Treatment activity of 0D/2D coordination complexes on gastric carcinoma by inhibiting the cancer cell viability

In the present study, via reaction of Ni(NO₃)₂·6H₂O with two flexible dicarboxylic ligands under the solvothermal reaction conditions, two new Ni(II)-containing coordination complexes with the chemical formulae of [Ni4(L1)₄(DMF)₄·2DMF]_n (1) and [Ni(L2)(DMF)]_n (2) (H2L1= 2,2'-(1,4-phenylenebis(methylene))bis(sulfanediyl)dinicotinic acid and H2L2 ?= ?2,2'-(1,2-phenylenebis(methylene))bis(sulfanediyl)dinicotinic acid) have been prepared. For the treatment of the gastric carcinoma, the Cell Counting Kit-8 kit was carried out for the detection of the gastric carcinoma cells viability after compound treatment. Additionally, the Annexin V-FITC/PI apoptosis assay was also conducted and the apoptosis levels of the gastric carcinoma cells were determined after compound exposure.     

Treatment and nursing values of a new mixed-ligand In(III)-based complex on acute ischemic stroke

In the current research, through employing the dual ligand method, a novel coordination polymer has been produced in success via the reaction between H₂glu and In(NO₃)₃·6H₂O in the existence of the nitrogen-donor chelating 2,2′-bpy ligand in CH₃CN In(III) and DMF mixed solvent, and its chemical formula is In(glu)(Hglu)(2,2′-bpy) (1, 2,2′-bpy is 2,2′-bipyridine and H₂glu is glutaric acid). Its application values on the acute stroke were assessed and the corresponding mechanism was investigated simultaneously. Firstly, the levels of inflammatory response in the astrocytes were evaluated by ELISA by measuring the content of inflammatory cytokines released into cerebrospinal fluid. Additionally, the miRNA199a relative expression levels in astrocytes were measured via exploiting real time RT-PCR. Molecular docking simulation demonstrated that synthesized In ion complex exhibited excellent biological activities, multiple binding interactions were formed by the carboxyl groups on the In ion complex.     

Application value of a new Cu(II)-coordination polymer in stroke rehabilitation treatment and nursing by reducing oxidative stress in nerve cells

In this current work, through employing the mixed-ligand generation approach, a fresh coordination polymer on the basis of Cu(II), that is, {(H₂bpe)[Cu(HL)₂(bpe)(H₂O)₂]·(H₂O)₄}_n (1) has been created with a reaction between 4-(2′,3′-dicarboxylphenoxy) benzoic acid (H₃L), a semi-rigid tricarboxylate acid and Cu(NO₃)₂·3H₂O, in the existence of the N-donor co-ligand 1,2-bis(4-pyridyl) ethylene (bpe) with HBF₄ as the pH modulator. Its application value in stroke rehabilitation treatment and nursing was explored and the associated mechanism was analyzed simultaneously. Through the molecular docking simulation, those experimentally observed biological activities can be attributed to the hydrogen bonding interactions between the carboxyl groups on the Cu coordination polymer and the active sites on the receptor protein.     

Structure,dynamics, and solvation in a disordered metal–organic coordination polymer: a multiscale study

Metal–organic coordination polymers are a growing class of technologically-important materials in which transition metal ions are connected by multitopic organic chelators to form a 3-D network structure. While the structures of many highly-ordered metal–organic frameworks have been determined, far less structural information is available about the more common disordered materials. Our study combines pair distribution function analysis from total X-ray scattering, ab initio quantum mechanical calculations, and all-atom molecular dynamics to explore the structure and dynamics of a poorly-ordered branched coordination polymer. The polymer structure is highly flexible and dynamic, and is dramatically affected by its solvation state, a finding with far-reaching implications for the incorporation of coordination polymers into nanocomposite materials.     

A new mixed-ligand coordination polymer based on V-shape carboxylate and pyridinyl co-linkers: Crystal structure,molecular docking,and antibladder cancer activity evolution

By applying the mixed-ligand approach, a new Cu(II)-containing coordination polymer [Cu₄(L)₄(4,4′-bpy)(H₂O)₂]·3H₂O ( 1 ) was successfully prepared through hydrothermal method using linear 4,4′-bipyridine (4,4′-bpy) and the V-shape carboxylate ligand 4,4′-(phenylazanediyl)dibenzoic acid (H₂L). The as-prepared complex 1 was determined by single-crystal X-ray crystallography and elemental analysis. Furthermore, we use the grinding method to prepare the samples of complex 1 in the nanoscale. In this research, the CCK-8 was performed first to detect the inhibitory activity of complex 1 on J82 bladder cancer cell viability. The apoptotic effect of complex 1 on J82 cancer cells was evaluated by Annexin V-FITC/PI staining. The reactive oxygen species (ROS) was also detected by detection kit in this study after complex 1 treatment. Beyond the experimental results, the molecular docking technique has been used to probe the anticancer activity that originated at the molecular level.     

Construction of a magnetic chiral coordination polymer based on a semi-rigid carboxylic acid

A 2-D chiral entangled coordination polymer, {Mn₃(2,2′-bpy)₂(3-cpta)₂·H₂O}_n (1) (3-H₃cpta=3-(3′-carboxyphenoxy)phthalic acid, 2,2′-bpy=2,2′-bipyridine), has been synthesized via the solvothermal method. X-ray diffraction analysis reveals that 1 consists of one right-handed helical chain and one wavelike 2-D plane, which are connected with each other through hydrogen bonds and π···π interactions to generate a 3-D supra-molecule. Thermal gravimetric analysis shows that 1 possesses good thermal stability. Temperature dependent magnetic susceptibilities have also been measured from 1.8 to 300 K, which shows 1 to be anti-ferromagnetic.     

Ultrasound assisted syntheses of a nano-structured two-dimensional mixed-ligand cadmium(II) coordination polymer and direct thermolyses for the preparation of cadmium(II) oxide nanoparticles

A nano-sized mixed-ligand Cd(II) coordination polymer, {[Cd(bpa)(4,4′-bipy)₂(H₂O)₂](ClO₄)₂}_n (1); bpa = trans-1,2-bis(4-pyridyl)ethane and 4,4′-bipy = 4,4′-bipyridine, has been synthesized by a sonochemical method and characterized by IR and ¹H NMR spectroscopy. Compound 1 grows in one dimension by two different bridging ligands, 4,4′-bipy and bpa. The thermal stability of compound 1 in the bulk form and nano-sized was studied by thermogravimetric (TG) and differential thermal analysis (DTA). The crystallinity of this compound was studied by X-ray powder diffraction and compared with an XRD simulation of the single crystal data. CdO nanoparticles were obtained by direct calcination at 500 °C and decomposition in oleic acid at 200 °C of the nano-sized compound 1. The obtained cadmium(II) oxide nano-particles were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM).     

Crystal structure and protective effect in osteoarthritis of Co(II)-mediated pyridinium-bearing coordination polymer

Abstract

By using a mixed-ligand approach, a new Co(II)-mediated pyridinium-bearing coordination polymer, {[Co(BCbpe)(ipa)]·3H₂O}_n (1), has been prepared by reaction of Co(NO₃)₂·6H₂O) and isophthalic acid (H₂ipa) in the presence of pyridinium chloride 1-(4-carboxybenzyl)4-[2-(4-pyridyl)-vinyl] (HBCbpeCl) in EtOH/H₂O (V:V?=?1:1). Furthermore, a green hand grinding technique has been implemented to reduce the particle size of 1 to generate nanosheets of 1 with good water dispersivity. The post-traumatic osteoarthritis (OA) model was constructed and the in vivo protective effect of nano 1 was evaluated. First, the inflammatory level of OA rats was measured by ELISA detection. Second, for further detection, the real-time RT-PCR was carried out to measure the relative expression of caspase-1, nlrp3 as well as il-1β inflammatory factors. Finally, molecular docking analysis of the complex indicated that all of the proposed drug candidates showed desirable drug-like criteria.     

Organotin-oxometalate coordination polymer catalyzed oxyfunctionalization of monoterpenes

The organotin-oxometalate coordination polymers [(nBu₃Sn)₂MO₄]·nH₂O (where, M = Mo or W) were prepared by the interaction of nBu₃SnCl with sodium salts of molybdate or tungstate and tested in oxyfunctionalization of monoterpenes with urea hydroperoxide (UHP) as an oxidizing agent. The oxyfunctionalization of monoterpenes gave commercially important products such as epoxides, ketones and hydroxyl derivatives. Among the two catalyst, organotin-oxomolybdate [(nBu₃Sn)₂MoO₄] showed higher activities and epoxide selectivities under selected liquid phase oxyfunctionalization conditions with most of the monoterpenes such as limonene, -pinene, β-pinene, carene, camphene, gerniol and linalool. The integrity of the organotin-oxometalates polymers were confirmed by X-ray diffraction BET surface area, FT-IR, FT-Raman, SEM, TG/DTA and MAS NMR (¹³C, ¹¹⁹Sn) analysis. The effects of reaction parameters on limonene conversions and product selectivities have been studied in detail using [(nBu₃Sn)₂MoO₄] catalyst. There was no leaching of the active catalyst into the reaction medium and catalyst was recyclable without loss in its activity in the oxidation reaction.     

Prevention and mechanism effect of Zn(II) coordination complex on oral implant restoration

In this study, by reaction of Zn(NO₃)₂·6H₂O with HL ligand under a slow evaporation reaction condition, a novel mononuclear Zn(II) complex [Zn(L)₂]·C₂H₅OH (1) with tetrahedral coordination geometry has been created by employment of an adamantan-type Schiff-base ligand 2-(adamantan-1-ylimino)methyl-4-methylphenol (HL). Its application values against the recurrent infection after oral implants were evaluated with ELISA assay and real time RT-PCR assay. The Zn(II) complex toxicity was evaluated in this research with CCK-8 assay. The molecular docking simulation confirmed that the adamantane functional group applied a hindrance effect on the connected nitrogen atom and therefore, the oxygen atom on the hydroxyl functional group could form binding interaction with receptor as expected.     

Sonochemical synthesis and characterization of a nanostructured 3-D lead(II) coordination polymer with 4-methoxybenzoyltrifluoroacetone

Nanoparticles of a 3-D coordination polymer, [Pb₂(mbtfa)₄] _n (1) (Hmbtfa?=?4-methoxybenzoyltrifluoroacetone), have been synthesized by a sonochemical method. The nanomaterial was characterized by scanning electron microscopy, X-ray powder diffraction, IR spectroscopy, and elemental analyses. Compound 1 was structurally characterized by single-crystal X-ray diffraction. The structure of 1 shows the compound is triclinic and consists of 3-D polymeric units.     

Treatment effects and mechanisms of Cu(II) coordination polymer in hypotension after anesthesia

A Cu(II) coordination polymer (CP) (that is, [Cu₂(OH)(H₂O)₂(cbca)·2H₂O]_n (1)) has been obtained with the reaction between Cu(II) salt and 4′-(1-carboxyethoxy)-[1,1′-biphenyl]-3,5-dicarboxylic acid (H₃cbca), a semi-rigid tricarboxylic acid ligand under the hydrothermal reaction condition. Prevention activity of the new compound on hypotension after anesthesia surgery was evaluated and the related mechanism was researched at the same time. The noninvasive blood pressure monitor was firstly conducted to measure the blood pressure of the animal after compound treatment. Besides, the real time RT-PCR assay was also used to determine theα receptor relative expression on vascular endothelial cells after compound treatment.     

Synthesis,crystal structure,and fluorescence of a 2-D coordination polymer

A 2-D coordination polymer with mixed ligands, [Zn₂(BDC)(4,4′-bipy) (HCOO)₂] (1) (BDC, 1,4-benzenedicarboxylate; 4,4′-bipy, 4,4′-bipyridine), has been synthesized by solvothermal reaction. Compound 1 provides the first coordination polymer structure constructed by bridging BDC, 4,4′-bipy, and formate. Both BDC and 4,4′-bipy link zincs alternatively, resulting in a zigzag coordination chain; adjacent chains are further linked by formates to form an infinite extended 2-D folding screen layer. The synthesis mechanism and fluorescence property are discussed.     

Synthesis and characterization of a new strontium(II) coordination polymer based on a μ2-tridentate bridging zwitterionic glycine

The synthesis and characterization of a new Sr(II) coordination polymer (CP), [Sr(H₂O)(H-gly)₂Cl₂] _n (1) (H-gly?=?glycine), is described. Compound 1 crystallizes in the centrosymmetric orthorhombic space group Pcnb and its structure consists of a central Sr(II), a water molecule, a zwitterionic glycine, and a chloride. The central metal is nine coordinate, bonded to six oxygens from four different bridging H-gly ligands, two symmetry-related chlorides, and a terminal water molecule. The μ₂-tridentate bridging zwitterionic glycine results in the formation of a 1-D CP with an Sr···Sr separation of 4.560?Å across the chain. The chloride, H-gly, and coordinated water are involved in five varieties of hydrogen bonding. A comparative study of the structural chemistry of several alkaline-earth glycine compounds is described.     

Sonochemical syntheses of a straw-like nano-structure two-dimensional mixed-ligand zinc(II) coordination polymer as precursor for preparation of nano-sized ZnO

Straw-like nano-structure of a new mixed-ligand Zn(II) two-dimensional coordination polymer, {[Zn(μ-4,4′-bipy)(μ-3-bpdb)(H₂O)₂](ClO₄)₂·4,4′-bipy·3-bpdb·H₂O}_n (1) {4,4′-bipy = 4,4′-bipyridine and 3-bpdb = 1,4-bis(3-pyridyl)-2,3-diaza-1,3-butadiene}, was synthesized by a sonochemical method. The new nano-structure was characterised by scanning electron microscopy, X-ray powder diffraction, IR spectroscopy and elemental analyses. Compound 1 was structurally characterised by single crystal X-ray diffraction and consists of two-dimensional polymeric units. ZnO nanoparticles were obtained by calcination of compound 1 at 500 °C under air atmosphere and were characterised by X-ray diffraction (XRD) and scanning electron microscopy (SEM).     

Synthesis and structural characterization of a yttrium coordination polymer formed by bridging of an acyclic polyether

The amide-type acyclic polyether, 1,2-ethylenedioxy-bis(N-pyridin-2-ylmethyl-benzamide) (L) was synthesized and characterized by EA, IR and ¹H NMR spectroscopy. The reaction of yttrium nitrate with L produced a rare chain structural coordination polymer {[Y(NO₃)₃L(H₂O)]?·?(H₂O)} _n (1) by use of the flexible ligand L as the building blocks. The structure of 1 was determined by X-ray crystallography and thermal analysis. In 1, L, as a bidentate bridging spacer, binds two neighboring Y atoms to form a one-dimensional chain polymer. The chain polymer was further connected into the three-dimensional network by hydrogen bonding interactions.     

Preferential deposition of cyanometallate coordination polymer nanoplates through evaporation of droplets

We reported a room-temperature method to deposit self-adhesive coordination polymers nanoplates on glass slides preferentially.     

A Cu(II) coordination polymer: Crystal structure and therapeutic effect on sepsis

Unique thiocyanate-connected 1-dimensional chain Cu(II) coordination polymer (CP), namely, [Cu₂L¹(μ_1,3-SCN) (η¹SCN)]_n (1), was produced in the existence of KSCN and Cu(NO₃)₂·3H₂O utilizing an underlying multisite N,O donor Schiff base ligand (L¹H₂). [N,N′-bis(3-methoxysalicylidenimino)-1,3-daminopropane] (L¹H₂), the Schiff base ligand is a 1:2 M ratio condensation product of 1,3-diaminopropane and O-vaniline in the methanol medium. The as-created CP 1 has been investigated with various characterization approaches like powder X-ray diffraction (PXRD), fourier transform infrared spectroscopy (FT-IR), elemental analysis (EA), -thermogravimetric analysis (TGA) and single crystal X-ray diffraction (SCXRD) analyses. And the mechanism and therapeutic effect of this CP on sepsis was discussed and its specific mechanism was also assessed. First of all, for the infected animals, their survival rate was recorded after the bacterial infection and treatment of complex. Besides this, utilizing the enzyme linked immunosorbent assay (ELISA) assay, the inflammatory cytokines levels that released into plasma were determined after the exposure of compound.