第二届全国生物物理化学会议(NCBPC2)暨国际华人生物物理化学发展论坛

由中国化学会主办,武汉大学、华中师范大学承办的第二届全国生物物理化学会议(TheSecondNationalConferenceonBiophysicalChemistry,NCBPC2)暨国际华人生物物理化学发展论坛,将于2012年10月15日-18日在武汉召开。会议的目的是为华人生物物理化学同行提供一个学术交流的平台,促进我国生物物理化学学科的发展。热忱邀请相关领域的科研、教学的科学工作者和研究生参加。     

第一届全国生物物理化学会议通知

<正>由中国化学会主办,北京大学承办的第一届全国生物物理化学会议(The First National Conference on Biophysical Chemistry,1st NCBPC)将于2010年7月5日-7日在北京召开.会议的目的是为生物物理化学同行提供一个学术交流的平台,促进我国生物物理化学学科的发展.热忱邀请相关领域的科学工作者和研究生投稿和参加.     

生物分子液-液相分离的物理化学机制

近年来,有关生物分子通过液-液相分离机制进行组织定位、功能调控的研究发展迅速。相分离产生的聚集体在众多细胞活动事件中发挥了关键作用。这些聚集体的生物功能是以相分离的物理化学性质为基础的。本文将从相分离聚集体的基本性质、相图、微观结构,相分离的统计热力学、实验和分子模拟研究等方面阐释相分离物理化学机制研究相关进展。对于生物分子相分离的重要功能体系进行了列举和归纳,收集了相分离研究的模式体系,探讨了生物分子相分离的生物功能同物理化学机制之间的关系,总结了生物分子相分离的调控机制和调控分子的设计方法,并对生物分子相分离物理化学机制研究的未来发展方向进行了展望。     

第一届全国生物物理化学会议通知

<正>由中国化学会主办,北京大学承办的第一届全国生物物理化学会议(The First National Conference on Biophysical Chemistry,1st NCBPC)将于2010年7月5日-7日在北京召开.会议的目的是为生物物理化学同行提供一个学术交流的平台,促进我国生     

第一届全国生物物理化学会议通知

<正>由中国化学会主办,北京大学承办的第一届全国生物物理化学会议(The First National Conference on Biophysical Chemistry,1st NCBPC)将于2010年7月5日-7日在北京召开.会议的目的是为生物物理化学同行提供一个学术交流的平台,促进我国生     

第一届全国生物物理化学会议通知

<正>由中国化学会主办,北京大学承办的第一届全国生物物理化学会议(The First National Conference on Biophysical Chemistry,1st NCBPC)将于2010年7月5日-7日在北京召开.会议的目的是为生物物理化学同行提供一个学术交流的平台,促进我国生     

水中铬污染治理的研究进展

综述了水中铬污染治理的研究进展,包括物理法、物理化学法、化学法、电化学法和生物处理法,并分别评述了各种处理方法的优缺点,提出了未来含铬废水治理的发展方向。     

水环境中纳米银的生成与转化研究

纳米银因具有优良的杀菌消炎特性及物理化学性能在工业生产、生物医药及日常生活中被广泛应用.纳米银产品的生产和使用会不可避免地向环境释放纳米银,纳米银已被认为是一种新型污染物.纳米银性质较活泼,进入水环境后可能会发生多种物理化学转化,影响其环境归趋、迁移转化及生物效应.因此,研究纳米银在水环境中的赋存形态及转化过程,是科学评估纳米银的环境和生物安全性的基础和前提.本文针对近年来水环境中纳米银的生成及转化方面的研究进展进行了较为全面的总结,包括纳米银的天然化学生成和生物生成,以及纳米银在水环境中的团聚、表面微层富集、氧化溶解、氯化、硫化等物理化学转化,并探讨了后续研究的发展方向.     

重金属生物吸附的研究进展

本文综述了重金属生物吸附的机理、影响生物吸附的物理化学因素和生理条件、生物吸附动力学、生物吸附过程的数学模型化、生物细胞的固定化和从生物量上回收被吸附的重金属等方面的研究进展。     

铅污染土壤的修复技术

综述了铅对土壤的污染及其修复技术。目前应用于污染土壤的修复技术可分为物理化学修复技术和生物修复技术。物理化学修复技术又可分为隔离包埋技术,固化稳定技术,Pyrometalluryical separation,化学稳定技术,电动修复技术等;生物修复技术可分为微生物修复技术和植物修复技术等。以期进一步推动铅污染土壤的治理和修复工作。     

Fluorescence based strategies for genetic analysis

Synthetic chemistry has been central to the design of modern methods of genetic analysis. In this article, we discuss the underlying chemistry and biophysical principles that have been used in the development of robust methods for the analysis of DNA in the diagnostic laboratory.     

Efficient reverse click labeling of azide oligonucleotides with multiple alkynyl Cy-Dyes applied to the synthesis of HyBeacon probes for genetic analysis

A convenient method of oligonucleotide labeling using click chemistry has been developed. A 2′-mesyloxyethyl ribothymidine phosphoramidite monomer was incorporated into DNA at several loci during solid phase oligonucleotide synthesis and converted to 2′-azidoethyl ribothymidine in high yield on the synthesis resin. The resultant azide oligonucleotides were doubly and triply labeled with alkyne-modified cyanine dyes and their biophysical properties were studied. The influence of the dye structures and method of labeling on the fluorescence properties of the DNA probes is discussed and compared with a standard labeling method using active esters of Cy-Dyes.     

Organic mixed-valence compounds: a playground for electrons and holes

Mixed-valence (MV) compounds are excellent model systems for the investigation of basic electron-transfer (ET) or charge-transfer (CT) phenomena. These issues are important in complex biophysical processes such as photosynthesis as well as in artificial electronic devices that are based on organic conjugated materials. Organic MV compounds are effective hole-transporting materials in organic light emitting diodes (OLEDs), solar cells, and photochromic windows. However, the importance of organic mixed-valence chemistry should not be seen in terms of the direct applicability of these species but the wealth of knowledge about ET phenomena that has been gained through their study. The great variety of organic redox centers and spacer moieties that may be combined in MV systems as well as the ongoing refinement of ET theories and methods of investigation prompted enormous interest in organic MV compounds in the last decades and show the huge potential of this class of compounds. The goal of this Review is to give an overview of the last decade in organic mixed valence chemistry and to elucidate its impact on modern functional materials chemistry.     

天然线型四吡咯化合物结构化学的进展

在动植物体内存在着多种线型四吡咯色素,由于它们的结构不同,生理功能也不同。本文从晶体结构、光异构化、在溶液中的构型以及与蛋白相连的结构等四个方面,对近年来胆红素、胆绿素、藻胆色素、植物光敏色素等四吡咯色素在结构化学研究方面所取得的进展作一简单综述。     

Ruthenium(II) polypyridyl complexes and DNA--from structural probes to cellular imaging and therapeutics

In the last few decades, coordination complexes based on d(6) metal centres and polypyridyl ligand architectures been developed as structure- and site-specific reversible DNA binding agents. Due to their attractive photophysical properties, much of this research has focused on complexes based on ruthenium(II) centres and, more recently, attention has turned to the use of these complexes in biological contexts. As the rules that govern the cellular uptake and cellular localisation of such systems are determined they are finding numerous applications ranging from imaging to therapeutics. This review illustrates how the interdisciplinary nature of this research-which takes in synthetic chemistry, biophysical and in cellulo studies-makes this an exciting area in which an array of further applications are likely to emerge.     

In Cellulo Generation of Fluorescent Probes for Live-Cell Imaging of Cylooxygenase-2

Live-cell imaging with fluorescent probes is an essential tool in chemical biology to visualize the dynamics of biological processes in real-time. Intracellular disease biomarker imaging remains a formidable challenge due to the intrinsic limitations of conventional fluorescent probes and the complex nature of cells. This work reports the in cellulo assembly of a fluorescent probe to image cyclooxygenase-2 (COX-2). We developed celecoxib-azide derivative 14 , possessing favorable biophysical properties and excellent COX-2 selectivity profile. In cellulo strain-promoted fluorogenic click chemistry of COX-2-engaged compound 14 with non/weakly-fluorescent compounds 11 and 17 formed fluorescent probes 15 and 18 for the detection of COX-2 in living cells. Competitive binding studies, biophysical, and comprehensive computational analyses were used to describe protein-ligand interactions. The reported new chemical toolbox enables precise visualization and tracking of COX-2 in live cells with superior sensitivity in the visible range.     

Hierachical classification of physiologically active substances

In a first attempt at a hierarchical classification of physiologically active substances, these substances were divided into two classes corresponding to their effect on the main cellular signaling systems. That some general principles of the chemical structure of drugs do exist has been demonstrated using quantum chemistry methods, artificial intelligence, and biophysical approaches. Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, 1 Murmanskaya ul., Kiev 253094, Ukraine. Translated from Teoreticheskaya i éksperimental'naya Khimiya, Vol. 34, No. 4, pp. 199–213, July–August, 1998.     

STRUCTURAL PROPOSALS FOR THE MANGANESE CENTERS OF THE OXYGEN EVOLVING COMPLEX: AN INORGANIC CHEMIST'S PERSPECTIVE*

Abstract— This contribution provides an analysis of the basic coordination tendencies of manganese with specific emphasis on the biological chemistry of this element. The review is broken into four parts. First, a discussion of the basic coordination chemistry of manganese is mononuclear and multinuclear environments is presented. Second, the biophysical data essential to the development of models for the active center of the photosystem is examined. Third, recently reported mononuclear and cluster manganese compounds are profiled with an emphasis on relating the physical parameters of the models to the structure and function of the enzymatic system. Finally, a comparison is made between the OEC and other known manganoenzymes which metabolize the O₂^n-moiety.     

Modulation of Hydrophobic Interaction by Mediating Surface Nanoscale Structure and Chemistry,not Monotonically by Hydrophobicity

The hydrophobic (HB) interaction plays a critical role in many colloidal and interfacial phenomena, biophysical and industrial processes. Surface hydrophobicity, characterized by the water contact angle, is generally considered the most dominant parameter determining the HB interaction. Herein, we quantified the HB interactions between air bubbles and a series of hydrophobic surfaces with different nanoscale structures and surface chemistry in aqueous media using a bubble probe atomic force microscopy (AFM). Surprisingly, it is discovered that surfaces of similar hydrophobicity can show different ranges of HB interactions, while surfaces of different hydrophobicity can have similar ranges of HB interaction. The increased heterogeneity of the surface nanoscale structure and chemistry can effectively decrease the decay length of HB interaction from 1.60 nm to 0.35 nm. Our work provides insights into the physical mechanism of HB interaction.     

Modulation of Hydrophobic Interaction by Mediating Surface Nanoscale Structure and Chemistry,not Monotonically by Hydrophobicity

The hydrophobic (HB) interaction plays a critical role in many colloidal and interfacial phenomena, biophysical and industrial processes. Surface hydrophobicity, characterized by the water contact angle, is generally considered the most dominant parameter determining the HB interaction. Herein, we quantified the HB interactions between air bubbles and a series of hydrophobic surfaces with different nanoscale structures and surface chemistry in aqueous media using a bubble probe atomic force microscopy (AFM). Surprisingly, it is discovered that surfaces of similar hydrophobicity can show different ranges of HB interactions, while surfaces of different hydrophobicity can have similar ranges of HB interaction. The increased heterogeneity of the surface nanoscale structure and chemistry can effectively decrease the decay length of HB interaction from 1.60 nm to 0.35 nm. Our work provides insights into the physical mechanism of HB interaction.