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1.
A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids [1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A
comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related
N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
*For Communication 151 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 214–222, February, 2009. 相似文献
2.
I. V. Ukrainets L. V. Sidorenko O. S. Golovchenko 《Chemistry of Heterocyclic Compounds》2007,43(11):1434-1439
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding
quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical
N,N′-di(4-hydroxy-2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds
has been carried out.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1687–1692, November, 2007. 相似文献
3.
I. V. Ukrainets L. V. Sidorenko L. A. Petrushova O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2006,42(1):64-69
Several variants were studied for the synthesis of esters of halogen derivatives of 4-hydroxy-2-oxo-1,2-dihydro-3-quinolinecarboxylic
acids, whose reaction with 2-amino-4-methylthiazole gives the corresponding hetarylamides. Results are given for a study of
the antitubercular activity of these products.
Communication 89, see ref. [1].
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 71–76, January, 2006. 相似文献
4.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova N. A. Jaradat 《Chemistry of Heterocyclic Compounds》2006,42(3):343-351
A preparative method is proposed and the synthesis of 4-arylamino-2-oxo-1,2-dihydroquinolines has been effected. An X-ray
structural investigation of 4-(4-chlorophenylamino)-2-oxo-1-propyl-1,2-dihydroquinoline-3-carboxylic acid has been carried
out enabling the ease of decarboxylating such compounds to be substantiated. Results are given of a study of the anti-inflammatory
activity of the synthesized compounds.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 386–395, March, 2006. 相似文献
5.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Slobodzyan 《Chemistry of Heterocyclic Compounds》2007,43(1):63-66
The reaction of 2-ethoxycarbonylmethyl-4H-3,1-benzoxazin-4-one with malononitrile in dry pyridine leads to 1-hydroxy-3,6-dioxo-4,6-dihydro-3H-pyrimido[1,2-a]quinoline-5-carbonitrile.
Acetoacetic and cyanoacetic esters under analogous conditions form anilides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acid while diethyl malonate gives N,N′-di-2-carboxyanilides of malonic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 75–79, January, 2007. 相似文献
6.
I. V. Ukrainets A. A. Tkach V. V. Kravtsova A. V. Turov 《Chemistry of Heterocyclic Compounds》2007,43(12):1525-1531
Treatment of the ethyl esters of 1-R-4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylic acids with zinc dust in glacial acetic
acid gives high yields of diethyl 2,2′-dioxo-1,2,3,4,1′,2′,3′,4′-octahydro[4,4′]biquinolinyl-3,3′-dicarboxylates. The structural
features of the synthesized compounds together with their NMR and mass spectra are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1799–1807, December, 2007. 相似文献
7.
I. V. Ukrainets O. V. Gorokhova L. V. Sidorenko N. L. Bereznyakova 《Chemistry of Heterocyclic Compounds》2007,43(1):58-62
A preparative method of obtaining 1-substituted 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acids is proposed. Features
of their spatial structure have been studied.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 69–74, January, 2007. 相似文献
8.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2006,42(6):776-781
Alkaline hydrolysis of the ethyl ester of 4-(cyanoethoxycarbonylmethyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid is accompanied
by decarboxylation with loss of two molecules of CO2 and leads to 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 887–893, June, 2006. 相似文献
9.
I. V. Ukrainets N. L. Bereznyakova S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2007,43(9):1154-1158
Treatment of ethyl 1-R-4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylates with sodium nitrite in DMSO is a convenient method
for their conversion to the corresponding 4-hydroxy derivatives.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1359–1364, September, 2007. 相似文献
10.
I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov 《Chemistry of Heterocyclic Compounds》2009,45(3):345-350
4-Methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hetarylamides can be prepared by two fundamentally different routes
with allowance made for the thermal stability of the starting hetarylamines.
* For Communication 152 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 426–432, March, 2009. 相似文献
11.
I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov O. I. Naboka 《Chemistry of Heterocyclic Compounds》2008,44(2):178-183
A large series of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides has been prepared as potential diuretic agents.
The effect of all of the synthesized compounds on the urinary function of the kidney has been investigated. The appearance
of a “structure — diuretic activity” relationship is discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 239–245, February, 2008. 相似文献
12.
I. V. Ukrainets A. A. Tkach L. V. Sidorenko O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2006,42(10):1301-1307
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides have been prepared. It has been shown experimentally that
these compounds are brominated by molecular bromine in glacial acetic acid at position 4 of the anilide fragment. The antitubercular
properties of the compounds synthesized are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1508–1516, October, 2006. 相似文献
13.
I. V. Ukrainets L. V. Sidorenko O. V. Gorokhova N. L. Bereznyakova S. V. Shishkina 《Chemistry of Heterocyclic Compounds》2006,42(10):1296-1300
The alkylation of the ethyl esters of 4-methyl, 4-chloro-, and 4-amino substituted 2-oxo-1,2-dihydroquinoline-3-carboxylic
acid by ethyl iodide in the system DMF/K2CO3 has been studied. Features of the structure of the starting compounds and their effect on the ratio of the N-and O-alkyl
products formed are discussed.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1502–1507, October, 2006. 相似文献
14.
I. V. Ukrainets N. L. Bereznyakova I. A. Turaibei 《Chemistry of Heterocyclic Compounds》2008,44(1):50-63
Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral
agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results
are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 61–77, January, 2008. 相似文献
15.
I. Ravina D. Zicane M. Petrova E. Gudriniece U. Kalejs 《Chemistry of Heterocyclic Compounds》2002,38(7):836-839
2-Pyridylaminomethyleneisopropylidenemalonates, prepared from ethoxymethyleneisopropylidenemalonate and 2-aminopyridines, form 4-oxo-4H-pyrido[1,2-a]pyrimidines at their melting points and are separated from the reaction mixture by sublimation. 相似文献
16.
I. V. Ukrainets I. A. Tugaibei N. L. Bereznyakova V. N. Kravchenko A. V. Turov 《Chemistry of Heterocyclic Compounds》2008,44(5):565-575
Alkyl-, arylalkyl-, and arylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid were prepared with a view
to establishing a structure-biological activity relationship. A comparative analysis has been made of their diuretic properties
and those of the structurally similar 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 718–729, May, 2008. 相似文献
17.
V. A. Kovtunenko T. T. Kucherenko O. V. Shishkin V. M Kisel 《Chemistry of Heterocyclic Compounds》2002,38(10):1242-1249
Condensation of 2-cyanomethylbenzoic acid with anthranilic acids gave a series of 2-(4-oxo-3,4-dihydro-2-quinazolinylmethyl)benzoic acids which are structural analogs of the alkaloid glycosminine (2-benzyl-1,2-dihydro-4-quinazolone). 相似文献
18.
I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov O. V. Gorokhova 《Chemistry of Heterocyclic Compounds》2008,44(12):1493-1499
A simple and efficient method for preparing 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid alkyl amides is proposed.
The results of a study of the diuretic activity of the compounds synthesized are reported.
*For communication 149 see [1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1841-1848, December, 2008. 相似文献
19.
I. V. Ukrainets N. L. Bereznyakova V. A. Parshikov V. N. Kravchenko 《Chemistry of Heterocyclic Compounds》2008,44(1):64-72
The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents
leads to the formation of a significant amount of colored side products, consequently it was proposed the reaction be carried
out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride
with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the
urine-excreting function of the kidney.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 78–87, January, 2008. 相似文献
20.
N. Z. Tugusheva L. M. Alekseeva A. S. Shashkov V. G. Granik 《Russian Chemical Bulletin》2006,55(8):1470-1474
The reactions of 3-cyano-3(5)-formyl-2-oxo-4-(phenylamino)-1,2-dihydropyridines with CH acids were studied. The previously
unknown fused 2-pyridone derivatives containing the 4-aminopyridine fragment were synthesized by the Knoevenagel reaction.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1416-1420, August, 2006. 相似文献