones. 相似文献
5.
V. N. Nesterov Yu. T. Struchkov G. E. Khoroshilov Yu. A. Sharanin V. E. Shklover 《Russian Chemical Bulletin》1989,38(12):2537-2540
1-Amino-3,5-diaryl-2,4,4,6,6-pentacyano-1-cyclohexenes are prepared by reaction of arylmethylenemalononitriles with malononitrile. The cyclohexene ring of (IVa) has a distorted N2-C1=C2-C7=N1 fragment. Steric effects in (IVa) cause a substantial increase in C6-C1 and C3-C4 bond length to 1.546(4) and 1.570(4) Å, respectively.For previous communication, see [1].Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2771–2775, December, 1989. 相似文献
6.
V. L. Gein M. I. Kazantseva A. A. Kurbatova 《Russian Journal of Organic Chemistry》2011,47(6):886-888
Cyclohexane-1,3-dione reacted with substituted benzaldehydes and N-arylacetoacetamides in the presence of ammonium acetate under solvent-free conditions (150–160°C, 10–20 min) to give the
corresponding 4,N-diaryl-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides. The product structure was determined by IR and 1H NMR spectroscopy and mass spectrometry. 相似文献
7.
4-Alkyl-6-amino-4-N 3,N 5-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides were obtained via tandem synthesis involving the Knoevenagel reaction, Michael reaction and intramolecular condensation. Alkylation of the obtained dicarboxamides proceeds regioselectively at the S atom to form the corresponding thioethers. Structure of 6-allylsulfanyl-2-amino-4-isobutyl-N 3,N 5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarboxamide was uniquely determined by XRD analysis. 相似文献
8.
I. S. Nizamov E. M. Mart’yanov I. D. Nizamov A. R. Nurmukhametov R. A. Cherkasov 《Russian Journal of Organic Chemistry》2013,49(4):526-529
Trimethylsilyl P-aryl-N-[(RS)-, (S)-(?)-, and (R)-(+)-(1-phenylethyl)]phosphonamidodithioates were synthesized by reactions of 2,4-diaryl-1,3,2λ5,4λ5-dithiadiphosphetane 2,4-disulfides with racemic and and enantiomerically pure trimethyl-N-(1-phenylethyl)silanamine. 相似文献
9.
M. V. Vovk O. V. Kushnir V. A. Sukach I. F. Tsymbal 《Russian Journal of Organic Chemistry》2010,46(5):709-715
1-Chlorobenzyl isocyanates react with N-arylfumarates with the formation of dialkyl 2-oxo-3,6-diaryl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates that on alkaline hydrolysis are converted into 6-alkoxycarbonyl-1,4-diaryl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids. The condensation of 1-chloro-1-phenyl-2,2,2-trifluoroethyl isocyanate with N-arylfumarates results in dialkyl 6-oxo-2,3-diaryl-2-trifluoromethyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates. 相似文献
10.
Khlebnikov A. F. Novikov M. S. Kusei E. Yu. Kopf J. Kostikov R. R. 《Russian Journal of Organic Chemistry》2003,39(4):559-573
Esters of (2,2-diaryl-3,3-dichloroaziridin-1-yl)acetic acid prepared from glycine derivatives under alkylation conditions afford esters of 2-[N-alkyl-N-(2,2-diaryl-1-cyanovinyl)amino]-3,3-diarylacrylic acid in 20-40% yield. The reaction resulting in these compounds proceeds through a cascade of 3-chloro-2-azadiene and ylide intermediates. 3-Chloro-2-azadienes originating from (2,2-diaryl-3,3-dichloroaziridin-1-yl)acetates react with primary and secondary amines at the carbon atom of imine group providing ketenimines which undergo ketenimine-nitrile rearrangement or fragmentation. The other bases (KOH, MeONa, DBU) effect dehydrochlorination of the mentioned 3-chloro-2-azadienes giving nitrile-ylides which are trapped by nucleophilic reagents. The 3-chloro-2-azadiene obtained from methyl (2,2-diaryl-3,3-dichloroaziridin-1-yl)acetate and DBU was relatively stable and was isolated as an individual compound. (2,2-diaryl-3,3-dichloroaziridin-1-yl)propionates behave as nonfunctionalized dichloroaziridines. 相似文献
11.
Alexander V. Stepakov Anna G. LarinaVitaly M. Boitsov Alexander P. MolchanovVladislav V. Gurzhiy Galina L. Starova 《Tetrahedron letters》2012,53(27):3411-3415
The reactions of unactivated bis(methylene)cyclopropanes with nitrones and nitrile oxides have been investigated. The 1,1-diaryl-2-isopropylidene-3-methylenecyclopropanes react with the C,N-diarylnitrones to give a mixture of 2,2-dimethyl-1,6-diaryl-3-(diarylmethylene)piperidin-4-ones and 5-methyl-1-aryl-1-(arylamino)-4-(diarylmethylene)hex-5-en-3-ones. 2,3-Dihydro-3-methylenepyridin-4(1H)-ones are obtained by reaction of 1,1-diaryl-2-isopropylidene-3-methylenecyclopropanes with nitrile oxides. 相似文献
12.
Polyphosphoric acid and N-aryl-N′-benzoylethylenediamines in a type of Bischler-Napieralski reaction afforded 1,2-diaryl-2-imidazolines in good yields, rather than the 2,3-dihydro-1H-[1,4]-benzodiazepines. Blocking of the amino nitrogen by a methyl or ethyl group, to avoid imidazoline formation, gave starting material rather than the expected dihydrobenzodiazepine. When p-tosyl was the blocking group, imidazoline was again the only product isolated. Analytical and spectroscopic data of several unreported 1,2-diaryl-2-imidazolines are presented. 相似文献
13.
Treatment of N-alkyl- and N-aryl-imines of 2,3-diaryl- and 2-alkyl-3-aryl-3-(benzotriazol-1-yl)propenals with trifluoroacetic anhydride in THF at room temperature gave 5-alkyl-4-aryl-6-[N-alkyl (and aryl)-N-trifluoroacetyl]amino-2,3-benzo-1,3a,6a-triazapentalenes in moderate to good yields. On heating triazapentalenes having R2=aryl in MeOH at reflux, detrifluoroacetylation of triazapentalene occurred to give title compounds in good yields. However, the same treatment of triazapentalenes having R2=alkyl did not give the corresponding detrifluoroacetylation product. The title compounds and 5-alkyl-4-aryl-6-(N-alkyl-N-trifluoroacetyl)amino-2,3-benzo-1,3a,6a-triazapentalenes were found to be good precursors for the synthesis of 1-(o-aminophenyl)-3-arylamino-4-alkyl (and aryl)-5-arylpyrazoles and 1-(o-aminophenyl)-3-(N-alkyl-N-trifluoroacetyl)amino-4-alkyl (and aryl)-5-arylpyrazoles, respectively. 相似文献
14.
A. A. Panasenko A. F. Kaprosh M. A. Rekhter E. P. Styngach M. Z. Krimer G. N. Grushetskaya 《Russian Chemical Bulletin》1994,43(3):391-394
13C NMR spectra (20 and 75 MHz, in DMSO-d6) of a series of 1,3-diaryl-3-(1H-1,2,4-triazol-1-yl)- and 1,3-diaryl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ones were registered. It was shown that the chemical shifts of both the carbon atom of the alkene group and C(3) reflect regio- and stereoisomerism of these compounds. Taking this into account the isomeric structures of several 1,3-diaryl-3-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ones were identified and the configurations relative to the double bond of a number of 1,3-diaryl-2-(1H-1,2,4-triazol-1-yl)prop-2-en-1-ones were determined. 相似文献
15.
Novel sulfur-containing spiro compounds such as 7,11-diaryl-9-thia-2,4-diazaspiro [5,5] undecane-1,3,5-trione 9,9-dioxides ( 2 ), 6,10-diaryl-8-thia-2,3-diazas-piro[4,5]decane-1,4-dione-8,8-dioxides ( 3 ) and 6,10-diaryl-2-oxo-8-thia-3-azaspiro [4,5] decane-1,4-dione-8,8-dioxides ( 5 ) have been prepared by the condensation of 4-dimethoxycarbonyl/diethoxycarbonyl-3,5-diaryl-1-thiane 1,1-dioxides ( 1 ) with urea, hydrazine hydrate, and hydroxylamine hydrochloride, respectively. The N-substituted derivatives ( 4 and 6 ) of 3 and 5 have also been prepared by acylation and nitrosation. The structures of 2, 3 , and 5 were established by IR, 1H NMR, and 13C NMR spectral studies, respectively. 相似文献
16.
A novel class of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols is synthesized
and characterized by melting point, elemental analysis, MS, FT-IR, 1H and 13C NMR, D2O exchanged 1H NMR, and two-dimensional HSQC spectra.
__________
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1183–1188, August, 2008. 相似文献
17.
M. T. Wu 《Journal of heterocyclic chemistry》1977,14(3):443-444
Two novel methods for the preparation of N, 1- and N′,1-diaryl-1H-1,2,4-lriazole-3,5-(Hamines are described. 相似文献
18.
The three-component condensation of aromatic aldehydes, methylurea, and α-nitroacetophenone affords both N(1)-and N(3)-methyl-substituted 4,6-diaryl-5-nitro-3,4-dihydropyrimidin-2(1H)-ones depending on the structure of aldehyde. Intermediate 4,6-diaryl-4-hydroxy-3-methyl-5-nitrohexahydropyrimidin-2-ones
and trisubstituted urea, which is the transformation product of the 4-hydroxy-3-methyl derivative in an acidic medium (retro-Henry
reaction), were identified in the reaction mixtures.
Dedicated to the memory of Academician N. N. Vorozhtsov on the 100th anniversary of his birth.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1141–1145, June, 2007. 相似文献
19.
N. V. Pchelintseva Ya. G. Kolevatova L. I. Markova O. V. Fedotova P. V. Reshetov 《Russian Journal of Organic Chemistry》2008,44(9):1267-1270
2-(1,3-Diaryl-3-oxopropyl)cyclohexan-1-ones underwent carbo-and heterocyclization in a mixture of acetic acid with acetic anhydride in the presence of perchloric acid. The transformation of 2-(1,3-diaryl-3-oxopropyl)cyclohexan-1-ones into 2,4-diaryl-5,6,7,8-tetrahydrochromenylium salts was shown to involve intermediate 2,4-diarylbicyclo[3.3.1]non-2-en-9-ones. The structure of 2,4-diaryl-substituted bicyclo[3.3.1]non-2-en-9-ones and products of their reactions with halogens and hydroxylamine hydrochloride was confirmed by 1H and 13C NMR spectroscopy. 相似文献
20.
3-Arylisoxazoles react with LDA in THF at 0 °C affording syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones (bis-azetidinones), via stereoselective dimerization of an azetinone anion intermediate. A fragmentation reaction affording arylnitriles may compete with electronic and steric effects of the substituent present in the aryl group being pivotal in determining the outcome of this reaction. An interesting behaviour with LDA of arylnitriles arising from the fragmentation reaction of some 3-arylisoxazoles was also observed. N,N-Diisopropylaminobenzonitriles were in fact formed (plausibly via a benzyne mechanism) from 3-(4-chlorophenyl)isoxazole and 3-(2-chlorophenyl)isoxazole, whereas 3-(2-methylphenyl)isoquinolin-1-amine was isolated starting from 3-(2-methylphenyl)isoxazole and LDA. 相似文献